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| 1 | Zircon U-Pb geochronological framework of Qitianling granite batholith, middle part of Nanling Range, South China显示文摘The Qitianling granite batholith (QGB) is located in the southern Hunan Province, middle part of the Nanling Range, South China. Its total exposure area is about 520 km2. Based on our 25 single grain zircon U-Pb age data and 7 published data as well as the geological, petrological, and space distribution characteristics, we conclude that QGB is an Early Yanshanian (Jurassic) multi-staged composite pluton. Its formation process can be subdivided into three major stages. The first stage, emplaced at 163―160 Ma with a peak at about 161 Ma, is mainly composed of hornblende-biotite monzonitic granites and locally biotite granites, and distributed in the eastern, northern, and western peripheral parts of the pluton. The second stage, emplaced at 157―153 Ma with a peak at 157―156 Ma, is mainly composed of biotite granites and locally containing hornblende, and distributed in the middle and southeastern parts of the pluton. The third stage, emplaced at 150―146 Ma with a peak at about 149 Ma, is mainly composed of fine-grained (locally porphyritic) biotite granites, and distributed in the middle-southern part of the pluton. Each stage can be further disintegrated into several granite bodies. The first two intrusive stages comprise the major phase of QGB, and the third intrusive stage comprises the additional phase. Many second stage fine-grained granite bosses and dykes intruded into the first stage host granites with clear chilling margin-baking phenomena at their intrusive contacts. They were emplaced in the open fracture space of the earlier stage consolidated rocks. Their isotopic ages are mostly 2―6 Ma younger than their hosts. Conceivably, the time interval from magma emplacement, through cooling, crystallization, solidification, up to fracturing of the earlier stage granites cannot exceed 2―6 Ma. During the Middle-Late Jurassic in the Qitianling area and neighboring Nanling Range, the coeval granitic and basic-intermediate magmatic activities were widely developed. It indicates that the Early Yanshanian period was the culmination time of magmatic activities in this region. The Nanling Range was under a post-orogenic, intracontinental geotectonic environment with an obvious lithospheric extension and thinning. The crust-mantle interaction played an important role in formation of granitic rocks in this region. | ZHU JinChu WANG RuCheng ZHANG PeiHua XIE CaiFu ZHANG WenLan ZHAO KuiDong XIE Lei YANG Ce CHE XuDong YU APeng WANG LuBin | 2009 | Science China Earth Sciences2009，52，9： | 27 |
| 2 | Origin of ore-forming fluid in the Piaotang tungsten deposit in Jiangxi Province:Evidence from helium and argon isotopes显示文摘The Piaotang tungsten deposit in Jiangxi Province is one of the most important tungsten deposits in the South China Tungsten Metallogenic Province.In this study,we selected wolframite and chalcopyrite from the main mineralizing stage of the Piaotang tungsten deposit,and analyzed the helium and argon isotopic compositions in fluid inclusions of these minerals.The results show a 3He/4He ratio of 0.17 to 0.86 R/Ra,which fall within the range between continental crust(0.01―0.05 R/Ra) and air-saturated water(1 R/Ra) ,but are significantly lower than those of the normal mantle(6―9 R/Ra) .Their 40 Ar/36 Ar ratios are between 354.5 and 590.7,which are slightly higher than the air-saturated water(295.5) .Along with the other geochemical observation such as the lithium enrichments in the ore bodies and the ore-related granites,we suggest that the ore-forming fluid in the Piaotang tungsten deposit was mainly derived from crustal fluid.It may have mixed with some amounts of air-saturated water,but there was no considerable involvement of mantle-derived fluid. | WANG XuDong 1,2,3,NI Pei 1,2,3,JIANG ShaoYong 1,3,ZHAO KuiDong 1,3 & WANG TianGang 1,2,3 1State Key Laboratory for Mineral Deposits Research,Nanjing University,Nanjing 210093,China 2Institute of Geo-Fluids,Nanjing University,Nanjing 210093,China 3 School of Earth Sciences and Engineering,Nanjing University,Nanjing 210093,China | 2010 | Chinese Science Bulletin2010，55，7： | 26 |
