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| 1 | The Ca^(2+)-activated chloride channel ANO1/TMEM16A:An emerging therapeutic target for epithelium-originated diseases?显示文摘Anoctamin 1(ANO1) or TMEM16 A gene encodes a member of Ca^(2+) activated Cl^(-) channels(CaCCs) that are critical for physiological functions,such as epithelial secretion,smooth muscle contraction and sensory signal transduction.The attraction and interest in ANO1/TMEM16 A arise from a decade long investigations that abnormal expression or dysfunction of ANO1 is involved in many pathological phenotypes and diseases,including asthma,neuropathic pain,hypertension and cancer.However,the lack of specific modulators of ANO1 has impeded the efforts to validate ANO1 as a therapeutic target.This review focuses on the recent progress made in understanding of the pathophysiological functions of CaCC ANO1 and the current modulators used as pharmacological tools,hopefully illustrating a broad spectrum of ANO1 channelopathy and a path forward for this target validation. | Yani Liu Zongtao Liu KeWei Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 5 |
| 2 | Angular color uniformity enhancement of white light-emitting diodes by remote micro-patterned phosphor film显示文摘Angular color uniformity(ACU)is a key factor used to evaluate the light quality of white-light emitting diodes(LEDs).In this study,a novel double remote micro-patterned phosphor film(double RMPP film)was used to enhance the ACU of a remote phosphor(RP)down-light lamp.A conventional RP film and remote phosphor film with single micro-patterned film(single RMPP film)also were examined for comparison.The angular correlated color temperature(CCT)distributions and the optical performance of the films were experimentally measured.The measurement results showed that double RMPP film configuration exhibited better color uniformity with a CCT deviation of only 441 K,compared with 556 K for the single RMPP film configuration and 1390 K for the RP film configuration.A simulation based on FDTD and ray tracing combined method also confirmed the ACU improvement.In addition,compared with the conventional RP film,the luminous efficiency of single and double RMPP film configurations was increased by 6.68% and 4.69%,respectively,at a driving current of 350 mA.The enhancement of the ACU and luminous efficiency are due to the scattering and mixing effect of the micropatterned film.Moreover,the double RMPP film configuration had better CCT stability at different currents than the other two configurations.The results demonstrated the effectiveness and superiority of double RMPP film in white LED applications. | Shudong Yu Zongtao Li Guanwei Liang Yong Tang Binhai Yu Kaihang Chen | 2016 | Photonics Research2016，4，4： | 5 |
| 3 | Sustainable Synthesis of Hierarchically Porous Silicalite-1 Zeolite by Steam-assisted Crystallization of Solid Raw Materials Without Secondary Templates显示文摘 | LIU Xiaofang ZENG Shangjing WANG Runwei ZHANG Zongtao QIU Shilun | 2018 | Chemical Research in Chinese Universities2018，34，3： | 4 |
| 4 | Synthesis and Visible-light Photocatalytic Performance of C-doped Nb2O5 with High Surface Area显示文摘 | DING Shuang WANG Runwei ZHANG Panpan KANG Bonan ZHANG Daliang ZHANG Zongtao QIU Shilun | 2018 | Chemical Research in Chinese Universities2018，34，2： | 3 |
| 5 | Review of blue perovskite light emitting diodes with optimization strategies for perovskite film and device structure显示文摘Perovskite light emitting diodes(PeLEDs)have attracted considerable research attention because of their external quantum efficiency(EQE)of>20%and have potential scope for further improvement.However,compared to red and green PeLEDs,blue PeLEDs have not been extensively investigated,which limits their commercial applications in the fields of luminance and full-color displays.In this review,blue-PeLED-related research is categorized by the composition of perovskite.The main challenges and corresponding optimization strategies for perovskite films are summarized.Next,the novel strategies for the design of device structures of blue PeLEDs are reviewed from the perspective of transport layers and interfacial layers.Accordingly,future directions for blue PeLEDs are discussed.This review can be a guideline for optimizing perovskite film and device structure of blue PeLEDs,thereby enhancing their development and application scope. | Zongtao Li Kai Cao Jiasheng Li Yong Tang Xinrui Ding Binhai Yu | 2021 | Opto-Electronic Advances2021，4，2： | 3 |
