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| 1 | Clinical effects of innovative tuina manipulations on treating cervical spondylosis of vertebral artery type and changes in cerebral blood flow显示文摘OBJECTIVE:To determine the clinical effect,treatment times,and rheoencephalogram changes in vertebral artery type cervical spondylosis patients treated with innovative Tuina manipulations.METHODS:One hundred and twenty six cervical spondylosis patients(vertebral artery type) were randomly divided into test and control groups.Patients in the test group were treated with innovative Tuina manipulations,while those in the control group were treated with the routine Tuina manipulations according to the textbook of Chinese Massage for Acupuncture and Moxibustion majors.The clinical effects,treatment times,clinical symptoms,and cerebral blood flow were measured.RESULTS:The response to the treatment was 100% in the test group and 88.71% in the control group.Patients in the test group required(7 ± 4) treatments before recovery,while those in the control group required(15 ± 7) treatments before recovery(P<0.05).The clinical symptoms exhibited greater improvement in the test group compared to the control group(P<0.05).There were no differences in cerebral blood flow between the two groups.CONCLUSION:Both innovative Tuina manipulations and routine Tuina manipulations produced satisfactory therapeutic results in vertebral artery type cervical spondylosis patients.However,the innovative manipulation was more effective in improving the functional symptoms,although there were no changes in the cerebral blood flow. | Quanmao Ding Mingru Yan Ji Zhou Lu Yang Jiang Guo Jun Wang Zhiyong Shi Yixi Wang Hongsheng Zhao | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 24 |
| 2 | Force-induced charge carrier storage:a new route for stress recording显示文摘Stress sensing is the basis of human-machine interface,biomedical engineering,and mechanical structure detection systems.Stress sensing based on mechanoluminescence(ML)shows significant advantages of distributed detection and remote response to mechanical stimuli and is thus expected to be a key technology of next-generation tactile sensors and stress recorders.However,the instantaneous photon emission in ML materials generally requires real-time recording with a photodetector,thus limiting their application fields to real-time stress sensing.In this paper,we report a force-induced charge carrier storage(FICS)effect in deep-trap ML materials,which enables storage of the applied mechanical energy in deep traps and then release of the stored energy as photon emission under thermal stimulation.The FICS effect was confirmed in five ML materials with piezoelectric structures,efficient emission centres and deep trap distributions,and its mechanism was investigated through detailed spectroscopic characterizations.Furthermore,we demonstrated three applications of the FICS effect in electronic signature recording,falling point monitoring and vehicle collision recording,which exhibited outstanding advantages of distributed recording,longterm storage,and no need for a continuous power supply.The FICS effect reported in this paper provides not only a breakthrough for ML materials in the field of stress recording but also a new idea for developing mechanical energy storage and conversion systems. | Yixi Zhuang Dong Tu Changjian Chen Le Wang Hongwu Zhang Hao Xue Conghui Yuan Guorong Chen Caofeng Pan Lizong Dai Rong-Jun Xie | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 3 | Facile preparation of low swelling,high strength,self-healing and pH-responsive hydrogels based on the triple-network structure显示文摘A polyacrylic acid(PAA)/gelatin(Gela)/polyvinyl alcohol(PVA)hydrogel was prepared by copolymerization,cooling,and freezing/thawing methods.This triplenetwork(TN)structure hydrogel displayed superior mechanical properties,low swelling ratio and self-healing properties,The superior mechanical properties are attributed to the triple helix association of Gela and PVA crystallites by reversible hydrogen bonding.The characterization results indicated that the fracture stress and the strain were 808 kPa and 370% respectively,while the compression strength could reach 4443 kPa