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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Cytoreduction and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from pseudomixoma peritonei显示文摘AIM:To investigate the most important aspects of hyperthermic intraperitoneal chemotherapy (HIPEC) that has been accepted as the standard treatment for pseudomyxoma peritonei (PMP),with special regard to morbidity,overall survival (OS) and disease free survival (DFS) over 10 years. METHODS:Fifty-three patients affected by PMP underwent cytoreduction (CCR) and HIPEC with a 'semi-closed' abdomen technique in our institution. The peritonectomy procedure and completeness of CCR were classifi ed according to Sugarbaker criteria. Preoperative evaluation always included thoracic and abdominal CT scan to stage peritoneal disease and exclude distant metastases. Fifty-one patients in our series were treated with a protocol based on administration of cisplatinum 100 mg/m2 plus mitomycin C 16 mg/m2,at a temperature of 41.5℃ for 60 min. Anastomoses were always performed at the end of HIPEC. The mean duration of surgery was 12 h including HIPEC. Continuous monitoring of hepatic and renal functions and hydroelectrolytic balance was performed in the postoperative period. RESULTS:Twenty-four patients presented with postoperative complications:surgical morbidity was observed in 16 patients and 6 patients were re-operated. All complications were successfully treated and no postoperative deaths were observed. Risk factors for postoperative morbidity were considered to be gender,age,body surface,duration of surgery,Peritoneal Cancer Index (PCI) and tumor residual value (CC score). No statistically signifi cant correlation was found during the multivariate analysis:only the CC score was statistically significant. The OS in our experience was 81.8%,with a DFS of 80% at 5 years and of 70% at 10 years. CONCLUSION:In our experience,even if HIPEC combined with cytoreductive surgery involves a high risk of morbidity,postoperative complications can be resolved favorably in most cases with correct patient selection and adequate postoperative care,thus minimizing mortality. The association of CCR and HIPEC can be considered as the standard treatment for PMP. The OS and DFS results confi rm the validity of this combined approach for the treatment of this rare neoplasm. The impact of preoperative chemotherapy on OS,in our opinion,is due to a major aggressiveness of tumors in treated patients. | Tommaso Cioppa Marco Vaira Camilla Bing Silvia D'Amico Alessandro Bruscino Michele De Simone | 2008 | World Journal of Gastroenterology2008，14，44： | 13 |
| 3 | Numerical simulations of water flow and contaminants transport near mining wastes disposed in a fractured rock mass显示文摘A numerical tool, called Hydro-Geosphere, was used to simulate unsaturated water flow and contaminants migration around an open pit filled with mining wastes. Numerical simulations had been carried out to assess the influence of various factors on water flow and solute transport in and around the surface openings including recharge, properties of the waste material and presence of fractures in the surrounding rock mass. The effect of the regional hydraulic gradient was also investigated. The analyses were conducted by simulating various 2D cases using experimentally obtained material properties and controlled boundary conditions. The effects of the hydrogeological properties of the filling material(i.e., water retention curve and hydraulic conductivity function), fracture network characteristics and conductivity of the joints were assessed. The results illustrate that fractures control water flow and contaminants transport around the waste disposal area. A fracture network can desaturate the system and improve the regional gradient effect. | Ben Abdelghani Farouk Aubertin Michel Simon Richard Therrien René | 2015 | International Journal of Mining Science and Technology2015，25，1： | 9 |
| 4 | Starring role of toll-like receptor-4 activation in the gutliver axis显示文摘Since the introduction of the term 'gut-liver axis', many studies have focused on the functional links of intestinal microbiota, barrier function and immune responses to liver physiology. Intestinal and extra-intestinal diseases alter microbiota composition and lead to dysbiosis, which aggravates impaired intestinal barrier function via increased lipopolysaccharide translocation. The subsequent increased passage of gut-derived product from the intestinal lumen to the organ wall and bloodstream affects gut motility and liver biology. The activation of the toll-like receptor 4(TLR-4) likely plays a key role in both cases. This review analyzed the most recent literature on the gut-liver axis, with a particular focus on the role of TLR-4 activation. Findings that linked liver disease with dysbiosis are evaluated, and links between dysbiosis and alterations of intestinal permeability