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| 1 | KLF7 promotes preadipocyte proliferation via activation of the Akt signaling pathway by Cis-regulating CDKN3显示文摘Krüppel-like transcription factor 7(KLF7)promotes preadipocyte proliferation;however,its target gene in this process has not yet been identified.Using KLF7 ChIP-seq analysis,we previously showed that a KLF7-binding peak is present upstream of the cyclin-dependent kinase inhibitor 3 gene(CDKN3)in chicken preadipocytes.In the present study,we identify CDKN3 as a target gene of KLF7 that mediates the effects of KLF7 on preadipocyte proliferation.Furthermore,5′-truncating mutation analysis shows that the minimal promoter is located between nt–160 and nt–7(relative to the translation initiation codon ATG)of CDKN3.KLF7 overexpression increases CDKN3 promoter activity in the DF-1 and immortalized chicken preadipocyte(ICP1)cell lines.Deletion of the putative binding site of KLF7 abolishes the promotive effect of KLF7 overexpression on CDKN3 promoter activity.Moreover,CDKN3 knockdown and overexpression assays reveal that CDKN3 enhances ICP1 cell proliferation.Flow cytometry analysis shows that CDKN3 accelerates the G1/S transition.Furthermore,we find that KLF7 promotes ICP1 cell proliferation via Akt phosphorylation by regulating CDKN3.Taken together,our results suggest that KLF7 promotes preadipocyte proliferation by activating the Akt signaling pathway by cis-regulating CDKN3,thus driving the G1/S transition. | Ziqiu Jia Zhao Jin Shuli Shao Hu Xu Wen Li Mahmood Khan Weiyu Wang Weiwei Zhang Yingning Sun | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 2 |
| 2 | A multifunctional and scalable fullerene electron transporting material for efficient inverted perovskite solar cells and modules显示文摘The interfacial properties between charge transporting material and perovskite(PVSK)play critical roles in governing the photovoltaic performances of perovskite solar cells(PVSCs).Herein,we develop a multifunctional fulleropyrrolidine(FMG)as an electron transporting material(ETM),which facilitates the construction of efficient and stable inverted PVSCs and modules.It revealed that the facile and scalable FMG possesses not only excellent electron extraction capabilities,but also multi-groups to simultaneously passivate PVSKs via Lewis acid-base and hydrogen bonding interactions.The coating of FMG onto PVSK interestingly yields a dense and interactive layer with the graded ETM-PVSK heterojunction architecture.As a result,FMGbased PVSCs demonstrate a champion efficiency of 23.8%,outperforming 21.0%of PCBM-based devices.FMG could also be utilized to improve photovoltaic performance of large-scale modules.In addition,FMG has successfully elongated the lifetime of the corresponding PVSCs,maintaining 85%of the initial performance after the continuous 60-day one sun equivalent illumination in ambient. | Kangrong Yan Ziqiu Shen Benfang Niu Yanchun Huang Di Wang Emely Gu Buyi Yan Jizhong Yao Hongzheng Chen Chang-Zhi Li | 2023 | Science China Chemistry2023，66，6： | 0 |
| 3 | Using psychodrama to relieve social barriers in an autistic child:A case study and literature review显示文摘Objective:To review and update the evidence for the effect of psychodrama for children with autism,and evaluate the effect of psychodrama on an autistic child with severe social barriers,using the theory of mind and psychodrama methodology as the analytical frameworks.Methods:A 5 year-old boy,the research object,was diagnosed as severe autism using behavior observation and autism screening tools,with an DSM-Ⅵcriteria.Autism symptom severity was usually measured by Childhood Autism Rating Scale(CARS)and Autism Behavior Checklist(ABC)in research of autism.In this study,the autistic boy accepted psychodrama training and was measured with CARS before and after the entire training program.The ABC was adopted to evaluate him after each intervention program.Meanwhile the entire training process was recorded.The evaluation criterion consists of four aspects including eye contact,following instructions,focusing attention and imitation ability.Finally,all live records and changes presented in volume tables were analyzed.Results:The patient's social barriers were relieved at the end of the third month of the training program.The CARS data shows a shift fromthe severe to moderate level of autism.Conclusions:It was possible for autistic children to relieve social barriers by implementing psychodrama training,then to improve the social cognitive ability and enhance the social function of the autistic children.These results provided basic Clinical implications for exploring a new intervention technique to reduce autistic symptom severity. | Jing Li Dangyang Wang Ziqiu Guo Kun Li | 2015 | International Journal of Nursing Sciences2015，2，4： | 0 |
