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| 1 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 2 | Phylogenetic and genetic characterization of a 2017 clinical isolate of H7N9 virus in Guangzhou,China during the fifth epidemic wave显示文摘Pathogenic H7N9 influenza viruses continue to pose a public health concern. The H7N9 virus has caused five outbreak waves of human infections in China since 2013. In the present study, a novel H7N9 strain(A/Guangdong/8 H324/2017) was isolated from a female patient with severe respiratory illness during the fifth wave of the 2017 H7N9 epidemic. Phylogenetic analysis showed that the H7N9 viruses collected during the fifth wave belong to two different lineages: the Pearl River Delta lineage and the Yangtze River Delta lineage. The novel isolate is closely related to the Pearl River Delta H7N9 viruses, which were isolated from patients in Guangdong Province. The novel H7N9 isolate has an insertion of three basic amino acids in the cleavage site of hemagglutinin(HA), which may enhance virulence in poultry. The 2017 isolate also possesses an R292 K substitution in the neuraminidase(NA)protein, which confers oseltamivir resistance. This study highlights the pandemic potential of the novel H7N9 virus in mammals;thus, future characterization and surveillance is warranted. | Yongqiang Deng Chunlin Li Jianfeng Han Yingfen Wen Jian Wang Wenxing Hong Xiaofeng Li Zhongyu Liu Qing Ye Jing Li Changshuai Zhou Lei Yu Chengfeng Qin Fuchun Zhang Tao Jiang | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
| 3 | Localization and characterization of the hypothetical protein CT440 in Chlamydia trachomatis-infected cells显示文摘The inclusion membrane proteins play potentially important roles in chlamydial biology and pathogenesis.Here we localized and characterized the hypothetical protein CT440 in Chlamydia trachomatis-infected cells.The open reading frame(ORF) encoding the CT440 protein from the C.trachomatis serovar D genome was cloned into the prokaryotic expression vector pGEX-6p and expressed as a glutathione-S-transferase(GST) fusion protein in E.coli XL1-Blue.The CT440 fusion protein was used to immunize mice to raise antigen-specific antibody.After verification by Western blot and immunofluorescence assay(IFA),the specific antibody was used to localize the endogenous CT440 protein and to detect its expression pattern in Chlamydia-infected cells.Cytosolic expression of CT440 in HeLa cells was also carried out to evaluate the effect of the CT440 protein on the subsequent chlamydial infection.The results showed that the hypothetical protein CT440 was localized in the C.trachomatis inclusion membrane,and was detectable 12 h after chlamydial infection.Expression of CT440 in the cytoplasm did not inhibit the subsequent chlamydial infection.In summary,we have identified a new inclusion membrane protein that may be an important candidate for understanding C.trachomatis pathogenesis. | LI ZhongYu HUANG QiuLin SU ShengMei ZHOU Zhou CHEN ChaoQun ZHONG GuangMing WU YiMou | 2011 | Science China(Life Sciences)2011，54，11： | 5 |
| 4 | Interactions between bubble and particles of key minerals of diasporic bauxite through the extended DLVO theory显示文摘The flotation of diasporic bauxite is to separate diaspore(valuable mineral)from aluminosilicate minerals(gangue minerals,mainly including kaolinite,illite and pyrophyllite),and the microscopic interaction force between the two types of minerals and air bubbles determines the separation efficiency.In this paper,based on the extended Derjaguin-Landau-Verwey-Overbeek(DLVO)theory,the van der Waals,electrostatic and hydrophobic interaction between particles of the four minerals mentioned above and air bubbles in collectorless solution were calculated first,and then diaspore and kaolinite were taken as examples to analyze the influence of various factors such as electrolyte concentration,mineral particle size,air bubble size,collector type(dodecylamine hydrochloride(DAH)and sodium oleate(NaOL))and concentration,and pulp pH on the interactions between the particles of valuable mineral and gangue minerals and air bubbles.The results showed