and motility are discussed. We also examine the mechanisms of translocated gut bacteria and/or the bacterial product activation of liver inflammation and fibrogenesis via activity on different hepatic cell types. | Simone Carotti Michele Pier Luca Guarino Umberto Vespasiani-Gentilucci Sergio Morini | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 5 | Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art显示文摘Indocyanine green(ICG)fluorescence imaging is widely used in abdominal surgery.The implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical systems.In that setting,ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic flow.The purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer surgery.Each type of use has been separately addressed and the evidence was investigated.During rectal resection,ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic leaks.In addition,ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from injury.This intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is performed.This is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the literature.Although further studies are need to investigate the real clinical benefits,these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications. | Roberto Peltrini Mauro Podda Simone Castiglioni Maria Michela Di Nuzzo Michele D'Ambra Ruggero Lionetti Maurizio Sodo Gaetano Luglio Felice Mucilli Salomone Di Saverio Umberto Bracale Francesco Corcione | 2021 | World Journal of Gastroenterology2021，27，38： | 3 |
| 6 | 聚氨酯粘结剂的透水路面砖研究显示文摘上世纪九十年代中期以来,经济发展所伴随人类居住面积和交通基础设施面积的扩张,对环境造成了重大影响,并导致发生洪水的风险增加、气候条件改变和自然水循环的巨大扭曲。现代市政污水管理系统的主要目标是促进密封区域的雨水重新回到自然水循环系统。一种可能的解决方法是采用透水性路面替代不透水路面。在城镇区域,路面砖路面常常用于将地表积存雨水渗入地下,以适应建筑占地面积比例提高的规划要求。在大多数情况下,路面地路面的透水性能归功于砖接缝处填充的透水材料;然而,这种路面的透水性能通常有限度的,因为大多数混凝土路面砖本身并不透水。由于细颗粒和杂质可能堵塞粒状填缝材料,所以无法完全保持这种透水路面在使用期限内的渗透性。本研究项目旨在开发一种以聚氨酯为胶结材料的自透水性路面砖。通过对材料强度、渗透率和表面性能的综合评价,提出方法和材料。 | lukas renken michel simon markus oeser 崔玉忠(译) 杜建东(校) | 2016 | 建筑砌块与砌块建筑2016，，4： | 2 |
| 7 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 8 | Bimanual microincision cataract surgery with implantation of the new Incise~? MJ14 intraocular lens through a 1.4 mm incision显示文摘AIM: To analyze the visual outcomes and the posterior capsule opacification(PCO) with the new Incise? MJ14 intraocular lens(IOL) implanted through a 1.4 mm clear corneal incision(CCI) in patients who underwent bimanual microincision cataract surgery(B-MICS). METHODS: Eighty eyes which underwent cataract surgery using B-MICS technique performed by the same experienced surgeon were included in the study: 40 eyes were implanted with an Incise? MJ14 IOL through a 1.4 mm CCI(group A)without enlargement of the main CCI, while 40 eyes were implanted with an Akreos? MI60 IOL with enlargement of the main CCI to 1.8 mm(group B). Best corrected visual acuity(BCVA), astigmatism and endothelial cell loss were evaluated before and after surgery at 7, 30 d and 6 mo.Anterior segment-optical coherence tomography(AS-OCT) of CCI was performed at 1, 3, 7, 30 d, 6 and 18 mo. PCO incidence was evaluated at 18 mo using EPCO 2000 Software. RESULTS: Mean BCVA improvement and endothelial cell loss were statistically significant at 18 mo in both groups with no difference between the two groups; no statistically significant difference in surgically induced astigmatism(SIA) was noticed in the two groups. At AS-OCT the only significant alterations in the CCI were endothelial gaping and local detachment of Descemet's membrane at 1 and 7 d after surgery; no statistically significant alterations were found at 1, 6 and 18 mo. PCO score at 18 mo was 0.03±0.07 for group A and 0.08±0.18 for group B(P=0.11) with no sign of central optic plate invasion in both groups.CONCLUSION: The implant of the new Incise? MJ14 IOL through a 1.4 mm CCI and B-MICS technique appeared to be a safe and effective procedure with rapid visual recovery. PCO rate resulted very low and the CCI presented few morphological alterations which were only detectable in the first days postoperatively and achieved fast corneal healing during the long-term follow-up. | Gian Maria Cavallini Tommaso Verdina Michele De Maria Elisa Fornasari Giulio Torlai Veronica Volante Simone Donati Carlo Cagini | 2017 | International Journal of Ophthalmology(English edition)2017，10，11： | 2 |
| 9 | Transcontinental Robot-Assisted Remote Telesurgery: Feasibility and Potential Applications显示文摘 | Jacques Marescaux Joel Leroy Francesco Rubino Michelle Smith Michel Vix Michele Simone Didier Mutter | 2002 | Annals of Surgery2002，，4： | 2 |
| 10 | Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin–Proteasome Activity显示文摘 | Raffaele Marfella Mario Siniscalchi Michele Portoghese Clara Di Filippo Franca Ferraraccio Concetta Schiattarella Basilio Crescenzi Paolo Sangiuolo Giuseppe Ferraro Silvio Siciliano Francesca Cinone Gennaro Mazzarella Simone Martis Mario Verza Ludovico Co | 2007 | Hypertension2007，，4： | 2 |
