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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | Ultrasensitive broadband phototransistors based on perovskite/organic-semiconductor vertical heterojunctions显示文摘Organolead halide perovskites have emerged as the most promising materials for various optoelectronic devices,especially solar cells,because of their excellent optoelectronic properties.Here,we present the first report of low-voltage high-gain phototransistors based on perovskite/organic-semiconductor vertical heterojunctions,which show ultrahigh responsivities of~10^(9)A W^(–1) and specific detectivities of~10^(14) Jones in a broadband region from the ultraviolet to the near infrared.The high sensitivity of the devices is attributed to a pronounced photogating effect that is mainly due to the long carrier lifetimes and strong light absorption in the perovskite material.In addition,flexible perovskite photodetectors have been successfully prepared via a solution process and show high sensitivity as well as excellent flexibility and bending durability.The high performance and facile solution-based fabrication of the perovskite/organic-semiconductor phototransistors indicate their promise for potential application for ultrasensitive broadband photodetection. | Chao Xie Peng You Zhike Liu Li Li Feng Yan | 2017 | Light(Science & Applications)2017，6，1： | 12 |
| 4 | Active Vaccine Safety Surveillance: Global Trends and Challenges in China显示文摘Importance.The great success in vaccine-preventable diseases has been accompanied by vaccine safety concerns.This has caused vaccine hesitancy to be the top 10 in threats to global health.The comprehensive understanding of adverse events following immunization should be entirely based on clinical trials and postapproval surveillance.It has increasingly been recognized worldwide that the active surveillance of vaccine safety should be an essential part of immunization programs due to its complementary advantages to passive surveillance and clinical trials.Highlights.In the present study,the framework of vaccine safety surveillance was summarized to illustrate the importance of active surveillance and address vaccine hesitancy or safety concerns.Then,the global progress of active surveillance systems was reviewed,mainly focusing on population-based or hospital-based active surveillance.With these successful paradigms,the practical and reliable ways to create robust and similar systems in China were discussed and presented from the perspective of available databases,methodology challenges,policy supports,and ethical considerations.Conclusion.In the inevitable trend of the global vaccine safety ecosystem,the establishment of an active surveillance system for vaccine safety in China is urgent and feasible.This process can be accelerated with the consensus and cooperation of regulatory departments,research institutions,and data owners. | Zhike Liu Ruogu Meng Yu Yang Keli Li Zundong Yin Jingtian Ren Chuanyong Shen Zijian Feng Siyan Zhan | 2021 | Health Data Science2021，，1： | 2 |
| 5 | Interfacial engineering of printable bottom back metal electrodes for full-solution processed flexible organic solar cells显示文摘Printing of metal bottom back electrodes of flexible organic solar cells(FOSCs) at low temperature is of great significance to realize the full-solution fabrication technology. However, this has been difficult to achieve because often the interfacial properties of those printed electrodes, including conductivity, roughness, work function,optical and mechanical flexibility, cannot meet the device requirement at the same time. In this work, we fabricate printed Ag and Cu bottom back cathodes by a low-temperature solution technique named polymer-assisted metal deposition(PAMD) on flexible PET substrates. Branched polyethylenimine(PEI) and ZnO thin films are used as the interface modification layers(IMLs) of these cathodes. Detailed experimental studies on the electrical, mechanical, and morphological properties, and simulation study on the optical properties of these IMLs are carried out to understand and optimize the interface of printed cathodes. We demonstrate that the highest power conversion efficiency over 3.0% can be achieved from a full-solution processed OFSC with the device structure being PAMDAg/PEI/P3 HT:PC_(61)BM/PH1000. This device also acquires remarkable stability upon repeating bending tests. | Hongyu Zhen Kan Li Yaokang Zhang Lina Chen Liyong Niu Xiaoling Wei Xu Fang Peng You Zhike Liu Dongrui Wang Feng Yan Zijian Zheng | 2018 | Journal of Semiconductors2018，39，1： | 2 |
