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| 1 | 在MR普美显增强下原发性肝癌的LI-RADS分型和预后显示文摘目的(a)评价各型肝脏影像报告和数据系统(LIRADS)原发性肝癌术后的预后意义;(b)确定2017版LIRADS在MR普美显增强中区分肝细胞肝癌(HCC)、肝内胆管细胞癌(IHCC)和肝细胞-胆管细胞混合型肝癌(cHCCCC)方面的作用。 | S.H.Choi S.S.Lee S.H.Park K.M.Kim E.Yu Y.Park 罗浩然(译) 杜明珊(校) | 2019 | 国际医学放射学杂志2019，0，2： | 21 |
| 2 | The Effects of Audit Committee Activity and Independence on Corporate Fraud显示文摘 | Abbott L.J Y.Park S.Parker | | 0，，： | 1 |
| 3 | 一个新的稳健ARCH检验和YJ-GARCH模型显示文摘众所周知,Engle(1982)的ARCH检验对于条件均值模型误设并不稳健,特别地,当条件均值是非线性过程而我们仅对之建立线性模型时,它过度地拒绝真实的原假设,导致出现严重的水平扭曲。因此,本文在文献当中首次利用Yeo-Johnson变换方法来转换均值模型的因变量以排除ARCH过程中均值部分的非线性,进而提出一个新的稳健ARCH检验以及一个新的GARCH模型——Yeo-Johnson(YJ)GARCH模型。蒙特卡罗模拟结果表明,稳健的ARCH检验在水平和势方面的表现要显著优于Engle(1982)的ARCH检验。对上证综指收益率的实证研究结果表明,YJ-GARCH模型的拟合效果要显著优于线性GARCH模型。 | 李海奇 Sung Y.Park | 2011 | 统计研究2011，28，7： | 1 |
| 4 | The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes显示文摘 | R.Loomba M. M.Rivera R.McBurney Y.Park V.Haynes‐Williams B.Rehermann H. J.Alter S. K.Herrine T. J.Liang J. H.Hoofnagle T.Heller | 2011 | Alimentary Pharmacology & Therapeutics2011，，5： | 1 |
| 5 | A Sieve Bootstrap For The Test Of A Unit Root显示文摘 | YOOSOONCHANG JOON Y.PARK | 2003 | Journal of Time Series Analysis2003，，4： | 1 |
| 6 | Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults显示文摘 | C.‐H.Kim J.‐Y.Park K.‐U.Lee J.‐H.Kim H.‐K.Kim | 2008 | Diabetic Medicine2008，，4： | 1 |
| 7 | The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children显示文摘 | S. K.Min Y. L.Kwak S. Y.Park J. S.Kim J. Y.Kim | 2007 | Anaesthesia2007，，5： | 1 |
| 8 | Conjugated linoleic acid and the control of cancer and obesity显示文摘 | Pariza M.W Y.Park | | 0，，2： | 1 |
| 9 | Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden显示文摘Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone loss.Debate persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft bone.Clinicians focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant material.Recent insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over metal.The current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and metal.Real-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were assessed.An orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous bone.The establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone infection.These study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical bone.The presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment. | Stephen D.Zoller Vishal Hegde Zachary D.C.Burke Howard Y.Park Chad R.Ishmael Gideon W.Blumstein William Sheppard Christopher Hamad Amanda H.Loftin Daniel O.Johansen Ryan A.Smith Marina M.Sprague Kellyn R.Hori Samuel J.Clarkson Rachel Borthwell Scott I.Simon Jeff F.Miller Scott D.Nelson Nicholas M.Bernthal | 2020 | Bone Research2020，8，4： | 0 |
| 10 | Loss of Notch signaling in skeletal stem cells enhances bone formation with aging显示文摘Skeletal stem and progenitor cells(SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed that Notch signaling becomes elevated in SSPCs during aging. To examine the role of increased Notch activity, we deleted Nicastrin, an essential Notch pathway component, in SSPCs in vivo. Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair. Thus, Notch regulates SSPC cell fate decisions, and moderating Notch signaling ameliorates the skeletal aging phenotype, increasing bone mass even beyond that of young mice. Finally, we identified the transcription factor Ebf3 as a downstream mediator of Notch signaling in SSPCs that is dysregulated with aging, highlighting it as a promising therapeutic target to rejuvenate the aged skeleton. | Lindsey H.Remark Kevin Leclerc Malissa Ramsukh Ziyan Lin Sooyeon Lee Backialakshmi Dharmalingam Lauren Gillinov Vasudev V.Nayak Paulo El Parente Margaux Sambon Pablo J.Atria Mohamed A.E.Ali Lukasz Witek Alesha B.Castillo Christopher Y.Park Ralf H.Adams Aristotelis Tsirigos Sophie M.Morgani Philipp Leucht | 2023 | Bone Research2023，11，4： | 0 |
