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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT 'Pie' 显示文摘 | Zoe R Emma LS Jackie CB | 2009 | 1)MD2009，37，11： | 1 |
| 3 | Force/position tracking for a robotic manipulator in compliant contact with a surface using neuro-adaptive control显示文摘 | YIANNIS K GEORGE R ZOE D | 2007 | Automatica2007，43，： | 1 |
| 4 | Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles显示文摘 | J Zoe Landens Jeannette N Williams Graeme R Jones | 2002 | J Clin M icrobiol2002，40，： | 1 |
| 5 | Characterisation of the selective 5-HTB receptor antagonist SB-616234-A(1 -- 1 -methanone hydrochloride): in vivo neurochemical and behaviouralevidence of anxiolytic/antidepressant activity显示文摘 | Lee A Dawson Zoe A Hughes Kathryn R Starr | 2006 | Neuropharmacology2006，50，8： | 1 |
| 6 | The Contraceptive Potential of ZP3 and ZP3 Peptides in a Primate model 显示文摘 | Margaret Paterson Zoe A Jennings Martin R Wilson | 2002 | Journal of Reproductive Immunology2002，53，： | 1 |
| 7 | Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthe- sopathy than those with normal nails显示文摘 | Zoe R Tinazzi I Gallego C | 2012 | Ann Rheum Dis2012，71，： | 1 |
| 8 | Review of the effect of fermentation on naturally occurring toxins显示文摘 | Andrew W Alan R Zoe B | | 0，，5： | 1 |
| 9 | Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline显示文摘 | Talbot Konrad Wang Hoau-Yan Kazi Hala Han Li-Ying Bakshi Kalindi P Stucky Andres Fuino Robert L Kawaguchi Krista R Samoyedny Andrew J Wilson Robert S Arvanitakis Zoe Schneider Julie A Wolf Bryan A Bennett David A Trojanowski John Q Arnold | 2012 | EN2012，，4： | 1 |
| 10 | 阿卡波糖心血管评估(ACE)试验依据与设计显示文摘心血管疾病(CVD)患者和糖耐量减低(IGT)者患2型糖尿病(T2DM)的风险较高。生活方式的调整或药物干预可以延缓T2DM的进展,但没有证据表明它们能够降低该人群的心血管风险。阿卡波糖是一种α-葡萄糖苷酶抑制剂,能够降低餐后血糖;其被证明能够使T2DM风险降低25%,并有可能降低无CVD的IGT受试者的心血管风险。阿卡波糖心血管评估(ACE)试验是一项随机、安慰剂对照、双盲、二级预防试验,受试者为7500例患有冠心病(定义为既往心肌梗死、不稳定型心绞痛或当前稳定的心绞痛)并伴有IGT且年龄I〉50岁的患者。以1:1的比例将患者随机分组,分别在标准CVD治疗药物基础上服用阿卡波糖50mg,每天3次或相匹配的安慰剂。排除标准包括糖尿病病史、过去3个月内发生过心血管事件、NYHAⅢ/Ⅳ级心力衰竭、重度肝病和重度肾功能损害。本研究在中国内地和中国香港的约150家医院内进行。主要复合心血管终点是至首次发生心血管死亡、非致死性心肌梗塞或非致死性卒中的时间。次要终点包括全因死亡和新发T2DM。ACE是一项对CVD进行二级预防的研究,用于评估冠心病患者和IGT者在标准心血管治疗的基础上加用阿卡波糖的效果。CVD的治疗与干预标准包括合理使用能降低心血管风险因素的药物,例如B肾上腺素能受体阻断剂、血管紧张素转换酶抑制剂、抗血小板药物和降血脂药物。在高血糖症患者中,血糖可能是另一个可调节的风险因素。流行病学证据表明,IGT会导致CVD发病率和死亡率上升,尽管其程度低于T2DM患者。餐后高血糖是餐后血糖代谢障碍的一个指标,它是心血管事件的一个独立的预测因子,因为负荷后血糖值与心血管事件的相关性比空腹血糖值更强,即使在非糖尿病受试者中也是这样。餐后代谢障碍影响动脉粥样硬化与CVD的机制包含多种因素。体内血糖的急性上升会诱导内皮功能障碍,可能是通过氧化应激引起。急性高血糖症也与血栓形成的激活以及炎性级联反应相关。用药物治疗来降低餐后高血糖会导致CVD的替代指标下降。在之前未用药物而被随机分配接受瑞格列奈(一种短效促泌剂,主要对餐后高血糖进行控制)或格列本脲(一种长效磺脲类药物)的患者中,使用瑞格列奈的患者C反应蛋白和白细胞介素-6的下降程度较大,颈动脉内一中膜厚度指标也是如此。阿卡波糖能够通过延缓碳水化合物的消化和吸收,降低餐后高血糖,改善内皮功能障碍,降低炎性指标(包括细胞核因子.xB活化及其核转位以及C反应蛋白),减少凝血因子(纤维蛋白原和凝血素),减少低密度脂蛋白氧化,降低颈动脉内一中膜厚度。相比那格列奈,阿卡波糖餐后血流量介导的血管扩张改善更显著。它也会放大二肽基肽酶4抑制剂阿格列汀的降血糖效应。IGT者中进行的降糖药物临床试验大都集中在预防T2DM上,而对心血管结局鲜有关注。STOP.NIDDM试验(1429名IGT受试者被随机分配阿卡波糖或安慰剂)显示,在平均3.3年的随访期后,阿卡波糖降低T2DM风险25%。后续分析也显示心肌梗死风险以及预先指定的任一心血管事件风险下降,但只有47名受试者发生了CVD。一项关于阿卡波糖的荟萃分析提示,阿卡波糖能显著降低T2DM患者的心肌梗死风险和心血管死亡、卒中、外周动脉疾病、心绞痛、心力衰竭和血管重建的风险。这些数据支持了该假设:使用阿卡波糖降低餐后高血糖能够消除IGT者的高CVD风险。目前为止唯一的有关降低餐后血糖药物的前瞻性CVD结局试验NAVIGATOR显示,那格列奈对心血管结局没有影响。ORIGIN试验(增大基础胰岛素用量以降低IGT者或早期T2DM患者的空腹血糖值)结果也显示对心血管结局没有影响。ACE试验的目的是确定阿卡波糖是否能够减少冠心病患者和IGT者中的心血管事件,其次要结局是T2DM的预防情况。 | Rury R Holman Mary A Bethel Juliana CN Chan Jean-Louis Chiasson Zoe Doran Junbo Ge Hertzel Gerstein Yong Huo John J McMurray Lars Ryden Winitha Liyanage Stefan Schroder Michal Tendera Michael J Theodorakis Jaakko Tuomilehto Wenying Yang Dayi Hu Changyu Pan 潘长玉 | 2016 | 国际内分泌代谢杂志2016，36，3： | 1 |