| 3 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 4 | A review on carrier aircraft dispatch path planning and control on deck显示文摘As an important part in sortie/recovery process,the dispatch of carrier aircraft not only affects the sortie/recovery efficiency and safety,but also has severe influence on the carrier's combat efficiency and the comprehensive support capability.Path planning is the key to improve the efficiency and safety during the dispatch process.The main purpose of this paper is to propose a comprehensive investigation of techniques and research progress for the carrier aircraft's dispatch path planning on the deck.Three different dispatch modes of carrier aircraft and the corresponding modeling technologies are investigated,and the aircraft's dispatch path planning techniques and algorithms have been classified into different classes.Moreover,their assumptions and drawbacks have been discussed for single aircraft and multiple aircraft.To make the research work more comprehensive,the corresponding tracking control methodologies are also discussed.Finally,due to the similarity of path planning problem between the carrier aircraft's dispatch and those in other fields,this paper provides an exploratory prospect of the knowledge or method learned from other fields. | Xinwei WANG Jie LIU Xichao SU Haijun PENG Xudong ZHAO Chen LU | 2020 | Chinese Journal of Aeronautics2020，33，12： | 14 |
| 5 | Laser performance of the SG-Ⅲ laser facility显示文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Xuewei Deng | 2016 | High Power Laser Science and Engineering2016，4，3： | 13 |
| 6 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 7 | First observations of low latitude whistlers using WHU ELF/VLF receiver system显示文摘The recently developed high-quality WHU ELF/VLF receiver system has been deployed in Suizhou, China(geomagnetic latitude 21.81°N, longitude 174.44°E, L=1.16) to detect low latitude extremely-low-frequency(ELF: 0.3-3 k Hz) and very-low-frequency(VLF: 3-30 k Hz) emissions originating from either natural or artificial sources since February 2016. During the first-month operation of the receiver system, a total of 3039 clear whistlers have been recorded at this low latitude station with the majority(97.0%) occurring on 28 February and 1 March 2016. Observed whistlers manifest various types including single one-hop, echo train, multi-flash, and multi-path. They tend to intensify after local midnight, reach the peak around 04-05 LT, and then weaken quickly. Both features of lower cutoff frequencies of most whistlers below ~1.6 k Hz and almost uniform dispersion for many successive multi-flash whistlers suggest that these whistlers propagate along the geomagnetic field lines in the duct mode. The computed dispersion varies between ~15 s^(1/2) and 23 s^(1/2) for observed one-hop whistlers and is greater than 50 s^(1/2) for three-hop echo train whistlers, indicating that the whistlers observed at the Suizhou station are low latitude whistlers. | CHEN YanPing NI BinBin GU XuDong ZHAO ZhengYu YANG GuoBin ZHOU Chen ZHANG YuanNong | 2017 | Science China(Technological Sciences)2017，60，1： | 12 |
| 8 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 9 | Using borehole core analysis to reveal Late Quaternary paleoearthquakes along the Nankou-Sunhe Fault,Beijing显示文摘The Nankou-Sunhe Fault is a buried active normal fault that traverses the urban area of Beijing.Its seismic risks have caused considerable concerns.This paper studies paleoearthquakes along this fault by analyzing and correlating bore-hole cores obtained from triple-tube coring,incorporating experience acquired from trenching.As a result,a model for identifying earthquake-derived colluvium by sediment-core analysis is proposed.Triple-tube coring technique is useful to collect continuous undis-turbed soil core near the Nankou-Sunhe Fault.By identifying fault-scarp colluviums,determining cumulative displacement,and analysing stratum thickening on the hanging wall,we are able to establish a preliminary paleoearthquake sequence consisting of 13 surface-rupturing events since 60 ka.The seismic history can be divided into three periods based on different recurrence intervals.Between 60 and 40 ka,three earthquakes occurred with recurrence interval of ~10 ka.From 40 to 25 ka,there were six earthquakes with the recurrence interval of about 2.5 ka.In the last 25 ka,four earthquakes have taken place with the recurrence interval varying considerably.The recurrence interval between the last three events is ~5 ka.Smaller recurrence intervals correspond to stages of faster fault slip.The coseismic displacement of a single event is 0.8 to 2.2 m,average 1.4 m,largely equivalent to moment magnitudes 6.7-7.1.This study demonstrates the feasibility of bore-hole drilling in investigating paleoearthquakes along normal faults.It also suggests that closely spaced boreholes with continuous undisturbed cores are essential for reconstructing the complete paleoearthquake sequence. | ZHANG ShiMin WANG DanDan LIU XuDong ZHANG GuoHong ZHAO JunXiang LUO MingHui REN JunJie WANG Rui ZHANG YingLi | 2008 | Science China Earth Sciences2008，51，8： | 11 |
