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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | What do medical students expect in a teacher?显示文摘 | Kiani Q Umar S Iqbal M | 2014 | Clin Teach2014，11，3： | 1 |
| 3 | Percutaneous deviceclosure for secundum-type atrial septal defect: short and intermediate-term results 显示文摘 | Abdi S Kiani R Momtahen M | 2012 | Arch Iran Med2012，15，11： | 1 |
| 4 | Production of single cell protein from rice polishings using Candida utilis显示文摘 | IBRAHIM R M KIANI M A KHAN S | 2004 | World Journal of Microbiology & Biotechnology2004，20，3： | 1 |
| 5 | Adaptation, coordination, and distributed resource allocation in interference-limited wireless networks 显示文摘 | Gesbert D Kiani S G Gjendemsjth A | 2007 | Proceedings of IEEE2007，95，12： | 1 |
| 6 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 7 | Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats显示文摘 | Ebrahimkhani MR kiani S Oakley F | 2006 | Gut2006，55，11： | 1 |
| 8 | Optimal and Distributed Scheduling for Multicell Capacity Maximization显示文摘 | KIANI S G GESBERT D | 2008 | IEEE Trans on Wireless Communications2008，7，1： | 1 |
| 9 | Thermoelectrical Buckling of Piezoelectric Functionally Graded Meterial Timoshenko Beams显示文摘 | Kiani Y Rezaei M Taheri S | 2011 | International Journal of Mechanics and Materials in Design2011，7，18： | 1 |
| 10 | High-performance liq- uid chromatographic determination of lamivudine in human serm using liquid-liquid extraction; application to pharmacokinetic studies显示文摘 | Bahrami G Mirzaeei S Kiani A | 2005 | J Chromatography B2005，823，： | 1 |
| 11 | Association of Gprotein beta-3 subunit gene ( GNB3 ) T825 allele with Type Ⅱ diabetes显示文摘 | KIANI J G SAEED M PARVEZ S H | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 12 | Survey of context provisioning middleware显示文摘 | Knappmeyer M Kiani S L Reetz E S | 2013 | Communications Surveys & Tutorials IEEE2013，15，3： | 1 |
| 13 | High Performance Supercapacitors Based on the Electrodeposited Co3 04 Nanoflakes on Electroetched Carbon Fibers显示文摘 | Kazemi S H Asghari A kiani M A | 2014 | Electrochimica Acta2014，138，： | 1 |
| 14 | Finding common weights based on the D M~ preference information显示文摘 | Jahaushahloo G R Zohrehbandian M Aliuezhad A Abbasian Naghneh S Abbasian H Kiani Mavi R | 2011 | Journal of the Operational Research Society2011，62，10： | 1 |
| 15 | Synthesis of nano-and micro-particles of LiMn204: Electrochemical investigation and as- sessment as a cathode in Li battery 显示文摘 | Kiani M A Mousavi M F Rahmanifar M S | 2011 | Int J Electrochem Sci2011，6，： | 1 |
| 16 | Synthesis and in vitro antibacterial evaluation of N- piperazinyl quinolones 显示文摘 | FOROUMADI A MANSOURI S KIANI Z | 2003 | Eur J Med Chem2003，38，9： | 1 |
| 17 | Optimal and distributed schedu- ling for multicell capacity maximization显示文摘 | KIANI S G GESBERT D | 2008 | IEEE Transac- tions on Wireless Communications2008，7，1： | 1 |
| 18 | Adaptation,Coordination,and Distributed Resource Allocation in Interference-Limited Wireless Networks显示文摘 | GESBERT D KIANI S G GJENDEMSJ(O) A | 2007 | Proceedings of the IEEE2007，95，12： | 1 |
| 19 | Genetic engineering of human pluripotent cells using TALE nu- cleases显示文摘 | Hoekemeyer D Wang H Kiani S Lai CS | 2011 | Nat Biotechnol2011，29，8： | 1 |
| 20 | Optimal and distributed scheduling for multicell capacity maximization 显示文摘 | Kiani S G Gesbert D | 2008 | IEEE Transactions on Wireless Communications2008，7，1： | 1 |
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