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| 1 | Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome显示文摘Dear Editor, Most disease-associated genomic mutations are base substitutions and approximately half of pathogenic human single nucleotide polymorphisms (SNPs)are related to C-to-T substitutions in the ClinVar database.Base editors (BEs),which combine Casg-DIOA nickase and APOBEC (apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like)or AID (activation-induced deaminase)cytidine deaminase family members, have been successfully applied to mediate C-to-T conversion in vitro and in vivo, providing a powerful tool to model or repair diseaserelated human SNPs. | Jianan Li Zhen Liu Shisheng Huang Xiao Wang Guanglei Li Yuting Xu Wenxia Yu Shanshan Chen Yu Zhang Hanhui Ma Zunfu Ke Jia Chen Qiang Sun Xingxu Huang | 2019 | Cell Research2019，29，2： | 3 |
| 2 | Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma显示文摘Despite the advance in targeted therapy,lung adenocarcinoma(LUAD)remains one of the leading causes of death in patients with cancer.CD155,a member of poliovirus receptor–related(PRR)family,has been identified as the ligand of the Ig-like receptors tactile(CD96)and DNAM-1(CD226)on T cells.The interaction of CD155 with CD96 transmits an inhibitory signal and suppresses immune response.The interaction of CD155 with CD226 enhances the immune response.1,2,3 CD155 expression has been shown to be elevated in many types of cancers4,5 and is involved with immune suppression in melanoma.6 However,how CD155/CD96 is involved in immune response in the tumor microenvironment of LUAD remains unknown. | Hui Zhang Qianwen Liu Yiyan Lei Jianwen Zhou Wenting Jiang Yongmei Cui Qiong He Junfeng Zhu Zheng Zhu Yu Sun Zunfu Ke | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 3 | Climate change impacts on regional winter wheat production in main wheat production regions of China显示文摘 | Lv Zunfu Liu Xiaojun Cao Weixing | 2013 | Agricultural and Forest Meteorology2013，，： | 1 |
| 4 | Diatomic active sites nanozymes:Enhanced peroxidase-like activity for dopamine and intracellular H2O2 detection显示文摘Considering intracellular hydrogen peroxide(H_(2)O_(2))plays pivotal roles in the regulation of serial biological processes,the in-situ detection of intracellular H2O2 has attracted an extensive attention.In the present work,an atomically dispersed diatomic active sites Nanozymes(FeN_(3)/PtN_(4)-single-atom nanozymes(SAzyme))was prepared exhibiting enhanced peroxidase-like activity.The obvious synergistic effect between Fe-Pt heteronuclear diatomic active sites was confirmed by series of characterization and density functional theory(DFT).The peroxidase-like activity of Fe-sites could be substantially enhanced by the bonded Pt-sites via the modulation effect.As a consequence,the gap between the d-band centre(εd)of Fe 3d orbitals and the Fermi energy level was narrowed and the electronic interaction could be strengthened,leading to a lower free energy barrier and a lower activation energy as well as fortified metal-O bonding in the kinetic pathway.Therefore,the constructed FeN3/PtN4-SAzyme exhibited higher peroxidase-like activity than that of FeN4-SAzyme.The FeN3/PtN4-SAzyme-assisted oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)facilitated the colorimetric detection of dopamine(DA),an important biomolecule.The linear detection range and limit of detection(LOD)of DA and H_(2)O_(2) were 1-10 μM,0.01-1.0 mM and 0.109 μM,7.97 μM,respectively.In addition,the constructed SAzymes were also applied for the in-situ detection of intracellular H2O2,expanding the application scope of the newborn SAzymes. | Shan Wang Zunfu Hu Qiulian Wei Huimin Zhang Weina Tang Yunqiang Sun Haiqiang Duan Zhichao Dai Qingyun Liu Xiuwen Zheng | 2022 | Nano Research2022，15，5： | 1 |
| 5 | Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis显示文摘Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis. | Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 6 | Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non–small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression显示文摘 | Shijun Sun Zunfu Ke Fen Wang Shuhua Li Wenfang Chen Anjia Han Zuo Wang Huijuan Shi Lian-tang Wang Xiaodong Chen | 2012 | Human Pathology2012，，7： | 1 |
| 7 | Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin显示文摘 | Junfeng Zhu Yupeng Feng Zunfu Ke Zheng Yang Junyi Zhou Xiaorong Huang Liantang Wang | 2012 | The American Journal of Pathology2012，，6： | 1 |
