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| 1 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 2 | Autophagy Attenuates MnCl2-induced Apoptosis in Human Bronchial Epithelial Cells显示文摘Objective To investigate the role of autophagy in MnC l2-induced apoptosis in human bronchial epithelial 16 HBE cells.Methods Cell proliferation was measured by MTT assay.Mitochondrial membrane potential(MMP) and apoptosis were measured by flow cytometry.Autophagic vacuoles were detected by fluorescence microscopy.Cellular levels of apoptosis and autophagy-related proteins were measured by western blotting.Results 16 HBE cell proliferation was inhibited by Mn Cl2 in a dose-and time-dependent manner.Mn Cl2-induced 16 HBE cell growth inhibition was related to MMP depolarization prior to the induction of apoptosis.Our data revealed that Mn Cl2-induced apoptosis in 16 HBE cells was mediated by decreased expression of Bcl-2 and increased levels of cleaved caspase-3.It was observed that when we exposed 16 HBE cells to MnCl_2 in a dose-dependent manner,the formation of autophagic vacuoles and the levels of LC-3B-II were elevated.RNA interference of LC3 B in these Mn Cl2-exposed cells demonstrated that MMP loss and apoptosis were enhanced.Additionally,the pan-caspase inhibitor Z-VAD-FMK increased the cellular levels of Bcl-2 and decreased apoptosis,but did not affect the cellular levels of LC3 B in Mn Cl2-treated 16 HBE cells.Conclusion Mn Cl2 dose-and time-dependently inhibits 16 HBE cell proliferation and induces MMP loss and apoptosis.Autophagy acts in a protective role against Mn Cl2-induced apoptosis in 16 HBE cells. | YUAN Zhun YING Xian Ping ZHONG Wei Jian TIAN Shi Min WANG Yu JIA Yong Rui CHEN Wen FU Juan Ling ZHAO Peng ZHOU Zong Can | 2016 | Biomedical and Environmental Sciences2016，29，7： | 5 |
| 3 | 120 mm Single-crystalline perovskite and wafers: towards viable applications显示文摘As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity resistance, it is expected that solar cells with high stable efficiency maybe attainable using the crystalline wafers. | Yucheng Liu Xiaodong Ren Jing Zhang Zhou Yang Dong Yang Fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu | 2017 | Science China Chemistry2017，60，10： | 5 |
| 4 | Computational functionality-driven design of semiconductors for optoelectronic applications显示文摘The rapid development of the semiconductor industry has motivated researchers passion for accelerating the discovery of advanced optoelectronic materials.Computational functionality-driven design is an emerging branch of material science that has become effective at making material predictions.By combining advanced solid-state knowledge and high-throughput firstprinciples computational approaches with intelligent algorithms plus database development,experts can now efficiently explore many novel materials by taking advantage of the power of supercomputer architectures.Here,we discuss a set of typical design strategies that can be used to accelerate inorganic optoelectronic materials discovery from computer simulations:In silico computational screening;knowledge-based inverse design;and algorithm-based searching.A few representative examples in optoelectronic materials design are discussed to illustrate these computational functionality-driven modalities.Challenges and prospects for the computational functionality-driven design of materials are further highlighted at the end of the review. | Zhun Liu Guangren Na Fuyu Tian Liping Yu Jingbo Li Lijun Zhang | 2020 | InfoMat2020，2，5： | 4 |
| 5 | Neuron navigator 2 is a novel mediator of rheumatoid arthritis显示文摘Rheumatoid arthritis(RA)is a systemic autoimmune disease mainly characterized by synovial tumor-like hyperplasia,synovial inflammation,and damage to adjacent cartilage and bones.^(1) Our previous study provided evidence that cystathionine-γ-lyase(CSE)and the histone demethylase JMJD3 are significantly increased in RA,and CSE was found to negatively regulate the inflammatory response in fibroblast-like synoviocytes(FLSs),which was mainly attributed to JMJD3 inhibition,in RA. | Ran Wang Meng Li Qian Ding Jianghong Cai Yue Yu Xinhua Liu Jianchun Mao Yi Zhun Zhu | 2021 | Cellular & Molecular Immunology2021，18，9： | 1 |
| 6 | A systematic procedure to study the influence of occupant behavior on building energy consumption 显示文摘 | Zhun Yu Benjamin CM Fung Fariborz Haghiahat | 2011 | Energy and Buildings2011，43，6： | 1 |
| 7 | A novel methodology for knowledge discovery through mining associations between building operational data显示文摘 | Yu Zhun Haghighat Fariborz Fung Benjamin C M | 2012 | Energy and Buildings2012，47，4： | 1 |
