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| 1 | The differences and similarities between two-sample t-test and paired t-test显示文摘临床研究中经常遇到比较实验组和对照组之间的结果。双样本t检验(又称为独立样本t检验)和配对t检验可能是运用于比较两个样本之间均值的最广泛的统计方法。然而,这两种方法的运用会产生混淆,从而导致使用不当。本文中,我们讨论了这两种t检验之间的异同性,并运用三个范例来阐述双样本t检验和配对t检验的计算过程。 | 徐曼菲 Drew FRALICK Julia Z.ZHENG Bokai Wang Xin M.TU Changyong FENG | 2017 | 上海精神医学2017，29，3： | 8 |
| 2 | 单因素与多因素逻辑回归的不一致性(英文)显示文摘逻辑回归是研究协变量对二元结果影响的一种常用的统计方法。它已被广泛应用于临床试验和观察性研究。然而,单因素回归得到的结果和多元逻辑回归得到的结果往往是相互矛盾的。在多元回归中可能对结果会显示出非常强烈的影响的一个协变量在单因素回归中可能不会,反之亦然。这些事实在生物医学研究中并没有引起足够的重视。误用逻辑回归在医学出版物中非常普遍。在本文中,我们研究了单因素和多因素逻辑回归分析的不一致性,并在多元逻辑回归分析的模型部分中给出建议。 | Hongyue WANG Jing PENG Bokai WANG Xiang LU Julia Z.ZHENG Kejia WANG Xin M.TU Changyong FENG | 2017 | 上海精神医学2017，29，2： | 5 |
| 3 | 三种常用危险度测量方法之间的关系:相对危险度、危险差和比值比(英文)显示文摘概述:相对危险度(relative risk)、危险差(risk difference)和比值比(odds ratio)是最常用的三种比较不同群体之间疾病风险的方法。虽然它们在生物医学和社会心理学研究中广泛流行,但是尚无文献明确这三种方法之间的关系。许多研究人员误以为它们之间的关系是单调变化的,即某种测量方式中较高(或较低)的值与其它测量方式中的较高(或较低)的值相关。本文中,我们讨论了三个定理,并提供例子解释之前大部分研究人员所认为这三种方法之间的关系是不对的;这些测量方法相互之间并没有逻辑关系。研究人员在说明不同种测量方法之间的相关性时或结合使用不同种风险测量方法所得的研究结果时必须非常谨慎。 | Changyong FENG Hongyue WANG Bokai WANG Xiang LU Hao SUN Xin M.TU | 2016 | 上海精神医学2016，28，1： | 2 |
| 4 | 有效性试验、非劣效性试验、和等效试验之间的比较(英文)显示文摘概述:一种新型药物或治疗的效果通常是通过临床随机对照试验获得的。然而,假设的设定对生物医学研究者来说仍然是具有挑战性的问题。在本调查中,我们讨论了有效性试验、非劣效性试验、和等效性试验。这三类试验对治疗效果均有不同的假设。我们比较了这些试验中的假设并提供了样本量计算公式。 | Bokai WANG Hongyue WANG Xin M. TU Changyong FENG | 2017 | 上海精神医学2017，29，6： | 2 |
| 5 | 赢率-医学研究中一个直观而易于解释的综合结果(英文)显示文摘对于医学研究中的多个结果,研究人员总是需要选择是否使用一个综合性结果(综合多个结果后所得的)作为主要结果。在本文中,我们回顾了治疗效果的一个新测量方式-赢率,它可以很容易地用于具有多个优先级结果的研究中。并且,我们在这块领域也提出了一些研究课题。 | hongyue wang jing peng juila z.zheng bokai wang xiang lu chongshu chen xin m.tu changyong feng | 2017 | 上海精神医学2017，29，1： | 1 |
| 6 | 辛普森悖论的范例(英文)显示文摘概述:辛普森悖论普遍存在于很多领域。它具有数据的条件性和边缘性解释之间的不一致特征。在本文中,我们通过一些例子来阐述辛普森悖论是如何在连续性、分类和时间-事件数据中产生的。 | Bokai WANG Pan WU Brian KWAN Xin M.TU Changyong FENG | 2018 | 上海精神医学2018，30，2： | 1 |
| 7 | Machine learning methods in psychiatry: a brief introduction显示文摘Machine learning(ML)techniques have been widely used to address mental health questions.We discuss two main aspects of ML in psychiatry in this paper,that is,supervised learning and unsupervised learning.Examples are used to illustrate how ML has been implemented in recent mental health research. | Zhirou Zhou Tsung-Chin Wu Bokai Wang Hongyue Wang Xin M Tu Changyong Feng | 2020 | General Psychiatry2020，33，1： | 1 |
| 8 | Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma显示文摘Pleomorphic adenoma(PA)is the most common benign tumour in the salivary gland and has high morphological complexity.However,the origin and intratumoral heterogeneity of PA are largely unknown.Here,we constructed a comprehensive atlas of PA at single-cell resolution and showed that PA exhibited five tumour subpopulations,three recapitulating the epithelial states of the normal parotid gland,and two PA-specific epithelial cell(PASE)populations unique to tumours.Then,six subgroups of PASE cells were identified,which varied in epithelium,bone,immune,metabolism,stemness and cell cycle signatures.Moreover,we revealed that CD36+myoepithelial cells were the tumour-initiating cells(TICs)in PA,and were dominated by the PI3K-AKT pathway.Targeting the PI3K-AKT pathway significantly inhibited CD36+myoepithelial cell-derived tumour spheres and the growth of PA organoids.Our results provide new insights into the diversity and origin of PA,offering an important clinical implication for targeting the PI3K-AKT signalling pathway in PA treatment. | Xiuyun Xu Jiaxiang Xie Rongsong Ling Shengqi Ouyang Gan Xiong Yanwen Lu Bokai Yun Ming Zhang Wenjin Wang Xiqiang Liu Demeng Chen Cheng Wang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 9 | The p-value and model specification in statistics显示文摘SUMMARY The p value has been widely used as a way to summarise the significance in data analysis. However, misuse and misinterpretation of the p value is common in practice. Our result shows that if the model specification is wrong, the distribution of the p value may be inappropriate, which makes the decision based on the p value invalid. | Bokai Wang Zhirou Zhou Hongyue Wang Xin M Tu Changyong Feng | 2019 | General Psychiatry2019，32，3： | 0 |