| 6 | Optical coherent dot-product chip for sophisticated deep learning regression显示文摘Optical implementations of neural networks(ONNs)herald the next-generation high-speed and energy-efficient deep learning computing by harnessing the technical advantages of large bandwidth and high parallelism of optics.However,due to the problems of the incomplete numerical domain,limited hardware scale,or inadequate numerical accuracy,the majority of existing ONNs were studied for basic classification tasks.Given that regression is a fundamental form of deep learning and accounts for a large part of current artificial intelligence applications,it is necessary to master deep learning regression for further development and deployment of ONNs.Here,we demonstrate a silicon-based optical coherent dot-product chip(OCDC)capable of completing deep learning regression tasks.The OCDC adopts optical fields to carry out operations in the complete real-value domain instead of in only the positive domain.Via reusing,a single chip conducts matrix multiplications and convolutions in neural networks of any complexity.Also,hardware deviations are compensated via in-situ backpropagation control provided the simplicity of chip architecture.Therefore,the OCDC meets the requirements for sophisticated regression tasks and we successfully demonstrate a representative neural network,the AUTOMAP(a cutting-edge neural network model for image reconstruction).The quality of reconstructed images by the OCDC and a 32-bit digital computer is comparable.To the best of our knowledge,there is no precedent of performing such state-of-the-art regression tasks on ONN chips.It is anticipated that the OCDC can promote the novel accomplishment of ONNs in modern AI applications including autonomous driving,natural language processing,and scientific study. | Shaofu Xu Jing Wang Haowen Shu Zhike Zhang Sicheng Yi Bowen Bai Xingjun Wang Jianguo Liu Weiwen Zou | 2021 | Light(Science & Applications)2021，10，12： | 2 |
| 7 | Unraveling Passivation Mechanism of Imidazolium-Based Ionic Liquids on Inorganic Perovskite to Achieve Near-Record-Efficiency CsPbI_(2)Br Solar Cells显示文摘The application of ionic liquids in perovskite has attracted wide-spread attention for its astounding performance improvement of perovskite solar cells(PSCs).However,the detailed mechanisms behind the improvement remain mysterious.Herein,a series of imidazolium-based ionic liquids(IILs)with different cations and anions is systematically investigated to elucidate the passivation mechanism of IILs on inorganic perovskites.It is found that IILs display the following advantages:(1)They form ionic bonds with Cs^(+)and Pb^(2+)cations on the surface and at the grain boundaries of perovskite films,which could effectively heal/reduce the Cs^(+)/I−vacancies and Pb-related defects;(2)They serve as a bridge between the perovskite and the hole-transport-layer for effective charge extraction and transfer;and(3)They increase the hydrophobicity of the perovskite surface to further improve the stability of the CsPbI_(2)Br PSCs.The combination of the above effects results in suppressed non-radiative recombination loss in CsPbI_(2)Br PSCs and an impressive power conversion efficiency of 17.02%.Additionally,the CsPbI_(2)Br PSCs with IILs surface modification exhibited improved ambient and light illumination stability.Our results provide guidance for an indepth understanding of the passivation mechanism of IILs in inorganic perovskites. | Jie Xu Jian Cui Shaomin Yang Yu Han Xi Guo Yuhang Che Dongfang Xu Chenyang Duan Wenjing Zhao Kunpeng Guo Wanli Ma Baomin Xu Jianxi Yao Zhike Liu Shengzhong Liu | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 8 | The application of bismuth- based oxides in organic-inorganic hybrid photovoltaie devices显示文摘 | Liu Zhike Yan Feng | 2012 | Journal of the American Ceramic Society2012，95，6： | 1 |