| 11 | Using simulation to train orthopaedic trainees in non-technical skills: A pilot study显示文摘AIM: To enhance non-technical skills and to analyse participant's experience of a course tailored for orth-opaedic surgeons.METHODS: A Delphi technique was used to develop a course in human factors specific to orthopaedic residents. Twenty-six residents(six per course) participated in total with seven course facilitators all trained in Crisis Resource Management providing structured feedback. Six scenarios recreated challenging real-life situations using high-fidelity mannequins and simulated patients. Environments included a simulated operating suite, clinic room and ward setting. All were undertaken in a purpose built simulation suite utilising actors, mock operating rooms, mock clinical rooms and a high fidelity adult patient simulator organised through a simulation control room. Participants completed a 5-point Likert scale questionnaire(strongly disagree to strongly agree) before and after the course. This assessed their understanding of non-technical skills, scenario validity, relevance to orthopaedic training and predicted impact of the course on future practice. A course evaluation questionnaire was also completed to assess participants' feedback on the value and quality of the course itself.RESULTS: Twenty-six orthopaedic residents participated(24 male, 2 female; post-graduation 5-10 years), mean year of residency program 2.6 out of 6 years required in the United Kingdom. Pre-course questionnaires showedthat while the majority of candidates recognised the importance of non-technical(NT) skills in orthopaedic training they demonstrated poor understanding of non-technical skills and their role. This improved significantly after the course(Likert score 3.0-4.2) and the perceived importance of these skills was reported as good or very good in 100%. The course was reported as enjoyable and provided an unthreatening learning environment with the candidates placing particular value on the learning opportunity provided by reflecting on their performance. All agreed that the course achieved its intended aims with realistic simulation scenarios. Participants believed patient care, patient safety and team working would all improve with further human factors training(4.4-4.6). and felt that NT skills learnt through simulation-based training should become an integral component of their training program.CONCLUSION: Participants demonstrated improved understanding of non-technical performance, recognised its relevance to patient safety and expressed a desire for its integration in training. | Samuel R Heaton Zoe Little Kash Akhtar Manoj Ramachandran Joshua Lee | 2016 | World Journal of Orthopedics2016，7，8： | 0 |