| 10 | Zircon U-Pb ages of granites at Changba and Huangzhuguan in western Qinling and implications for source nature显示文摘Mesozoic granitoids are widespread in the Qinling-Dabie-Sulu orogenic belt. Precise U-Pb dating on these granitoids can reveal the evolution of the continental collision orogen and thus provide information on the nature of magma sources. This study pre-sents zircon LA-ICP-MS U-Pb dating and whole-rock geochemical analyses for two intrusions at Changba and Huangzhuguan in western Qinling. Zircon U-Pb ages for central and marginal phases of the Huangzhuguang intrusion are 214±1 Ma and 213±3 Ma, respectively. Zircons from the Changba intrusion yield a dominant cluster with an U-Pb age of 213±2 Ma. Collectively, these ages are younger than ages of 220 to 240 Ma for ultrahigh-pressure metamorphism due to the continental collision between the South China Block and the North China Block, corresponding to syn-exhumation magmatism. Some inherited zircons occur in the Changba intrusion, yielding a weighted mean of 206Pb/238U ages at 757±14 Ma. This indicates that the Changba intrusion has the crustal source of mid-Neoproterozoic ages and a tectonic affinity to the South China Block. Geochemically, the two intrusuons are both rich in LILE and LREE but depleted in HFSE and HREE, similar to arc-type igneous rocks. The Huangzhuguang intrusion exhibits linear correlations between SiO2 and the other major oxides, implying chemical evolution from a cognate magma source. It contains mafic enclaves, suggesting possible mixing of felsic-mafic magmas. The Changba granite is rich in Si and K but poor in Fe and Mg as well as has a high value of Fe, suggesting strong differentiation of granitic magma. Therefore, the two intrusions were derived from the Late Triassic anatexis of the continental crust of different compositions in the northern margin of South China Block. This process may be coupled with exhumation of the subducted continental crust in the stage of late collision. | WANG TianGang NI Pei SUN WeiDong ZHAO KuiDong WANG XuDong | 2011 | Chinese Science Bulletin2011，56，7： | 11 |
| 11 | Influence of Mg and Ti on the microstructure and electrochemical performance of aluminum alloy sacrificial anodes显示文摘The experiments focused on the influence of magnesium and titanium as additional alloying elements on the microstructure and electro-chemical behavior of Al-Zn-In sacrificial anodes. The electrochemical behavior of the aluminum sacrificial anode with 3 wt.% sodium chloride solution was studied by electrochemical impedance spectroscopy (EIS) tests. It was found that a microstructure with few precipitates and refined grains could be achieved by adding 1 wt.% Mg and 0.05 wt.% Ti to the Al-Zn-In alloy,resulting in the improved current capacity and efficiency of the alloy. The equivalent circuit based on the EIS experimental data revealed less corrosion and lower adsorbed corrosion production on the surface of the aluminum alloy with a combination of 1 wt.% Mg and 0.05 wt.% Ti,which suggested that the corrosion behavior seemed to be strongly related to the presence of precipitate particles in the aluminum alloy,and moderate amounts of precipitate particles could be beneficial to the electrochemical performance of the aluminum alloy sacrificial anode. | Ma Jingling Wen Jiuba Li Xudong Zhao Shengli Yan Yanfu | 2009 | Rare Metals2009，28，2： | 9 |
| 12 | Micro-Channel Heat Sink:A Review显示文摘The method to cool a high heat flux device is an important research direction for the heat exchanger design.Micro-channels are an eflfective heat exchange structure both for single-phase and two-phase flow.In this paper,the heat transfer correlations of single-phase,two-phase and nanofluid in a micro-channel are discussed and analyzed.The correlations of pressure drop for single-phase and two-phase fluids are also presented.Excluding the different working fluids used in the micro-channel,the diameter and aspect ratio,shape and structure,surface roughness,internal and external factor and layout of micro-channel pipe are considered to analyze their influence on the heat transfer performance and pressure drop.Micro-channel technology applications include industry,air-conditioning,solar energy systems,heat pipe technology and computer data center cooling.Compared to the conventional heat exchangers used in these fields,a micro-channel heat sink showed a much better heat transfer coefficient and low volume,indicating that it is a good choice and has huge potential for cooling application.Finally,existing problems and future scopes are described,and drawing up design standard,experimental and simulated methods for evaluating its performance are the urgent actions which need to be carried out.This review paper serves as guidance for researchers to design and predict the performance of micro-channel heat sinks. | ZHOU Jinzhi CAO Xiaoling ZHANG Nan YUAN Yanping ZHAO Xudong HARDY David | 2020 | Journal of Thermal Science2020，29，6： | 9 |
