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| 1 | Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof显示文摘For a long time,the total synthesis of proteins was considered as a 'mission impossible' because of the tedious and complex synthetic steps and demanding purification processes.However,with the development of modern synthetic methodologies,many protein syntheses have now been reported.More importantly,through chemical synthesis,desired modifications can be installed to target proteins precisely,which is a major advantage over trad卜tional bio-synthesis approaches.This review summarizes the techniques developed for protein assembly,including native chemical ligation,5e-mediated ligation,and a range of other ligation methods. . | Siyao Wang Yogesh Abaso Thopate Qingqing Zhou Ping Wang | 2019 | Chinese Journal of Chemistry2019，37，11： | 7 |
| 2 | Synthesis of Spirostanol Saponins via Gold(Ⅰ)-Catalyzed Glycosylation in the Presence of Ga(Otf)3, In(Otf)3, or HOTf显示文摘Summary of main observation and conclusion An effective approach relying on a Lewis acid-or Brφnsted acid-assisted gold(Ⅰ)-catalyzed glycosylation has been reported in the synthesis of a panel of the representative natural spirostanol saponins,namely polyphyllin D (1),polyphyllin V (2),dioscin (3),formosanin C (4),and a derivative of polyphyllin D bearing a terminal azide group (5).This approach highlights the engagement of low Ioadings of Ph3AuPOTf (≤ 0.5mol%) in the presence of Ga(OTf)3,In(OTf)3,or HOTf (~10 mol%) as a co-catalyst,at practical reaction rates as an alternative to the conventional ~10 mol%Ioadings of the gold(Ⅰ) catalyst in the glycosylation.Polyphyllin D (1) was obtained in 41% overall yield over six steps compared to the maximum 30% yield in previous syntheses,where conventional donors and promoters were used.By exploiting a regioselective rhamnosylation,a 'one-pot' approach was adopted to assemble 1 and 5,thus further strengthening the efficiency of the gold(Ⅰ)-catalyzed glycosylation. | Teddy Stephen Ehianeta Dacheng Shen Peng Xu Biao Yu | 2019 | Chinese Journal of Chemistry2019，37，8： | 2 |
| 3 | 中草药活性成分在化妆品中的应用显示文摘中草药是中国传统的纯天然药物,具有来源极广、药物残留少、毒副作用微小和无抗药性等优点。中药材中的一些活性成分具有抗炎、抗氧化、抗菌等功效,被广泛应用于日常保健和临床医疗中。近几年来,越来越多的高安全性、温和、低刺激性的中草药活性成分作为天然添加剂应用在化妆品中。同时,含中草药的化妆品在全球市场上的需求量正在不断增加,这为中草药及其活性成分在化妆品中的应用研究提供了思路和动力。首先,总结了中草药中6种常见活性成分,如酚类化合物、类黄酮、皂苷、萜类化合物、类胡萝卜素和天然多糖的结构和功能;接着,综述了中草药活性成分的5大功效:保湿、祛斑美白、防晒、抗皱与祛痘及作用机制;最后,提出了中草药功效性成分在化妆品应用中存在的问题,并指出了未来发展方向。 | 张婉萍 林梅 王恒 岳恒 郑时莲 | 2023 | 精细化工2023，40，7： | 2 |
| 4 | Effects of 105 traditional Chinese medicines on the detection ofβ-agonists in medicine extracts and swine urine based on colloidal gold immunochromatographic assay显示文摘Colloidal gold immunochromatographic assay(CGIA)is commonly used for the on-site detection ofβ-agonists that are sometimes used illegally as feed additives in swine diets.However,few studies have evaluated the causes of false-positive results that sometimes occur when applying CGIA in agricultural settings.In this study,we investigated if this false-positive phenomenon is related to the addition of certain traditional Chinese medicines(TCMs)to swine feed.We established and verified an extraction method for TCMs,and then applied CGIA to detectβ-agonists in the extracts of 105 TCMs and in the urine of swine dosed with TCMs,respectively.Liquid chromatography-tandem mass spectrometry was used to validate the results of the urine samples tested positive forβ-agonists using CGIA.The results were also verified using TCMs and colloidal gold test strips produced by different manufacturers.The extracts of Citri Reticulatae Pericarpium Viride,Citri Reticulatae Pericarpium,Magnoliae Officinalis Cortex,Chaenomelis Fructus,and Rhodiolae Crenulatae Radix Et Rhizoma were tested positive forβ-agonists.Meanwhile,the addition of Citri Reticulatae Pericarpium Viride and Citri Reticulatae Pericarpium to swine feed resulted in false-positive results forβ-agonists in swine urine.The results provide a new way to explain false-positive CGIA results and provide valuable information for livestock feeding programs. | WANG Zi-lin FENG Ke-ying GE Xiu-feng MAI Jia-cheng WANG Han-chuan LIU Wen-zi ZHANG Jia-hui SHEN Xiang-guang | 2021 | Journal of Integrative Agriculture2021，20，6： | 2 |
| 5 | 2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides显示文摘Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules.However,their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. | Xianglai Liu Yetong Lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao Yu Wei Li | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 6 | Carbohydrate-based drugs launched during 2000-2021显示文摘Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host defense systems,and forming antibiotics secondary metabolites.The naturally occurring carbohydrates and their derivatives have been extensively studied as therapeutic agents for the treatment of various diseases.During 2000 to 2021,totally 54 carbohydrate-based drugs which contain carbohydrate moities as the major structural units have been approved as drugs or diagnostic agents.Here