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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 4 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 5 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 6 | Experimental investigation on breaching of embankments显示文摘Breaching of embankments has recently drawn more and more attention due to its importance in the development of early warning systems for embankment failures,in the evacuation plans of people at risk,in the design method of embankments based on a risk-approach,etc. The erosion process observed during embankment breaching tests in the laboratory and the analysis of the results are described in this paper. Five embankments,one constructed with pure sand,four with different sand-silt-clay mixtures were tested. The height of the embankments was 75 cm and the width at the crest was 60 cm. Examination of the data from these tests indicated that headcut erosion played an important role in the process of breach growth in the embankments made of cohesive soil mixtures. Flow shear erosion,fluidization of the headcut slope surface,undermining of the headcut due to impinging jet scour and discrete soil mechanical slope mass failure from the headcut were all observed during these tests. For the embankment constructed with pure sand,the breach erosion process was dominated by shear erosion,which led to a gradual and relatively uniform retreat of the downstream slope. The cohesive proportion in the sand-silt-clay mixtures strongly slowed down the erosion process. | ZHU YongHui VISSER P J VRIJLING J K WANG GuangQian | 2011 | Science China(Technological Sciences)2011，54，1： | 17 |
| 7 | A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease.显示文摘 | Huang J Liu H Gu W Yan Z Xu Z Yang Y Zhu X Li Y | 2006 | 中国生物学文摘2006，20，9： | 16 |
| 8 | Variation and mechanisms of clastic reservoir quality in the Paleogene Shahejie Formation of the Dongying Sag, Bohai Bay Basin, China显示文摘Reservoir quality varies greatly in the Shahejie Formation in the Dongying Sag. It is essential to analyze the variation and mechanisms of reservoir quality for determining the controlling factors based on cores, porosity measurements and fluid inclusion techniques and so on. The sandstones in the fluvial,(fan) delta-front have the best reservoir quality due to the depositional conditions mechanically controlling the petrology configuration and the primary porosity, and chemically influencing the diagenesis and development of secondary pores. The activity of the boundary faults and the sedimentary facies dominate the variation of reservoir quality in different areas and intervals. The reservoir quality varies with the position of sandstone beds in different vertical models of sandstone and mudstone. This mainly arose from the strong cementation or strong dissolution in the sandstone caused by the diagenesis evolution of adjacent mudstone. With higher oil saturation reservoir quality is better because the hydrocarbon charge favors dissolution and restricts cementation. Diagenesis, depositional conditions and tectonic setting are the key controls of reservoir quality in the Shahejie Formation of the Dongying Sag. | Zhang Qin Zhu Xiaomin Ronald J Steel Zhong Dakang | 2014 | Petroleum Science2014，11，2： | 16 |
| 9 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 10 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 11 | Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level显示文摘 | Liu, LM Li, Y Zhu, Y Du, GC Chert, J | 2007 | 中国生物学文摘2007，21，10： | 12 |
| 12 | Estimation of methane and nitrous oxide emissions from biomass waste in China:A case study in Hebei Province显示文摘Crop residue,animal manure and MSW are selected as representative biomass waste.Greenhouse gas emissions from treatment and disposal process of biomass waste in Hebei province are estimated for the period from 2002 to 2007,using the methodologies recommended by the Intergovernmental Panel on Climate Change.Greenhouse gas emission was about 10 Mt CO2-equivalent annually.About 6% of greenhouse gas emission came from open burning of crop residue,74% from management system of animal manure,and 20% from MSW disposal.Among all the greenhouse gas sources,landfill is the most concentrated one,and has significant potential of emission reduction. | LUO YuXiang1,WANG Wei1,WAN Xiao2,DENG Zhou2 & ZHU CuiPing2 1 Department of Environmental Science and Engineering,Tsinghua University,Beijing 10084,China 2 J&K China Cleaning Energy Technology Company Limited,Beijing 100085,China | 2010 | Science China(Technological Sciences)2010，53，1： | 6 |