and the compressive modulus was up to 39 MPa under the deformation of 90%.The hydrogen bonding in PVA contributed to maintain and improve the self-healing ability of hydrogels.Every type of hydrogels exhibited a higher swelling ratio under alkaline conditions,and the swelling ratios of PAA,PAA/PVA and PAA/Gela hydrogels were 27.71,12.30 and 9.09,respectively.The PAA/Gela/PVA TN hydrogel showed the lowest swelling ratio(6.57)among these hydrogels.These results indicate that the novel TN hydrogels possess good environmental adaptability and have potential applications in the biomedical engineering and sensor field. | Zhicun WANG Xiaoman HAN Yixi WANG Kenan MEN Lin CUI Jianning WU Guihua MENG Zhiyong LIU Xuhong GUO | 2019 | Frontiers of Materials Science2019，13，1： | 4 |
| 4 | Enabling robust and hour-level organic long persistent luminescence from carbon dots by covalent fixation显示文摘The first carbon dot(CD)-based organic long persistent luminescence(OLPL)system exhibiting more than 1 h of duration was developed.In contrast to the established OLPL systems,herein,the reported CDs-based system(named m-CDs@CA)can be facilely and effectively fabricated using a household microwave oven,and more impressively,its LPL can be observed under ambient conditions and even in aqueous media.XRD and TEM characterizations,afterglow decay,time-resolved spectroscopy,and ESR analysis were performed,showing the successful composition of CDs and.CA,the formation of exciplexes and long-lived charged-separated states.Further studies suggest that the production of covalent bonds between CA and CDs plays pivotal roles in activating LPL and preventing its quenching from oxygen and water.To the best of our knowledge,this is a very rare example of an OLPL system that exhibits hourlevel afterglow under ambient conditions.Finally,applications of m-CDs@C.A in glow-in-the-dark paints for emergency signs and multicolored luminous pearls were preliminarily demonstrated.This work may provide new insights for the development of rare earth-free and robust OLPL materials. | Kai Jiang Yuci Wang Cunjian Lin Licheng Zheng Jiaren Du Yixi Zhuang Rongjun Xie Zhongjun Li Hengwei Lin | 2022 | Light(Science & Applications)2022，11，4： | 3 |
| 5 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 6 | Automatic Design of P Systems for Five Basic Arithmetic Operations within One Framework显示文摘To solve the programmability of a membrane system, this paper presents an automatic design method of a cell-like P system framework for performing five basic arithmetic operations. This method proved that different P systems can be designed with same framework by programming. A technique is introduced to remove redundant rules in the process of the design of a P system.The effectiveness and feasibility of this method is verified by experimental results. | CHEN Yixi ZHANG Gexiang WANG Tao HUANG Xiaoli | 2014 | Chinese Journal of Electronics2014，23，2： | 3 |
| 7 | Novel robust cellulose-based foam with pH and light dual-response for oil recovery显示文摘 | Qian WANG Guihua MENG Jianning WU Yixi WANG Zhiyong LIU Xuhong GUO | 2018 | Frontiers of Materials Science2018，12，2： | 2 |
| 8 | Physical and chemical characteristic of particulate matter from biodiesel exhaust e- mission using non - thermal plasma technology 显示文摘 | Wang Pan Cai Yixi Zhang Lefu | 2010 | Energy and Fuels2010，24，5： | 1 |
| 9 | Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation显示文摘The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack of neovascularization upon implantation and subsequently diminished ingrowth of host bone,most likely resulted from the inability to replicate appropriate endogenous crosstalk between cells.Human umbilical vein endothelial cell-derived decellularized extracellular matrix(HdECM),which contains a collection of angiocrine biomolecules,has recently been demonstrated to mediate endothelial cells(ECs)-osteoprogenitors(OPs)crosstalk.We employed the HdECM to create a PCL(polycaprolactone)/fibrin/HdECM(PFE)hybrid scaffold.We hypothesized PFE scaffold could reconstitute a bio-instructive microenvironment that reintroduces the crosstalk,resulting in vascularized bone regeneration.Following implantation in a rat femoral bone defect,the PFE scaffold demonstrated early