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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | Overview, prevention and management of chemotherapy extravasation显示文摘Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, pre-vention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused. | Firas Y Kreidieh Hiba A Moukadem Nagi S El Saghir | 2016 | World Journal of Clinical Oncology2016，7，1： | 8 |
| 3 | Domiciliary nasal intermittent p ositive pressure ventilation in severe COPD:effects on lung function and qua lity of life显示文摘 | Perrin C El Far Y Vandenbos F | 1997 | Eur Resp J1997，10，： | 2 |
| 4 | High Nitrogen Steel Powder for NearNet Shape Products 显示文摘 | Tao Y Gammal T El | 1999 | Steel Research1999，70，45： | 2 |
| 5 | Molecular and conventional taxonomy of the Microsporum canis complex显示文摘 | Graser Y Kuijpers AF El Fari M | 2000 | Med-Mycol2000，38，2： | 2 |
| 6 | A DNA vector-based RNAi technology to suppress gene expression in mammalian cells显示文摘 | Sui G Soohoo C Affar el B Gay F Shi Y Forrester W C Shi Y | | 0，，： | 2 |
| 7 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 8 | Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells显示文摘 | Damiens E Mazurier J el Y | 1998 | Biochimica et Biophysica Acta1998，1402，3： | 1 |
| 9 | The effects of atorvastatin on coronary endothelial function in patients with recent myocardial infarction 显示文摘 | Hosokawa S Hiasa Y Tomokane T el al | 2006 | Clin Cardiol2006，29，8： | 1 |
| 10 | Micro-computed tomography evaluation of trabeular bone structure on loaded mice tail vertebrae显示文摘 | Walsh A Lu Y el at | 2003 | Spine2003，28，2： | 1 |
| 11 | Significance of angiogenesis and microvascular invasion in renal cell carcinoma显示文摘 | Koren R Kugel V el al | 2002 | Pathology Oncology Research2002，8，2： | 1 |
| 12 | lnterteukin-23 rather than interleukin-12 is the critical eytokine for autoimmune inflammation of the brain显示文摘 | Cua D J Sherlock J Chen Y el al | 2003 | Nature2003，421，6924： | 1 |
| 13 | An irmnunogenicity stud)' of a newl~ fusion protein Can-FnBP vaccinated against Staphylococcus aureus irffeetions in a mice model 显示文摘 | ZHOU H XIONG Z Y ZHENG Y X el al | 2006 | Vaccine2006，24，： | 1 |
| 14 | Clinical and angiographic analysis of congenital coronary artery fistulae in adulthood 显示文摘 | Nawa S Miyaehi Y Shiba T el al | 1996 | Jpn Heart J1996，37，1： | 1 |
| 15 | Chemerin enhances insulin signaling and po|entiates insulin-stimula- ted glucose uptake in 3T3-L1 adipocytes 显示文摘 | Takahashi M Takahashi Y Takahashi K el al | 2008 | FEBS Lett2008，582，5： | 1 |
| 16 | Antioxidant activity of extracts from roasted wheat germ显示文摘 | Krings U El Saharty Y S Berger R G | 2000 | Food Chemistry2000，71，1： | 1 |
| 17 | GABA and its agonists improved visual cortical function in senescent monkeys 显示文摘 | Leventhal AG Wang Y Pu M el al | 2003 | Science2003，300，5620： | 1 |
| 18 | Combination therapy of malignant glioma cells with2-5A-antisense telomerase RNA and recombinant adenovirus p53 显示文摘 | Komata T Kondo Y Koga S at el | 2000 | Gene Ther2000，7，： | 1 |
| 19 | Serum thymidine kinase 1 correlates to clinical stagesand clinical reactions and monitors the outcome of therapy of 1247 can-cer patients in routine clinical settings显示文摘 | Chen Y Ying M’el al | 2010 | Int J Clin Oncol2010，15，4： | 1 |
| 20 | Rolordy-namic fluid force moments on an open-type centrifugalcompressor impeller in precessing motion 显示文摘 | Yoshida Y Tsujimoto Y Yokoyama D el al | 2001 | Interna-tional Journal of Rotating Machinery2001，7，4： | 1 |
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