| 11 | Male-sterility induction in transgenic tobacco plants with an unedited atp9 mitochondrial gene from wheat显示文摘 | MICHEL HERNOULD SONY SUHARSONO SIMON LITVAK | 1993 | Plant Biology1993，90，： | 1 |
| 12 | Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases显示文摘 | Edward G. McIver Justin Bryans Kristian Birchall Jasveen Chugh Thomas Drake Stephen J. Lewis Joanne Osborne Ela Smiljanic-Hurley William Tsang Ahmad Kamal Alison Levy Michelle Newman Debra Taylor J. Simon C. Arthur Kristopher Clark Philip Cohen | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，23： | 1 |
| 13 | Formamide hydrolysis investigated by multiple-steering ab Initio molecular dynamics显示文摘 | Simone R Paolo C | 2004 | J Phys Chem B2004，108，1： | 1 |
| 14 | Retrospective Comparison of External Beam Radiotherapy and Radical Prostatectomy in High-Risk, Clinically Localized Prostate Cancer显示文摘 | Giorgio Arcangeli Lidia Strigari Stefano Arcangeli Maria Grazia Petrongari Biancamaria Saracino Sara Gomellini Rocco Papalia Giuseppe Simone Piero De Carli Michele Gallucci | 2009 | International Journal of Radiation Oncology Biology Physics2009，，4： | 1 |
| 15 | FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis显示文摘 | Pauline Andreu Magnus Johansson Nesrine I. Affara Ferdinando Pucci Tingting Tan Simon Junankar Lidiya Korets Julia Lam David Tawfik David G. DeNardo Luigi Naldini Karin E. de Visser Michele De Palma Lisa M. Coussens | 2010 | Cancer Cell2010，，2： | 1 |
| 16 | Rapid Exclusion of Acute Myocardial Infarction in Patients With Undetectable Troponin Using a High-Sensitivity Assay显示文摘 | Richard Body Simon Carley Garry McDowell Allan S. Jaffe Michael France Kennedy Cruickshank Christopher Wibberley Michelle Nuttall Kevin Mackway-Jones | 2011 | Journal of the American College of Cardiology2011，，13： | 1 |
| 17 | Grazing Management Plans improve pasture selection by cattle and forage quality in sub-alpine and alpine grasslands显示文摘Over the last decades, the reduction of manpower for herd management has led to an increase of continuous grazing systems(CGS) in the Italian Alps, which allow cattle to roam freely. Under CGS, due to high selectivity, livestock exploit grasslands unevenly, over-and under-using specific areas at the same time with negative effects on their conservation. To counteract these effects, a specific policy and management tool(i.e. Grazing Management Plan) has been implemented by Piedmont Region since 2010. The Grazing Management Plans are based on the implementation of rotational grazing systems(RGS), with animal stocking rate adjusted to balance it with grassland carrying capacity. A case study was conducted on alpine summer pastures to test the 5-year effects produced by the implementation of a Grazing Management Plan in grasslands formerly managed under several years of CGS on 1) the selection for different vegetation communities by cattle, 2) the abundance of oligo-, meso-, and eutrophic plant species(defined according to Landolt N indicator value), and 3) forage yield, quality, and palatability. A total of 193 vegetation surveys were carried out in 2011 and repeated in 2016. Cows were tracked yearly with Global Positioning System collars to assess their grazing selectivity, and forage Pastoral Value(PV) was computed to evaluate forage yield, quality, and palatability. Five years after RGS implementation, cow selectivity significantly decreased and the preference for the different vegetation communities was more balanced than under CGS. The abundance of meso-and eutrophic species increased, whereas oligotrophic ones decreased. Moreover, the abundance of moderately to highly palatable plant species increased, whereas non-palatable plant species decreased, with a consequent significant enhancement of the PV. Our findings indicate that the implementation of Grazing Management Plans can be considered a sustainable and effective management tool for improving pasture selection by cattle and forage quality in mountain pastures. | Marco PITTARELLO Massimiliano PROBO Elisa PEROTTI Michele LONATI Giampiero LOMBARDI Simone RAVETTO ENRI | 2019 | Journal of Mountain Science2019，16，9： | 1 |
| 18 | Inhibitory Action of Aqueous Garlic Peel Extract on the Corrosion of Carbon Steel in HCl Solution显示文摘 | SIMONE S de A A P MICHELLE M P TATIANA L F | | 0，，： | 1 |
| 19 | Impairment of tapetum and mitochondria in engineered male-sterile tobacco plants显示文摘 | Michel Hernould S. Suharsono Eduardo Zabaleta Jean Pierre Carde Simon Litvak Alejandro Araya Armand Mouras | 1998 | Plant Molecular Biology1998，，4： | 1 |
| 20 | Human colonic myogenic dysfunction induced by mucosal lipopolysaccharide translocation and oxidative stress显示文摘 | Michele Pier Luca Guarino Rosa Sessa Annamaria Altomare Silvia Cocca Marisa Di Pietro Simone Carotti Giovanni Schiavoni Rossana Alloni Sara Emerenzian Sergio Morini Carola Severi Michele Cicala | 2013 | Digestive and Liver Disease2013，，： | 1 |
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