| 10 | Tests for paired count outcomes显示文摘Paired t-tests are widely used to compare differences in paired continuous outcomes. This test, however, does not apply to non-continuous outcomes. For binary outcomes,McNemar's test is the de facto method for comparing differences in paired binary variables. For count or frequency outcomes, there is not much discussion in the literature. The Wilcoxon signed-rank test is often used to assess differences in paired count outcomes. However, like the Mann-Whitney U test, or Wilcoxon rank-sum test for comparing two independent groups, the Wilcoxon signedrank test is generally not efficient(powerful). In this essay,we consider some alternative methods for comparing paired count outcomes and compare them with the Wilcoxon signed-rank test using Monte Carlo simulations. | James A Proudfoot Tuo Lin Bokai Wang Xin M Tu | 2018 | General Psychiatry2018，31，4： | 0 |
| 11 | Sample sizes based on three popular indices of risks显示文摘Sample size justification is a very crucial part in the design of clinical trials. In this paper, the authors derive a new formula to calculate the sample size for a binary outcome given one of the three popular indices of risk difference.The sample size based on the absolute difference is the fundamental one, which can be easily used to derive sample size given the risk ratio or OR. | Hongyue Wang Bokai Wang Xin M Tu Jinyuan Liu Changyong Feng | 2018 | General Psychiatry2018，31，6： | 0 |
| 12 | Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory显示文摘tDiabetic neuropathic pain(DNP)is the most common disabling complication of diabetes.Emerging evi-dence has linked the pathogenesis of DNP to the aberrant sprouting of sensory axons into the epidermal area;however,the underlying molecular events remain poorly understood.Here we found that an axon guidance molecule,Netrin-3(Ntn-3),was expressed in the sensory neurons of mouse dorsal root ganglia(DRGs),and downregulation of Ntn-3 expression was highly correlated with the severity of DNP in a diabetic mouse model.Genetic ablation of Ntn-3 increased the intra-epidermal sprouting of sensory axons and worsened the DNP in diabetic mice.In contrast,the elevation of Ntn-3 levels in DRGs significantly inhibited the intra-epidermal axon sprouting and alleviated DNP in diabetic mice.In con-clusion,our studies identified Ntn-3 as an important regula-tor of DNP pathogenesis by gating the aberrant sprouting of sensory axons,indicating that Ntn-3 is a potential druggable target for DNP treatment. | Weiping Pan Xueyin Huang Zikai Yu Qiongqiong Ding Liping Xia Jianfeng Hua Bokai Gu Qisong Xiong Hualin Yu Junbo Wang Zhenzhong Xu Linghui Zeng Ge Bai Huaqing Liu | 2023 | Neuroscience Bulletin2023，39，5： | 0 |
| 13 | Inconsistency between overall and subgroup analyses显示文摘Suppose we have a sample of subjects in two treatment groups.To study the difference of the treatment effects,we can analyse the data using all subjects(overall analysis).We may also divide the subjects into several subgroups based on some covariates of interest(eg,gender),and study the treatment effects within each subgroup.The results of these two analyses may be different or even in opposite directions.In this paper,we give a general sufficient condition of consistency between the overall and subgroup analyses. | Hongyue Wang Bokai Wang Xin M Tu Changyong Feng | 2022 | General Psychiatry2022，35，3： | 0 |
| 14 | Advanced machine learning methods in psychiatry: an introduction显示文摘Mental health questions can be tackled through machine learning(ML)techniques.Apart from the two ML methods we introduced in our previous paper,we discuss two more advanced ML approaches in this paper:support vector machines and artificial neural networks.To illustrate how these ML methods have been employed in mental health,recent research applications in psychiatry were reported. | Tsung-Chin Wu Zhirou Zhou Hongyue Wang Bokai Wang Tuo Lin Changyong Feng Xin M Tu | 2020 | General Psychiatry2020，33，2： | 0 |
| 15 | Relations among sensitivity,specificity and predictive values of medical tests based on biomarkers显示文摘Diagnostic tests are usually based on some quantitative biomarkers.Two key parameters used to characterise the quality of a test are test sensitivity and specificity.Predictive values of the disease status based on test results are also of interest in medical research and public health management.In this paper,we study the relations among sensitivity,specificity and predictive values of the test.The core concept is risk function,which is assumed to be an increasing function of the biomarker.Our results show that test sensitivity and specificity change in opposite directions.The positive predictive value and the sensitivity also change in opposite directions.Likewise,the negative predictive value and the specificity change in opposite directions. | Hongyue Wang Bokai Wang Xunan Zhang Changyong Feng | 2021 | General Psychiatry2021，34，2： | 0 |
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