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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 3 | Molecular Epidemiology of Echovirus 18 Circulating in China's Mainland from 2015 to 2016显示文摘Echovirus 18(E18), a serotype of Enterovirus B(EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in China's Mainland, but became the predominant pathogen associated with viral encephalitis(VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in China's Mainland, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease(HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from China's Mainland after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 50-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiplerecombinant viruses. Overall, these findings supported that E18 caused HFMD, VE, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics. | Xiangpeng Chen Tianjiao Ji Jiayun Guo Wei Wang Wenbo Xu Zhengde Xie | 2019 | Virologica Sinica2019，34，1： | 10 |
| 4 | Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China:A nationwide retrospective study显示文摘Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China. | Mengjia Liu Xinyu Wang Linlin Zhang Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie | 2022 | Virologica Sinica2022，37，5： | 10 |
| 5 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 6 | Primary Study on Quantitative Reconstruction of Middle-Late Eocene Climate in Jianghan Basin显示文摘This paper reports our primary effort in the quantitative reconstruction of paleoclimate based on the thrine in phytoecology of the affinity parent plants in the stratigraphic pollen records. The Eocene pollen data come from our former study on the Mingjia borehole 1 in the Jianghan basin. The fluctuating trend in the parameter curve of climate shows that the climate in the Middle Eocene in the Jianghan basin was more or less comparable with that of the present 22°-26°N, characteristic of a humid, semi humid central southern subtropical climate. The annual temperature at that time dropped by 1 ℃-4 ℃ in the Late Eocene, approximately equal to that of the present 23°-28°N of northern central subtropical climate. However, the climate composite at that time, characterized by higher temperature, small annual range and big fluctuation in precipitation, was quite different from the present one. The average temperature in January in the Middle Eocene, higher than that of today, ranged between 5 ℃ and 9 ℃, indicating that no effect of winter monsoon occurred in the Middle Eocene, though such an effect may have occurred occasionally in the Late Eocene. Major temperature decline is recognized at the depth of 2 100 m in the borehole, as was indicated by the decline in average January temperature, the increase in annual range, and the increase in the deciduous broad leaved types of trees in the spore pollen assemblage. The sharp fluctuation in the annual precipitation, usually raging from 300 to 1 700 mm, was favorable for the migration and accumulation of salty deposit. When the precipitation was lower than 1 000 mm, ephemera shrub increased at the same depth as that of the salty deposit. It is, therefore, deduced that the formation of the salty deposit was attributed mainly to the dry and hot environment in the high mountains and deep basins. The small annual precipitation and the intense fluctuation are favorable for the sustainable accumulation of the salts, which is different from the present salty accumulation in the Northwest China. | Tong Guobang Liu Zhiming Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Zhengding 050803 Open Laboratory of Saline Lake Resources and Environment, Chinese Academy of Geological Sciences, Beijing 100037 Zheng Mianping Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037 Research & Development Center of Saline Lake and Epithermal Deposit, Chinese Academy of Geological Sciences, Beijing 100037 Wang Weiming Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008 | 2002 | Journal of China University of Geosciences2002，13，3： | 5 |
| 7 | A Novel Image Enhancement Method for SIFT Feature Extraction of Low Resolution Palmprint Images显示文摘 | LIU Di SUN Dongmei QIU Zhengding | 2011 | Chinese Journal of Electronics2011，20，1： | 4 |
| 8 | Pay attention to SARS-CoV-2 infection in children显示文摘The novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS・CoV-2)has been prevalent for nearly two months.The first case of COVID-19 was reported in Wuhan,Hubei Province,China in mid-December,2019.On January 9,2020,Chinese scientists isolated and obtained the genome sequence of the new virus;they shared the genome information on releva nt international websites one day later. | Zhengde Xie | 2020 | Pediatric Investigation2020，4，1： | 3 |
