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| 1 | Preparation and evaluation of nattokinaseloaded self-double-emulsifying drug delivery system显示文摘In the present study,we prepared nattokinase-loaded self-double-emulsifying drug delivery system(SDEDDS)and investigated its preliminary pharmacodynamics.The type and concentration of oil phase,inner aqueous phase and emulsifier were screened to prepare optimum nattokinase-loaded SDEDDS.Next,the optimum formulations were characterized based on microstructure,volume-weighted mean droplet size,self-emulsifying rate,yield,storage stability,in vitro release and in vivo pharmacodynamics studies.The water/oil/watermultiple emulsions exhibited typicalmultiple structure,with relatively small volumeweighted mean droplet size 6.0±0.7μm and high self-emulsifying ability(self-emulsifying time<2 min).Encapsulation of nattokinase was up to 86.8±8.2%.The cumulative release of nattokinase within 8 h was about 30%,exhibiting a sustained release effect.The pharmacodynamics study indicated that nattokinase-loaded SDEDDS could significantly prolong the whole blood clotting time in mouse and effectively improve the carrageenan-induced tail thrombosis compared with nattokinase solution.Moreover,we showed that SDEDDS could successfully self-emulsify into water/oil/water multiple emulsions upon dilution in dispersion medium with gentle stirring and effectively protect nattokinase activity in gastric environment.Our findings suggested that SDEDDS could be a promising strategy for peptide and protein drugs by oral administration. | Xiaona Wang Sifan Jiang Xinyue Wang Jie Liao Zongning Yin | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，5： | 9 |
| 2 | The influence of Sc addition on microstructure and tensile mechanical properties of Mg-4.5Sn-5Zn alloys显示文摘The microstructure and tensile properties of the as-cast and as-rolled Mg-4.5Sn-5Zn alloys by adding various Sc content were investigated.Improvement of the tensile properties in as-cast Sc-containing alloys is attributed to the grain refinement and modification of secondary phase morphology.Three types of precipitates,namely spherical Mg2Sn,rod-like MgZn and Sc-rich phases were dispersed in the matrix of the Sc added M g-4.5Sn-5Zn alloys after hot rolling deformation.In addition,weakening and deflecting of the basal texture in as-rolled alloys were found and were attributed to Sc addition.Further increasing the Sc addition rate to 0.4 wt.%,however,resulted in the clustering of the Sc-rich phases and was found to reduce the tensile properties of the alloy,especially the elongation.The as-rolled Mg-4.5Sn-5Zn-0.3Sc alloy exhibits an optimum combination of tensile properties.The ultimate tensile strength,yield strength and elongation are 293.0MPa,164.2Mpa and 21.5%,respectively,and the elongation is about 68%higher than that of Sc-free alloy. | Pengqi Wang Enyu Guo Xuejian Wang Huijun Kang Zongning Chen Zhiqiang Cao Tongmin Wang | 2019 | Journal of Magnesium and Alloys2019，7，3： | 6 |
| 3 | Grain nucleation and growth behavior of a Sn-Pb alloy affected by direct current: An in situ investigation显示文摘In situ synchrotron X-ray radiography was used to study the effect of direct current(DC) on the grain nucleation and growth of Sn-50 wt.%Pb alloy. The results showed that applying DC adequately during solidification could effectively enhance the grain nucleation and inhibit its growth. Imaging of comparative experiments with varying DC intensity indicated that the final grain size, determined by the competition between grain nucleation and growth, was sensitively dependent on the DC intensity. It was found that the average grain size was decreased from 1632 to 567 μm with DC density of 1.5 A/mm^2 compared to the case without DC. Beyond this value, raising the current density may cause a significant decrease in the nucleation rate, and thus lead to a coarsening of the grain structure. | Fenfen Yang Zongning Chen Fei Cao Rong Fan Huijun Kang Wanxia Huang Qingxi Yuan Tiqiao Xiao Yanan Fu Tongmin Wang | 2017 | Journal of Materials Science & Technology2017，33，10： | 5 |
