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| 1 | Clindamycin-induced acute cholestatic hepatitis显示文摘我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 | Cem Aygün Orhan Kocaman Yesim Gürbüz mer Sentürk Sadettin Hülagü | 2007 | World Journal of Gastroenterology2007，13，40： | 6 |
| 2 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 3 | Derivatization of (±) dihydrotetrabenazine for copper-64 labeling towards long-lived radiotracers for PET imaging of the vesicular monoamine transporter 2显示文摘 | Amit Kumar Su-Tang Lo Orhan K. ?z Xiankai Sun | 2014 | Bioorganic & Medicinal Chemistry Letters2014，，： | 1 |
| 4 | The role of paraoxonase (PON)enzyme in the extent and severity of the coronary artery disease in type-2 diabetic patients显示文摘 | Tartan Z Orhan G Kasikcioglu H Uyarel H Unal S Ozer N | 2007 | Heart Vessels2007，22，3： | 1 |
| 5 | Comparison ofsevoflurane and ketamine for anesthetic induction in children withcongenital heart disease显示文摘 | Sungur Ulke Z Kartal U Orhan Sungur M | 2008 | Paediatr Anaesth2008，18，8： | 1 |
| 6 | Curcumin ameloriates heat stress via inhibition of oxidative stress and modula- tion of Nrf2/HO-1 pathway in quail 显示文摘 | Sahin K Orhan C Tuzeu Z | 2012 | Food Chem Toxieo12012，50，11： | 1 |
| 7 | Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum显示文摘 | Oktas B Orhan Z Erbil B | 2014 | Joint Diseases&Related Surgery2014，25，3： | 1 |
| 8 | Pseudoaneurysm and renal ar- teriovenous fistula after nephrectomy: two cases treated by transcath- eter coil embolization显示文摘 | Bozgeyik Z Ozdemir H Orhan I | 2008 | Emerg Radiol2008，15，： | 1 |
| 9 | Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres 显示文摘 | Cevher E Orhan Z Mulazimoolu L | 2006 | Int JPharm2006，317，2： | 1 |
| 10 | Comparison of sevoflu- rane and ketamine for anesthetic induction in children with congenital heart disease显示文摘 | Sungur Ulke Z Kartal U Orhan Sungur M | 2008 | Paediatr Anaesth2008，18，8： | 1 |
| 11 | The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres:their evaluation in an animal osteomyelitis mode1显示文摘 | Orhan Z Cevher E Mulazimoglu L | 2006 | Bone Joint Surg Br2006，，： | 1 |
| 12 | Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids显示文摘 | Berrin ? z? elik Murat Kartal Ilkay Orhan | 2011 | Pharmaceutical Biology2011，，4： | 1 |
| 13 | Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis 显示文摘 | ORHAN Z CEVHER E YILDIZ A | 2010 | Arch Orthop Trauma Surg2010，130，1： | 1 |
| 14 | Curcumin ameloriates heat stress via inhibition of oxidative stress and modula- tion of Nrf2/HO-1 pathway in quai显示文摘 | Sahin K Orhan C Tuzcu Z | 2012 | Food Chem Toxi- eol2012，50，11： | 1 |
| 15 | An unusual cause of gastric perforation in childhood: trichobezoar (Rapunzel syndrome). A case report显示文摘 | Orhan Ko? Fesih Do?an Y?ld?z Adnan Narc? Tolga Altu? ?en | 2009 | European Journal of Pediatrics2009，，4： | 1 |
| 16 | Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres显示文摘 | Cevher E orhan Z Mulazimoglu L | 2006 | International Journal of Pharmaceutics2006，317，2： | 1 |
| 17 | Pseudoaneurysm and renal arteriovenous fistula after nephrectomy: two cases treated by transeatheter coil embolization 显示文摘 | Bozgeyik Z Ozdemir H Orhan I | 2008 | Emerg Radiol2008，15，： | 1 |
| 18 | Mean platelet volume in patients with slow coronary flow and its relationship with clinical presentation显示文摘 | Nurkalem Z Alper AT Orhan AL | 2008 | Turk Kardiyol Dern Ars2008，36，6： | 1 |
| 19 | An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: a case report 显示文摘 | Orhan Z Oktas B Umran Y | 2009 | Knee Surg Sports Traumatol Arthrosc2009，17，5： | 1 |
| 20 | One-dimen- sional heteropolynuclear tetracyanopalladate (11) com- plexes : Syntheses, crystal structures, thermal analyses and spectroscopic investigations 显示文摘 | Mehran A Okan Z Y Orhan B | 2014 | Journal of Molec- ular Structure2014，1059，： | 1 |
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