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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Spatio-temporal framework of tectonic uplift stages of the Tibetan Plateau in Cenozoic显示文摘Four intensive uplift periods, i.e., 60–35, 25–17 and 12–8 Ma (but 18–13 Ma in the Himalayas of the southern Tibet), and since about 5 Ma, can be determined on the Tibetan Plateau by synthetical analysis of low-temperature thermo-chronology data, sedimentary deposit records, and structural deformation records of different areas. The strong tectonic uplift periods in different areas on the Tibetan Plateau are penecontemporaneous, except for the Himalayan area of the southern Tibet, where a rapid uplift and exhumation period, controlled by the activity of the South Tibetan Detachment System faults, occurred during 18–13 Ma. These strong uplift and exhumation periods correspond well to intensive deformation activity periods, suggesting tectonically-controlled uplift and exhumation. The deposit records, such as the distribution of coarse clastic sediments, the distribution of tectonically-controlled basins, stratigraphic discontinuousness or unconformity, and fault-controlled geomorphologic evolution, also match well with the strong uplift and exhumation periods. Expanding processes of the plateau are also discussed. | WANG GuoCan CAO Kai ZHANG KeXin WANG An LIU Chao MENG YanNing XU YaDong | 2011 | Science China Earth Sciences2011，54，1： | 49 |
| 3 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 4 | Intelligent and connected vehicles: Current status and future perspectives显示文摘Intelligent connected vehicles(ICVs) are believed to change people's life in the near future by making the transportation safer,cleaner and more comfortable. Although many prototypes of ICVs have been developed to prove the concept of autonomous driving and the feasibility of improving traffic efficiency, there still exists a significant gap before achieving mass production of high-level ICVs. The objective of this study is to present an overview of both the state of the art and future perspectives of key technologies that are needed for future ICVs. It is a challenging task to review all related works and predict their future perspectives, especially for such a complex and interdisciplinary area of research. This article is organized to overview the ICV key technologies by answering three questions: what are the milestones in the history of ICVs; what are the electronic components needed for building an ICV platform; and what are the essential algorithms to enable intelligent driving? To answer the first question, the article has reviewed the history and the development milestones of ICVs. For the second question, the recent technology advances in electrical/electronic architecture, sensors, and actuators are presented. For the third question, the article focuses on the algorithms in decision making, as the perception and control algorithm are covered in the development of sensors and actuators. To achieve correct decision-making, there exist two different approaches: the principle-based approach and data-driven approach. The advantages and limitations of both approaches are explained and analyzed. Currently automotive engineers are concerned more with the vehicle platform technology, whereas the academic researchers prefer to focus on theoretical algorithms. However, only by incorporating elements from both worlds can we accelerate the production of high-level ICVs. | YANG DianGe JIANG Kun ZHAO Ding YU ChunLei CAO Zhong XIE ShiChao XIAO ZhongYang JIAO XinYu WANG SiJia ZHANG Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 31 |
| 5 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 6 | Evaluation of the Effects of Standard Rescue Procedure on Severe Trauma Treatment in China显示文摘 | Xiao-Feng Yin Tian-Bing Wang Pei-Xun Zhang Yu-Hui Kou Dian-Ying Zhang Kai Yu De-Cheng Lyu Mao-Zheng Liu Dong-Sheng Zhou Peng Zhang Jue-Hua Jing Wei-Wei Ge Li-Ying Cao Guo-Sheng Wang Shao-Jie Deng Weng-Hua Liu Mao Zhang Yong-An Xu Kun Zhang Bing Li Wei Wang Zhong-Li Gao Cheng-La Yi Bao-Guo Jiang | 2015 | Chinese Medical Journal2015，，10： | 18 |