| 4 | Microstructural characteristics and mechanical behavior of B4Cp/6061Al composites synthesized at different hot-pressing temperatures显示文摘B4Cp/6061Al composites have become important structural and functional materials and can be fabricated by powder metallurgy and subsequent hot rolling. In this work, the effects of the hot-pressing temperature on microstructures and mechanical behaviors of the B4Cp/6061Al composites were investigated. The results showed that compared with the T4 heat treated B4Cp/6061Al composite hot pressed at 560℃, the yield strength and failure strain of the composites hot pressed at 580℃ were increased to 235 MPa and 18.4%, respectively. This was associated with the interface bonding strength between the B4C particles and the matrix. However, the reaction products, identified to be MgAl2O4 phases, were detected in the composites hot pressed at 600℃. The formation of the MgAl2O4 phases resulted in the Mg depletion, thus reducing the yield strength to 203.5 MPa after the T4 heat treatment due to the effect of the solid solution strengthening being weakened. In addition, the variation of hardness and electrical conductivity was mainly related to the Mg content in the matrix. Based on the as-rolled microstructures observed by SEM, SR-μCT and fracture surfaces, the deformation schematic diagram was depicted to reflect the tensile deformation process of the composites. | Minqiang Gao Zongning Chen Huijun Kang Enyu Guo Rengeng Li Ying Fu Honglan Xie Tongmin Wang | 2019 | Journal of Materials Science & Technology2019，35，8： | 4 |
| 5 | Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis显示文摘To achieve targeted thrombolysis, a targeted delivery system of lumbrokinase(LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GP Ⅱ b/Ⅲ a expressed on the surface of membrane of activated platelet, LK loaded targeted micelles(LKTM) can be delivered to thrombus. The hybrid micelles were composed of polycaprolactone-block-poly(2-(dimethylamino) ethyl methacrylate)(PCL-PDMAEMA), methoxy polyethylene glycol-block-polycaprolactone(mPEG-PCL)and RGDfk conjugated polycaprolactone-block-polyethylene glycol(PCL-PEG-RGDfk). PCLPDMAEMA was synthesized via ring open polymerization(ROP) and atom transfer radical polymerization(ATRP). PCL-PEG-RGDfk was synthesized via ROP and carbodiimide chemistry. The prepared LKTM was characterized by dynamic light scattering(DLS) and transmission electron microscope(TEM). Colloidal stability assay showed the prepared LKTM was stable. Biocompatibility assay was performed to determine the safe concentration range of polymer. The assay of fluorescent distribution in vivo demonstrated that LKTM can be efficiently delivered to thrombi in vivo. Thrombolysis in vivo indicated the thrombolytic potency of LKTM was optimal in all groups. Notably, the laboratory mice treated with LKTM exhibited a significantly shorter tail bleeding time compared to those treated with LK or LK-loaded micelles without RGDfk, which suggested that the targeted delivery of LK using RGDfk-conjugated hybrid micelles effectively reduced the bleeding risk. | Yang Pan Xiahui Wang Zongning Yin | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 4 |
| 6 | Physical characterization of meloxicam-β-cyclodextrin inclusion complex pellets prepared by a fluid-bed coating method显示文摘Meloxicam-β-cyclodextrin (ME-β-CD) inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a binding agent to facilitate good coating. The resultant pellets were spherical and intact in shape with good flowability and friability. SEM analysis showed that the pellets were smooth and had a tightly coated inclusion complex layer. In vitro dissolution of the inclusion complex pellets in pH 7.4 phosphate buffer was dramatically enhanced at an ME/CD ratio of 1/1. DSC and powder X-ray diffractometry proved the absence of crystallinity in the ME/CD inclusion complexes. Moreover, Fourier transform-infrared spectrometry together with Raman spectrometry indicated that the thiazole ring of ME was possibly included in the cavity of β-CD. | Yi Lu Xingwang Zhang Jie Lai Zongning Yin Wei Wu | 2009 | Particuology2009，7，1： | 4 |
| 7 | Mould taper optimization for continuous casting steels by numerical simulation显示文摘A transient,two-dimensional,coupled finite element model was employed to simulate the solidification and shrinkage of continuous casting steels by means of ANSYSTM.In the model,a gap-dependent heat transfer condition was introduced to modify the heat flux function,and the variations of material thermal properties,mechanical properties as well as the yield function with temperature were considered.The solidification and shrinkage processes of four round billets and two square billets were simulated by indirect coupled method.Simulation results show that carbon content,pouring temperature,casting speed and shape of billets have distinct influence on the solidification shrinkage of billets.Ideal continuous parabolic tapers were designed and optimized according to the calculated shrinkage curves of billets. | Wang Tongmin Cai Shaowu Li Jun Xu Jingjing Chen Zongning Zhu Jing Cao Zhiqiang Li Tingju | 2010 | China Foundry2010，7，1： | 4 |