| 4 | Reactive SPS of Al_(2)O_(3)–RE:YAG(RE=Ce;Ce+Gd)composite ceramic phosphors显示文摘Ultrafine-grained Al_(2)O_(3)–rare earth:yttrium aluminium garnet(Al_(2)O_(3)–RE:YAG)(RE=Ce;Ce+Gd)composite ceramics were obtained for the first time by reactive spark plasma sintering(SPS)using commercially available initial oxide powders.The effect of key sintering parameters(temperature,dwell time,and external pressure(P_(load)))on densification peculiarities,structural-phase states,and luminescent properties of composites was studied comprehensively.Differences in phase formation and densification between Ce-doped and Ce,Gd-codoped systems were shown.Parameters of reactive SPS,at which there is partial melting with the formation of near-eutectic zones of the Al_(2)O_(3)–YAG system/coexistence of several variations of the YAG-type phase,were established.Pure corundum–garnet biphasic ceramics with an optimal balance between microstructural and luminescence performance were synthesized at 1425℃/30 min/30–60 MPa.The external quantum efficiency(EQE)of the phosphor converters reached 80.7%and 72%with close lifetime of~63.8 ns,similar to those of commercial Ce:YAG materials,which is promising for further applications in the field of high-power white light-emitting diodes(WLEDs)and laser diodes(LDs). | Denis Yu.Kosyanov Anastasia A.Vornovskikh Oleg O.Shichalin Evgeniy K.Papynov Anton A.Belov Aleksandra A.Kosianova Aleksandr N.Fedorets Andrei A.Leonov Alexey P.Zavjalov Sergey A.Tikhonov Yanbin Wang Ziqiu Cheng Xin Liu Jiang Li | 2023 | Journal of Advanced Ceramics2023，12，5： | 0 |
| 5 | Highly Thermally Conductive and Structurally Ultra‑Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management显示文摘Highly thermally conductive graphitic film(GF)materials have become a competitive solution for the thermal management of high-power electronic devices.However,their catastrophic structural failure under extreme alternating thermal/cold shock poses a significant challenge to reliability and safety.Here,we present the first investigation into the structural failure mechanism of GF during cyclic liquid nitrogen shocks(LNS),which reveals a bubbling process characterized by“permeation-diffusion-deformation”phenomenon.To overcome this long-standing structural weakness,a novel metal-nanoarmor strategy is proposed to construct a Cu-modified graphitic film(GF@Cu)with seamless heterointerface.This well-designed interface ensures superior structural stability for GF@Cu after hundreds of LNS cycles from 77 to 300 K.Moreover,GF@Cu maintains high thermal conductivity up to 1088 W m^(−1)K^(−1)with degradation of less than 5%even after 150 LNS cycles,superior to that of pure GF(50%degradation).Our work not only offers an opportunity to improve the robustness of graphitic films by the rational structural design but also facilitates the applications of thermally conductive carbon-based materials for future extreme thermal management in complex aerospace electronics. | Peijuan Zhang Yuanyuan Hao Hang Shi Jiahao Lu Yingjun Liu Xin Ming Ya Wang Wenzhang Fang Yuxing Xia Yance Chen Peng Li Ziqiu Wang Qingyun Su Weidong Lv Ji Zhou Ying Zhang Haiwen Lai Weiwei Gao Zhen Xu Chao Gao | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 6 | Multifunctional Perovskite Photodetectors: From Molecular-Scale Crystal Structure Design to Micro/Nano-scale Morphology Manipulation显示文摘Multifunctional photodetectors boost the development of traditional optical communication technology and emerging artificial intelligence fields, such as robotics and autonomous driving. However, the current implementation of multifunctional detectors is based on the physical combination of optical lenses, gratings, and multiple photodetectors, the large size and its complex structure hinder the miniaturization, lightweight, and integration of devices. In contrast, perovskite materials have achieved remarkable progress in the field of multifunctional photodetectors due to their diverse crystal structures, simple morphology manipulation, and excellent optoelectronic properties. In this review, we first overview the crystal structures and morphology manipulation techniques of perovskite materials and then summarize the working mechanism and performance parameters of multifunctional photodetectors. Furthermore, the fabrication strategies of multifunctional perovskite photodetectors and their advancements are highlighted, including polarized light detection, spectral detection, angle-sensing detection, and selfpowered detection. Finally, the existing problems of multifunctional detectors and the perspectives of their future