|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 2 | Incidence and mortality of primary bone cancers in China, 2014显示文摘Objective: In this study, we aimed to estimate the updated incidence and mortality of primary bone cancers based on population-based cancer registration data in 2014, collected by the National Central Cancer Registry of China(NCCRC).Methods: In 2017, 339 registries' data were qualified based on data quality criteria set down by the NCCRC.Cases of primary bone cancers were retrieved from the national database. We estimated numbers of primary bone cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex, age-group(0, 1-4, 5-9, 10-14, …, 85+). Chinese standard population in 2000 and Segi's World population were applied for the calculation of age-standardized incidence and mortality rates.Results: In 2014, 24,000 primary bone cancer cases and 17,200 deaths attributable to primary bone cancers were estimated to have occurred in China. The crude incidence rate of primary bone cancers was 1.76/100,000, with agestandardized incidence rate by Chinese standard population(ASIRC) and by World standard population(ASIRW)being 1.35/100,000 and 1.32/100,000, respectively. The crude mortality rate of primary bone cancers was1.26/100,000, with age-standardized mortality rate by Chinese standard population(ASMRC) and by World standard population(ASMRW) being 0.88/100,000 and 0.86/100,000, respectively. Age-specific incidence curve was bimodally distributed with age, with the first peak occurring in the second decade of the life and the second peak in the elderly. Males had higher crude and age-standardized rates for both incidence and mortality compared with females. Both crude and age-standardized incidence rates were higher in rural areas than in urban areas, so were the crude and age-standardized mortality rates.Conclusions: This population-based study presents the most recently available estimates on primary bone cancers in China, revealing that the males are 1.34 times as much as females suffering from primary bone cancers and the adolescents in puberty and the elderly are predominantly affected groups by these cancers. High-quality cancer registration data are a prerequisite for undertaking further study for gaining insight into the causes and risk factors for primary bone cancers in China. | Liang Xia Rongshou Zheng Yanjun Xu Xiaojun Xu Siwei Zhang Hongmei Zeng Lifeng Lin Wanqing Chen | 2019 | Chinese Journal of Cancer Research2019，31，1： | 13 |
| 3 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 4 | Cancer incidence and mortality in Gansu province,2012显示文摘Objective: Population-based cancer registration data in 2012 from all available cancer registries in Gansu province were collected by the Central Cancer Registry of Gansu. The numbers of new cancer cases and cancer deaths in Gansu province with compiled cancer incidence and mortality rates were estimated.Methods: In 2015, data from 7 registries in Gansu province were qualified. The pooled data were stratified by area(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding population of Gansu province in 2012. The Chinese census data in 2000 and Segi's population were applied for age-standardized rates. All the rates were expressed per 100,000 person-years.Results: Qualified 7 cancer registries(3 urban and 4 rural registries) covered 2,956,560 populations of Gansu province in 2012. The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 72.41% and 1.65%, respectively, and the mortality to incidence rate ratio(M/I) was 0.63. It was estimated that there were 575,600 new cancer cases and 331,300 cancer deaths in Gansu province in 2012. The incidence rate was 223.29/100,000(244.14/100,000 in males and 201.50/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 208.95/100,000 and 206.41/100,000 with the cumulative incidence rate(0-74 years old) of 22.49%. The crude incidence rate in urban areas was equal to that in rural areas. However, after adjusted by age, the cancer incidence rate in urban was the same as that of rural areas. The crude mortality in Gansu province was 128.54/100,000(135.04/100,000 in males and 124.43/100,000 in females), the age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 109.54/100,000 and 108.44/100,000, respectively, and the cumulative mortality rate(0-74 years old) was 12.91%. The crude cancer mortality rate in urban areas was higher than that of rural areas. However, the agestandardized rate in urban areas was the same as that of rural areas. Cancers of stomach, liver, lung, esophagus, female breast, colorectum, cervix, brain, pancreas and ovary were the most common cancers, accounting for about 83.56% of all cancer new cases. Stomach cancer, liver