| 8 | Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation显示文摘There has been increasing interest in research and development of nanocrystals for the delivery of poorly water-soluble drugs that can be directly produced from solution. Compared with traditional carrier-based or encapsulation designs, drug nanocrystals circumvent possible side-effects due to carrier polymers and poor stability issues associated with encapsulation. The production of carrier-free nanocrystals requires careful control of nucleation and thus a thorough understanding of the relevant solution's metastable zone. A solution may stay supersaturated without forming any nuclei and become metastable. The maximal degree of supersaturation is known as the metastable zone width. When nucleation is triggered directly from the metastable zone, it helps to produce homogeneous nuclei leading to uniform nanocrystals. Herein, we report a study in which the solubility and metastable limit of paclitaxel(PTX) in ethanol aqueous solution were measured at 40 °C. A wide range of metastable compositions were studied to prepare carrier-free PTX nanocrystals with particle size smaller than250 nm and PDI less than 0.25. Compared with the raw material, dissolution rate of PTX nanocrystals was significantly increased. The study enables production of high-quality drug nanocrystals for treating patients. | Xiaoting Ren Jianping Qi Wei Wu Zongning Yin Tonglri Li Yi Lu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 3 |
| 9 | Influence of deformation on the corrosion behavior of LZ91 Mg-Li alloy显示文摘The effect of rolling and forging on the microstructure and corrosion behavior of LZ91 alloy was investigated using an electron probe micro-analyzer,immersion and electrochemical tests.Results showed that the area fraction of theβ-Li phase remained unchanged,and the grain size of theβ-Li phase decreased after forging.The as-rolled forged alloy(FR-LZ91)exhibited the highest area fraction of theβ-Li phase and the longest grains.The corrosion resistance of the forged LZ91 alloy increased due to grain refinement that prevented further corrosion during the immersion test.Among the experimental alloys,FR-LZ91 showed the highest resistance of corrosion film and charge transfer resistance values due to its protective film caused by the high area fraction of theβ-Li phase. | Xueqin Liu Xuejian Wang Enyu Guo Zongning Chen Huijun Kang Tongmin Wang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 3 |
| 10 | Enhancing mechanical properties and corrosion resistance of nickel-aluminum bronze via hot rolling process显示文摘The mechanical properties and corrosion behavior of as-cast, as-annealed and hot-rolled nickelaluminum bronze(NAB) alloy(Cu-9 Al-10 Ni-4 Fe-1.2 Mn, all in wt.%) in 3.5 wt.% Na Cl solution were investigated. The results show that annealing introduces a large number of k phases to precipitate in the k phase. However, after further hot rolling, the original continuous k phases are spheroidized and dispersed, increasing the strength, hardness, and elongation of the alloy. In addition to the enhanced mechanical properties, the corrosion resistance of the NAB samples is also improved significantly by hot rolling, as revealed by the mass loss measurements, electrochemical impedance spectroscopy(EIS), and cross-sectional corrosion morphology. Selective phase corrosion occurs by the preferential corrosion of the k phase, which acts as an anode to the k phases, and the uncorroded k phases are retained in the corrosion product film. The interfaces between the k phases and the surrounding corrosion products become discontinuous caused by the spheroidization of k phases, reducing the corrosion of the substrate by the corrosive medium via the channels. As a result, the corrosion rate and the maximum local corrosion depth of the hot-rolled NAB sample are greatly reduced. | Yanhua Zeng Fenfen Yang Zongning Chen Enyu Guo Minqiang Gao Xuejian Wang Huijun Kang Tongmin Wang | 2021 | Journal of Materials Science & Technology2021，，2： | 3 |