| 6 | Enhanced optical and thermal performance of white light-emitting diodes with horizontally layered quantum dots phosphor nanocomposites显示文摘Due to their good color rendering ability, white light-emitting diodes(WLEDs) with conventional phosphor and quantum dots(QDs) are gaining increasing attention. However, their optical and thermal performances are still limited especially for the ones with QDs-phosphor mixed nanocomposites. In this work, we propose a novel packaging scheme with horizontally layered QDs-phosphor nanocomposites to obtain an enhanced optical and thermal performance for WLEDs. Three different WLEDs, including QDs-phosphor mixed type, QDsoutside type, and QDs-inside type, were fabricated and compared. With 30 wt. % phosphor and 0.15 wt. % QDs nanocomposite, the QDs-outside type WLED shows a 21.8% increase of luminous efficiency, better color rendering ability, and a 27.0% decrease of the maximum nanocomposite temperature at 400 mA, compared with the mixed-type WLED. The reduced re-absorption between phosphor and QDs is responsible for the performance enhancement when they are separated. However, such reduced absorption can be traded off by the improper layered configuration, which is demonstrated by the worst performance of the QDs-inside type. Further, we demonstrate that the higher energy transfer efficiency between excitation light and nanocomposite in the QDs-outside type WLED is the key reason for its enhanced optical and thermal performance. | SHUDONG Yu YONG TANG ZONGTAO LI KAIHANG CHEN XINRUI DING AND BINHAI Yu | 2018 | Photonics Research2018，6，2： | 2 |
| 7 | A Service Oriented Voting Authorization Model显示文摘 | WANG Xiaoming ZHAO Zongtao | 2006 | Chinese Journal of Electronics2006，15，1： | 2 |
| 8 | Improvement of oxidation resistance of ultrafine copper powders by phos- phating treatment 显示文摘 | Zhao Bin Liu Zhijie Zhang Zongtao | 1997 | Journal of Solid State Chemistry1997，130，： | 1 |
| 9 | 显示文摘 | Zhao Bin Liu Zhijie Zhang Zongtao | 1997 | J Solid Chem1997，30，1： | 1 |
| 10 | Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma显示文摘 | Jicai Z Zongtao Y Jun L | 2006 | Mol Carcinog2006，45，7： | 1 |
| 11 | Preparation of bicontinuous mesoporous silica and organosilica materials containing gold nanoparticles by co-synthesis method显示文摘 | Lee Byunghwan Zhu Haoguo Zhang Zongtao | 2004 | Microporous and Mesoporous Materials2004，70，： | 1 |
| 12 | Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators显示文摘RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer burden.As a well-recognized target in malignancy,RAS has been intensively studied in the past decades.Despite the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS proteins.Phosphorylation at several residues has been recently determined as regulators for wild-type and mutated RAS proteins.Therefore,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic strategies.In this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated pathways.Importantly,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed. | Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 13 | Improvement of Oxidation Resistance of Ultrafine Copper Powders by Phosphating Treatment显示文摘 | Zhao Bin Liu Zhijie Zhang Zongtao | 1997 | Journal of Solid State Chemistry1997，130，： | 1 |
| 14 | Optimization for biodissimilation of glycerol to 1,3-propanediol by Klebsiella pneumoniae in one-and two-stage continuous anaerobic cultures显示文摘 | SONG Binghui WANG Zongtao | 2004 | Biochem Eng2004，，19： | 1 |
| 15 | PVP Protective Mechanism of Uhrafine Silver Powder Synthesized by Chemical Reduction Processes 显示文摘 | Zongtao Zhang Bin Zhao Liming Hu | 1996 | JOURNAL OF SOLID STATE CHEMISTRY1996，，121： | 1 |
| 16 | Nanoceramic VO2 thermochromic smart glass: A review on progress in solutions processing显示文摘 | GAO Yanfeng LUO Hongjie ZhANG Zongtao | 2012 | Nano Energy2012，1，22： | 1 |
| 17 | Improvement of oxidation resistance of ultrafine copper powders by phosphating treatment显示文摘 | Zhao Bin Liu Zhijie Zhang Zongtao | 1997 | Solid State Chemistry1997，130，： | 1 |
| 18 | The secretory pathway and the actomyosin motility system are required for plasmodesmatal localization of the P7-1 of rice black-streaked dwarf virus显示文摘 | Zongtao Sun Shanglin Zhang Li Xie Qisong Zhu Zilong Tan Jing Bian Liying Sun Jianping Chen | 2013 | Archives of Virology2013，，5： | 1 |
| 19 | Simulation of ad- sorption of gold nanopartieles carried by gas ascending from the Earth's interior in alluvial cover of the middle-lower reaches of the Yangtze River显示文摘 | Cao Jianjin Hu Xianyong Jiang Zongtao | 2010 | Geofluids2010，10，3： | 1 |
| 20 | Experimental Study on CTOD Fracture Toughness of Welded Joints of LowTemperature Steel 显示文摘 | FANG Zongtao SUN Bo LI Chunrun | 2011 | Advanced Materials Research2011，，328330： | 1 |
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