cancer, lung cancer, esophageal cancer, female breast cancer, colorectal cancer, brain cancer, lymphoma, pancreatic cancer and cervix cancer were the leading causes of cancer death, accounting for about 85.58% of all cancer deaths. The burden between urban and rural, males and females was different.Conclusions: Registration data of Gansu province were qualified to provide basic information on population-based cancer incidence, mortality for cancer prevention and control. The digestive tract cancer burden in Gansu province, especially for males in rural areas, was higher. The incidence rate of female breast cancer was higher in urban areas. Targeted prevention, early detection and treatment programs should be carried out by health department to control the cancer burden. | yuqin liu xiaodong zhang lili chen qin zhao xiaojun xia | 2016 | Chinese Journal of Cancer Research2016，28，3： | 5 |
| 5 | Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen显示文摘Dear Editor,Haploidentical allogeneic hematopoietic stem cell transplantation(haplo-HSCT),a curative therapy for severe aplastic anemia(SAA)patients,has been used clinically for decades.Two models,not involving ex vitro T-cell depletion,have been adopted for haplo-HSCT in patients with SAA.The first is referred to as the'Beijing protocol'(Xu et al.,2017),and comprises a conditioning regimen using busulfex(BU),cyclophosphamide(CY). | Lanping Xu Bin Fu Wenjing Wang Yajing Xu Depei Wu Shunqing Wang Qifa Liu Linghui Xia Sujun Gao Ming Jiang Jianmin Wang Xi Zhang Hai Bai Huiren Chen Chunfu Li Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 6 | Spectral Petrov-Galerkin Methods for the Second Kind Volterra Type Integro-Differential Equations显示文摘This work is to provide general spectral and pseudo-spectral Jacobi-Petrov-Galerkin approaches for the second kind Volterra integro-differential equations.The Gauss-Legendre quadrature formula is used to approximate the integral operator and the inner product based on the Jacobi weight is implemented in the weak formulation in the numerical implementation.For some spectral and pseudo-spectral Jacobi-Petrov-Galerkin methods,a rigorous error analysis in both L2_(ω^(α,β))^(2),and L^(∞)norms is given provided that both the kernel function and the source function are sufficiently smooth.Numerical experiments validate the theoretical prediction. | Xia Tao Ziqing Xie Xiaojun Zhou | 2011 | Numerical Mathematics(Theory,Methods and Applications)2011，4，2： | 2 |
| 7 | A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy显示文摘During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug resistance.Therefore,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing an activable platform is promising for precise and efficient anticancer treatment.Herein,we report a“pro-drug-photosensitizer”agent,LMB-S-CPT,bearing a disulfide bond as the glutathione(GSH)-activatable linker.LMB-S-CPT can be selectively activated by GSH to release activated drug,camptothecin(CPT),for chemotherapy and activated photosensitizer,methylene blue(MB),for PDT.LMB-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice,as well as specific cancer therapy with negligible toxic side effects.The activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise,selective and excellent antitumor effect. | Yanjun Yang Yifeng Zhang Ran Wang Xiang Rong Ting Liu Xiang Xia Jiangli Fan Wen Sun Xiaojun Peng | 2022 | Chinese Chemical Letters2022，33，10： | 2 |
| 8 | Analysis of common canopy vegetation indices for indicating leaf nitrogen accumulations in wheat and rice显示文摘 | Yan Zhu Xia Yao YongChao Tian XiaoJun Liu WeiXing Cao | 2007 | International Journal of Applied Earth Observations and Geoinformation2007，，1： | 2 |
| 9 | Surface characterization of ICF capsule by AFM-based profilometer显示文摘Outside surface fluctuations of inertial confinement fusion(ICF) capsule greatly affect the implosion performance. An atomic force microscope(AFM)-based profilometer is developed to precisely characterize the capsule surface with nanometer resolution. With the standard nine surface profiles and the complete coverage data, 1D and 2D power spectra are obtained to quantitatively qualify the capsule. Capsule center fast aligning, orbit traces automatic recording, 3D capsule orientation have been studied to improve the accuracy and efficiency of the profilometer. | Jie Meng Xuesen Zhao Xing Tang Yihao Xia Xiaojun Ma Dangzhong Gao | 2017 | High Power Laser Science and Engineering2017，5，3： | 2 |
| 10 | Ca 3 Al 2 (SiO 4 ) 3? δ Cl 4 δ :Eu 2+ , Mn 2+ : A potential phosphor with energy transfer for near-UV pumped white-LEDs显示文摘 | Wei Lü Zhendong Hao Xia Zhang Xingyuan Liu Xiaojun Wang Jiahua Zhang | 2011 | Optical Materials2011，，8： | 2 |