| 7 | Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation显示文摘瞄准:Epigallocatechin-3-gallate (EGCG ) 是绿茶多酚的主要部件,其生物性质的宽范围包括 anti-fibrogenic 活动。Matrixmetalloproteinases (MMP ) 参予细胞外的矩阵降级涉及肝的纤维变性的发展。现在的学习调查 EGCG 是否在老鼠禁止主要 gelatinase 矩阵 metalloproteinase-2 (MMP-2 ) 的激活肝的星形的房间(HSC ).METHODS:MMP-2 的表示, metalloproteinases-2 (TIMP-2 ) 的织物禁止者, andmembrane 类型 1-MMP (MT1-MMP ) 被 RT-PCR 和西方的污点分析估计。MMP-2 活动被 zymography 评估, MT1-MMP 活动被酶的试金估计。HSC 移植被弯屈的愈合的试金测量,房间侵略用 Transwell 房间文化房间被执行。结果:在 HSC 的 MMP-2 mRNA 和蛋白质的表示被 EGCGtreatment 实质地减少。EGCG 处理也减少了导致的 concanavalin A (ConA ) 分泌 MMP-2and 的激活以一种剂量依赖者方式减少了 MT1-MMP 活动。另外, EGCG 禁止了 HSCmigration 或侵略。结论:EGCG 的能力建议那 EGCG 可能在肝的纤维变性的处理和预防是有用的压制 MMP-2 激活和 HSCinvasiveness。 | Mao-chuan ZHEN Xiao-hui HUANG Qian WANG Kai SUN Yun-jian LIU Wen LI Long-juan ZHANG Liang-qi CAO Xi-ling CHEN | 2006 | Acta Pharmacologica Sinica2006，27，12： | 17 |
| 8 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 9 | An Object-based Approach for Two-level Gully Feature Mapping Using High-resolution DEM and Imagery: A Case Study on Hilly Loess Plateau Region, China显示文摘Gully feature mapping is an indispensable prerequisite for the motioning and control of gully erosion which is a widespread natural hazard. The increasing availability of high-resolution Digital Elevation Model(DEM) and remote sensing imagery, combined with developed object-based methods enables automatic gully feature mapping. But still few studies have specifically focused on gully feature mapping on different scales. In this study, an object-based approach to two-level gully feature mapping, including gully-affected areas and bank gullies, was developed and tested on 1-m DEM and Worldview-3 imagery of a catchment in the Chinese Loess Plateau. The methodology includes a sequence of data preparation, image segmentation, metric calculation, and random forest based classification. The results of the two-level mapping were based on a random forest model after investigating the effects of feature selection and class-imbalance problem. Results show that the segmentation strategy adopted in this paper which considers the topographic information and optimal parameter combination can improve the segmentation results. The distribution of the gully-affected area is closely related to topographic information, however, the spectral features are more dominant for bank gully mapping. The highest overall accuracy of the gully-affected area mapping was 93.06% with four topographic features. The highest overall accuracy of bank gully mapping is 78.5% when all features are adopted. The proposed approach is a creditable option for hierarchical mapping of gully feature information, which is suitable for the application in hily Loess Plateau region. | LIU Kai DING Hu TANG Guoan ZHU A-Xing YANG Xin JIANG Sheng CAO Jianjun | 2017 | Chinese Geographical Science2017，27，3： | 11 |
| 10 | Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer显示文摘BACKGROUND The Borrmann classification system is used to describe the macroscopic appearance of advanced gastric cancer,and Borrmann typeⅣdisease is independently associated with a poor prognosis.AIM To evaluate the prognostic significance of lymphatic and/or blood vessel invasion(LBVI)combined with the Borrmann type in advanced proximal gastric cancer(APGC).METHODS The clinicopathological and survival data of 440 patients with APGC who underwent curative surgery between 2005 and 2012 were retrospectively analyzed.RESULTS In these 440 patients,LBVI+status was associated with Borrmann typeⅣ,low histological grade,large tumor size,and advanced pT and pN status.The 5-year survival rate of LBVI+patients was significantly lower than that of LBVI– patients,although LBVI was not an independent prognostic factor in the multivariate analysis.No significant difference in the prognosis of patients with Borrmann typeⅢ/LBVI+disease and patients with Borrmann typeⅣdisease was observed.Therefore,we proposed a revised Borrmann typeⅣ(r-BorⅣ)as Borrmann typeⅢplus LBVI+,and found that r-BorⅣwas associated with poor prognosis in patients with APGC,which outweighed the prognostic significance of pT status.CONCLUSION LBVI is related to the prognosis of APGC,but is not an independent prognostic factor.LBVI status can be used to differentiate Borrmann typesⅢandⅣ,and the same approach can be used to treat r-BorⅣand Borrmann typeⅣ. | Shan Gao Guo-Hui Cao Peng Ding Yang-Yang Zhao Peng Deng Bin Hou Kai Li Xiao-Fang Liu | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 11 |