that the total extended DLVO interactions between the four minerals and air bubbles were repulsive in most cases in collectorless solution.The increase in electrolyte concentration reduced the interaction force or even changed the direction of the force under certain circumstances.The addition of DAH and NaOL can reduce the adhesion energy barrier of kaolinitebubble and diaspore-bubble respectively.Each type of minerals exhibited a specific interface interaction response with air bubbles in each collector with different pH values.The research results have theoretical guiding significance for the optimization and directional control of diasporic bauxite flotation conditions. | Ningning Zhang Tian Pang Rui Han Songjiang Chen Zhen Li Yuexian Yu Zhongyu Shi Lijun Liu Jinzhou Qu Anning Zhou | 2022 | International Journal of Mining Science and Technology2022，32，1： | 3 |
| 5 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 6 | Investigation of Two-Dimensional Ultrasonic Surface Burnishing Process on 7075-T6 Aluminum显示文摘A novel two-dimensional ultrasonic surface burnishing process(2D-USBP)is proposed.7075-T6 aluminum samples are processed by a custom-designed 2D-USBP setup.Parameter optimization of 2D-USBP is conducted to determine the best processing strategy of 7075-T6 aluminum.A uniform design method is utilized to optimize the 2D-USBP process.U〔3(133)and 4(72)tables are established to conduct parameter optimization.Burnishing depth,spindle speed,and feed rate are taken as the control parameters.The surface roughness and Vickers hardness are taken as the evaluation indicators.It establishes the active control models for surface quality.Dry wear tests are conducted to compare the wear-resistance of the 2D-USBP treated sample and the original sample.Results show that the machining quality of 2D-USBP is best under 0.24 mm burnishing depth,5000 r/min spindle speed,and 25 mm/min feed rate.The surface roughness of the sample is reduced from 2517.758 to 50.878 nm,and the hardness of the sample surface is improved from 167 to 252 HV.Under the lower load,the wear mechanism of the 2D-USBP treated sample is mainly abrasive wear accompanied by delamination wear,while the wear mechanism of the original sample is mainly delamination wear.Under the higher load,the accumulation of frictional heat on the sample surface transforms the wear mechanisms of the original and the 2D-USBP treated samples into thermal wear. | Zhenyu Zhou Qiuyang Zheng Cong Ding Guanglei Yu Guangjian Peng Zhongyu Piao | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 7 | Adsorption and reduction of palladium (Pd^(2+)) by Bacillus licheniformis R08显示文摘Preliminary study on the mechanism of Pd2+ biosorption by resting cells of Bacillus licheniformis R08 biomass has been carried out by means of chemical kinetics and AAS, TEM, XRD and FTIR methods. The results showed that at 30°C and pH 3.5, when dry R08 biomass powder (800 mg/L) was mixed with Pd2+ (100 mg/L) for 45 min, the rate constant k of biosorption of Pd2+ attained a maximum of 5.97×10-2 min-1 and the half life period of the reaction reached 12 min. The part of Pd2+ adsorbed by R08 biomass was reduced to elemental, cell-bound Pd0 at the same condition. The cell wall of R08 biomass was the primary location for accumulating Pd2+, and aldoses, i. e. hy-drolysate of a part of polysaccharides on the peptidoglycan layer in the acidic medium, serving as the electron donor, in situ reduced the Pd2+ to Pd0. | LIN Zhongyu, ZHOU Chaohui, WU Jianming, CHENG Hu, LIU Bilan, Nl Zimian, ZHOU Jianzhang & FU JinkunState Key Laboratory for Physical Chemistry of Solid Surface, Department of Chemistry, Xiamen University, Xiamen 361005, China | 2002 | Chinese Science Bulletin2002，47，15： | 2 |
