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| 1 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 2 | 显示文摘 | ZHUNa(朱娜) | 2012 | 实验室研究与探索2012，31，1： | 1 |
| 3 | Processing Technology of Mongolian Artemisia frigida Willd. and Pharmacological Study on Processed Products显示文摘[Objectives] To optimize the processing technology of Mongolian Artemisia frigida Willd. and observe the safety and effectiveness of processed products. [Methods] The orthogonal test was conducted with the content of chlorogenic acid( CGA) in processed products and quercetin as the main indicator and reference factors. The impact of frying temperature and time and medicinal material granularity were examined to determine the optimal process. The safety and effectiveness were evaluated through adopting acute toxicity test in mice,and the bleeding time was determined by tail docking experiments,the blood coagulation time was determined with orbital venous plexus,the total number of platelets was counted for the whole blood. [Results]When the product was flipped and fried at the temperature of 270 ℃ for 20 min,the best effect was achieved. From the variance analysis,it proved that the frying temperature and the time and granularity had no significant effect on the content of the two components monitored. After processing,Artemisia frigida Willd.,it can shorten the bleeding time of mice and significantly increase the platelet number. [Conclusions]Appropriate frying can improve the safety and hemostatic effect. Therefore,this study can provide reference for verifying the theory of use of traditional Mongolian Artemisia frigida Willd. | Zhuna Sarula Nashengsang | 2017 | Medicinal Plant2017，8，1： | 0 |
| 4 | The Synthesis of Some 17-(2'-Oxazolyl)-androsta-5,16-diene Deriva-tives as 17α-Hydroxylase/C17,20 -Lyase Inhibitors显示文摘Several 4'- and 5'-substituted 17-(2'-oxazolyl)-androsta-5,16-diene derivatives were designed and synthesized as inhibitors of 17α-hydroxylase/C17,20 -Lyase (P45017α) for the treatment of prostatic cancer, the results of the preliminary pharmacological screening showed that compound 6c, i.e. 17-(2'-oxazoly)-androsta-5,16-diene-3-ol was a strong inhibitor, comparable with that of the reference compound VN-85. The introduction ofmethyl or phenyl group at the 4' or 5' position of oxazole ring decreased the activity. The in vitro activities of 3- acetate 5a-c and 8 were lower than their 3-ol counterparts 6a-c and 9 as expected. The further pharmacological study of 6c is in progress. | ZhuNa ZhaoNa LeiXiaoping LingYangzhi VenkatechHundratta AngelaBrodie | 2001 | Journal of Chinese Pharmaceutical Sciences2001，10，1： | 0 |
| 5 | Comparative Study on the Effect of Mongolian Medicine Euphorbia pekinensis and Pharbitidis Semen(Black)显示文摘[Objectives]To explore the difference of purgative effect of Mongolian medicine Euphorbia pekinensis and Pharbitidis Semen(black)by animal experiment,taking Euphorbia pekinensis and Pharbitidis Semen(black)as the research object.[Methods]Sixty Kunming mice were randomly divided into blank group(n=20),Euphorbia pekinensis group(n=20)and Pharbitidis Semen(black)group(n=20).After fasted but provided with free acess to drinking water for 3 d,the mice were intragastrically administered with drinking water,Euphorbia pekinensis test solution and Pharbitidis Semen(black)test solution,respectively.The mice were then placed separately in a mouse cage covered with filter paper for purgation test and intestinal propulsion test.[Results]The time of the first purgation in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group was longer than that in the blank group(P<0.05).The total times of purgation and defecation within 5 h in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group were higher than those in the blank group(P<0.05);the purgation index and intestinal propulsion rate in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group were higher than those in the blank group(P<0.05).[Conclusions]The Mongolian medicine Euphorbia pekinensis was similar to Pharbitidis Semen(black)in purgation test and intestinal propulsion test,and could play a substitute role. | Zhuna Sudenamu Jingli MA Yujie YE | 2020 | Medicinal Plant2020，11，2： | 0 |
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