| 11 | Prevention and control of coalfield fire technology:A case study in the Antaibao Open Pit Mine goaf burning area,China显示文摘It is very difficult to clearly detect the location of a burning area in a coal mine since it is hidden underground.So we conducted research on the distribution of the burning area before controlling it.Firstly,the original drilling technique was used to analyze and determine the loose and scope of caving of burning area through field test,and then obtained the gases and the temperature data in this area were according to the borehole data.By analyzing these data,we found out that the location of burning area concentrated in the loose and caving area;and finally,the location and development of the burning area within the tested area were accurately determined.Based on this theory,we used the ground penetrating radar(GPR) to find out the loose and caving scale in the burning area during the control process of the burning area,and then located the fire-extinguishing boreholes within target which we used to control burning fire in the section.A mobile comprehensive fire prevention and extinguishing system based on the three-phase foam fire prevention and control technique was then adopted and conducted in the burning area which took only 9 months to extinguish the 227,000 m 2 of burning area of 9# coal.This control technology and experience will provide a very important reference to the control of other coalfield fire and hillock fire in the future. | Cao Kai Zhong Xiaoxing Wang Deming Shi Guoqing Wang Yanming Shao Zhenlu | 2012 | International Journal of Mining Science and Technology2012，22，5： | 10 |
| 12 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 13 | A Bio-Inspired Biped Water Running Robot Incorporating the Watt-I Planar Linkage Mechanism显示文摘 | Linsen Xu Tao Mei Xianming Wei Kai Cao Mingzhou Luo | 2013 | Journal of Bionic Engineering2013，10，4： | 10 |
| 14 | A buried Neolithic paddy soil reveals loss of microbial functional diversity after modern rice cultivation显示文摘It has been documented that human activities are causing the rapid loss of taxonomic, phylogenetic, genetic and functional diversity in soils. However, it remains unclear how modern intensive rice cultivation impacts the soil microbiome and its functionality. Here we examined the microbial composition and function differences between a buried Neolithic paddy soil and an adjacent,currently-cultivated paddy soil using high throughput metagenomics technologies. Our results showed that the currently cultivated soil contained about 10-fold more microbial biomass than the buried one. Analyses based on both 16S rRNA genes and functional gene array showed that the currently cultivated soil had significantly higher phylogenetic diversity, but less functional diversity than the buried Neolithic one. The community structures were significantly different between modern and ancient soils,with functional structure shifting towards accelerated organic carbon(C) degradation and nitrogen(N) transformation in the modern soils. This study implies that, modern intensive rice cultivation has substantially altered soil microbial functional structure, leading to functional homogenization and the promotion of soil ecological functions related to the acceleration of nutrient cycling which is necessary for high crop yields. | Yong-Guan Zhu Jian-Qiang Su Zhihong Cao Kai Xue John Quensen Guang-Xia Guo Yun-Feng Yang Jizhong Zhou Hai-Yan Chu James M.Tiedje | 2016 | Science Bulletin2016，61，13： | 10 |
