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| 1 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 2 | Clinical trial:a nutritional supplement Viusid,in combination with diet and exercise,in patients with nonalcoholic fatty liver disease显示文摘 | Vilar gomez E Rodriguez de miranda A Gra oramas B | | 0，，10： | 1 |
| 3 | A note on the chemical composition of faeces and urine of grazing cows显示文摘 | Gutierrez O Oramas A Cairo J | 1998 | Cuba Journal of Agricultural Science1998，32，1： | 1 |
| 4 | Complexation of and mixed stereoisomers of N, N '-ethylenediaminedisuccinic acid (EDDS) with Fe(Ⅲ), Cu(Ⅱ), Zn(Ⅱ) and Mn(Ⅱ) ions in aqueous solution 显示文摘 | Orama M Hyvonen H Saarinen H | 2002 | J Chemical Society-Dalton Transactions2002，24，： | 1 |
| 5 | Complexation of and mixed atereoisomers of N,N-ethylenediarninedisuceinie acid (EBBS) with Fe(Ⅲ),Cu(Ⅱ),Zn(Ⅱ) and Mn(Ⅱ) ions in aqueous solution显示文摘 | Orama M Hyvonen H Saarinen H | 2002 | J Chem Soc Dalton Trans2002，，： | 1 |
| 6 | Polyethylenimine-based transfection method as a simple and effective way to producerecombinant lentiviral vectors 显示文摘 | Toledo J R Prieto Y Oramas N | 2009 | Appl Biochem Biotechnol2009，157，3： | 1 |
| 7 | Polyethylenimine-based transfection method as a simple and effective way to produce recombinant lentiviral vectors显示文摘 | Toledo JR Prieto Y Oramas N | 2009 | Appl Biochem2009，157，3： | 1 |
| 8 | TeachingDiagnosis, School Curriculum and the Quality of Education 显示文摘 | Margarita Silvestre Oramas | 2003 | Prospects2003，33，1： | 1 |
| 9 | Clinic- al trial:a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease显示文摘 | Vilar gomez E Rodriguez de miranda A Gra oramas B et aI | 2009 | Aliment Pharmacol Ther2009，30，10： | 1 |
| 10 | Studies on biodegradable chelating ligands: complexation of iminodisuecinic acid (ISA)with Cu(Ⅱ), Zn(Ⅱ), Mn(Ⅱ) and Fe(Ⅲ) ions in aqueous solution显示文摘 | Hyvonen H Orama M Saarinen H | 2003 | Green Chemistry2003，5，4： | 1 |
| 11 | Polyethylenimine-based trans- feetian method as a simple and effective way to produce recombinant lentiviral vectors显示文摘 | Toledo JR Prieto Y Oramas N | 2009 | Appl Biochem Biotechnol2009，157，3： | 1 |
| 12 | Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors显示文摘 | Santos J L Oramas E Pêgo A P | 2009 | J Control Release2009，1，134： | 1 |
| 13 | Os teogenic differentiation of mesenchymal stem cells using PAM AM dendrimers as gene delivery vectors显示文摘 | Jose Luis Santos Elena Oramas Ana Paula Pego | 2009 | Journal of Con trolled Release2009，134，： | 1 |
| 14 | An efficient protocol for sugarcane (Saccharum spp. L.) transformation mediated by Agrobacterium tumefaciens显示文摘 | Ariel D. Arencibia Elva R. Carmona Pilar Tellez Ming-Tsair Chan Su-May Yu Luis E. Trujillo Pedro Oramas | 1998 | Transgenic Research1998，，3： | 1 |
| 15 | Studies on biodegradable chelating ligands:complexation of iminodisuccinic acid(ISA) with Cu(II), Zn(II),Mn(II) and Fe(III) ions in aqueous solution显示文摘 | Hyvonen H Orama M Saarinen H | 2003 | Green Chemistry2003，5，4： | 1 |
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