| 13 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 14 | 单个移植中心连续4000例肝移植后长期生存情况回顾显示文摘目的:评价大样本肝移植病人长期生存情况和分析影响移植疗效的动静态因素。背景回顾:自1983年以来肝移植被接受为治疗终末期肝病的主要选择之一,随着免疫抑制剂的发展、手术技术的不断完善、取肝及保存方法的改进,生存期获不断延长。虽然报告影响近期生存因素的文章甚众,但分析影响长期生存因素者却不多见。方法:回顾性分析1981年2月至1998年4月连续施行的4000例肝移植资料(随访至2000年3月),并对移植时供、受体年龄、受体性别和诊断以及移植年份等因素进行比较;也统计了再移植率、再移植原因和死亡原因。结果:全组的总生存率为59%,统计18年生存率为48%;小儿、女性和1990年以后接受移植的病人生存情况显著较好。以FK506为基础的免疫抑制剂使因急、慢性排斥反应而施行的再移植率显著下降。手术一年后,移植肝脏丧失功能病人死亡的曲线相对趋于平稳,疾病复发、恶性肿瘤和与年龄相关的并发症是移植物丧失功能的最主要因素。结论:随着年代的推移,病人和移植物的生存活情况获显著改善,由急性、慢性排斥反应所致的移植物失功已属十分罕见,与年龄相关和疾病相关的移植物失功,已构成肝移植患者长期生存的最大威胁。 | Zhu Yue Jain Ashok Fung John J 周光文 | 2002 | 外科理论与实践2002，7，2： | 5 |
| 15 | A meta-analysis of case-control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China显示文摘 | Shi J Zhu L Liu S Xie WF | 2006 | 第二军医大学学报2006，27，5： | 5 |
| 16 | Giant magneto-impedance effects in nanocrystalline soft magnetic alloy ribbons显示文摘SINCE the discovery of the giant magneto-impedance (GMI) effects in amorphous wire (or rib-bon) of CoFeSiB and nanocrystalline wire (or film) of FeCuNbSiB, it has attracted greatattention due to its promising potential applications in industry. Amorphous (and nanocrys-talline) soft magnetic alloys have very large magnetic permeability, when an ac driving currentand an external magnetic field (EMF) are applied, the EMF will damp the magnetic fluxchange caused by the ac driving current, thus the magnetic permeability will decrease; as a re- | Ku, WJ Ge, FD Yan, G Wang, XY Zhu, J | 1997 | Chinese Science Bulletin1997，42，12： | 5 |
| 17 | Cloning of environmental genomic fragments as physical markers for monitoring microbial populations in coking wastewater treatment system显示文摘 | Yan X Xu ZM Feng XX Liu YD Liu BB Zhang X J Zhu CG Zhao LP | 2007 | 中国生物学文摘2007，21，8： | 4 |
| 18 | Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells显示文摘尽管发信号的 Activin/Nodal 调整人的胚胎的茎(ES ) 的 pluripotency 细胞,这个发信号怎么在老鼠 ES 细胞行动,仍然保持大部分不清楚。调查这,我们证实了房间拥有活跃调停 Smad2 的 Activin/Nodal 发信号的那老鼠 ES 并且发现调停 Smad2 的 Activin/Nodal 发信号为自强维护是非必需的,但是向 mesendoderm 系为合适的区别被要求。到进内在的机制的获得卓见,联系 Smad2 的基因被染色体宽的染色质 immunoprecipitation 薄片分析识别。结果证明在 Smad2 绑定和 Activin/Nodal 发信号调整之间有 transcriptional 关联,并且发展相关的基因在 Smad2 固定的目标之中被充实。我们进一步在 Activin/Nodal-Smad2 小径下游地行动的老鼠 ES 房间的 mesendoderm 区别作为一个关键播放器识别了 Tapbp。一起拿,我们的调查结果建议发信号的调停 Smad2 的 Activin/Nodal 通过相应发展管理者表示的直接调整安排鼠标 ES 房间的 mesendoderm 系承诺。 | Teng Fei Shanshan Zhu Kai Xia Jianping Zhang Zhongwei Li Jing-Dong J Han Ye-Guang Chen | 2010 | Cell Research2010，20，12： | 4 |
| 19 | High spin states in stable nucleus ^(84)Sr显示文摘High spin states of 84Sr were populated through the reaction 70Zn(18O,4n)84Sr at 75 MeV beam energy.Measurement of excitation function,γ-γ coincidences,directional correlation from oriented state (DCO) ratios and γ-transition intensities were performed using eight anticompton HPGe detectors and one planar HPGe detector.Based on the measured results,a new level scheme of 84Sr was established in which 12 new states and nearly 30 new γ-transitions were identified in the present work.The positive-parity states of the new level scheme were compared with the results from calculations in the framework of the projected shell model (PSM).One negative-parity band was extended to spin Iπ=19-and it can be found that in the high spin states,the γ-transition energies show the nature of signature staggering.The negative-parity band levels are in good agreement with deformed configuration-mixing shell model (DCM) calculations. | KANG XuZhong1,2,SHEN ShuiFa1,2,3,4*,HAN GuangBing5,PAN Feng3,4,GU JianZhong6,DRAAYER J P4,WU XiaoGuang6,ZHU LiHua6 & WEN TingDun7 1 Key Laboratory of Nuclear Resources and Environment (East China Institute of Technology),Ministry of Education,Nanchang 330013,China 2 School of Nuclear Engineering and Technology,East China Institute of Technology,Fuzhou 344000,China 3 Department of Physics,Liaoning Normal University,Dalian 116029,China 4 Department of Physics and Astronomy,Louisiana State University,Baton Rouge,LA 70803-4001,USA 5 School of Physics,Shandong University,Jinan 250100,China 6 China Institute of Atomic Energy,Beijing 102413,China 7 Department of Physics,North University of China,Taiyuan 030051,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 4 |
| 20 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
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