| 15 | Research on semi-solid thixoforming process of AZ91D magnesium alloy brackets for generators in JH70-type motorbikes显示文摘The investment on semi-solid die casting processes of AZ91D magnesium alloy brackets for generators in JH70-type motorbikes is introduced. The processes of low super-heat and cooling slope for the preparation of billets with non-dendritic microstructure, the remelting of billets for thixoforming and the parameters in the process of semi-solid thixoforming have been researched. The results show that primary billets with non-dendritical structures can be prepared by forming great amount of nuclei in melt via the process of low super heat. By optimizing the remelting process through ad- justing the current of the induced equipment, semi-solid billets with a structure of spherical grains were obtained from the primary billets with non-dendritical structure. The range of 580°C to 583°C is the proper remelting temperatures by which the billets have an expected thixotropy and can be transferred to a die-casting machine. The optimized parameters of semi-solid forming in a die-casting machine are as follows: the area of the ingate in the die is 383.5 mm2, the speed of the pierce of the machine 5 m/s, the shot pressure of the pierce 75 MPa, and the maintenance pressure of the pierce 350 MPa. The castings of brackets for supporting generators in JH70 type motorbikes were formed by adopting the optimized proc- esses and parameters mentioned above. | WANG Kai LIU Changming HAN Zhaotang CAO Jianyong ZHANG Zonghe | 2005 | Rare Metals2005，24，4： | 9 |
| 16 | Type D personality negatively associated with self-care in Chinese heart failure patients显示文摘 | Xi CAO Xiu-Hua WANG Eliza ML Wong Choi Kai Chow Sek Ying Chair | 2016 | Journal of Geriatric Cardiology2016，13，5： | 9 |
| 17 | Microstructures and tensile properties of Mg-Zn-(Gd)-Zr alloys extruded at various temperatures显示文摘The microstructures and tensile properties of Mg-6.0 Zn-0.6 Zr(ZK60) and ZK60 + 1.8 Gd(ZEK620(RE = Gd)) alloys extruded at 290, 305, 320, 340 and360 ℃ were investigated. The results indicate that Gd addition can refine the microstructures of ZK60 alloy and the extrusion parameters such as the extrusion temperature will influence the tensile properties of both as-extruded ZK60 and ZEK620 alloys, although it is much slighter for ZK60 alloy. And the sensitivity is closely related to the textures developed during extrusion. In addition, Gd addition will also clearly improve the tensile strength at room temperature(24 ℃) and particularly at high temperatures(150 and 200 ℃), due to the much finer grains and smaller intermetallic particles. The highest strength is achieved in the as-extruded ZEK620 alloy with extrusion temperature of 320 ℃, with ultimate tensile strength(UTS) and tensile yield strength(TYS) of 405 and375 MPa, respectively, which are improved by approximately 9% and 11% than those of the as-extruded ZK60 alloy which owns the highest strength at extrusion temperature of 290 ℃. | Xin Qiu Qiang Yang Kai Guan Fanqiang Bu Zhan-Yi Cao Yong-Bing Liu Jian Meng | 2017 | Rare Metals2017，36，12： | 9 |
| 18 | Combustion characteristics and synergy behaviors of biomass and coal blending in oxy-fuel conditions: A single particle co-combustion method显示文摘Co-combustion biomass and coal can effectively reduce the emission of CO_2. O_2/H_2O combustion is regarded as the next generation of oxy-fuel combustion technology. By co-combustion biomass and coal under oxy-fuel condition, the emission of CO_2 can be minimized. This work investigates the co-combustion characteristics of single particles from pine sawdust(PS) and bituminous coal(BC) in O_2/N2, O_2/CO_2 and O_2/H_2O atmospheres at different O_2 mole fractions(21%, 30% and 40%). The experiments were carried out in a drop tube furnace(DTF), and a high speed camera was used to record the combustion process of fuel particles. The combustion temperature was measured by a two-color method. The experiments in O_2/N2 atmosphere indicate that the particles from pine sawdust and bituminous coal all ignite homogeneously. After replacing H_2O for N2, the combustion temperature of volatiles of blended