| 9 | Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance显示文摘The bioaccumulation of mercury(Hg)in aquatic ecosystem poses a potential health risk to human being and aquatic organism.Bioaccumulations by plankton represent a crucial process of Hg transfer from water to aquatic food chain.However,the current understanding of major factors affecting Hg accumulation by plankton is inadequate.In this study,a data set of 89 aquatic ecosystems worldwide,including inland water,nearshore water and open sea,was established.Key factors influencing plankton Hg bioaccumulation(i.e.,plankton species,cell sizes and biomasses)were discussed.The results indicated that total Hg(THg)and methylmercury(MeHg)concentrations in plankton in inland waters were significantly higher than those in nearshore waters and open seas.Bioaccumulation factors for the logarithm of THg and MeHg of phytoplankton were 2.4–6.0 and 2.6–6.7 L/kg,respectively,in all aquatic ecosystems.They could be further biomagnified by a factor of 2.1–15.1 and 5.3–28.2 from phytoplankton to zooplankton.Higher MeHg concentrations were observed with the increases of cell size for both phyto-and zooplankton.A contrasting trend was observed between the plankton biomasses and BAF_(MeHg),with a positive relationship for zooplankton and a negative relationship for phytoplankton.Plankton physiologic traits impose constraints on the rates of nutrients and contaminants obtaining process from water.Nowadays,many aquatic ecosystems are facing rapid shifts in nutrient compositions.We suggested that these potential influences on the growth and composition of plankton should be incorporated in future aquatic Hg modeling and ecological risk assessments. | Zhike Li Jie Chi Zhenyu Wu Yiyan Zhang Yiran Liu Lanlan Huang Yiren Lu Minhaz Uddin Wei Zhang Xuejun Wang Yan Lin Yindong Tong | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 1 |
| 10 | In-situ photoisomerization of azobenzene to inhibit ion-migration for stable high-efficiency perovskite solar cells显示文摘Ion migration is a notorious problem in perovskite solar cells(PSCs)that severely mutilates device performance.Herein,a strategy to inhibit ion migration in situ is developed by using photoisomerization of azobenzene(AZO)to immobilize cations in the lattice.During the nucleation process,the photoisomerized cis-AZO reacts with FA^(+),MA^(+)and Pb2+cations in the perovskite precursor by synergistic cation-πinteraction and Lewis base coordination,leading to heterogeneous nucleation to produce uniform perovskite film.Meanwhile,it accelerates conversion of intermediate yellowδ-phase to desired black aphase of FAPb I3for improved crystallinity with well-passivated grain surface.Consequently,defect density is effectively reduced for the perovskite film to demonstrate suppressed carrier recombination and enhanced carrier extraction.Subsequently,the solar cell efficiency is elevated from 21.29%to 23.58%with negligible J-V hysteresis.Long-term stability is also improved,with the bare device without any encapsulation retaining 84%of its initial efficiency after aging 744 hours in ambient. | Xuejiao Zuo Yiyang He Hongyu Ji Yong Li Xiuying Yang Binxun Yu Tao Wang Zhike Liu Wenliang Huang Jing Gou Ningyi Yuan Jianning Ding Shengzhong Frank Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 11 | The application of highly doped single- layer graphene as the top elec- trodes of semitransparent organic solar cells 显示文摘 | Liu Zhike Li Jinhua Sun Zhenhua | 2012 | ACS Nano2012，6，1： | 1 |
| 12 | Probing the cytotoxicity of CdSe quantum dots with surface modification显示文摘 | Guoning Guo Wei Liu Jiangong Liang Zhike He Huibi Xu Xiangliang Yang | 2006 | Materials Letters2006，，8： | 1 |
| 13 | High efficient ultraviolet photocatalytic activity of BiFeO3 nanoparticles synthesized by a chemical coprecipitation process显示文摘 | Zhike Liu Yajun Qi Chaojing Lu | 2010 | Mater Electron2010，，21： | 1 |
| 14 | A Special Additive Enables All Cations and Anions Passivation for Stable Perovskite Solar Cells with Efficiency over 23%显示文摘Passivating undercoordinated ions is an effective way to reduce the defect densities at the surface and grain boundaries(GBs)of perovskite materials for enhanced photovoltaic performance and stability of perovskite solar cells(PSCs).Here,(BBF)complex is chosen as a multifunctional additive,which contains both C7H9N and BF3 groups working as Lewis base and Lewis acid,respectively,can bond with Pb^(2+)/I^(−) and FA+on the surface and in the GBs in the perovskite film,affording passivation of both cation and anion defects.The synergistic effect of the C7H9N and BF3 complex slows the crystallization during the perovskite film deposition to improve the crystalline quality,which reduces the trap density and the recombination in the perovskite film to suppress nonradiative recombination loss and minimizes moisture permeation to improve the stability of the perovskite material.Meanwhile,such an additive improves the energy-level alignment between the valence band of the perovskite and the highest occupied molecular orbital of the hole-transporting material,Spiro-OMeTAD.Consequently,our work achieves power conversion efficiency of 23.24%,accompanied by enhanced stability under ambient conditions and light illumination and opens a new avenue for improving the performance of PSCs through the use of a multifunctional complex. | Wenjing Zhao Jie Xu Kun He Yuan Cai Yu Han Shaomin Yang Sheng Zhan Dapeng Wang Zhike Liu Shengzhong Liu | 2021 | Nano-Micro Letters2021，13，11： | 1 |