vascular infiltration and enhanced bone regeneration by microangiography(μ-AG)and micro-computational tomography(μ-CT).Based on the immunofluorescence studies,PFE mediated the endogenous angiogenesis and osteogenesis with a substantial number of type H vessels and osteoprogenitors.In addition,superior osseointegration was observed by a direct host bone-PCL interface,which was likely attributed to the formation of type H vessels.The bio-instructive microenvironment created by our innovative PFE scaffold made possible superior osseointegration and type H vessel-related bone regeneration.It could become an alternative solution of improving the osseointegration of bone substitutes with the help of induced type H vessels,which could compensate for the inherent biological inertness of synthetic polymers. | Yijun He Wenhao Wang Shaozhang Lin Yixi Yang Lizhi Song Yihan Jing Lihao Chen Zaopeng He Wei Li Ao Xiong Kelvin W.K.Yeung Qi Zhao Yuan Jiang Zijie Li Guoxian Pei Zhi-Yong Zhang | 2022 | Bioactive Materials2022，7，3： | 1 |
| 10 | ThermalDesign and Simulation of Automotive Headlamps UsingWhite LEDs 显示文摘 | WANG Jing CAI Yixi ZHAO Xinjie | 2014 | Microelectronics Journal2014，45，2： | 1 |
| 11 | Frequency-domain principle of pattern multiplication for array-fed reflector antennas显示文摘 | ZHANG Yixi FU Junmei WANG Wenbing | 2004 | IEEE Microwave and Wireless Components Letters2004，14，7： | 1 |
| 12 | Physical and chemical characteristic of particulate matter from biodiesel exhaust emission using non-thermal plasma technology显示文摘 | Wang Pan Cai Yixi Zhang Lefu | 2010 | Energy and Fuels2010，24，5： | 1 |
| 13 | Physical and chemical characteristics of particulate matter from biodiesel exhaust emission using non-thermal plasma technology显示文摘 | Wang Pan Cai Yixi Zhang Lefu | 2010 | Energy and Fuels2010，24，5： | 1 |
| 14 | Regional difference and dynamic mechanism of locality of the Chinese farming-pastoral ecotone based on geotagged photos from Panoramio显示文摘Cross-regional locality research reflects the influences of natural environment and the human activities due to the abundant land types and the multiple landscape combinations in related regions. The Chinese farming-pastoral ecotone is a typical large-scale region but few studies were conducted. This research contributed to the understanding of cross-regional locality of the Chinese farming-pastoral ecotone from different scales, including national, sectional, and provincial administrative units by utilizing geotagged photos(GTPs) obtained from the Panoramio website. The major results were as follows:(1) the locality elements of the Chinese farming-pastoral ecotone included 52 free nodes classified into 8 types of scene attributes;(2) there were huge differences between locality elements of different regions, and there was a negative correlation between the similarity degree of elements of different provinces and their spatial distances;(3) the Chinese farming-pastoral ecotone could be divided into the northern, central and southern sections, whose localities had differences in element constitution, association structure and the strength of elements, system stability and the anti-interference capability; and(4) the evolution of the localities of the northern and central sections was mainly influenced by human activities, while the locality of southern section retained more natural features. On a theoretical level, this research aimed to establish the research methodology of locality from the perspective of open data on the web with strong operability and replicability. On a practical level, this research could enrich the structuring recognition of the locality of the Chinese farming-pastoral ecotone and the comprehension of its dynamic mechanism. The results provide a reference for locality differentiation protection and the development of a cross-regional scale. | WANG Fang LI Yixi DONG Ying ZHU Xiaohua | 2018 | Journal of Arid Land2018，10，2： | 1 |
| 15 | Physicaland Chemical Characteristics of Particulate Matter FromBiodiesel Exhaust Emission Using Non-Thermal PlasmaTechnology显示文摘 | WANG Pan CAI Yixi ZHANG Lefu | 2010 | Energy Fuels2010，24，： | 1 |