development are presented. | Yingjie Zhao Xing Yin Pengwei Li Ziqiu Ren Zhenkun Gu Yiqiang Zhang Yanlin Song | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 7 | Composition and luminescence properties of highly robust green-emitting LuAG:Ce/Al_(2)O_(3)composite phosphor ceramics for high-power solid-state lighting显示文摘The major advantage of laser lighting over white light-emitting-diode is the possibility to achieve ultra-high luminance.However,phosphors usually suffer laser-induced luminescence saturation,which limits the peak luminance of laser lighting devices.The aim of the present study is to develop LuAG:Ce/Al_(2)O_(3)composite ceramics(LACCs)with a high saturation threshold for high-luminance laser lighting.Owning to the rigid crystal structure,proper synthetic process,and optimized thermal design,the LACCs possess small thermal quenching(16%loss in luminescence at 225℃),high quantum yield(>95%),and excellent luminescence properties.When the LACCs are irradiated by blue laser diodes in a reflection mode,a high luminous flux of 4634 lm and luminous efficacy of 283 lm·W^(−1)are realized.Furthermore,they show no sign of luminescence saturation even when the power density reaches 20.5 W·mm^(−2).With these favorable properties,the designed LACCs show great potential in high-luminance laser lighting. | Ziqiu Cheng Xin Liu Xinrong Chen Jian Xu Yanbin Wang Tengfei Xie Lexiang Wu Zhengfa Dai Guohong Zhou Jun Zou Jiang Li | 2023 | Journal of Advanced Ceramics2023，12，3： | 0 |
| 8 | A hybrid CNN-LSTM model for diagnosing rice nutrient levels at the rice panicle initiation stage显示文摘Nitrogen(N)and potassium(K)are two key mineral nutrient elements involved in rice growth.Accurate diagnosis of N and K status is very important for the rational application of fertilizers at a specific rice growth stage.Therefore,we propose a hybrid model for diagnosing rice nutrient levels at the early panicle initiation stage(EPIS),which combines a convolutional neural network(CNN)with an attention mechanism and a long short-term memory network(LSTM).The model was validated on a large set of sequential images collected by an unmanned aerial vehicle(UAV)from rice canopies at different growth stages during a two-year experiment.Compared with VGG16,AlexNet,GoogleNet,DenseNet,and inceptionV3,ResNet101 combined with LSTM obtained the highest average accuracy of 83.81%on the dataset of Huanghuazhan(HHZ,an indica cultivar).When tested on the datasets of HHZ and Xiushui 134(XS134,a japonica rice variety)in 2021,the ResNet101-LSTM model enhanced with the squeeze-and-excitation(SE)block achieved the highest accuracies of 85.38 and 88.38%,respectively.Through the cross-dataset method,the average accuracies on the HHZ and XS134 datasets tested in 2022 were 81.25 and 82.50%,respectively,showing a good generalization.Our proposed model works with the dynamic information of different rice growth stages and can efficiently diagnose different rice nutrient status levels at EPIS,which are helpful for making practical decisions regarding rational fertilization treatments at the panicle initiation stage. | Fubing Liao Xiangqian Feng Ziqiu Li Danying Wang Chunmei Xu Guang Chu Hengyu Ma Qing Yao Song Chen | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 9 | PU.1 interacts with KLF7 to suppress differentiation and promote proliferation in chicken preadipocytes显示文摘Krüppel-like factor 7(KLF7)is a negative regulator of preadipocyte differentiation.Our previous KLF7 ChIP-seq analysis showed that the binding motif of PU.1 was found among the KLF7 binding peaks,indicating that an interaction between KLF7 and PU.1 at preadipocyte gene promoters and other regulatory elements might be common.Here,Co-IP and FRET assays are used to confirm that PU.1 can directly bind to KLF7 and enhance the transcription activity of cyclin-dependent kinase inhibitor 3(CDKN3),which is a downstream target gene of KLF7.We show that the PU.1 expression level is decreased during preadipocyte differentiation.Furthermore,PU.1 overexpression and knockdown experiments reveal that PU.1 negatively regulates chicken preadipocyte differentiation,as evidenced by appropriate changes in lipid droplet accumulation and altered expressions of PPARγ,FAS,and PLIN.In addition,PU.1 overexpression promotes preadipocyte proliferation,while knockdown of PU.1 inhibits preadipocyte proliferation.We further demonstrate that PU.1 inhibits differentiation and promotes proliferation in preadipocytes,in part by directly interacting with KLF7. | Ming Tan Hu Xu Jinwei Li Ziqiu Jia Xin Zhang Shuli Shao Weiwei Zhang Weiyu Wang Yingning Sun | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
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