| 13 | Prognostic Factors Predicting the Postoperative Survival Period Following Treatment for Primary Retroperitoneal Liposarcoma显示文摘 | Xudong Zhao Peiyu Li Xiaohui Huang Lin Chen Na Liu Yaoguang She | 2015 | Chinese Medical Journal2015，，1： | 9 |
| 14 | Petrogenetic differences between the Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range,South China: A case study of the Tongshanling and Weijia deposits in southern Hunan Province显示文摘The Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range have distinctly different mineralogical and geochemical signatures. The Cu-Pb-Zn-bearing granites are dominated by metaluminous amphibole-bearing granodiorites, which have higher CaO/(Na2O+K2O) ratios, light/heavy rare earth element(LREE/HREE) ratios, and δEu values,lower Rb/Sr ratios, and weak Ba, Sr, P, and Ti depletions, exhibiting low degrees of fractionation. The W-bearing granites are highly differentiated and peraluminous, and they have lower CaO/(Na2O+K2O) ratios, LREE/HREE ratios, and δEu values,higher Rb/Sr ratios, and strong Ba, Sr, P, and Ti depletions. The Cu-Pb-Zn-bearing granites were formed predominantly between155.2 and 167.0 Ma with a peak value of 160.6 Ma, whereas the W-bearing granites were formed mainly from 151.1 to 161.8Ma with a peak value of 155.5 Ma. There is a time gap of about 5 Ma between the two different types of ore-bearing granites.Based on detailed geochronological and geochemical studies of both the Tongshanling Cu-Pb-Zn-bearing and Weijia W-bearing granites in southern Hunan Province and combined with the other Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range, a genetic model of the two different types of ore-bearing granites has been proposed. Asthenosphere upwelling and basaltic magma underplating were induced by the subduction of the palaeo-Pacific plate. The underplated basaltic magmas provided heat to cause a partial melting of the mafic amphibolitic basement in the lower crust, resulting in the formation of Cu-Pb-Zn mineralization related granodioritic magmas. With the development of basaltic magma underplating,the muscovite-rich metasedimentary basement in the upper-middle crust was partially melted to generate W-bearing granitic magmas. The compositional difference of granite sources accounted for the metallogenic specialization, and the non-simultaneous partial melting of one source followed by the other brought about a time gap of about 5 Ma between the Cu-Pb-Zn-bearing and W-bearing granites. | HUANG XuDong LU JianJun Stanislas SIZARET WANG RuCheng MA DongSheng ZHANG RongQing ZHAO Xu WU JinWei | 2017 | Science China Earth Sciences2017，60，7： | 9 |
| 15 | Synthesis of covalently bonded reduced graphene oxide-Fe_(3)O_(4) nanocomposites for efficient electromagnetic wave absorption显示文摘High-performance electromagnetic(EM)wave absorbers,covalently bonded reduced graphene oxideFe_(3)O_(4) nanocomposites(rGO-Fe_(3)O_(4)),are synthesized via hydrothermal reaction,amidation reaction and reduction process.The microstructure,surface element composition and morphology of rGO-Fe_(3)O_(4) nanocomposites are characterized and corresponding EM wave absorption properties are analyzed in great detail.It demonstrates that Fe_(3)O_(4) nanoparticles are successfully covalently grafted onto graphene by amide bonds.When the mass ratio of rGO and Fe_(3)O_(4) is 2:1(sample S2),the absorber exhibits the excellent EM wave absorption performance that the maximum reflection loss(RL)reaches up to-48.6 dB at 14.4 GHz,while the effective absorption bandwidth(RL<-10 dB)is 6.32 GHz(11.68-18.0 GHz)with a matching thickness of 2.1 mm.Furthermore,radar cross section(RCS)simulation calculation is also adopted to evaluate the ability of absorbers to scatter EM waves,which proves again that the absorption performance of absorber S2 is optimal.The outstanding EM wave absorption performance is attributed to the synergistic effect between dielectric and magnetic loss,good attenuation ability and excellent impedance matching.Moreover,covalent bonds considered to be carrier channels can facilitate electron migration,adjust EM parameters and then enhance EM wave absorption perfo rmance.This work provides a possible method for preparing efficient EM wave absorbers. | Xudong Liu Ying Huang Ling Ding Xiaoxiao Zhao Panbo Liu Tiehu Li | 2021 | Journal of Materials Science & Technology2021，，13： | 8 |
