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| 1 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 2 | Cancer incidence and mortality in Shandong province,2012显示文摘Objective: Population-based cancer registration data in 2012 from all available cancer registries in Shandong province were collected by Shandong Center for Disease Control and Prevention(SDCDC). SDCDC estimated the numbers of new cancer cases and cancer deaths in Shandong province with compiled cancer incidence and mortality rates.Methods: In 2015, there were 21 cancer registries submitted data of cancer incidence and deaths occurred in 2012. All the data were checked and evaluated based on the National Central Cancer Registry(NCCR) criteria of data quality. Qualified data from 15 registries were used for cancer statistics analysis as provincial estimation. The pooled data were stratified by area(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+ years) and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding provincial population in 2012. The Chinese census data in 2000 and Segi's population were applied for age-standardized rates. All the rates were expressed per 100,000 person-year.Results: Qualified 15 cancer registries(4 urban and 11 rural registries) covered 17,189,988 populations(7,486,039 in urban and 9,703,949 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 66.12% and 2.93%, respectively, and the mortality to incidence rate ratio(M/I) was 0.60. A total of 253,060 new cancer cases and 157,750 cancer deaths were estimated in Shandong province in 2012. The incidence rate was 263.86/100,000(303.29/100,000 in males, 223.23/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 192.42/100,000 and 189.50/100,000 with the cumulative incidence rate(0-74 years old) of 22.07%. The cancer incidence, ASIRC and ASIRW in urban areas were 267.64/100,000, 195.27/100,000 and 192.02/100,000 compared to 262.32/100,000, 191.26/100,000 and 188.48/100,000 in rural areas, respectively. The cancer mortality was 164.47/100,000(207.42/100,000 in males, 120.23/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 117.54/100,000 and 116.90/100,000, and the cumulative mortality rate(0-74 years old) was 13.53%. The cancer mortality, ASMRC and ASMRW were 141.59/100,000, 101.17/100,000 and 100.33/100,000 in urban areas, and 173.79/100,000, 124.20/100,000 and 123.64/100,000 in rural areas, respectively. Cancers of the lung, stomach, liver, esophagus, colorectum, female breast, brain, leukemia, bladder and pancreas were the most common cancers, accounting for about 82.12% of all cancer new cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer, colorectal cancer, female breast cancer, pancreatic cancer, brain tumor, leukemia and lymphoma were the leading causes of cancer death, accounting for about 89.01% of all cancer deaths. The cancer spectrum showed difference between urban and rural, males and females both in incidence and mortality rates.Conclusions: Cancer surveillance information in Shandong province is making great progress with the increasing number of cancer registries, population coverage and the improving data quality. Cancer registration plays a fundamental role in cancer control by providing basic information on population-based cancer incidence, mortality, survival and time trend. The disease burden of cancer is serious in Shandong province, and so cancer prevention and control in Shandong province should be enhanced including health education, health promotion, cancer screening and cancer care services. | Zhentao Fu Zilong Lu Yingmei Li jiyu Zhang Gaohui Zhang Xianxian Chen Jie Chu Jie Ren Haiyan Liu Xiaolei Guo | 2016 | Chinese Journal of Cancer Research2016，28，3： | 17 |
| 3 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 4 | Evaluation of regional water security using water poverty index显示文摘Water security is a widely concerned issue in the world nowadays.A new method,water poverty index(WPI),was applied to evaluate the regional water security.Twelve state farms in Heilongjiang Province,Northeastern China were selected to evaluate water security status based on the data of 2006 using WPI and mean deviation grading method.The method of WPI includes five key indices:resources(R),access(A),capacity(C),utilization(U)and environment(E).Each key index further consists of several sub-indices.According to the results of WPI,the grade of each farm was calculated by using the method of mean deviation grading.Thus,the radar images can be protracted of each farm.From the radar images,the conclusions can be drawn that the WPI values of Farm 853 and Hongqiling are under very safe status,while that of Farm Raohe is under safe status,those of Farms Youyi,597,852,291 and Jiangchuan are under moderate safe status,that of Farm Beixing is under low safe status and those of Farm Shuangyashan,Shuguang and Baoshan are under unsafe status.The results from this study can provide basic information for decision making on rational utilization of water resources and regulations for regional water safety guarantee system. | Fu Qiang Gary Kachanoski Liu Dong Wang Zilong | 2008 | International Journal of Agricultural and Biological Engineering2008，1，2： | 1 |
