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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Toxicity of Graphene Quantum Dots in Zebrafish Embryo显示文摘Objective To evaluate the bio-safety of graphene quantum dots(GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/m L for 4-96 h post-fertilization(hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs(200 μg/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 μg/mL. The larval behavior testing(visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 μg/mL showed hyperactivity while exposure to higher concentrations(25, 50, 100, and 200 μg/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 μg/mL. | WANG Zhen Guo ZHOU Rong JIANG Dan SONG Jing E XU Qian SI Jing CHEN Yun Ping ZHOU Xin GAN Lu LI Jian Zhen ZHANG Hong LIU Bin | 2015 | Biomedical and Environmental Sciences2015，28，5： | 6 |
| 3 | Chaperone-mediated autophagy:roles in neuroprotection显示文摘Chaperone-mediated autophagy(CMA), one of the main pathways of lysosomal proteolysis, is characterized by the selective targeting and direct translocation into the lysosomal lumen of substrate proteins containing a targeting motif biochemically related to the pentapeptide KFERQ. Along with the other two lysosomal pathways, macro- and micro-autophagy, CMA is essential for maintaining cellular homeostasis and survival by selectively degrading misfolded, oxidized, or damaged cytosolic proteins. CMA plays an important role in pathologies such as cancer, kidney disorders, and neurodegenerative diseases. Neurons are post-mitotic and highly susceptible to dysfunction of cellular quality-control systems. Maintaining a balance between protein synthesis and degradation is critical for neuronal functions and homeostasis. Recent studies have revealed several new mechanisms by which CMA protects neurons through regulating factors critical for their viability and homeostasis. In the current review, we summarize recent advances in the understanding of the regulation and physiology of CMA with a specific focus on its possible roles in neuroprotection. | Zhibiao Cai Weijun Zeng Kai Tao Zhen E Bao Wang Qian Yang | 2015 | Neuroscience Bulletin2015，31，4： | 4 |
| 4 | Multiple sgRNAs facilitate base editingmediated i-stop to induce complete and precise gene disruption显示文摘Dear Editor,Gene editing is a process to introduce desired changes into targeted loci of genomic DNA.Recently,type II clustered regularly in terspaced short palindromic repeats-associated Cas9 endonuclease(CRISPR/Cas9)system has been demonstrated as a versatile tool for engineering eukaryote genome(Hsu et al.,2014),such as in mice(Zuo et al.,2017). | Kun Jia Zongyang Lu Fei Zhou Zhiqi Xiong Rui Zhang Zhiwei Liu Yu'e Ma Lei He Cong Li Zhen Zhu Dejing Pan Zhengxing Lian | 2019 | Protein & Cell2019，10，11： | 3 |
| 5 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non--sta- tionary time series analysis 显示文摘 | HUANG N E ZHEN Shen LONG SR etal | 1998 | Proc R Soc Lond A1998，454，： | 1 |
| 6 | The empirical mode decomposition and the Hilbert spectrum for nolinear and non-stationary time series a- nalysis 显示文摘 | Huang Norden E Zhen Shen Long Steven R | 1998 | Proceedings: Mathematical Physical and Engineering Sciences Royal Society Lond1998，，： | 1 |
| 7 | Further studied on an improved finite element method for moving conductor eddy current problems 显示文摘 | Zhenning Liu Anthony R Eastham Graham E Dawson | 1994 | IEEE Transaction on Magnetics1994，30，5： | 1 |
| 8 | Acidic residues necessary for pyrophosphate-energized pumping and inhibition of the vacuolar H+-pyrophosphatase by N,N'-dicyclohexylcarbodiimide显示文摘 | Zhen R G Kim E J Rea P A | 1997 | Journal of Biological Chemistry1997，272，22： | 1 |
| 9 | A New View of Nonlinear Water Waver:the Hilbert Spectrum显示文摘 | Norden E Huang Zhen Shen | 1999 | Ann Rev Fluid Mech1999，31，： | 1 |
| 10 | Human coronaviruses are uncommon in patients with gastrointestinal illness显示文摘 | Frank E Zhen O Yung T H | 2010 | J Clin Virol2010，48，2： | 1 |
| 11 | Ultrahigh-aspect-ratio Titania Nanotubes显示文摘 | RICHTER C WU Zhen PANAITESCU E | 2007 | Advanced Materials2007，19，7： | 1 |
| 12 | Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers显示文摘 | Hugh E Criswell Zhen Ming Nathanial Pleasant Benjamin L Griffith Robert A Mueller George R Breese | 2004 | Brain Research2004，，1： | 1 |
| 13 | An ecoepidemiological predator- prey model with standard disease incidence 显示文摘 | Haque M Zhen Jin Venturino E | 2009 | Mathematical Methods in the Applied Sciences2009，32，7： | 1 |
| 14 | A decision model for berth allocation under uncertainty显示文摘 | ZHEN L LEE L H CHEW E P | | 0，，： | 1 |
| 15 | Blocking artifact reduction using a transform-domain markov random field moel显示文摘 | LI Zhen Delp E J | | 0，，12： | 1 |
| 16 | The empirical mode decomposition and Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | Huang N E Zhen S Long S R eta | 1998 | Proceedings of the Royal Society of London1998，454，： | 1 |
| 17 | Non-invasive exclusion of fetal aneuploidy in an at-risk couple with a bal- anced translocation显示文摘 | Wang J Y Zhen D K Zilberstein M E | 2000 | Mol Hum Rep rod2000，6，2： | 1 |
| 18 | A new view of nonlinear water waves: the Hilbert spectrum 显示文摘 | Huang N E Zhen S Long S R | 1999 | Annum Review of Fluid Mechanics1999，31，： | 1 |
| 19 | Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop 显示文摘 | Woo W 'M Zhen H H Oro A E | 2012 | Genes Dev2012，26，11： | 1 |
| 20 | Deformation behavior and microstructure evolution of 7050 aluminum alloy during high temperature deformation显示文摘 | HU H E ZHEN L YANG L SHAO W Z ZHANG B Y | 2008 | Materials Science and Engineering A2008，488，： | 1 |
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