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| 1 | Effects of Saccharomyces cerevisiae fermentation products on performance and rumen fermentation and microbiota in dairy cows fed a diet containing low quality forage显示文摘Background: A possible option to meet the increased demand of forage for dairy industry is to use the agricultural byproducts, such as corn stover. However, nutritional value of crop residues is low and we have been seeking technologies to improve the value. A feeding trial was performed to evaluate the effects of four levels of Saccharomyces cerevisiae fermentation product(SCFP; Original XP; Diamond V) on lactation performance and rumen fermentation in mid-lactation Holstein dairy cows fed a diet containing low-quality forage. Eighty dairy cows were randomly assigned into one of four treatments: basal diet supplemented with 0, 60, 120, or 180 g/d of SCFP per head mixed with 180, 120, 60, or 0 g of corn meal, respectively. The experiment lasted for 10 wks, with the first 2 weeks for adaptation.Results: Dry matter intake was found to be similar(P > 0.05) among the treatments. There was an increasing trend in milk production(linear, P ≤ 0.10) with the increasing level of SCFP supplementation, with no effects on contents of milk components(P > 0.05). Supplementation of SCFP linearly increased(P < 0.05) the N conversion, without affecting rumen pH and ammonia-N(P > 0.05). Increasing level of SCFP linearly increased(P < 0.05) concentrations of ruminal total volatile fatty acids, acetate, propionate, and butyrate, with no difference in molar proportion of individual acids(P > 0.05). The population of fungi and certain cel ulolytic bacteria(Ruminococcus albus, R. flavefaciens and Fibrobacter succinogenes)increased linearly(P < 0.05) but those of lactate-utilizing(Selenomonas ruminantium and Megasphaera elsdeni) and lactate-producing bacteria(Streptococcus bovis) decreased linearly(P ≤ 0.01) with increasing level of SCFP. The urinary purine derivatives increased linearly(P < 0.05) in response to SCFP supplementation, indicating that SCFP supplementation may benefit for microbial protein synthesis in the rumen.Conclusions: The SCFP supplementation was effective in maintaining milk persistency of mid-lactation cows receiving diets containing low-quality forage. The beneficial effect of SCFP could be attributed to improved rumen function; 1)microbial population shift toward greater rumen fermentation efficiency indicated by higher rumen fungi and cel ulolytic bacteria and lower lactate producing bacteria, and 2) rumen microbial fermentation toward greater supply of energy and protein indicated by greater ruminal VFA concentration and increased N conversion. Effects of SCFP were dose-depended and greater effects being observed with higher levels of supplementation and the effect was more noticeable during the high THI environment. | Wen Zhu Zihai Wei Ningning Xu Fan Yang Ilkyu Yoon Yihua Chung Jianxin Liu Jiakun Wang | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 13 |
| 2 | Effects of the dietary nonfiber carbohydrate content on lactation performance, rumen fermentation, and nitrogen utilization in mid-lactation dairy cows receiving corn stover显示文摘Background: Corn stover(CS) is an abundant source of feed for livestock in China. However, it is low in nutritional value that we have been seeking technologies to improve. Previous studies show that non-fiber carbohydrate(NFC)might limit the utilization of a CS diet by lactating dairy cows. Thus, this study was conducted to investigate the lactation performance and rumen fermentation characteristics in lactating cows consuming CS with two contents of NFC compared to an alfalfa hay-containing diet. Twelve Holstein cows were used in a replicated 3 × 3 Latin square design with three dietary treatments:(1) low-NFC diet(NFC = 35.6%, L-NFC),(2) high-NFC diet(NFC = 40.1%,H-NFC), and(3) alfalfa hay diet(NFC = 38.9%, AH).Results: Intake of DM was lower for cows fed H-NFC compared to L-NFC and AH, while the milk yield was higher in AH than in H-NFC and L-NFC(P < 0.01). The feed efficiency(milk yield/DM intake, 1.15 vs. 1.08, P < 0.01) were greater for cows fed H-NFC than L-NFC. The contents of milk protein and lactose were not different among the groups(P > 0.11), but milk fat content was higher for cows fed H-NFC and L-NFC compared to AH(P < 0.01). The rumen ammonia nitrogen concentration and the concentrations of urea nitrogen in blood and milk were lower for cows fed H-NFC and AH compared to L-NFC(P < 0.05). The concentrations of rumen propionate and total volatile fatty acids were different among groups(P < 0.05) with higher concentration for cows fed AH compared to H-NFC and L-NFC, and acetate concentration tended to be different among groups(P = 0.06).Conclusions: From the results obtained in this study, it was inferred that the increased NFC content in a diet containing corn stover can improve the feed efficiency and benefit the nitrogen conversion. | Zihai Wei Baoxin Zhang Jianxin Liu | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 2 |
| 3 | Heat shock protein-peptide complexes, reconstituted in vitro, elicit pepdde-specific cytotoxic T lymphocyte response and tumor immunity显示文摘 | Lachere N E Zihai L Rajiv Y | 1997 | J Exp Med1997，186，8： | 1 |