| 12 | Seasonal variation and living alone are related to pulmonary rehabilitation non-completion显示文摘AIM: To identify baseline characteristics that independently predict pulmonary rehabilitation non-completion and compare these findings against the participant's reasons for non-completion. METHODS: Participants with chronic obstructive pulmonary disease(COPD) who attended a standardised twice weekly, eight week pulmonary rehabilitation program(located in the sub-tropics, latitude 27°29' South) between 2010 and 2012 were recruited. Thebaseline characteristics of program completers and non-completers were compared in a case-controlled design. Participants who attended < 12/16 sessions were classified as a non-completer. Non-completers(those who missed > 4 session of the program) were asked by one independent investigator to participate in a survey about their pulmonary rehabilitation experience. Baseline characteristics were assessed for differences between program completers and non-completers. The baseline characteristics included disease severity, exercise capacity, smoking history, participant's social support and the season when each participant commenced rehabilitation. Non-completers that agreed to participate in the survey were asked to indicate what personal factors or external factors contributed to their program non-completion. Comparisons of completers and non-completers baseline characteristics were performed using cross-tabulations and t-tests, with significant measures analysed in a multivariate binary logistic regression model. Non-completers survey responses were compared to the identified independent predictors using cross-tabulations.RESULTS: Twenty-six participants(23.4%) of the 111 participants with COPD [(mean ± SD) age was 67.4 ± 9.2 years and FEV1 54.6% ± 22.3%)], were classified as non-completers. Forty-five participants(40.5%) commenced pulmonary rehabilitation during winter. Thirty-six participants(32.4%) were living alone at program commencement. In the multivariate analysis(n = 111), only programs that commenced in winter(Exp B: 0.255, 95%CI: 0.090-0.727, P = 0.011) and participants that lived alone(Exp B: 2.925, 95%CI: 1.039-8.229, P = 0.042) were identified as independent predictors of program non-completion. Twenty participants of the twenty-six non-completers agreed to participate in the survey about their pulmonary rehabilitation experience. The reasons given for non-completion were grouped into: medical reasons(75%), other personal reasons(30%) and external barriers(45%), with ten non-completers reporting more than one reason.No participant reported living alone or that the program commenced during winter as a reason for noncompletion. There was no relationship between illness being the participant's reason for non-completion and the programs that commenced in winter(P = 0.135). CONCLUSION: Despite winter commencing programs and participants who lived alone being independent predictors of program non-completion, neither measure was reported by participants as a reason for noncompletion. | James R Walsh Zoe J Mc Keough Norman R Morris Stephanie T Yerkovich Michelle E Wood Jenny D Paratz | 2013 | World Journal of Respirology2013，3，2： | 0 |
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