| 15 | Hybrid solar cells based on poly(3-hexylthiophene) and electrospun TiO_2 nanofibers modified with CdS nanoparticles显示文摘Organic–inorganic hybrid solar cells based on poly(3-hexylthiophene) and electrospun TiO2 nano bers were fabricated by solution process.The ef ciency of the device was improved by modifying CdS nanoparticles on the surface of TiO2 by electrochemical method.The CdS layer can lead to the increase of both open circuit voltage and short circuit current of the device,which are attributed to enhanced exciton dissociation and light absorption and suppressed carrier recombination by CdS at the heterojunction.However,too thick CdS layer led to increased series resistance and decreased ef ciency of the device.Therefore,the optimum condition of the CdS deposition was obtained,which increased the power conversion ef ciency of the device for about 50%.Our results indicate that the surface modi cation on the inorganic semiconductor layer is an effect way to improve the performance of the hybrid solar cells. | Shingchung Lo Zhike Liu Jinhua Li Helen Laiwa Chan Feng Yan | 2013 | Progress in Natural Science:Materials International2013，23，5： | 0 |
| 16 | Multifunctional indaceno[1,2-b:5,6-b']dithiophene chloride molecule for stable high-efficiency perovskite solar cells显示文摘The additive strategy has emerged as an effective approach to improving the performance of perovskite solar cells(PSCs).Herein,a small acceptor-donor-acceptor type molecule indaceno[1,2-b:5,6-b’]dithiophene chloride(IDT-Cl)is designed and synthesized to advance both the efficiency and stability of FA_(0.85)MA_(0.15)PbI_(3)PSCs.Within the IDT-Cl molecule,the S-group with high electron density promotes chemical bonding with the lead cations in the perovskite,resulting in enlarged grain size and smoother surface topography of the perovskite absorber.In addition,the undercoordinated lead ions in the perovskite layer may be passivated by the carbonyl group in the 5-chloroindolin-2-one unit,thereby reducing the number of nonradiative recombination centers.Meanwhile,the IDT-Cl adjusts the energy level mismatch between the perovskite and two adjacent carrier transport layers,leading to easy charge collection.By the multifunctional effect of the IDT-Cl molecule,the modified device yields a high power conversion efficiency(PCE)of 24.46%,8.8%higher than that of the control PSC(22.48%).More importantly,the hydrophobic alkyl side-chain of the IDT-Cl molecule further ensures enhanced humidity stability of the perovskite film and environmental,thermal,and light stabilities of the PSC devices. | Yong Li Qian Zhang Lidan Liu Dapeng Wang Zhike Liu Ningyi Yuan Jianning Ding Qiang Wang Shengzhong(Frank) Liu | 2023 | Science China Chemistry2023，66，1： | 0 |
| 17 | Room-temperature sputtered-SnO_(2) modified anode toward efficient TiO_(2)-based planar perovskite solar cells显示文摘It is of the utmost importance to promote the charge transport and retard the heterojunction barrier in the functional layers and at their adjacent interfaces to pursuit excellent photovoltaic characteristics of the perovskite solar cells(PSCs). Here, roomtemperature sputtered-SnO_(2) films are introduced to modify FTO anode for improving carrier extraction and aligning energy band in the TiO_(2)-based planar PSCs. For the SnO_(2)-modified substrate with suitable sputtering duration, the following TiO_(2) film exhibits smoother surface roughness, less surface defects, and lower the trap-assisted interfacial recombination than that directly on the FTO, further facilitating the growth of perovskite grain size and promoting the extraction efficiency of charge carriers. On the basis of the optimized SnO_(2)(6 nm)/TiO_(2) stack layer as electron transport layer(ETL), the PSC exhibits an outstanding power conversion efficiency of 21.45%, which is much better than that of the single TiO_(2)-based device(19.68%). More importantly, the cell with the bilayer ETL shows a long-term stability against air, maintaining over 76% of its initial efficiency after 40 d. These achievements suggest that this study provides a feasible path to design energy level alignment and low temperature ETL for highly efficient and stable PSCs. | LI Dan LI Yong LIU ZhiKe WANG DaPeng LIU ShengZhong(Frank) | 2021 | Science China(Technological Sciences)2021，64，9： | 0 |