| 11 | 去除冰层对P波响应的影响来计算地壳和上地幔波速结构:以南极洲地震研究为例显示文摘极地环境下进行标准的P波接收函数分析是非常困难的,因为厚厚的冰层里面的多次反射信号往往会掩盖来自深地下结构的P-S转换波,并增加背景噪声水平,显著降低数据的信噪比。本文提出了另外一种冰盖之下地下结构成像方法。我们利用P波响应向下延拓和波场分解来获取不受冰层影响的上行、下行P波和S波波场势函数。在某一参考深度波形分解得到的上行P波波场,可以用来计算冰层厚度。这个简单的步骤可以使迭代反演过程中不必模拟冰层效应,同时也可加快向下延拓所需的整体波速分析。上行S波通过标准反演方法模拟,即采用最小二乘法得到自由表面的接收函数。为了验证我们的设想,本文检验了南极洲数据网中的数据资料,同时也对比了之前通过P波和S波接收函数以及体波或面波层析成像分析的结果。该方法很好地去除了冰层的影响,同时建立了模拟地壳和上地幔结构的数据库。模型解给出了地壳厚度以及地壳和上地幔剪切波平均波速。电子补充测量数据图,反褶积采用的垂向分量叠加,以及产生的垂向。 | j.h.graw s.e.hansen c.a.langston b.a.young a.mostafanejad y.park 李翠平(译) 唐茂云(译) 张天中(校) | 2018 | 世界地震译丛2018，49，4： | 0 |
| 12 | Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data:a multi-phased study of prostate cancer显示文摘Background:DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer(PCa).However,it has not yet been possible to incorporate information of DNA methylation and gene expression into polygenic risk scores(PRSs).Here,we aimed to develop and validate an improved PRS for PCa risk by incorporating genetically predicted gene expression and DNA methylation,and other genomic information using an integrative method.Methods:Using data from the PRACTICAL consortium,we derived multiple sets of genetic scores,including those based on available single-nucleotide polymorphisms through widely used methods of pruning and thresholding,LDpred,LDpred-funt,AnnoPred,and EBPRS,as well as PRS constructed using the genetically predicted gene expression and DNA methylation through a revised pruning and thresholding strategy.In the tuning step,using the UK Biobank data(1458 prevalent cases and 1467 controls),we selected PRSs with the best performance.Using an independent set of data from the UK Biobank,we developed an integrative PRS combining information from individual scores.Furthermore,in the testing step,we tested the performance of the integrative PRS in another independent set of UK Biobank data of incident cases and controls.Results:Our constructed PRS had improved performance(C statistics:76.1%)over PRSs constructed by individual benchmark methods(from 69.6%to 74.7%).Furthermore,our new PRS had much higher risk assessment power than family history.The overall net reclassification improvement was 69.0%by adding PRS to the baseline model compared with 12.5%by adding family history.Conclusions:We developed and validated a new PRS which may improve the utility in predicting the risk of developing PCa.Our innovative method can also be applied to other human diseases to improve risk prediction across multiple outcomes. | Chong Wu Jingjing Zhu Austin King Xiaoran Tong Qing Lu Jong Y.Park Liang Wang Guimin Gao Hong-Wen Deng Yaohua Yang Karen E.Knudsen Timothy R.Rebbeck Jirong Long Wei Zheng Wei Pan David V.Conti Christopher A Haiman Lang Wu | 2021 | Cancer Communications2021，41，12： | 0 |
| 13 | On-skin ultrathin and stretchable multifunctional sensor for smart healthcare wearables显示文摘The flexible and stretchable multifunctional sensors for the precise monitoring of the human physiological health indicators is an emerging requirement of next-generation electronics.However,the integration of multifunctional sensors into a common substrate for simultaneous detection of such signals without interfering with each other is the most challenging work.Here,we propose MXene-Ti_(3)C_(2)T_(x) and 3,4-ethylene dioxythiophene(EDOT)deposited on laser-induced graphene(LIG/MXene-Ti_(3)C_(2)T_(x)@EDOT)composite-based flexible and stretchable multifunctional sensors for strain,temperature,and electrocardiogram(ECG)monitoring.In-situ electrophoretic deposition(EPD)of MXene-Ti_(3)C_(2)T_(x)@EDOT composite into LIG outperforms high strain sensitivity of 2,075,temperature coefficient of resistance(TCR)of 0.86%,and low skin-contact impedance.The sensor platform is integrated into an ultrathin and highly resilient polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene(SEBS).Finally,we demonstrate onsite detection of human body-induced deformations and physiological health indicators,such as temperature and ECG.The proposed approach paves a promising route to future wearables for smart skin and healthcare applications. | Shipeng Zhang Ashok Chhetry MdAbu Zahed Sudeep Sharma Chani Park Sanghyuk Yoon Jae Y.Park | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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