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| 1 | A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants显示文摘 | Nan Yu Dexian Luo Xiaowei Zhang Junzhong Liu Wanxiao Wang Yue Jin Wentao Dong Jiyun Liu Huan Liu Weibing Yang Longjun Zeng Qun Li Zuhua He Giles E D Oldroyd Ertao Wang | 2014 | Cell Research2014，24，1： | 9 |
| 2 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 3 | F'mite elenent analysis of internal gem' in highspeed plan-gear ,gear units显示文摘 | C e Nan 2hamag Jtm | 2008 | transctiorns of tianjin university2008，14，1： | 1 |
| 4 | Bioinformatics and structural characterization of a hypothetical protein from streptococcus mutans: implication of antibiotic resistance显示文摘 | Nan J Brostromer E Liu X Y | 2009 | PLoS One2009，4，10： | 1 |
| 5 | Prevalence and impact of mental and physical comorbidity in the adult Singapore population显示文摘 | Chong SA Abdin E Nan L | | 0，，： | 1 |
| 6 | Antifibrotic effect of Stephania tetrandra on experimental liver fibrosis induced by bile duct ligation and scission in rats显示文摘 | Nan J X Park E J Lee S H | 2000 | Arch Pharm Res2000，23，5： | 1 |
| 7 | A simple and sen- sitive assay for the quantitative analysis of paclitaxel in hu- man and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry显示文摘 | Stokvis E Ouwehand M Nan L G etal | 2004 | J Mass Spectrom2004，39，12： | 1 |
| 8 | Protective effect of Rhodiola sachalinensis extract on carbon tetrachloride-induced liver injury in rats显示文摘 | Nan J X Jiang Y Z Park E J | 2003 | J Ethnopharmacol2003，84，： | 1 |
| 9 | Analytical calculation of the collimated detec- tor response for the characterization of nuclear waste drums by segmented gamma scanning显示文摘 | NAN Q THOMAS K MAUERHOFER E | 2012 | Journal of Radioanalytical and Nuclear Chemis- try2012，292，3： | 1 |
| 10 | Assessment of a two-step partial nitritation/ anammox system with implementation of multivariate data analysis 显示文摘 | L Gut E Phza B Hul~nan | 2007 | Chemometrics and/ntelligent Laboratory Systems2007，86，： | 1 |
| 11 | Mapping the relationship between cortical convolution and intelligence: effects of gender显示文摘 | Luders E Nan' KL Bilder RM | 2008 | Cerebral Cortex2008，18，9： | 1 |
| 12 | Water-soluble poiysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D- galactosamine and lipopolysaccharide in mice 显示文摘 | Park E J Nan J X Zhao Y Z | 2004 | Basic Clin Pharmacol Toxicol2004，94，6： | 1 |
| 13 | Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues显示文摘 | Du E He Honghui Nan Zeng | 2014 | Journal of Biomedical Optics2014，19，07： | 1 |
| 14 | Scutellaria baicalensis inhibits liv-er fibrosis induced by bile duct ligation or Carbon tetrachloride inrats显示文摘 | Nan J-x Park E J YC K | 2002 | J Pharm Phamlacol2002，54，4： | 1 |
| 15 | Global elimination of mother-to-child transmission of hepatitis B: revisiting the current strategy显示文摘 | Chloe L Thio Nan Guo Chan Xie Kenrad E Nelson Stephan Ehrhardt | 2015 | The Lancet Infectious Diseases2015，，8： | 1 |
| 16 | Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women显示文摘 | Nan H Giovannucci E L Wu K | 2013 | PLoS One2013，8，59： | 1 |
| 17 | Anti-fibrotic effects of a hotwater extract from Salvia miltiorrhiza roots on liver fibrosis induced by biliary obstruction in rats显示文摘 | Nan X Park E J Kang H C | 2001 | J Pharm Pharmacol2001，53，2： | 1 |
| 18 | Pulmonary nodule volumetric measurement variability as a function of CT slice thickness and nodule morphology显示文摘 | Petrou M Quint L E Nan B | 2007 | AJR2007，188，2： | 1 |
| 19 | Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats显示文摘 | Nan J X Park E J Yang B K | 2001 | Arch Pharm Res2001，24，4： | 1 |
| 20 | Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats显示文摘 | Gao Yang Atanasova E Sui Nan | 2005 | Mol Pharmacol2005，67，1： | 1 |
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