| 5 | High temperature thermoelectric properties of Bi 2 Sr 2 Co 2 O y /Ag composites显示文摘 | Shufang Wang Zilong Bai Haifeng Wang Qing Lü Jianglong Wang Guangsheng Fu | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 6 | The effect of microstructure on the laser-induced transverse voltage in Pb-doped Bi 2 Sr 2 Co 2 O y thin films on tilted substrates显示文摘 | Guoying Yan Shufang Wang Shanshan Chen Fuqiang Liu Zilong Bai Jianglong Wang Wei Yu Guangsheng Fu | 2013 | Applied Physics A2013，，4： | 1 |
| 7 | Adsorption mechanism of bisphenol A in aqueous solution using anionic-cationic surfactant modified attapulgite显示文摘 | Zhao Zilong Fu Dafang | 2012 | Journal of Southeast University2012，42，5： | 1 |
| 8 | DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery<link href='#nss'/>显示文摘 | Rong Hu Xiaobing Zhang Zilong Zhao Guizhi Zhu Tao Chen Ting Fu Weihong Tan | 2014 | Angew Chem Int Ed2014，，23： | 1 |
| 9 | Method of Chaotic Prediction Based on Wavelet BP Network and Its Application显示文摘 | Qiang Fu Guoliang Li Zilong Wang | 2008 | Journal of Systems Science and Information2008，6，1： | 0 |
| 10 | Dynamic simulation of China’s water-grain-meat system and evaluation of its support capability based on water footprint theory显示文摘The supply capacity of water resources,food and meat products is of great importance to the people’s livelihood of a country.In recent years,although China has introduced many policies on water resources and grain production,the current situation of China’s food self-sufficiency and imbalance between supply and demand of water resources has not been fundamentally changed.Food security and water security are facing a serious situation.This paper takes the water footprint as the connection point,and combines the water food meat system with mutual influence,mutual causation and dynamic feedback into a composite system.At the same time,the simulation model of the composite system is established by using system dynamics,and the dynamic simulation of water grain meat in China from 2000 to 2050 is carried out to explore the current situation and future development trend of China’s water,grain and meat supply capacity.It was found that during the simulated period,the agricultural blue-green water footprint on the demand side would continue to dominate,followed by the gray water footprint.The blue water footprint on the supply side remained stable,whereas the green water footprint and the circulating water footprint showed an upward trend.According to the contemporary social and economic development and the model of water resources in China,there will be no meat shortage in the future,but issues have been found in the ability to guarantee water and food supply.The root of China’s food support capability problem is excessive grain consumption due to meat production,whereas the cause of the water support capability problem is the slow development of the water conservation.Food support capability issues can be solved by regulating the meat output of livestock farming and fishery operations,reducing excess production capacity,and stabilizing the meat supply and demand.To solve the water support capability issue,China should focus on accelerating the pace of agricultural water-conservation development,improving the sewage treatment system,building rainwater-collection projects,and promoting the research and development of water recycling technology.This study provides support for optimizing the structures of the meat and grain industries and the policy formulation of the efficient use of water resources in China. | Qiuxiang Jiang Haoyu Liao Xingtao Ouyang Qiang Fu Xiaolong He Yunxing Wu Zilong Wang | 2023 | International Journal of Agricultural and Biological Engineering2023，16，5： | 0 |