| 8 | Pt nanocrystallines/TiO_2 with thickness-controlled carbon layers:Preparation and activities in CO oxidation显示文摘In this work, a series of Pt nanocrystallines(Pt NCs) supported on TiO_2 substrate with controlled thickness of carbon layers(C-Pt/TiO_2) were synthesized. Well-dispersed Pt NCs were facilely synthesized at room temperature by a photo-reduction process in lytropic liquid crystal(LCs). Surface tuning of the carbon layers on Pt/TiO_2 catalysts was achieved by varying the calcination atmospheres(in argon, air, and oxygen) and characterized by XPS and HRTEM. The influence of the coated carbon layers on the catalytic activity of catalysts is investigated by CO oxidation reaction which presented the following ranks: C-Pt/TiO_2-O_2> C-Pt/TiO_2-Air > C-Pt/TiO_2-Ar. It is found that the carbon layer coating can stabilize the Pt NCs and enable them anti-sintering at high temperature. This finding provides new insight into understanding the C-Pt/TiO_2 ternary system for tuning their catalytic performance. | Man Zhou Muhong Li Chujun Hou Zhongyu Li Yongzheng Wang Kun Xiang Xuefeng Guo | 2018 | Chinese Chemical Letters2018，29，6： | 2 |
| 9 | Tumor Cell Detection Device Based on Surface Plasmon Resonance Imaging and Image Processing显示文摘 | YANG Mengchao JIN Xinyu YUAN Maokai LIU Fan LANG Yicong WU Zhongyu XIANG Liancheng ZHOU Chao OUYANG Bo JIN Wei MU Ying | 2014 | Chemical Research in Chinese Universities2014，30，2： | 2 |
| 10 | Antitumor activity of bee pollen polysaccharides from Rosa rugosa显示文摘 | Bo Wang Qiyu Diao Zhongyu Zhang Yang Liu Qipin Gao Yifa Zhou Shanshan Li | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 11 | 中国男性乳腺癌患者临床特征:公开发表文章的总结(英文)显示文摘Objective:The extremely low incidence of male breast cancer (MBC) leads to lack of prospective randomized phase III studies worldwide. Especially in China,all studies on Chinese patients with MBC were based on small sample size and single institute experience. The aim of this study was to provide overall view of characteristics of Chinese patients with MBC by means of summarizing all related papers published in Chinese journals. Methods: An online search was made in CBM,VIP,CNKI,and CBA databases to find all published articles of interest on Chinese patients with MBC. And eight subjects including the proportion of MBC in all breast cancer,age,tumor location,clinical stages,pathological subtypes,treatment modalities,ER/PR expression,and 5-year survival rate were selected to calculate the proportion and their 95% interval confidence. Results: There were 122 papers with 2584 patients enrolled. The basic features of Chinese patients with MBC included:(1) MBC only with a proportion of 1.06% of all the breast cancer; (2) The mean age at diagnosis was 57.6 years old; (3) Tumor mainly located in the areolar region (74.83%) with obvious nipple and/or skin involvement; (4) Nearly 62.62% patients were in early stage before accepting treatment; (5) Infiltrating ductal carcinoma accounted for 79.05% of all pathological subtypes; (6) ER/PR expression rate was 65.86%; (7) Radical resection was up to 86.06% in all surgical modalities; (8) The 5-year survival rate was 57.33%. Conclusion: The results showed in this study were an overall view of Chinese patients with MBC whose characteristics were similar to that reported in the West. Though this study provided a little bit stronger confidence than a single study collected in this paper,studies with more powerful evidence are urgently demanding in China. | Liangping Xia Zhongyu Yuan Xi Wang Jiehua He Bei Zhang Guifang Guo Feifei Zhou Fang Wang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 1 |
| 12 | A MEMS-Based Ionization Gas Sensorusing Carbon Nanotubes 显示文摘 | Hou Zhongyu Wu Jiahao Zhou Weimin | 2007 | IEEE Transactionson Electron Devices2007，54，6： | 1 |
| 13 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 14 | Single-electron charging and ultrafast dynamics of bimetallic Au_(144−x)Agx(PET)_(60) nanoclusters显示文摘Alloying is an important strategy in tailoring the functionality of materials.In metal nanoclusters(NCs),the introduction of a heterometal leads to alloy nanoclusters that often outperform the homometal ones in terms of the physical and chemical properties.In this work,a series of four M_(144)(PET)60 alloy NCs(where,M=Au/Ag,PET=–SCH_(2)CH_(2)Ph)are synthesized and characterized.The silver doping into the homogold template(Au_(144))leads to more prominent optical absorption features in the steady-state spectrum in the visible range.Femtosecond transient absorption spectroscopy reveals the effect of Ag doping on the electronic relaxation dynamics compared to Au_(144)and the pump fluence independent dynamics.Electrochemical results reflect a narrowing of HOMO–LUMO gap(E_(g))induced by Ag doping.A temperature dependence of the single-electron charging is also observed for the series of alloy NCs,in which the E_(g)values of the alloy NCs enlarge as the temperature decreases,which is characteristic of semiconducting behavior. | Xiangsha Du Hedi Ma Xinwen Zhang Meng Zhou Zhongyu Liu He Wang Gangli Wang Rongchao Jin | 2022 | Nano Research2022，15，9： | 1 |
