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| 1 | Oral health in China: from vision to action显示文摘Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China. We also described and analyzed the recently released health policies of the Chinese government, which aim to guide midterm and long-term oral health promotion in China. More importantly, we called for specific actions to fulfill the larger goal of oral health for the nation. The implementation of primordial prevention efforts against oral diseases, the integration of oral health into the promotion of overall health, and the management of oral diseases in conjunction with other chronic non-communicable diseases with shared risk factors were highly recommended. In addition, we suggested the reform of standard clinical residency training, the development of domestic manufacturing of dental equipment and materials, the revitalization traditional Chinese medicine for the prevention and treatment of oral diseases, and integration of oral health promotion into the Belt and Road Initiative. We look forward to seeing a joint effort from all aspects of the society to fulfill the goal of Healthy China 2030 and ensure the oral health of the nation. | Xuedong Zhou Xin Xu Jiyao Li Deyu Hu Tao Hu Wei Yin Yujiang Fan Xingdong Zhang | 2018 | International Journal of Oral Science2018，10，1： | 7 |
| 2 | 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction显示文摘The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone repair.To satisfy these requirement,we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials(Ca-P bioceramics),which is expected to present a controllable biodegradation rate for patients who need bone regeneration.Physicochemical properties,porosity,compressive strength and degradation properties of the scaffolds were studied.3D printed Ca-P scaffold(3DS),gas foaming Ca-P scaffold(FS)and autogenous bone(AB)were used in vivo for personalized beagle skull defect repair.Histological results indicated that the 3DS was highly vascularized and well combined with surrounding tissues.FS showed obvious newly formed bone tissues.AB showed the best repair effect,but it was found that AB scaffolds were partially absorbed and degraded.This study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction. | Boqing Zhang Huan Sun Lina Wu Liang Ma Fei Xing Qingquan Kong Yujiang Fan Changchun Zhou Xingdong Zhang | 2019 | Bio-Design and Manufacturing2019，2，3： | 5 |
| 3 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 4 | Can local ecological knowledge be used to assess status and extinction drivers in a threatened freshwater cetacean?显示文摘 | Samuel T. Turvey Claire L. Risley Jeffrey E. Moore Leigh A. Barrett Hao Yujiang Zhao Xiujiang Zhou Kaiya Wang Ding | 2013 | Biological Conservation2013，，： | 1 |
| 5 | 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction显示文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction. | Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang | 2023 | Bio-Design and Manufacturing2023，6，4： | 0 |
| 6 | Vehicle Matching Based on Similarity Metric Learning显示文摘With the development of new media technology,vehicle matching plays a further significant role in video surveillance systems.Recent methods explored the vehicle matching based on the feature extraction.Meanwhile,similarity metric learning also has achieved enormous progress in vehicle matching.But most of these methods are less effective in some realistic scenarios where vehicles usually be captured in different times.To address this cross-domain problem,we propose a cross-domain similarity metric learning method that utilizes theGANto generate vehicle imageswith another domain and propose the two-channel Siamese network to learn a similarity metric from both domains(i.e.,Day pattern or Night pattern)for vehicle matching.To exploit properties and relationships among vehicle datasets,we first apply the domain transformer to translate the domain of vehicle images,and then utilize the two-channel Siamese network to extract features from both domains for better feature similarity learning.Experimental results illustrate that our models achieve improvements over state-of-the-arts. | Yujiang Li Chun Ding Zhili Zhou | 2022 | Journal of New Media2022，4，1： | 0 |
| 7 | Preliminary investigation of building damage in Hatay under February 6,2023 Turkey earthquakes显示文摘On February 6,2023,an M_(w)7.8 earthquake hit the south of Kahramanmaras prefecture,Turkey,followed by another M_(w)7.5 earthquake after nine hours in the middle region of the Kahramanmaras prefecture.More than 84,000 buildings collapsed or were severely damaged,and more than 50,000 lives were lost in Turkey and Syria.Some of the authors,as members of Chinese rescue team,entered Antakya,Hatay prefecture,and investigated the damaged buildings.This paper first summarizes the damage patterns of buildings and provides three reasons for the massive number of collapsed buildings;i.e.,the lack of seismic measures for better ductility,site effects such as liquefaction and surface rupture,and pronounced low-frequency components of the ground motions.Next,the seismic responses of two typical buildings are calculated based on the geometric data estimated by visual inspection.The results imply that the resonance of the whole structure and the poorer ductility of key members resulted in the collapse of buildings.Finally,some conclusions are drawn.Note that although a large number of buildings were seriously damaged to collapse,the majority of buildings in the areas of extreme shaking were lightly or moderately damaged,which implies that well designed and constructed buildings were able to survive and protect human lives even in over-design earthquakes. | Wang Tao Chen Jie Zhou Yujiang Wang Xiaoqing Lin Xuchuan Wang Xiaoting Shang Qingxue | 2023 | Earthquake Engineering and Engineering Vibration2023，22，4： | 0 |
| 8 | Biofabrication (3D Bioprinting) Laboratory at Sichuan University显示文摘Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ biofabrication.In the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012. | Changchun Zhou Kefeng Wang Yong Sun Qiguang Wang Qing Jiang Jie Liang Xuan Pei Boqing Zhang Yujiang Fan Xingdong Zhang | 2021 | Bio-Design and Manufacturing2021，4，2： | 0 |
| 9 | Autophagy and circadian rhythms:interactions and clinical implications显示文摘Autophagy is a widespread biological process that controls cellular growth,survival,development,and death.Circadian rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightness and obscurity.Most of the fundamental physiological processes in mammals,such as the sleep-wake pattern and the rhythm of nutrition and energy metabolism,are governed by circadian rhythms.Research has indicated that autophagy exhibits a specific circadian pattern in both normal and abnormal conditions.Autophagy can modulate circadian rhythms by breaking down proteins that regulate the circadian clock.The potential regulatory connection between the two has been a popular subject of clinical and fundamental research.Understanding the interaction between circadian rhythm and autophagy could potentially lead to the development of novel approaches for disease treatment in the future.The present analysis presented a summary of the molecular processes implicated in the interplay between autophagy and circadian rhythm,as well as the pathological importance of the disrupted regulatory association between these two phenomena. | TIANKAI DI ZHIFEI ZHOU FEN LIU YUJIANG CHEN LULU WANG | 2024 | BIOCELL2024，48，1： | 0 |
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