| 11 | Fault diagnosis for gearboxes based on Fourier decomposition method and resonance demodulation显示文摘Condition monitoring and fault diagnosis of gearboxes play an important role in the maintenance of mechanical systems.The vibration signal of gearboxes is characterized by complex spectral structure and strong time variability,which brings challenges to fault feature extraction.To address this issue,a new demodulation technique,based on the Fourier decomposition method and resonance demodulation,is proposed to extract fault-related information.First,the Fourier decomposition method decomposes the vibration signal into Fourier intrinsic band functions(FIBFs)adaptively in the frequency domain.Then,the original signal is segmented into short-time vectors to construct double-row matrices and the maximum singular value ratio method is employed to estimate the resonance frequency.Then,the resonance frequency is used as a criterion to guide the selection of the most relevant FIBF for demodulation analysis.Finally,for the optimal FIBF,envelope demodulation is conducted to identify the fault characteristic frequency.The main contributions are that the proposed method describes how to obtain the resonance frequency effectively and how to select the optimal FIBF after decomposition in order to extract the fault characteristic frequency.Both numerical and experimental studies are conducted to investigate the performance of the proposed method.It is demonstrated that the proposed method can effectively demodulate the fault information from the original signal. | Shuiguang TONG Zilong FU Zheming TONG Junjie LI Feiyun CONG | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，5： | 0 |
| 12 | Coordination and order risk assessment of water and land resource system based on periphery and synergetics theories显示文摘Coordinated and orderly water and land resource system is vital to ensure the economic and social development of a region.Grain production in Heilongjiang Province has increased consecutively every year since 2003,and numerous water and land resource-related problems have become increasingly prominent and have had significant adverse effects on social and economic development and stability in the region.In this study,Heilongjiang Province and its 13 prefecture-level cities were selected as the study area,and the degrees of coordination of the social,economic and ecological subsystems were evaluated using periphery theory and the theory of synergetics.To ensure that the assessment was objective and accurate,weights were calculated using the projection pursuit technique,and similarity degrees were calculated using a modified(by introducing the chi-square distance)order of preference by similarity to ideal solution(TOPSIS)technique.Moreover,to reflect the variations in the overall degree of coordination in Heilongjiang Province,the risk level of the coordination of the water and land resource system was predicted through the year 2020 using a dynamic neural network.This study provides a reference for establishing effective and balanced coordination between society and water and land resources. | Qiuxiang Jiang Zhimei Zhou Zilong Wang Qiang Fu Youzhu Zhao Tian Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 0 |
| 13 | New Insights from Chemical Biology:Molecular Basis of Transmission,Diagnosis,and Therapy of SARS-CoV-2显示文摘Coronavirus disease 2019(COVID-19)is caused by a novel strain of coronavirus,designated as severe acute respiratory syndrome coronavirus 2(SARSCoV-2).It has caused a global pandemic rapidly sweeping across all countries,bringing social and economic hardship to millions.Most countries have implemented early warning measures to detect,isolate,and treat patients infected with SARS-CoV-2.This minireview summarizes some of those steps,in particular,testing methods and drug development in the context of chemical biology,and discusses the molecular basis of COVID-19’s virulent transmissibility. | Zilong Zhao Yaling Wang Liping Qiu Ting Fu Yu Yang Ruizi Peng Mengyu Guo Lichun Mao Chunying Chen Yuliang Zhao Weihong Tan | 2021 | CCS Chemistry2021，3，1： | 0 |
| 14 | 大规模无创产前检测的基因组分析揭示了多个性状的遗传关联、病毒的感染模式以及中国人群的遗传历史显示文摘文章简介本研究分析了参与无创产前基因检测(NIPT)的141,431名中国女性的全基因组低深度测序数据。研究团队使用这些数据描绘了中国人的群体遗传特征,并探索了遗传因素与母婴健康等性状的相互关联情况。 | Siyang Liu Shujia Huang Fang Chen Lijian Zhao Yuying Yuan Stephen Starko Francis Lin Fang Zilong Li Long Lin Rong Liu Yong Zhang Huixin Xu Shengkang Li Yuwen Zhou Robert W.Davies Qiang Liu Robin G.Walters Kuang Lin Jia Ju Thorfinn Korneliussen Melinda A.Yang Qiaomei Fu Jun Wang Lijun Zhou Anders Krogh Hongyun Zhang Wei Wang Zhengming Chen Zhiming Cai Ye Yin Huanming Yang Mao Mao Jay Shendure 汪建 Anders Albrechtsen 金鑫 Rasmus Nielsen 徐讯 | 2019 | 科学新闻2019，0，2： | 0 |
| 15 | Research Progress on Toxicity of Natural Compounds显示文摘There are many active substances in natural resources.After years of research,researchers at home and abroad have extracted active compounds and proved that these compounds have low toxicity and high efficiency,but the toxicity of these compounds cannot be ignored.In this paper,the research progress on the toxicity of compounds isolated from various natural substances is reviewed,which provides a reference for the further development and rational utilization of natural compounds. | Zhangping Zhou Zilong Fu Yan Li Biao Ren Ling Duan Song Teng Zhuoxuan Liang | 2021 | Proceedings of Anticancer Research2021，5，2： | 0 |
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