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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | Improving the stability and bioavailability of tea polyphenols by encapsulations:a review显示文摘Tea polyphenols(TPPs)have attracted significant research interest due to their health benefits.However,TPPs are sensitive to certain environmental and gastrointestinal conditions and their oral bioavailability was found to be very low.Delivery systems made of food-grade materials have been reported to improve the shelf-life,bioavailability and bioefficacy of TPPs.This review discusses the chemistry of TPPs;the setbacks of TPPs for application;and the strategies to counteract application limitations by rationally designing delivery systems.An overview of different formulations used to encapsulate TPPs is provided in this study,such as emulsion-based systems(liposome,nanoemulsion,double emulsion,and Pickering emulsion)and nano/microparticles-based systems(protein-based,carbohydrate-based,and bi-polymer based).In addition,the stability,bioavailability and bioactivities of encapsulated TPPs are evaluated by various in vitro and in vivo models.The current findings provide scientific insights in encapsulation approaches for the delivery of TPPs,which can be of great value to TPPs-fortified food products.Further explorations are needed for the encapsulated TPPs in terms of their applications in the real food industry as well as their biological fate and functional pathways in vivo. | Zhiya Yin Ting Zheng Chi-Tang Ho Qingrong Huang Qingli Wu Man Zhang | 2022 | Food Science and Human Wellness2022，11，3： | 7 |
| 3 | Synthesis and surface modification of magnetic particles for application in biotechnology and biomedicine显示文摘Magnetic particles have numerous applications in biotechnology and biomedicine. In this paper we reviewed the synthesis, surface modification and some applications of magnetic particles with focus on their synthesis and surface modification. Various methods have been developed for the production of magnetic particles (magnetic nanoparticles and magnetic composite particles). For future application magnetic particles must be modified to obtain stability and surface functional groups. Finally, the application of magnetic particles in magnetic separation, drug delivery, hyperthermia, and magnetic resonance imaging are discussed. | Zhiya Ma Huizhou Liu | 2007 | China Particuology2007，5，1： | 6 |
| 4 | Applications of gold nanorods in biomedical imaging and related fields显示文摘Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered. | MA ZhiYa XIA HongXing LIU YuPing LIU Bo CHEN Wei ZHAO YuanDi | 2013 | Chinese Science Bulletin2013，58，21： | 6 |
| 5 | Metamaterials: Reshape and Rethink显示文摘Metamaterials are composite materials whose material properties(acoustic, electrical, magnetic, or optical, etc.) are determined by their constitutive structural materials, especially the unit cells. The development of metamaterials continues to redefine the boundaries of materials science. In the field of electromagnetic research and beyond, these materials offer excellent design flexibility with their customized properties and their tunability under external stimuli. In this paper, we first provide a literature review of metamaterials with a focus on the technology and its evolution. We then discuss steps in the industrialization process and share our own experience. | Ruopeng Liu Chunlin Ji Zhiya Zhao Tian Zhou | 2015 | Engineering2015，1，2： | 2 |
| 6 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 7 | Superparamagnetic silica nanoparticles with immobilized metal affinity ligands for protein adsorption显示文摘 | Ma Zhiya Guan Yueping Liu Huizhou | 2006 | Journal of Magnetism and Magnetic Materials2006，301，： | 1 |
| 8 | Covalent Immobilization of Albumin on Micron-sized Magnetic Poly(Methyl Methacrylate-divinylboenzeneglycidyl Methacrylate)Microspheres Preparde by Modified Suspension Polymerization显示文摘 | Ma Zhiya Guan Yueping Liu Xuanqiao | 2005 | Polymers for Advanced Technologies2005，，16： | 1 |
| 9 | The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency 显示文摘 | Guoying C Zhiya D Wei W | 2012 | J Pediatr Endocrinol Metab2012，25，34： | 1 |
| 10 | Surface modification and characterization of magnetic polymer nanosph eres prepared by miniemulsion polymerization 显示文摘 | Liu Xianqiao Guan Yueping Ma Zhiya | 2004 | Langmuir2004，20，10： | 1 |