| 16 | Immunoregulatory and Anti-Tumor Effects of Polysaccharopeptide and Astragalus polysaccharides on Tumor-Bearing Mice显示文摘 | Li Jin Bao Yixi Lam Waikei Li Wenwen Lu Fang Zhu Xuan Liu Jing Wang Hongping | 2008 | Immunopharmacology and Immunotoxicology2008，，4： | 1 |
| 17 | 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction显示文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction. | Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang | 2023 | Bio-Design and Manufacturing2023，6，4： | 0 |
| 18 | Cuticular compounds inhibit cannibalism of early-instar spiderlings by pulli-carrying Pardosa pseudoannulata females显示文摘Cannibalism is common in spiders.Wolf spider(Lycosidae)females,which exhibit extensive maternal care,have been reported to cannibalize less when they are carrying egg sacs and juveniles.In a laboratory experiment,we demonstrated that cannibalism of early-instar spiderlings(EIS)by a wolf spider(Pardosa pseudoannulata)mother was almost completely inhibited when she was carrying spiderlings.Compared with virgin and mated-females,mother spiders tolerated more and predated fewer spiderlings,including gregarious pulli and newly dispersed spiderlings(NDS).Cannibalism of EIS by females during their reproductive period exhibited a V-shaped pattern,with a gradual decrease from the egg sac-carrying to pulli-carrying(PC)stage,and a recovery from the PC stage to post-reproductive(PR)stage.Notably,there was 0 cannibalism at the PC stage.PC females exhibited no interest in pulli,while PR females were attracted to and predated pulli and NDS as they did their natural prey,Nilaparvata lugens.Interestingly,PC females captured and released NDS in a foraging assay,although attraction was observed from olfactometer measurements.PC mothers possessed a cuticular volatile profile that was closer to that of pulli and NDS than to that of PR females.Moreover,NDS cuticular extract provoked an electrophysiological response in legs of PC females.Therefore,cuticular compound-mediated chemical communication may be involved in inhibiting cannibalism of EIS by spider mothers,and especially in eliminating cannibalism by PC mothers.Future studies will aim to characterize the specific cuticular compounds and chemoreception mechanism in females,which will facilitate our understanding of intraspecific recognition and cannibalism in spiders. | Na Yu Yunru Chen Guangming Xu Zhiming Yang Shijie Wang Tianyu Lu Yixi Zhang Zewen Liu | 2022 | Insect Science2022，29，5： | 0 |
| 19 | A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber显示文摘High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell activity.The Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal conditions.Furthermore, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results provide important insights into the heat response mechanism of CsSPT in cucumber and its potential as a target for breeding heat-resistant crops. | Yonggui Liang Chenyu Yang Fangyan Ming Bingwei Yu Zhihua Cheng Yixi Wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 20 | Analysis of Food Safety Supervision and Spot-Check in Sichuan Province in 2019显示文摘Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions were finally put forward.The analysis results showed that in 2019,the overall trend of food safety in Sichuan Province was stable and improved.A total of 30 categories of unqualified samples were detected,and a total of 12135 batches of unqualified samples were detected,with an average sample unqualified rate of 5.73%.Among them,the main problems of unqualified samples were as follows:the use of food additives beyond the scope and limit,accounting for 40.17%of the total number of unqualified samples,microbial contamination in food,accounting for 23.61%of the total unqualified samples,the residue index of agricultural and veterinary drugs in food not meeting the standard,accounting for 15.61%of the total unqualified samples,the quality index in food not meeting the standard,accounting for 8.51%of the total number of unqualified samples,and heavy metals and other pollutants in food exceeding the standard,accounting for 7.10%of the total unqualified samples. | Pengyu CHEN Wei WANG Xueli WU Lili JI Jiamin ZHANG Zhipin ZHAO Rui ZHANG Ting BAI Bo HOU Yixi YANG Lin CHEN | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
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