| 15 | Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China显示文摘The oral hexavalent live human-bovine reassortant rotavirus vaccine(RV6)developed by Wuhan Institute of Biological Products Co.,Ltd(WIBP)has finished a randomized,placebo-controlled phase III clinical trial in four provinces of China in 2021.The trail demonstrated that RV6 has a high vaccine efficacy against the prevalent strains and is safe for use in infants.During the phase III clinical trial(2019–2021),200 rotavirus-positive fecal samples from children with RV gastroenteritis(RVGE)were further studied.Using reverse transcription-polymerase chain reaction and high-throughput sequencing,VP7 and VP4 sequences were obtained and their genetic characteristics,as well as the differences in antigenic epitopes of VP7,were analyzed in detail.Seven rotavirus genotypes were identified.The predominant rotavirus genotype was G9P[8](77.0%),followed by prevalent strains G8P[8](8.0%),G3P[8](3.5%),G3P[9](1.5%),G1P[8](1.0%),G2P[4](1.0%),and G4P[6](1.0%).The amino acid sequence identities of G1,G2,G3,G4,G8,and G9 genotypes of isolates compared to the vaccine strains were 98.8%,98.2%–99.7%,88.4%–99.4%,98.2%,94.2%–100%,and 93.9%–100%,respectively.Notably,the vaccine strains exhibited high similarity in amino acid sequence,with only minor differences in antigenic epitopes compared to the Chinese endemic strains.This supports the potential application of the vaccine in preventing diseases caused by rotaviruses. | Wenqi Zou Qingchuan Yu Yan Liu Qingliang Li Hong Chen Jiamei Gao Chen Shi Ying Wang Wei Chen Xuan Bai Biao Yang Jiuwei Zhang Ben Dong Bo Ruan Liuyifan Zhou Gelin Xu Zhongyu Hu Xiaoming Yang | 2023 | Virologica Sinica2023，38，6： | 0 |
| 16 | A novel optical high-pressure apparatus for studying the combustion of solid propellant under periodic strain显示文摘The combustion of solid propellants can provide tremendous thrust to drive solid rocket motors.Solid propellant grains are subjected to mechanical loads during practical combustion applications.The causes of mechanical loads include,but are not limited to,impulsive loads during ignition and periodic loads(>5 Hz)due to mechanical oscillation[1,2]. | OUYANG JianFeng GU MingMing WANG ShaoJie CUI CunHao SHI XiaoMing HOU KaiYu ZHOU ZhongYue QI Fei | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 17 | Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination显示文摘 | Yunlong Si Shiqiong Feng Jin Gao Yue Wang Zhongyu Zhang Yue Meng Yifa Zhou Guihua Tai Jiyong Su | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 0 |
| 18 | Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1显示文摘Introduction:Siva-1,as a pro-apoptotic protein,has been shown to induce extensive apoptosis in a number of different cell lines.In our previous study,we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer cells.So,we believe that it can also work as an anti-apoptotic protein.The present study aimed to determine the specific role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism.Materials and Methods:A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was established.The effect of Siva-1 downregulation on chemotherapeutic drug resistance was assessed by measuring the IC50 and pump rate of doxorubicin.Proliferation,apoptosis of cells,and cell cycle were detected via colony formation assay andflow cytometry,respectively.Additionally,migration and invasion of cells was detected via wound healing and transwell assays.Moreover,we determined in vivo effects of LV-Siva-1-RNAi on tumor size,and apoptotic cells in tumor tissues were detected using