| 11 | Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles显示文摘 | Arnaud Beduneau Zhiya Ma Cassi B Grotepas | 2009 | PLoS One2009，4，： | 1 |
| 12 | Synthesis and characteriza- tion of micron-sized monodisperse superparamagnetic polymer parti- cles with amino croups 显示文摘 | Ma Zhiya Guan Yueping Liu Huizhou | 2005 | Journal of Polymer Science : Part A : poly- mer Chemistry2005，43，15： | 1 |
| 13 | A compact tri - band PIFA antenna for WLAN And WiMAX applications 显示文摘 | Shanli Zuo Zhiya Zhang Wei jun Wu Yingzeng Yin | 2010 | Microwave And Optical Technology Letters2010，52，4： | 1 |
| 14 | Surface modification and characterization of magnetic polymer nanospheres prepared by miniemulsion polymerization显示文摘 | Liu Xianqiao Guan Yueping Ma Zhiya | 2004 | Langmuir2004，20，10： | 1 |
| 15 | Wideband Circularly Polarized Antenna With Cain Improvement显示文摘 | Zhang Zhiya Liu Nengwu Zhao Jiayue etal | 2013 | IEEEAntennas and Wireless Propagation Letters2013，12，： | 1 |
| 16 | Synthesis of magnetic silica nanospheres with metal ligands and application in affinity separation of proteins 显示文摘 | Ma Zhiya Liu Xianqiao Guan Yueping | 2006 | Colloids and Surfaces A2006，，13： | 1 |
| 17 | Preparation of ultra-broadband antireflective coatings for amplifier blast shields by a sol–gel method显示文摘A type of λ/4–λ/4 ultra-broadband antireflective coating has been developed using modified low refractive silica and high refractive silica layers by a sol–gel dip coating method for amplifier blast shields of the Shen Guang Ⅱ high power laser facility(SG-Ⅱ facility). Deposition of the first layer(high refractive index silica) involves baking at 200℃ in the post-treatment step. The second layer(low refractive index, n = 1.20) uses low refractive index silica sol modified by acid catalysis. Thermal baking at temperatures no less than 500℃ for 60 min offers chemical stability, ethanol scratch resistance, and resistance to washing with water. The average residual reflection of dual-side-coated fused silica glass was less than 1% in the spectral range from 450 to 950 nm. Transmission gain has been evaluated by taking into account angular light, and the results show that the transmission gain increases with increasing light incidence. Even at 60°, the transmission spectrum of the broadband antireflective coating effectively covered the main absorption peak of Nd:glass. | Huai Xiong Bin Shen Zhiya Chen Xu Zhang Haiyuan Li Yongxing Tang Lili Hu | 2017 | High Power Laser Science and Engineering2017，5，4： | 1 |
| 18 | Preparation and characterization of amino-silane modified super paramagnetic silica nanospheres 显示文摘 | Liu Xianqiao Ma Zhiya Xing Jianmin | 2004 | J Magn Magn Mater2004，270，1： | 1 |
| 19 | Metamaterials beyond negative refractive index: Applications in telecommunication and sensing显示文摘Metamaterials have earned their name with extraordinary properties such as negative refractive index and invisibility cloaking. With over 15 years of research and development, metamaterials show their debut in real world applications, especially in the areas of telecommunication, sensing, aerospace & defense, optics and medical instrumentation. In the meanwhile, metamaterials are expanding their concept in areas beyond electromagnetics. In this paper, the authors would like to focus on the research and applications in telecommunication and sensing. Octave-bandwidth horn antennas, flat-panel satellite antennas and air-borne holographic satellite antennas are all fabulous examples of clever implementation that bring metamaterials into practical devices. We would like to discuss the features that differentiate metamaterials from conventional counterparts in case studies. With the advancement in design, manufacturing, packaging, detection and testing, more sophisticated features are expected in the telecommunication, sensing, and beyond. | LIU RuoPeng ZHAO ZhiYa JI ChunLin ZHOU Tian | 2016 | Science China(Technological Sciences)2016，59，7： | 1 |
| 20 | Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice显示文摘 | Chinnasamy Dhanalakshmi Yu Zhiya Theoret Marc R Zhao Yangbing Shrimali Rajeev K Morgan Richard A Feldman Steven A Restifo Nicholas P Rosenberg Steven A | 2010 | Journal of Clinical Investigation2010，，11： | 1 |
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