fuel particles decreases, while the combustion temperature of char increases. The ignition delay time in O_2/H_2O atmosphere is shorter than that in O_2/N2 or O_2/CO_2 atmosphere. The combustion temperature of volatiles of blended fuel particles increases as the mass fraction of bituminous coal increases, while the combustion temperature of char of blended fuel particles is higher than that of biomass or bituminous coal. The ignition delay time of blended fuel particles increases with the increasing mass fraction of bituminous coal, and the experimental ignition delay time of blend fuel particles is shorter than the theoretical one. These reveal a synergy during co-combustion process of pine sawdust and bituminous coal. | ZHANG Rui LEI Kai YE BuQing CAO Jin LIU Dong | 2018 | Science China(Technological Sciences)2018，61，11： | 9 |
| 19 | Perineural invasion status, Gleason score and number of positive cores in biopsy pathology are predictors of positive surgical margin following laparoscopic radical prostatectomy显示文摘这研究被设计在 laparoscopic 激进分子前列腺切除术以后定义积极外科的边缘的可能的外科手术前的预言者。我们回顾地分析了 296 个病人的记录,前列腺癌症由前列腺活体检视诊断了,并且最后与 laparoscopic 激进分子前列腺切除术对待。年龄的预示的影响,前列腺体积,外科手术前的前列腺特定的抗原,活体检视格利森分数,最大的百分比肿瘤每核心,积极核心的数字,活体检视 perineural 侵略,成像上的囊侵略,和外科的边缘上的肿瘤对一个侧面的偏重被估计。全面积极外科的边缘率是 29.1% 。格利森分数,积极核心的数字, perineural 侵略,在活体检视标本的肿瘤对一个侧面的偏重,和前列腺体积显著地由 univariate 分析与积极外科的边缘的风险相关(P < 0.05 ) 。格利森分数(机会比率[或]= 2.286 ,95%信心间隔[95% CI ]= 1.431-3.653 , P = 0.001 ), perineural 侵略(或= 4.961 ,95% CI = 2.656-9.270 , P < 0.001 ),并且积极核心的数字(或= 4.403 ,95% CI = 1.878-10.325 , P = 0.001 )是在 multivariable 的积极外科的边缘的独立预言者逻辑回归分析。有在活体检视病理的 perineural 侵略,更高的活体检视格利森分数或很多积极核心的病人有囊侵略的更多的可能性。在有囊侵略(49.5%) 的病人的积极外科的边缘率与局部性的疾病(17.8%) 比那高得多。相反,前列腺体积对积极外科的边缘显示出保护的效果(或 = 0.572, 95% CI = 0.346-0.945, P = 0.029 ) 。当前列腺体积是对积极外科的边缘的一个保护的因素时,在活体检视标本的积极核心的格利森分数, perineural 侵略,和数字是在 laparoscopic 激进分子前列腺切除术以后的积极外科的边缘的外科手术前的独立预言者。 | Rong Yang Kai Cao Tao Han Yi-Feng Zhang Gu-Tian Zhang Lin-Feng XU Hui-Bo Lian Xiao-Gong Li Hong-Qian Guo | 2017 | Asian Journal of Andrology2017，19，4： | 9 |
| 20 | Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis显示文摘AIM: To identify and understand the relationship between co-expression pattern and clinic traits in uveal melanoma, weighted gene co-expression network analysis(WGCNA) is applied to investigate the gene expression levels and patient clinic features. Uveal melanoma is the most common primary eye tumor in adults. Although many studies have identified some important genes and pathways that were relevant to progress of uveal melanoma, the relationship between co-expression and clinic traits in systems level of uveal melanoma is unclear yet. We employ WGCNA to investigate the relationship underlying molecular and phenotype in this study.METHODS: Gene expression profile of uveal melanoma and patient clinic traits were collected from the Gene Expression Omnibus(GEO) database. The gene co-expression is calculated by WGCNA that is the R package software. The package is used to analyze the correlation between pairs of expression levels of genes.The function of the genes were annotated by gene ontology(GO).RESULTS: In this study, we identified four co-expression modules significantly correlated with clinictraits. Module blue positively correlated with radiotherapy treatment. Module purple positively correlates with tumor location(sclera) and negatively correlates with patient age. Module red positively correlates with sclera and negatively correlates with thickness of tumor. Module black positively correlates with the largest tumor diameter(LTD). Additionally, we identified the hug gene(top connectivity with other genes) in each module. The hub gene RPS15 A, PTGDS, CD53 and MSI2 might play a vital role in progress of uveal melanoma.CONCLUSION: From WGCNA analysis and hub gene calculation, we identified RPS15 A, PTGDS, CD53 and MSI2 might be target or diagnosis for uveal melanoma. | Kai Shi Zhi-Tong Bing Gui-Qun Cao Ling Guo Ya-Na Cao Hai-Ou Jiang Mei-Xia Zhang | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 9 |
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