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| 1 | Impact of immunosuppression minimization and withdrawal in long-term hepatitis C virus liver transplant recipients显示文摘AIM:To investigate the effects of different immunosuppressive regimens and avoidance on fibrosis progression in hepatitis C virus(HCV)liver transplant(LT)recipients.METHODS:We retrospectively compared the liver biopsies of well-matched HCV LT recipients under calcineurin inhibitors(CNI group,n=21)and mycophenolate(MMF group,n=15)monotherapy,with those patients who successfully withdrawn immunosuppression(IS)therapy from at least 3 years(TOL group,n=10).To perform the well-matched analysis,all HCV transplanted patients from December 1993 were screened.Only those HCV patients who reached the following criteria were considered for the analysis:(1)at least3 years of post-operative follow-up;(2)patients with normal liver graft function under low dose CNI monotherapy(CNI group);(3)patients with normal liver graft function under antimetabolite(Micophenolate Mofetil or coated mycophenolate sodium)monotherapy(MMF group);and(4)recipients with normal liver function without any IS.We excluded from the analysis recipients who were IS free or under monotherapy for<36 mo,recipients with cirrhosis or with unstable liver function tests.RESULTS:Thirty six recipients were enrolled in the study.Demographics,clinical data,time after LT and baseline liver biopsies were comparable in the three groups.After six years of follow-up,there was no worsening of hepatic fibrosis in the MMF group(2.5±1.5Ishak Units vs 2.9±1.7 Ishak Units,P=0.5)and TOL group(2.7±10.7 vs 2.5±1.2,P=0.2).In contrast,a significant increase in the fibrosis score was observed in the CNI group(2.2±1.7 vs 3.9±1.6,P=0.008).The yearly fibrosis progression rate was significantly worse in the CNI group(0.32±0.35)vs MMF group(0.03±0.31,P=0.03),and TOL group(-0.02±0.27,P=0.02).No differences have been reported in grading scores for CNI group(2.79±1.9,P=0.7),MMF group(3.2±1.5,P=0.9)and TOL group(3.1±1.4,P=0.2).Twenty four patients were treated with low dose ribavirin(8TOL,7 MMF,9 CNI).The hepatitis C titers were comparable in the three groups.No episodes of rejection have been reported despite differences of liver function test in the three groups during the observational period.CONCLUSION:IS withdrawal and MMF monotherapy is safe and seems to be associated with the slowest fibrosis progression in HCV LT recipients. | Tommaso Maria Manzia Roberta Angelico Paolo Ciano Jon Mugweru Kofi Owusu Daniele Sforza Luca Toti Giuseppe Tisone | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 2 | Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer显示文摘 | Di Ciano P Robbins TW Everitt BJ | 2008 | Neuropsychophamlacology2008，33，6： | 1 |
| 3 | Central role for Rho in TGF-beta 1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition显示文摘 | Masszi A Di Ciano C Sirokmány G | | 0，，： | 1 |
| 4 | Sleep-related tongue biting may not be a sign of epilepsy: a case of sleep-related faciomandibular myoclonus显示文摘 | Dylgjeri S Pincherle A Ciano C | 2009 | Epilepsia2009，50，： | 1 |
| 5 | Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A显示文摘 | Di Ciano P Underwood RJ Hagan JJ | 2003 | Neuropsychopharmacology2003，28，2： | 1 |
| 6 | 查看详情显示文摘 | Carretero L Acebal P Blaya S Garcia C Fimia A Madrigal R Mur- ciano A | | 0，，： | 1 |
| 7 | DC characterization of lateral bipolar devices in standard CMOS technology: a new model for base current partitioning 显示文摘 | Di Ciano M | 1999 | Solid-State Electronics1999，43，5： | 1 |
| 8 | Disruptingreconsolidation of drug memories reduces cocaineseekingbehavior显示文摘 | Lee J L Di Ciano P Thomas K L | 2005 | Neuron2005，47，6： | 1 |
| 9 | A signet-ring cell carcinoma of the ampulla of Vater显示文摘 | Gardner H A Matthews J Ciano P S | 1990 | Arch Pathol Lab Med1990，114，： | 1 |
| 10 | Disrupting reconsolidation of drug memories reduces cocaine-seek- ing behavior显示文摘 | Lee JL Di Ciano P Thomas KL et cd | 2005 | Neuron2005，47，6： | 1 |
| 11 | Chronic inflammatory demyelinating polyradiculoneuropathy: long term course and treatment of 60 patients显示文摘 | Solari A Ciano C | 2000 | Neurol Sci2000，21，： | 1 |
| 12 | Childhood -onset multifocal motor neuropathy with conduction blocks 显示文摘 | Moroni I Bugisni M Ciano C | 2006 | Neurology2006，66，6： | 1 |
| 13 | Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition显示文摘 | Masszi A Di Ciano C Sirokmány G Arthur WT Rotstein OD Wang J | 2003 | Am J Physiol Renal Physiol2003，284，5： | 1 |
| 14 | Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior 显示文摘 | Lee JL Di Ciano P Thomas K L Everitt BJ | 2005 | Neuron2005，47，： | 1 |
| 15 | Treahnent of painful hand neuromas by their transfer into bone 显示文摘 | Mass DP Ciano MC Tortosa R | 1984 | Plast Reamstr Surg1984，74，： | 1 |
| 16 | Central role for Rho in TGF-betalinduced alpha-smooth muscle actin expression during epithelial-mesenchymal transition显示文摘 | Masszi A Di Ciano C Sirokmany G | 2003 | Am J Physiol Renal Physiol2003，284，5： | 1 |
| 17 | Disrupting reconsolidation of drug memories reduces cocaineseeking behavior显示文摘 | Lee J L Di Ciano P Thomas K L Everitt B J | 2005 | Neuron2005，47，： | 1 |
| 18 | Liver transplantation for the treatment of nodular regenerative hyperplasia显示文摘 | Tommaso Maria Manzia Gianpiero Gravante Daniele Di Paolo Giuseppe Orlando Luca Toti Maria Irene Bellini Paolo Ciano Mario Angelico Giuseppe Tisone | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 19 | Heated Intraperitoneal Chemotherapy in Appendiceal Cancer Treatment显示文摘 | CIANOS R LAFEVER S MILLS N | 2013 | Clin J Oncol Nurs2013，17，1： | 1 |
| 20 | Everolimus and Enteric-Coated Mycophenolate Sodium Ab Initio after Liver Transplantation: Midterm Results显示文摘 | T.M. Manzia D. Sforza R. Angelico M.I. Bellini P. Ciano M. Manuelli L. Toti G. Tisone | 2012 | Transplantation Proceedings2012，，7： | 1 |
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