| 18 | m^(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration显示文摘Neutrophil migration into the site of infection is necessary for antibacterial innate defense,whereas impaired neutrophil migration may result in excessive inflammation and even sepsis.The neutrophil migration directed by extracellular signals such as chemokines has been extensively studied,yet the intrinsic mechanism for determining neutrophil ability to migrate needs further investigation.N6-methyladenosine(m^(6)A)RNA modification is important in immunity and inflammation,and our preliminary data indicate downregulation of RNA m^(6)A demethylase alkB homolog 5(ALKBH5)in neutrophils during bacterial infection.Whether m^(6)A modification and ALKBH5 might intrinsically modulate neutrophil innate response remain unknown.Here we report that ALKBH5 is required for antibacterial innate defense by enhancing intrinsic ability of neutrophil migration.We found that deficiency of ALKBH5 increased mortality of mice with polymicrobial sepsis induced by cecal ligation and puncture(CLP),and Alkbh5-deficient CLP mice exhibited higher bacterial burden and massive proinflammatory cytokine production in the peritoneal cavity and blood because of less neutrophil migration.Alkbh5-deficient neutrophils had lower CXCR2 expression,thus exhibiting impaired migration toward chemokine CXCL2.Mechanistically,ALKBH5-mediated m^(6)A demethylation empowered neutrophils with high migration capability through altering the RNA decay,consequently regulating protein expression of its targets,neutrophil migration-related molecules,including increased expression of neutrophil migration-promoting CXCR2 and NLRP12,but decreased expression of neutrophil migration-suppressive PTGER4,TNC,and WNK1.Our findings reveal a previously unknown role of ALKBH5 in imprinting migrationpromoting transcriptome signatures in neutrophils and intrinsically promoting neutrophil migration for antibacterial defense,highlighting the potential application of targeting neutrophil m^(6)A modification in controlling bacterial infections. | Yang Liu Renjie Song Lu Zhao Zhike Lu Yini Li Xinyi Zhan Fengjiao Lu Jiang Yang Yamei Niu Xuetao Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 19 | Decorating hole transport material with −CF_(3) groups for highly efficient and stable perovskite solar cells显示文摘The hole transport material (HTM) plays an extremely important role to determine the power conversion efficiency (PCE) and the stability of perovskite solar cells (PSCs). Herein, we report an effective strategy to improve the performance of HTMs by introducing −CF_(3) groups via the rational decorative mode. Upon direct attachment or nonconjugated alkoxyl bridging of −CF_(3) groups on the terminal diphenylamines, the resulting molecular HTMs, i.e., 2,7-BCzA4CF_(3) and 2,7-BCzA4OCCF_(3), show distinct properties. Compared with 2,7-BCzA4CF_(3), the nonconjugated alkoxyl bridging −CF_(3) group-based 2,7-BCzA4OCCF_(3) exhibits better thermal stability, hydrophobicity, and a dramatically upgraded hole mobility by 135.7-fold of magnitude to 1.71 × 10^(−4) cm^(2) V^(−1) S^(−1). The PSCs with 2,7-BCzA4OCCF_(3) as HTM exhibit an PCE of up to 20.53% and excellent long-term stability, maintaining 92.57% of their performance for 30 days in air with humidity of 30% without encapsulation. This work provides beneficial guidelines for the design of new HTMs for efficient and stable PSCs. | Bin Li Yuan Cai Xia Tian Xiaozhong Liang Da Li Zheng Zhang Sijing Wang Kunpeng Guo Zhike Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 0 |
| 20 | Progress of Active Surveillance for Vaccine Safety in China显示文摘Vaccination is one of the most cost-effective interventions for saving lives and promoting public health.The coronavirus disease 2019(COVID-19)pandemic is providing a stark reminder of the importance and power of vaccines(1).However,vaccines can cause harm,and their rare safety concerns have increased in relative visibility as successful control and prevention of vaccine preventable diseases has diminished awareness of these diseases. | Zhike Liu Ruogu Meng Yu Yang Keli Li Zundong Yin Jingtian Ren Chuanyong Shen Zijian Feng Siyan Zhan | 2021 | China CDC weekly2021，3，27： | 0 |
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