| 11 | Three dimensional microstructures and wear resistance of Al-Bi immiscible alloys with different grain refiners显示文摘The three dimensional(3D) microstructures of Al-Bi alloys with different grain refiners(Al-5Ti-B, Al-3B and Al-3Ti) have been studied using synchrotron X-ray microtomography. The relationships between the microstructures and the corresponding wear behavior are verified through the friction and wear tests. The worn surfaces of the samples with grain refiners tested under 15 and 60 N loads are analyzed using Scanning Electron Microscopy(SEM). The results indicate that the addition of grain refiners is beneficial to the size and distribution of the Bi-rich particles in Al-Bi alloys. Compared with Al-5Ti-B and Al-3B grain refiners, the Bi-rich particles are more uniformly distributed and spherical with finer size with the addition of Al-3Ti grain refiner. The refinement renders the Al-20wt%Bi alloy refined by Al-3Ti the superior wear resistance with respect to those refined by Al-5Ti-B and Al-3B grain refiners, corresponding to the microstructures with fine and uniformly distributed Bi-rich particles in the Al matrix. | WANG TongMin CAO Fei CHEN ZongNing KANG HuiJun ZHU Jing FU YaNan XIAO TiQiao LI TingJu | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 12 | Grain refining potency of al-B master alloy on pure alumi- num显示文摘 | Wang Tongmin Chen Zongning Fu Hongwang | 2011 | Scr Mater2011，64，： | 1 |
| 13 | Development of an 8090/3003 bimetal slab using a modified direct-chill casting process显示文摘 | Tongmin Wang Chunhui Liang Zongning Chen Yuanping Zheng Huijun Kang Wei Wang | 2014 | Journal of Materials Processing Tech2014，，： | 1 |
| 14 | A promising new class of plasticine: Metallic plasticine显示文摘Soft, malleable, and non-dry on exposure in air are the typical features for plain plasticine, which lead plasticine to be widely used in many industrial fields and our daily life. As a kind of clay, poorly electric conductivity and thermal conductivity of plain plasticine seriously limit its applications. Therefore,synthesizing a kind of plasticine having metallic bond is of importance for extending its applications in some special cases, such as thermal-cooling medium, anti-static electricity, electromagnetic shielding,etc. Here, we report a novel GaInSnCdZn_2 alloy, which exhibits similar behavior as compared to those of plasticine at near room temperature(30–40℃), and a good electrical conductivity due to its nature of metal. This new GaInSnCdZn_2 alloy can be called as metallic plasticine that contains the near-eutectic structure with low melting point and the other relatively high melting point phases. In this metallic plasticine, the near-eutectic structure with low melting point plays the same role as the oily ingredient in plain plasticine, dominating the plastic deformation, while the other relatively high melting point phases act as the stuffing like the CaCO3 in plain plasticine. The creation of metallic plasticine offers a general strategy for designing/preparing a new class of plasticine which possesses both the nature of metal and plasticine. | Yiping Lu Zhongyi Tang Bin Wen Gang Wang Shiwei Wu Tongmin Wang Yubo Zhang Zongning Chen Zhiqiang Cao Tingju Li | 2018 | Journal of Materials Science & Technology2018，34，2： | 1 |
| 15 | Real time observation of equiaxed growth of Sn–Pb alloy under an applied direct current by synchrotron microradiography显示文摘 | Jing Zhu Tongmin Wang Fei Cao Wanxia Huang Hongwang Fu Zongning Chen | 2012 | Materials Letters2012，，： | 1 |
| 16 | A novel fading-resistant Al–3Ti–3B grain refiner for Al–Si alloys显示文摘 | Tongmin Wang Hongwang Fu Zongning Chen Jun Xu Jing Zhu Fei Cao Tingju Li | 2011 | Journal of Alloys and Compounds2011，，： | 1 |
| 17 | Study on diffusion behavior and microstructural evolution of Al/Cu bimetal interface by synchrotron X-ray radiography显示文摘 | Tongmin Wang Fei Cao Peng Zhou Huijun Kang Zongning Chen Yanan Fu Tiqiao Xiao Wanxia Huang Qingxi Yuan | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 18 | TiBz reinforced aluminum in situ composites fabricated by stir casting显示文摘 | Chen Fei Chen Zongning Mao Feng | 2015 | Mater Sci Eng A2015，625，： | 1 |
| 19 | Isolation of mesenchymal stem cells from human placenta: Comparison with human bone marrow mesenchymal stem cells显示文摘 | Zongning Miao Jun Jin Lei Chen | 2006 | Cell Biology International2006，30，1： | 1 |
| 20 | Grain refining potency of Al–B master alloy on pure aluminum显示文摘 | Tongmin Wang Zongning Chen Hongwang Fu Jun Xu Ying Fu Tingju Li | 2011 | Scripta Materialia2011，，12： | 1 |
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