| 9 | Blast furnace ironmaking process with super high TiO_(2) in the slag:Density and surface tension of the slag显示文摘Aiming at the process of smelting ultra-high(>80%)or even full vanadium titanomagnetite in blast furnace,we are conducting a series of works on physics character of high TiO_(2) bearing blast furnace slag(BFS)for slag optimization.This work discussed the density and surface tension of high TiO_(2) bearing BFS using the Archimedean principle and the maximum bubble pressure method,respectively.The influence of TiO_(2) content and the MgO/CaO mass ratio on the density and surface tension of CaO-SiO_(2)-TiO_(2)-MgO-Al_(2)O_(3)slags were investigated Results indicated that the density of slags decreased with the TiO_(2) content increasing from 20wt%to 30wt%,but it increased slightly with the MgO/CaO mass ratio increasing from 0.32 to 0.73.In view of silicate network structure,the density and the degree of polymerization(DOP)of network structure have a consistent trend.The addition of TiO_(2) reduced(Q^(3))^(2)/(Q^(2)) ratio(Q^(2) and Q^(3) represent structural unit with bridge oxygen number of 2 and 3,respectively)and then decreased DOP,which led to the decrease of slag density.The surface tension of CaO-SiO_(2)-TiO_(2)-MgO-Al_(2)O_(3) slags decreased dramatically with the TiO_(2) content increasing from 20wt%to 30wt%.Conversely,it increased with the MgO/CaO mass ratio increasing from 0.32 to 0.73.Furthermore,the iso-surface tension lines were obtained under 1723 K using the Tanaka developed model in view of Butler formula.It may be useful for slag optimization of ultra-high proportion(>80%)or even full vanadium titanomagnetite under BF smelting. | Zhengde Pang Yuyang Jiang Jiawei Ling Xuewei Lü Zhiming Yan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 3 |
| 10 | Recombinant GII.4[P31] Was Predominant Norovirus Circulating in Beijing Area, China, 2018–2020显示文摘Dear Editor,Acute gastroenteritis(AGE)is a leading infectious cause of morbidity worldwide,particularly among children in developing countries(Mortality and Causes of Death2016).With the introduction of rotavirus vaccines,noroviruses have been identified as a leading cause of AGE outbreaks and sporadic disease worldwide(Hall et al. | Junhong Ai Meng Zhang Fang Jin Zhengde Xie | 2021 | Virologica Sinica2021，36，5： | 2 |
| 11 | ANALYSIS OF WAVEGUIDE PROBLEMS USING A RELAXED ITERATIVE DOMAIN DECOMPOSITION METHOD COMBINED WITH MULTIFRONTAL ALGORITHM显示文摘In this paper, an absorbing Fictitious Boundary Condition (FBC) is presented to generate an iterative Domain Decomposition Method (DDM) for analyzing waveguide problems.The relaxed algorithm is introduced to improve the iterative convergence. And the matrix equations are solved using the multifrontal algorithm. The resulting CPU time is greatly reduced.Finally, a number of numerical examples are given to illustrate its accuracy and efficiency. | Zhu Hanqing Wu Zhengde (Applied Physics Institute, University of Electronic Science and Technology of China, Chengdu 610054)K. M. Luk(Department of Electronic Eng., City University of Hong Kong, Kowloon, Hong Kong SAR, China) | 2003 | Journal of Electronics(China)2003，20，2： | 2 |
| 12 | Seroprevalence of SARS-CoV-2 infections among children visiting a hospital显示文摘Importance:In this study,we retrospectively investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibodies within serum samples from children in Beijing,China.These findings provide preliminary guidance regarding population susceptibility to SARS-CoV-2,which will aid in establishing policy toward coronavirus disease 2019(COVID-19)prevention and control.Objective:To understand the seropositivity of anti-SARS-CoV-2 IgM/IgG antibodies among children in Beijing,China,evaluate the susceptibility of children in Beijing to SARS-CoV-2,and provide prima facie evidence to guide SARS-CoV-2 prevention and control.Methods:IgM/IgG antibody kits(colloidal gold)were used to conduct preliminary screening of SARS-CoV-2 IgM/IgG antibodies in serum samples of children who presented to Beijing Children’s Hospital,Capital Medical University,having fever or requiring hospitalization,from March 2020 to August 2020.Statistical analysis of anti-SARS-CoV-2 antibody seropositivity was performed according to the children’s general demographic characteristics,timing of admission to hospital,presence of pneumonia,and viral nucleic acid test results.Results:The study included 19797 children with both IgM and IgG antibody results.Twenty-four children had anti-SARS-CoV-2 IgM-positive results(positive rate of 1.2‰),twelve children had anti-SARS-CoV-2 IgG-positive results(positive rate of 0.6‰).Viral nucleic acid test results were negative for the above-mentioned children with positive antibody findings;during the study,two children exhibited positive viral nucleic acid test results,but their anti-SARS-CoV-2 IgM/IgG antibody results were negative.Anti-SARS-CoV-2 IgM antibody seropositivity was higher in the<1-year-old group than in the≥6-year-old group.The rates of anti-SARS-CoV-2 IgM seropositivity was highest in August from