| 8 | Case Analysis of a Pump-Driven Heat Pipe Heat Recovery Ventilator in an Existing Experiment Building显示文摘The building energy consumption is an important part among the total society energy consumption,in which the energy consumption for air conditioning occupies almost 70%.The energy consumption of the air conditioning system for fresh air handling can be saved effectively when the exhaust air energy could be recovered to preheat or precool the fresh air.Considering the install locations requirements on field,the pump-driven heat pipes(PHP)were developed as heat recovery ventilators(HRVs)and used in an existing experiment building in Beijing Urban.The thermal performance of the PHP HRVs was tested in real operation time periods under winter running mode.Both the power and heat consumption of the modular air handling units with and without HRVs were monitored and obtained,as well as the hourly power and heat consumption.The energy savings of HRVs were analyzed.The results indicate that the PHP HRVs can work steadily and meet the energy recovery need well.The temperature effectiveness of the HRVs can be kept from 60%to 70%.The test total energy saving rate was 24.48%,and the average hourly heat consumption reduced by 28.54%.The daily energy consumption can be saved by 118 kWh,and the energy savings can reach to 9440 kWh for a whole winter. | Zhun Li Zhengrong Ouyang Tianbao Sun Qiang Li Xiaobo Zhao Rong Yu | 2022 | Energy Engineering2022，119，4： | 0 |
| 9 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 10 | Efficacy and safety of remimazolam-based sedation for intensive care unit patients undergoing upper gastrointestinal endoscopy:a cohort study显示文摘BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospective study that compared remimazolam to propofol and midazolam in patients undergoing upper gastrointestinal endoscopy.The primary outcome was the incidence of treatment-related AEs.The secondary outcomes were the time to extubation,the length of ICU stay,and the average cost of sedative per case.RESULTS:Of the 88 patients analyzed,47 were treated with remimazolam(mean dose,7.90±4.84mg),and 41 were treated with propofol(21.19±17.98 mg)or midazolam(3.08±2.17 mg).There was no statistically significant difference in the average duration of the endoscopic procedure(35.89±13.37 min vs.44.51±21.68 min,P=0.133)or the time to extubation(15.00±9.75 h vs.20.59±18.71 h,P=0.211)in the remimazolam group(group I)compared to the propofol or midazolam group(group II).ICU stays(5.40±2.93 d vs.4.63±3.31 d,P=0.072)and treatment-related AEs(48.61%vs.51.38%,P=0.056)were similar between groups.The average cost of sedative per case was significantly lower in the group I than in the group II(RMB 16.07±10.58 yuan vs.RMB 24.37±15.46 yuan,P=0.016).CONCLUSION:Remimazolam-based sedation was noninferior to the classic sedatives and had lower average cost per case,indicating that it may be used as a promising sedative for high-risk patients during endoscopic procedures in the ICU setting. | Yuan-rui Zhao Ke-sheng Huang Guo Hou Lan Yao Li-ping Lu Song Xu Ying-tao Lian Zhun Yao Zhui Yu | 2023 | World Journal of Emergency Medicine2023，14，1： | 0 |
| 11 | Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for desalination显示文摘High performance is essential for the polyamide(PA)reverse osmosis(RO)membranes during the desalination process.Herein,RO membranes with high permselectivity and anti-biofouling properties were fabricated by nanoparticles incorporation and anti-biofouling grafting.Hydrotalcite(HT)incorporation was performed with a dual role,enhancing water flux and acting as grafting sites.The HT incorporation increased the water flux without sacrificing the salt rejection,compensating for the loss caused by the following grafting reaction.The exposed surface of HT acted as grafting sites for anti-biofouling agent dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride(DMOTPAC).The combination of HT incorporation and DMOTPAC grafting endowed RO membranes with high permselectivity and anti-biofouling properties.The water flux of the modified membrane PA-HT-0.06 was 49.8 L/m^(2)·h,which was 16.4%higher than that of the pristine membrane.The salt rejection of PA-HT-0.06 was 99.1%,which was comparable to that of the pristine membrane.As to the fouling of negatively charged lysozyme,the modified membrane’s water flux recovery was superior to that of the pristine membrane(e.g.86.8%of PA-HT-0.06 compared to 78.2%of PA-pristine).The sterilization rates of PA-HT-0.06 for E.coli and B.subtilis were 97.3%and 98.7%,much higher than those of the pristine membrane(24.0%for E.coli and 26.7%for B.subtilis). | Xinxia Tian Hui Yu Jun Yang Xiaotai Zhang Man Zhao Yang Yang Wei Sun Yangyang Wei Yin Zhang Jian Wang Zhun Ma | 2022 | Frontiers of Environmental Science & Engineering2022，16，7： | 0 |
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