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| 1 | Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation显示文摘The potential medicinal value of Ma bamboo(Dendrocalamus latiflorus), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that D. latiflorus leaf extract(DLE) reduced fasting blood glucose levels, body weight,and low-density lipoprotein cholesterol with low liver toxicity in db/db mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways.Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase(G6 PC) and phosphoenolpyruvate carboxykinase 1(PCK1) expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor(IGF1 R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients. | Kun Luo Wenting Huang Liansheng Qiao Xiaoling Zhang Di Yan Zhiyu Ning Chengmei Ma Honglei Dang Dong Wang Hongyan Guo Lan Xie Jing Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 2 | Textbook Outcome as a measure of surgical quality assessment and prognosis in gastric neuroendocrine carcinoma:A large multicenter sample analysis显示文摘Objective:Quality assurance is crucial for oncological surgical treatment assessment.For rare diseases,singlequality indicators are not enough.We aim to develop a comprehensive and reproducible measurement,called the'Textbook Outcome'(TO),to assess the quality of surgical treatment and prognosis of gastric neuroendocrine carcinoma(G-NEC)patients.Methods:Data from patients with primary diagnosed G-NEC included in 24 high-volume Chinese hospitals from October 2005 to September 2018 were analyzed.TO included receiving a curative resection,≥15 lymph nodes examined,no severe postoperative complications,hospital stay≤21 d,and no hospital readmission≤30 d after discharge.Hospital variation in TO was analyzed using a case mix-adjusted funnel plot.Prognostic factors of survival and risk factors for non-Textbook Outcome(non-TO)were analyzed using Cox and logistic models,respectively.Results:TO was achieved in 56.6%of 860 G-NEC patients.TO patients had better overall survival(OS),disease-free survival(DFS),and recurrence-free survival(RFS)than non-TO patients(P<0.05).Moreover,TO patients accounted for 60.3%of patients without recurrence.Multivariate Cox analysis revealed non-TO as an independent risk factor for OS,DFS,and RFS of G-NEC patients(P<0.05).Increasing TO rates were associated with improved OS for G-NEC patients,but not hospital volume.Multivariate logistic regression revealed that nonlower tumors,open surgery,and>200 mL blood loss were independent risk factors for non-TO patients(P<0.05).Conclusions:TO is strongly associated with multicenter surgical quality and prognosis for G-NEC patients.Factors predicting non-TO are identified,which may help guide strategies to optimize G-NEC outcomes. | Qiyue Chen Zhongliang Ning Zhiyu Liu Yanbing Zhou Qingliang He Yantao Tian Hankun Hao Wei Lin Lixin Jiang Gang Zhao Ping Li Chaohui Zheng Changming Huang on behalf of the Study Group for Gastric Neuroendocrine Tumors | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 3 | Apelin inhibits motor neuron apoptosis in the anterior horn following acute spinal cord and sciatic nerve injuries显示文摘Rat models of acute spinal cord injury and sciatic nerve injury were established.Apelin expression in spinal cord tissue was determined.In normal rat spinal cords,apelin expression was visible;however,2 hours post spinal cord injury,apelin expression peaked.Apelin expression increased 1 day post ligation of the sciatic nerve compared with normal rat spinal cords,and peaked at 3 days.Apelin expression was greater in the posterior horn compared with the anterior horn at each time point when compared with the normal group.The onset of neuronal apoptosis was significantly delayed following injection of apelin protein at the stump of the sciatic nerve,and the number of apoptotic cells after injury was reduced when compared with normal spinal cords.Our results indicate that apelin is expressed in the normal spinal cord and central nervous system after peripheral nerve injury.Apelin protein can reduce motor neuron apoptosis in the spinal cord anterior horn and delay the onset of apoptosis. | Zhiyue Li Weiguo Wang Qun Zhao Weiquan Ning Bin Yang Suling Zhang Siyin Feng | 2011 | Neural Regeneration Research2011，6，20： | 2 |
| 4 | Optimal Energy Efficiency Resource Allocation Strategy for Cognitive Clustering Network under PUEA Attack显示文摘5G has pushed the use of radio spectrum to a new level,and cognitive clustering network can effectively improve the utilization of radio spectrum,which is a feasible way to solve the growing demand for wireless communications.However,cognitive clustering network is vulnerable to PUEA attack,which will lead to the degradation of system detection performance,thereby reducing the energy efficiency.Aiming at these problems,this paper investigates the optimal energy efficiency resource allocation scheme for cognitive clustering network under PUEA attack.A cooperative user selection algorithm based on selection factor is proposed to effectively resist PUEA user attack and improve detection performance.We construct the energy efficiency optimization problem under multi-constraint conditions and transform the nonlinear programming problem into parametric programming problem,which is solved by Lagrangian function and Karush-Kuhn-Tucker condition.Then the sub-gradient iterative algorithm based on optimal energy efficiency under PUEA attack is proposed and its complexity is analyzed.Simulation results indicate that proposed method is effective when subjected to PUEA attacks,and the impact of different parameters on energy efficiency is analyzed. | Linna Hu Ning Cao Rui Shi Xue Cai Minghe Mao Zhiyu Chen | 2020 | China Communications2020，17，10： | 0 |
| 5 | A novel multi-shot target platform for laser-driven laboratory astrophysics experiments显示文摘A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is presented.With the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of stars.An important factor for success in these experiments is targetry.To date,targets have mainly relied on expensive and challenging microfabrication methods.The design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental geometry.This can make targets cheaper and faster to manufacture,while maintaining robustness and reproducibility.The platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental setups.Examples of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field coil.Experimental results are included,demonstrating the performance of the targets. | Pablo Perez-Martin Irene Prencipe Manfred Sobiella Fabian Donat Ning Kang Zhiyu He Huiya Liu Lei Ren Zhiyong Xie Jun Xiong Yan Zhang Florian-Emanuel Brack MichalČervenák Pavel Gajdoš Lenka Hronová Kakolee Kaniz Michaela Kozlová Florian Kroll Xiayun Pan Gabriel Schaumann Sushil Singh MichalŠmíd Francisco Suzuki-Vidal Panzheng Zhang Jinren Sun Jianqiang Zhu Miroslav Krůs Katerina Falk | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
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