4篇
您的检索式：作者名="Zikai Zhou"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Randomized controlled multicenter clinical trial for integrated treatment of community-acquired pneumonia based on Traditional Chinese Medicine syndrome differentiation显示文摘OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe. | Jiansheng Li Xueqing Yu Suyun Li Haifeng Wang Yunping Bai Minghang Wang Zikai Sun Wei Zhang Zhaoshan Zhou Xianhua Jia Qingwei Zhou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 2 | Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production显示文摘Japanese encephalitis virus(JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a52-amino acid C-terminal extension of NS1, is generated with a-1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1' plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1' defected(rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus(pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type Ⅰ interferon(IFN) response than that by pSA14, and JEV NS1' significantly inhibited the production of IFN-b and IFN-stimulated genes. Taken together, our results reveal that NS1' plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication. | Dengyuan Zhou Fan Jia Qiuyan Li Luping Zhang Zheng Chen Zikai Zhao Min Cui Yunfeng Song Huanchun Chen Shengbo Cao Jing Ye | 2018 | Virologica Sinica2018，33，6： | 3 |
| 3 | p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties显示文摘 | Wayne Huang Zikai Zhou Suhail Asrar | 2011 | Molecular and Cellular Biology2011，31，： | 1 |
| 4 | Fbxl4作为节律输出分子通过周期性降解GABAA受体调控睡眠行为显示文摘文章简介睡眠是一种保守、可逆的行为状态,该过程受到生物节律和睡醒稳态的调控。然而生物节律到底是以何种输出形式调控睡眠的一直不清楚。 | Qian Li Yi Li Xiao Wang Junxia Qi Xi Jin Huawei Tong Zikai Zhou Zi Chao Zhang 韩俊海 | 2018 | 科学新闻2018，0，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员