| 16 | A detailed investigation of low latitude tweek atmospherics observed by the WHU ELF/VLF receiver:2.Occurrence features and associated ionospheric parameters显示文摘As a companion paper to Zhou RX et al.(2020),this study describes application of the automatic detection and analysis module to identify all the tweek atmospherics detectible in the WHU ELF/VLF receiver data collected at Suizhou station during the period of 3 February through 29 February 2016.Detailed analysis of the identified low-latitude tweek events reveals that the occurrence rate varies considerably—from 800 to 6000 tweeks per day,and exhibits a strong diurnal and local time dependence,the peak occurring before local midnight.The diurnal variation of identified tweeks was similar to that of the lightning data obtained by the World-Wide Lightning Location Network(WWLLN)..Estimates of the propagation distance and ionospheric reflection height of tweek atmospherics suggest that the majority(~92%)of the low latitude tweeks originate from the lightning activity within a radius of 4000 km and that they are very likely to reflect from the lower ionospheric D-region at the height range of 75–85 km.At these lower ionospheric reflection altitudes,~74%of the corresponding electron densities from the tweek spectral measurements are within 24.5–27.5 cm^-3.The daily variation of estimated D-region electron densities in the considered period(February 2016)also exhibits a small overall increasing trend from early to later in the month. | Juan Yi XuDong Gu Wen Cheng XinYue Tang Long Chen BinBin Ni RuoXian Zhou ZhengYu Zhao Qi Wang LiQing Zhou | 2020 | Earth and Planetary Physics2020，4，3： | 8 |
| 17 | A detailed investigation of low latitude tweek atmospherics observed by the WHU ELF/VLF receiver:Ⅰ. Automatic detection and analysis method显示文摘As a dispersive wave mode produced by lightning strokes, tweek atmospherics provide important hints of lower ionospheric(i.e., D-region) electron density. Based on data accumulation from the WHU ELF/VLF receiver system, we develop an automatic detection module in terms of the maximum-entropy-spectral-estimation(MESE) method to identify unambiguous instances of low latitude tweeks.We justify the feasibility of our procedure through a detailed analysis of the data observed at the Suizhou Station(31.57°N, 113.32°E) on17 February 2016. A total of 3961 tweeks were registered by visual inspection;the automatic detection method captured 4342 tweeks, of which 3361 were correct ones, producing a correctness percentage of 77.4%(= 3361/4342) and a false alarm rate of 22.6%(= 981/4342).A Short-Time Fourier Transformation(STFT) was also applied to trace the power spectral profiles of identified tweeks and to evaluate the tweek propagation distance. It is found that the fitting accuracy of the frequency–time curve and the relative difference of propagation distance between the two methods through the slope and through the intercept can be used to further improve the accuracy of automatic tweek identification. We suggest that our automatic tweek detection and analysis method therefore supplies a valuable means to investigate features of low latitude tweek atmospherics and associated ionospheric parameters comprehensively. | RuoXian Zhou XuDong Gu KeXin Yang GuangSheng Li BinBin Ni Juan Yi Long Chen FuTai Zhao ZhengYu Zhao Qi Wang LiQing Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 7 |
| 18 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 19 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 20 | Joint Precoding Schemes for Flexible Resource Allocation in High Throughput Satellite Systems Based on Beam Hopping显示文摘Beam hopping technology provides a foundation for the flexible allocation and efficient utilization of satellite resources,which is considered as a key technology for the next generation of high throughput satellite systems.To alleviate the contradiction between resource utilization and co-frequency interference in beam hopping technology,this paper firstly studies dynamic clustering to balance traffic between clusters and proposes cluster hopping pool optimization method to avoid inter-cluster interference.Then based on the optimization results,a novel joint beam hopping and precoding algorithm is provided to combine resource allocation and intra-cluster interference suppression,which can make efficient utilization of system resources and achieve reliable and near-optimal transmission capacity.The simulation results show that,compared with traditional methods,the proposed algorithms can dynamically adjust to balance demand traffic between clusters and meet the service requirements of each beam,also eliminate the co-channel interference to improve the performance of satellite network. | Chen Zhang Xudong Zhao Gengxin Zhang | 2021 | China Communications2021，18，9： | 5 |
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