March to August;IgG results did not significantly differ over time.The rates of anti-SARS-CoV-2 IgM or IgG seropositivity among children with and without suspected pneumonia did not significantly differ between groups.Interpretation:During the study period,the rates of anti-SARS-CoV-2 IgM/IgG antibody seropositivity were low among children who presented to Beijing Children’s Hospital,Capital Medical University.The findings suggest that children in Beijing are generally susceptible to SARS-CoV-2 infection;COVID-19 prevention and control measures should be strengthened to prevent disease in children. | Ran Wang Fang Jin Shuhui Cao Hong Yuan Jingchen Qu Jiaqi Zhang Yuxuan Li Xiangpeng Chen Wenqi Song Zhengde Xie | 2020 | Pediatric Investigation2020，4，4： | 2 |
| 13 | SIMPLE QUALITY ASSESSMENT FOR BINARY IMAGES显示文摘Usually image assessment methods could be classified into two categories: subjective as-sessments and objective ones. The latter are judged by the correlation coefficient with subjective quality measurement MOS (Mean Opinion Score). This paper presents an objective quality assessment algorithm special for binary images. In the algorithm, noise energy is measured by Euclidean distance between noises and signals and the structural effects caused by noise are described by Euler number change. The assessment on image quality is calculated quantitatively in terms of PSNR (Peak Signal to Noise Ratio). Our experiments show that the results of the algorithm are highly correlative with subjective MOS and the algorithm is more simple and computational saving than traditional objective assessment methods. | Zhang Chun'e Qiu Zhengding | 2007 | Journal of Electronics(China)2007，24，2： | 2 |
| 14 | Fe_3O_4@PAM@NTA-Ni^(2+) Magnetic Composite Nanoparticles for Highly Specific Separation of His-tagged Proteins显示文摘A facile approach has been developed to synthesize Fe_3O_4@PAM(polyacrylamide) nanoparticles(NPs) with carboxyl groups on the surfaces by copolymerization with acrylamide and acrylic acid in Fe_3O_4 NPs aqueous suspension. Nitrilotriacetic acid(NTA) was conjugated to the magnetic NPs via well-known carboniimide chemistry using EDC and NHS. The Ni^(2+) ions loaded on the surface of NPs provide abundant docking sites for immobilization of His-tagged green fluorescent proteins(His-tagged GFP). The high magnetic property of Fe_3O_4@PAM@NTA-Ni^(2+) allows an easy separation of the NPs from solution under an external magnetic field, with high His-tagged protein binding capacity(42 μg protein/mg of NPs). The NPs can be recycled for at least four times without significant loss of binding capacity to proteins. These materials show great potential to separate His-tagged protein with low-cost purification at industrial scale. | 郭惠玲 SUN Honghao SU Zhengding HU Shuchao WANG Xiaotao | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，3： | 2 |
| 15 | Exponential attractors of the nonlinear wave equations显示文摘The (E, E)-type exponential attractors for the nonlinear wave equation were obtained by using the decomposition of operators and finite covering method.This results solves the open problem of Eden et al. | DAI Zhengde 1 and MA Dacai 2 1. Department of Mathematics, Yunnan University, Kunming 650031, China 2. Department of Mathematics, Shangrao Teachers College, Shangrao 334000, China | 1998 | Chinese Science Bulletin1998，43，16： | 2 |
| 16 | Trust Degree of Web Services and Its Evaluation with Neural Network显示文摘The concept and definition of trust degree of Web service is given. Evaluating trust degree of Web services with the method of neural network from the aspect of trust history sequence is proposed. The principle of the method, applicable neural network structure, neural network constructing, input standardization, training sample constructing, and the procedure of evaluating trust degree of Web services with trained neural network are described. Experiments show that it is feasible and effective to evaluate trust degree of Web Service with neural network. | HUANG Baohua HU Heping LU Zhengding YAO Hanbing LI Ruixuan | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 2 |
| 17 | A Formal Model for BPEL4WS Description of Web Service Composition显示文摘Communicating Sequential Processes (CSP) is a kind of process algebra, which is suitable for modeling and verifying Web service composition. This paper describes how to model Web service composition with CSP. A set of rules for translating composition constructor of Business Process Execution Language for Web Services (BPEL4WS) to CSP notations is defined. According to the rules that have been defined, the corresponding translation algorithm is designed and illustrated with examples . The methods for model checking, model verification and model simulation are also introduced. | GU Xiwu LU Zhengding | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 2 |