| 4 | Heat shock proteins transfer peptides during antigen processing and CTL priming显示文摘 | Pramod K. Srivastava Heiichiro Udono Nathalie E. Blachere Zihai Li | 1994 | Immunogenetics1994，，2： | 1 |
| 5 | Strength degra dation analysis of an aging RC girder bridge using FE crack analysis and simple capacity-evaluation equations 显示文摘 | Jianhong Wang Zihai Shi Nakano M | 2013 | Engineering Fracture Mechanics2013，108，8： | 1 |
| 6 | Numerical analysis of mixed-mode fracture in concrete using extended fictitious crack model显示文摘 | | 2004 | Journal of Structural Engineering2004，130，11： | 1 |
| 7 | Heat shock proteins transfer peptides during antigen processing and CTL priming显示文摘 | Pramod K. Srivastava Heiichiro Udono Nathalie E. Blachere Zihai Li | 1994 | Immunogenetics1994，，2： | 1 |
| 8 | Heat-shock proteins显示文摘 | Li Zihai Srivastava P | 2004 | Curr Protoc Immunol2004，1，： | 1 |
| 9 | Heat shock protein-peptide complexes,reconstituded in vitro,elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity显示文摘 | Nathalie E Blachere Z Zihai L | 1997 | J Exp Med1997，8，： | 1 |
| 10 | A New Solar Broadband Radio Spectrometer (SBRS) in China显示文摘 | Qijun Fu Huirong Ji Zihai Qin Zhicai Xu Zhiguo Xia Hongao Wu Yuying Liu Yihua Yan Guangli Huang Zhijun Chen Zhenyu Jin Qijun Yao Congling Cheng Fuying Xu Min Wang Libei Pei Shanhuai Chen Guo Yang Chenming Tan Suobiao Shi | 2004 | Solar Physics2004，，1： | 1 |
| 11 | Heat shock proteins transfer peptides during antigen processing and CTL priming显示文摘 | Pramod K. Srivastava Heiichiro Udono Nathalie E. Blachere Zihai Li | 1994 | Immunogenetics1994，，2： | 1 |
| 12 | Hibino Y, Numerical analysis of multiple cracks in concrete using the discrete approach显示文摘 | Zihai Shi Ohtsu M Suzuki M | 1998 | Journal of Structure Engineering1998，127，9： | 1 |
| 13 | Activation of NK cells by extra- cellular heat shock protein 70 through induction of NKG2D hgands on dendritic cells显示文摘 | Qiao Yi Liu Bei Li Zihai | 2008 | Cancer Immu2008，8，1： | 1 |
| 14 | Heat shock proteins transfer peptides during antigen processing and CTL priming显示文摘 | Pramod K. Srivastava Heiichiro Udono Nathalie E. Blachere Zihai Li | 1994 | Immunogenetics1994，，2： | 1 |
| 15 | Heat shock protein-peptide com-plexes,reconstituded in vitro,elicit peptide-specific cytotoxic T lynpho-cyte response and tumor immunity显示文摘 | NATHALIE E BLACHERE Z ZIHAI L | 1997 | J Exp Med1997，8，： | 1 |
| 16 | Roles of heat-shock proteins in antigen presentation and cross-presentation显示文摘 | Zihai Li Antoine Menoret Pramod Srivastava | 2002 | Current Opinion in Immunology2002，，1： | 1 |
| 17 | Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism显示文摘How tumor-associated macrophages transit from a predominant antitumor M1-like phenotype to a protumoral M2-like phenotype during the development of pancreatic ductal adenocarcinoma (PDA) remains to be elucidated. We thus conducted a study by employing a PDA-macrophage co-culture system, an “orthotopic” PDA syngeneic mouse model, and human PDA specimens, together with macrophages derived from GARP knockout mice and multiple analytic tools including whole-genome RNA sequencing, DNA methylation arrays, multiplex immunohistochemistry, metabolism measurement, and invasion/metastasis assessment. Our study showed that PDA tumor cells, through direct cell–cell contact, induce DNA methylation and downregulation of a panel of glucose metabolism and OXPHOS genes selectively in M1-like macrophages, leading to a suppressed glucose metabolic status in M1-like but not in M2-like macrophages. Following the interaction with PDA tumor cells, M1-like macrophages are reprogrammed phenotypically to M2-like macrophages. The interaction between M1-like macrophages and PDA cells is mediated by GARP and integrin αV/β8, respectively. Blocking either GARP or integrin would suppress tumor-induced DNA methylation in Nqo-1 gene and the reprogramming of M1-like macrophages. Glucose-response genes such as Il-10 are subsequently activated in tumor-educated M1-like macrophages. Partly through Il-10 and its receptor Il-10R on tumor cells, M1-like macrophages functionally acquire a pro-cancerous capability. Both exogenous M1-like and M2-like macrophages promote metastasis in a mouse model of PDA while such a role of M1-like macrophages is dependent on DNA methylation. Our results suggest that PDA cells are able to reprogram M1-like macrophages metabolically and functionally through a GARP-dependent and DNA methylation-mediated mechanism to adopt a pro-cancerous fate. | Mengwen Zhang Xingyi Pan Kenji Fujiwara Noelle Jurcak Stephen Muth Jiaojiao Zhou Qian Xiao Anqi Li Xu Che Zihai Li Lei Zheng | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 1 |
| 18 | Numerical analysis of multiple cracks in concrete using the discrete approach显示文摘 | Zihai Shi Ohtsu M Suzuki M | 1998 | Journal of Structure Engineering1998，127，9： | 1 |
| 19 | Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma显示文摘 | Yunpeng Hua Shai White-Gilbertson Joshua Kellner Saleh Rachidi Saad Z. Usmani Gabriela Chiosis Ronald DePinho Zihai Li Bei Liu | 2013 | Clinical Cancer Research2013，，： | 1 |
| 20 | Heat shock protein-peptide complexes reconstituted in vitro elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity显示文摘 | Blachere NE Zihai Li Chandawarkar RY | 1997 | J Exp Med1997，186，8： | 1 |
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