| 11 | Simple hybrid dithiafulvenes-triphenylamine systems as dopant-free hole-transporting materials for efficient perovskite solar cells显示文摘Two extended hybrid conjugated systems based on a triphenylamine(TPA) core with two and three peripheral 1,4-dithiafulvenes(DTF) units coded WH-2 and WH-3 as hole-transporting materials(HTMs) applied in perovskite solar cells(PSCs) are synthesized by facile one-step reaction in good yield over 75%. DTF unit as electron donor can enhance the electron donating ability and the fusion of benzenic ring of TPA with DTF unit may lead to reinforced intermolecular interactions in the solid state. In addition,WH-2 and WH-3 exhibit a pyramid shape containing partial planarity and quasi three-dimensionality features, which is also conducive to enhancing the π-π stacking of molecules in the solid state. The above-mentioned structural characteristics make the two HTMs have good hole mobilities. As a result,WH-2 and WH-3 obtained the high intrinsic hole mobilities of 4.69 × 10^(-4)and 2.18 × 10^(-3)cm^(2)V^(-1)s^(-1)respectively. Finally, the power conversion efficiencies(PCEs) of PSCs with WH-2 and WH-3 as cost-effective dopant-free HTMs are 15.39% and 19.22% respectively and the PCE of PSC with WH-3 is on a par with that of PSC with Li-TFSI/t-BP doped Spiro-OMe TAD(19.67%). | Zhongquan Wan Yunpeng Zhang Jinyu Yang Jianxing Xia Fangyan Lin Xiaojun Yao Junsheng Luo Chunyang Jia | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 12 | The clinical application of the fiberoptic ductoscopy in the diagnosis and treatment of the nipple discharge显示文摘 | ZHANG Xia WEI Jian GUO Xiaojun | 2012 | Chinese Journal of Aesthetic Medicine2012，21，11： | 1 |
| 13 | Modeling and optimizing maintenance schedule for energy systems subject to degradation显示文摘 | XIA Tangbin XI Lifeng ZHOU Xiaojun | 2012 | Computers - Industrial Engineering2012，63，3： | 1 |
| 14 | Motivating Ru-bri site of RuO_(2)by boron doping toward high performance acidic and neutral oxygen evolution显示文摘The electrocatalysis of oxygen evolution reaction(OER)plays a key role in clean energy storage and transfer.Nonetheless,the sluggish kinetics and poor durability under acidic and neutral conditions severely hinder practical applications such as electrolyzer compatible with the powerful proton exchange membrane and biohybrid fuel production.Here,we report a borondoped ruthenium dioxide electrocatalyst(B-RuO_(2))fabricated by a facile boric acid assisted strategy which demonstrates excellent acidic and neutral OER performances.Density functional theory calculations and advanced characterizations reveal that the boron species form an anomalous B–O covalent bonding with the oxygen atoms of RuO_(2)and expose the fully coordinately bridge ruthenium site(Ru-bri site),which seems like a switch that turns on the inactive Ru-bri site into OER-active,resulting in more exposed active sites,modified electronic structure,and optimized binding energy of intermediates.Thus,the B-RuO_(2)exhibits an ultralow overpotential of 200 mV at 10 mA/cm^(2)and maintains excellent stability compared to commercial RuO_(2)in 0.5 M sulfuric acid.Moreover,the superior performance is as well displayed in neutral electrolyte,surpassing most previously reported catalysts. | Chongjing Liu Beibei Sheng Quan Zhou Dengfeng Cao Honghe Ding Shuangming Chen Pengjun Zhang Yujian Xia Xiaojun Wu Li Song | 2022 | Nano Research2022，15，8： | 1 |
| 15 | Identificationand characterization of a pan-allergen profilin, a major al-lergen from Caryota mitis pollen 显示文摘 | Liu Xiaoyu Xiao Xiaojun f Xia Lixin | 2014 | Asian Pacific Jour-nal of Allergy and Immunology2014，32，1： | 1 |
| 16 | NLRX1 negatively reg- ulates TLR-induced NFkappaB signaling by targeting TRAF6 and IKK显示文摘 | Xia Xiaojun Cui Jun Helen Y | 2011 | Immunity2011，34，6： | 1 |
| 17 | In-service light path PMD (polarization mode dispersion) monitoring by PMD compensation 显示文摘 | YAO X Steve CHEN Xiaojun XIA T J | 2010 | Optics Express2010，18，27： | 1 |
| 18 | Dynam- ic maintenance decision-making for series-parallel man- ufacturing system based on MAM-MTW methodology 显示文摘 | Xia Tangbin Xi Lifeng Zhou Xiaojun etal | 2012 | European Journal of Operational Research2012，221，1： | 1 |
| 19 | NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways显示文摘 | Jun Cui Liang Zhu Xiaojun Xia Helen Y. Wang Xavier Legras Jun Hong Jiabing Ji Pingping Shen Shu Zheng Zhijian J. Chen Rong-Fu Wang | 2010 | Cell2010，，3： | 1 |
| 20 | NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK显示文摘 | Xiaojun Xia Jun Cui Helen Y. Wang Liang Zhu Satoko Matsueda Qinfu Wang Xiaoang Yang Jun Hong Zhou Songyang Zhijian J. Chen Rong-Fu Wang | 2011 | Immunity2011，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员