| 18 | Volatility spillover effect between financial markets:evidence since the reform of the RMB exchange rate mechanism显示文摘The volatility spillover effect between the foreign exchange and stock markets has been a major issue in economic and financial studies.In this paper,GC-MSV model was used to study the spillover effect between the foreign exchange market and the stock market after the reform of the RMB exchange rate mechanism.The empirical results show that there is a negative correlation of dynamic price spillovers between the foreign exchange and stock markets.There are asymmetric volatility spillover effects between these two markets for both RMB stages—continued RMB appreciation or constant RMB shock(a significant reduction in appreciation).However,this has been reduced over time.In conclusion,The RMB exchange rate is a key variable that can affect the internal and external equilibrium of the national economy in an open economic environment,and the stock market is capable of quickly reflecting subtle changes in the real economy.In order to keep the stability of the financial markets and the healthy and rapid development of national economy,some suggestions were proposed. | Zhengde Xiong Lijun Han | 2015 | Financial Innovation2015，1，1： | 2 |
| 19 | Genetic Analysis of Human Adenovirus Type 7 Strains Circulating in Different Parts of China显示文摘To investigate the molecular epidemiology and genetic variation of human adenovirus type 7(HAdV-7)in children with acute respiratory infections(ARI)in China.HAdV-7-positive respiratory samples collected from children with ARI in Beijing,Shijiazhuang,Wenzhou and Guangzhou from 2014–2018 were selected for gene amplification and sequence analysis.Fifty-seven HAdV-7 clinical strains with hexon,penton base and fiber gene sequences were obtained.Meanwhile17 strains were selected randomly from different cities for whole genome sequencing.Phylogenetic and variation analyses were performed based on the obtained sequences,HAdV-7 prototype strain Gomen(AY594255),vaccine strains(AY495969 and AY594256)and representative sequences of strains.The phylogenetic trees constructed based on whole genome sequences,major capsid protein genes(hexon,penton base and fiber)and the early genes(E1,E2,E3 and E4)were not completely consistent.The HAdV-7 strains obtained in this study always clustered with most of the circulating strains worldwide from the 1980 s to the present.Compared with the HAdV-7 prototype strain Gomen(AY594255),some amino acid mutations in loop1 and loop2 of hexon and the RGD loop region of the penton base gene were observed.Recombination analysis showed that partial regions of 55 k Da protein and 100 kDa hexon-assembly associated protein genes among all HAdV-7 strains in this study were from HAdV-16 and HAdV-3,respectively.Our study demonstrated the molecular evolution characteristics of HAdV-7 strains circulating in China and provided basic reference data for the prevention,control and vaccine development of HAdV-7. | Yali Duan Changchong Li Li Deng Shuhua An Yun Zhu Wei Wang Meng Zhang Lili Xu Baoping Xu Xiangpeng Chen Zhengde Xie | 2021 | Virologica Sinica2021，36，3： | 2 |
| 20 | A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019显示文摘Human respiratory syncytial virus(RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we performed a molecular epidemiological study during 2015–2019. A total of 964 RSV-positive specimens were identified from 5529 enrolled patients during a multi-center study. RSV subgroup A(RSV-A) was the predominant subgroup during this research period except in2016. Totally, 535 sequences of the second hypervariable region(HVR-2) of the G gene were obtained. Combined with182 Chinese sequences from GenBank, phylogenetic trees showed that 521 RSV-A sequences fell in genotypes ON1(512),NA1(6) and GA5(3), respectively;while 196 RSV-B sequences fell in BA9(193) and SAB4(3). ON1 and BA9 were the only genotypes after December 2015. Genotypes ON1 and BA9 can be separated into 10 and 7 lineages, respectively. The HVR-2 of genotype ON1 had six amino acid changes with a frequency more than 10%, while two substitutions H258 Q and H266 L were co-occurrences. The HVR-2 of genotype BA9 had nine amino acid substitutions with a frequency more than10%, while the sequences with T290 I and T312 I were all from 2018 to 2019. One N-glycosylation site at 237 was identified among ON1 sequences, while two N-glycosylation sites(296 and 310) were identified in the 60-nucleotide duplication region of BA9. To conclusion, ON1 and BA9 were the predominant genotypes in China during 2015–2019. For the genotypes ON1 and BA9, the G gene exhibited relatively high diversity and evolved continuously. | Xiangpeng Chen Yun Zhu Wei Wang Changchong Li Shuhua An Gen Lu Rong Jin Baoping Xu Yunlian Zhou Aihuan Chen Lei Li Meng Zhang Zhengde Xie | 2021 | Virologica Sinica2021，36，6： | 2 |
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