| 8 | Construction of highly dispersed Pt single sites and high-efficiencyheterocatalysis silylation of alcohols with silanes显示文摘The construction of silicon-oxygen bonds has been highlighted as an exciting achievement in organosilicon and green chemistry,but their synthetic efficiency has great improvement potential,so it is crucial to explore and achieve an effective approach for synthesizing such compounds.In this study,we successfully prepared the highly dispersed platinum single-atom catalyst(Pt SAC/N-C)through a coordination-assisted strategy with a mixture of ligands(H2bpdc and H2bpydc),which were used for the Osilylation of alcohols with silanes.The strong coordination between Pt2+and the Pyridine N at the skeleton of UiO-67 plays a critical role in accessing the atomically isolated dispersion of Pt sites.Without the assistance of the H2bpydc ligands,the Pt/UiO-67-bpdc precursor is prone to aggregation during the pyrolysis process,resulting in the formation of Pt nanoparticles.Aided by advanced characterization techniques of high-angle annular dark-field scanning transmission electron microscopy(HAADFSTEM)and X-ray absorption fine structure(XAFS)spectroscopy,it has been demonstrated that atomically dispersed Pt was formed on the UiO-67 through a local structure of four-coordinated Pt-N4,exhibiting a high actual Pt loading content(0.6962 wt.%).In the oxidation of silanes,the Pt SAC/N-C catalyst showed a high turnover frequency(TOF)value(up to 9,920 h−1)when the catalyst loading decreased to 0.005%.Excellent performance was maintained during recycling experiments,indicating high stability of the catalyst. | Qiulian Wei Yunqiang Sun Shan Wang Zunfu Hu Qingyun Liu Xiuwen Zheng | 2023 | Nano Research2023，16，4： | 0 |
| 9 | A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance显示文摘Lenvatinib,a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer,facing limitations due to drug resistance.Here,we applied a multidimensional,high-throughput screening platform comprising patient-derived resistant liver tumor cells(PDCs),organoids(PDOs),and xenografts(PDXs)to identify drug susceptibilities for conquering lenvatinib resistance in clinically relevant settings.Expansion and passaging of PDCs and PDOs from resistant patient liver tumors retained functional fidelity to lenvatinib treatment,expediting drug repurposing screens.Pharmacological screening identified romidepsin,YM155,apitolisib,NVP-TAE684 and dasatinib as potential antitumor agents in lenvatinib-resistant PDC and PDO models.Notably,romidepsin treatment enhanced antitumor response in syngeneic mouse models by triggering immunogenic tumor cell death and blocking the EGFR signaling pathway.A combination of romidepsin and immunotherapy achieved robust and synergistic antitumor effects against lenvatinib resistance in humanized immunocompetent PDX models.Collectively,our findings suggest that patient-derived liver cancer models effectively recapitulate lenvatinib resistance observed in clinical settings and expedite drug discovery for advanced liver cancer,providing a feasible multidimensional platform for personalized medicine. | Lei Sun Arabella H.Wan Shijia Yan Ruonian Liu Jiarui Li Zhuolong Zhou Ruirui Wu Dongshi Chen Xianzhang Bu Jingxing Ou Kai Li Xiongbin Lu Guohui Wan Zunfu Ke | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 10 | New insights into the correlations between circulating tumor cells and target organ metastasis显示文摘Organ-specific metastasis is the primary cause of cancer patient death.The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment.During an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic tumors.CTCs harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further lesions.In the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et al.Furthermore,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific metastasis.Based on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced tumor.Recently,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical strategies.In the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs. | Qinru Zhan Bixia Liu Xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling He Zunfu Ke | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 11 | ECC:Edge Collaborative Caching Strategy for Differentiated Services Load-Balancing显示文摘Due to the explosion of network data traffic and IoT devices,edge servers are overloaded and slow to respond to the massive volume of online requests.A large number of studies have shown that edge caching can solve this problem effectively.This paper proposes a distributed edge collaborative caching mechanism for Internet online request services scenario.It solves the problem of large average access delay caused by unbalanced load of edge servers,meets users’differentiated service demands and improves user experience.In particular,the edge cache node selection algorithm is optimized,and a novel edge cache replacement strategy considering the differentiated user requests is proposed.This mechanism can shorten the response time to a large number of user requests.Experimental results show that,compared with the current advanced online edge caching algorithm,the proposed edge collaborative caching strategy in this paper can reduce the average response delay by 9%.It also increases the user utility by 4.5 times in differentiated service scenarios,and significantly reduces the time complexity of the edge caching algorithm. | Fang Liu Zhenyuan Zhang Zunfu Wang Yuting Xing | 2021 | Computers, Materials & Continua2021，，11： | 0 |
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