TUNEL and hematoxylin and eosin staining.Results:Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug treatment.Siva-1 negatively regulated proliferation and promoted apoptosis of cells by potentiality G2-M phase arresting.Inhibition of Siva-1 expression in MKN-28/VCR cells significantly weakened wound healing ability and decreased invasion ability.Poly(C)-binding protein 1(PCBP1)was identified as a Siva-1-interacting protein in yeast two-hybrid screening.Semiquantitative RT-PCR and western blotting revealed that Siva-1 downregulation could inhibit expression of PCBP1,Akt,and NF-κB and eventually decrease the expression of MDR1 and MRP1.Conclusion:The current study demonstrated that the downregulation of Siva-1,which functions as a regulator of MDR1 and MRP1 gene expression in gastric cancer cells by inhibiting PCBP1/Akt/NF-κB signaling pathway expression,enhanced the sensitivity of gastric cancer cells to certain chemotherapies. | FANBIAO KONG KUN WU LIMING PANG YULIANG HUANG LEI LI JING XU FEITONG LI YAN QING ZHONGYU WANG XIURONG HUANG SHENG XU XIAOGANG ZHONG ZHOU ZHU XIAOTONG WANG JIANRONG YANG | 2022 | Oncology Research2022，30，6： | 0 |
| 19 | Prediction of high-density polyethylene pyrolysis using kinetic parameters based on thermogravimetric and artificial neural networks显示文摘Pyrolysis is considered an attractive option and a promising way to dispose waste plastics.The thermogravimetric experiments of high-density polyethylene(HDPE)were conducted from 105℃ to 900℃ at different heating rates(10℃/min,20℃/min,and 30℃/min)to investigate their thermal pyrolysis behavior.We investigated four methods including three model-free methods and one modelfitting method to estimate dynamic parameters.Additionally,an artificial neural network model was developed by providing the heating rates and temperatures to predict the weight loss(wt.%)of HDPE,and optimized via assessing mean squared error and determination coefficient on the test set.The optimal MSE(2.6297×10^(−2))and R^(2) value(R^(2)>0.999)were obtained.Activation energy and preexponential factor obtained from four different models achieves the acceptable value between experimental and predicted results.The relative error of the model increased from 2.4%to 6.8%when the sampling frequency changed from 50 s to 60 s,but showed no significant difference when the sampling frequency was below 50 s.This result provides a promising approach to simplify the further modelling work and to reduce the required data storage space.This study revealed the possibility of simulating the HDPE pyrolysis process via machine learning with no significant accuracy loss of the kinetic parameters.It is hoped that this work could potentially benefit to the development of pyrolysis process modelling of HDPE and the other plastics. | Xiaoxiao Yin Junyu Tao Guanyi Chen Xilei Yao Pengpeng Luan Zhanjun Cheng Ning Li Zhongyue Zhou Beibei Yan | 2023 | Frontiers of Environmental Science & Engineering2023，17，1： | 0 |
| 20 | Advanced flexible humidity sensors:structures,techniques,mechanisms and performances显示文摘Flexible humidity sensors are widely used in many fields,such as environmental monitoring,agricultural soil moisture content determination,food quality monitoring and healthcare services.Therefore,it is essential to measure humidity accurately and reliably in different conditions.Flexible materials have been the focusing substrates of humidity sensors because of their rich surface chemical properties and structural designability.In addition,flexible materials have superior ductility for different conditions.In this review,we have summarized several sensing mechanisms,processing techniques,sensing layers and substrates for specific humidity sensing requirements.Aadditionally,we have sorted out some cases of flexible humidity sensors based on different functional materials.We hope this paper can contribute to the development of flexible humidity sensors in the future. | Yuzhe Zhang Yuxi Liu Lifei Lin Man Zhou Wang Zhang Liwei Lin Zhongyu Li Yuanzhe Piao Sun Ha Paek | 2023 | Frontiers of Materials Science2023，17，4： | 0 |
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