we provide a comprehensive review on the chemical structures,activities,and clinical trial results of these carbohydrate-based drugs,which are categorized by their indications into antiviral drugs,antibacterial/antiparasitic drugs,anticancer drugs,antidiabetics drugs,cardiovascular drugs,nervous system drugs,and other agents. | Xin Cao Xiaojing Du Heng Jiao Quanlin An Ruoxue Chen Pengfei Fang Jing Wang Biao Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 7 | Pd-Catalyzed Ortho-Directed C-H Glycosylation of Arenes Using N-linked Bidentate Auxiliaries显示文摘Main observation and conclusion A set of Pd-catalyzed ortho-directed C-H glycosylation reactions with glycosyl chloride donors using various N-linked bidentate auxil-iaries has been developed for synthesis of C-aryglycosides.A broad range of pyranose and furanose moieties can be installed on the ortho position of arylamine,carbazole,indole and benzylamine type substrates in high yield and with high regio-and diastereoselec-tivity.These auxiliaries can be readily installed and removed under relatively mild conditions. | Quanquan Wang Wanjun Zhu Qikai Sun Gang He Gong Chen | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 8 | Photolabile Protecting Group-Mediated Synthesis of 2-Deoxy-Glycosides显示文摘A green and efficient photolabile protecting group(PPG)-mediated glycosidation approach for the synthesis of 2-deoxy-glycosides is reported.By employing ortho-nitrobenzyl carbonate(oNBC)as PPG,N,N-dimethylformamide(DMF)-modulated SPhosAuNTf_(2)-promoted glycosidation with per-oNBC-protected 2-deoxy-glycosyl ynenoates affords the 2-deoxy-glycosides with moderate to excellentα-selectivities presumably depending on the reactivities of the acceptor alcohols.Based on the PPG-mediated glycosidation approach,oligosaccharides with three to six oNBC groups are effectively achieved.The multiple oNBC groups in the 2-deoxy-glycosides are completely cleaved by irradiation at 365 nm,resulting in the desired 2-deoxy-glycosides in an efficient manner without affecting the common alkyne,alkene,azide functional groups and the traditional protecting groups on the aglycones. | Xiaoqian Li Zhi Ma Rongkun Liu Mattan Hurevich You Yang | 2021 | Chinese Journal of Chemistry2021，39，12： | 0 |
| 9 | Automated Chemical Solid-Phase Synthesis of Glycans显示文摘Automated chemical solid-phase synthesis is an automation platform for rapid and reliable synthesis of glycans.Since the seminal work of Automated Glycan Assembly(AGA)disclosed by Seeberger in 2001,AGA has evolved from a proof-of-concept to a robust and reliable technology for streamlined production of various types of glycans.Through more than 20 years of unceasing efforts,the major breakthroughs in AGA including linkers,approved building blocks,and synthesizers have been acquired,and numerous influential achievements have been made in complex glycan synthesis.In addition,the HPLC-assisted automated synthesis emerges as a promising automation platform to access glycans.In this review,we highlight the key advances in the field of automated chemical solid-phase synthesis,especially in AGA.The synthesis of representative glycans based on AGA is also described. | Xiaona Li You Yang | 2022 | Chinese Journal of Chemistry2022，40，14： | 0 |
| 10 | Synthesis and Antiproliferative Activities of OSW-1 Analogues Bearing 2'-0-p-Acylaminobenzoyl Residues显示文摘Summary of main observation and conclusion OSW-1 is a well-known natural saponin with potent antitumor activities.We have designed and pre-pared a small library of 22 OSW-1 analogues with a variety of p-acylamino-benzoyl groups installed at C2'of the xylose residue,wherein a regioselective(1>3)-glycosylation of arabinoside 3,4-diol has been achieved by manipulatian of the protecting groups on the imidate donors.Bioassays lead to new structure-activity relationships as well as two aplicable fluorescent probes,which are found to localize to lysosomes in HeLa cells and could be used in further antitumor mechanism studies of OSW-1 in living cells. | Lijun Sun Di Zhu Laura Olde Groote Beverborg Ruina Wang Yongjun Dang Mingming Ma Wei Li Biao Yu | 2020 | Chinese Journal of Chemistry2020，38，10： | 0 |
| 11 | Chemical approaches for the stereocontrolled synthesis of 1,2-cis-β-D-rhamnosides显示文摘In carbohydrate chemistry,the stereoselective synthesis of 1,2-cis-glycosides remains a formidable challenge.This complexity is comparable to the synthesis of 1,2-cis-β-D-mannosides,primarily due to the adverse anomeric andΔ-2 effects.Over the past decades,to attainβ-stereoselectivity in D-rhamnosylation,researchers have devised numerous direct and indirect methodologies,including the hydrogen-bond-mediated aglycone delivery(HAD)method,the synthesis ofβ-D-mannoside paired with C6 deoxygenation,and the combined approach of 1,2-trans-glycosylation and C2 epimerization.This review elaborates on the advancements inβ-Drhamnosylation and its implications for the total synthesis of tiacumicin B and other physiologically relevant glycans. | CAI Juntao YUAN Xin KONG Yuanfang HU Yulong LI Jieming JIANG Shiqing DONG Chunhong DING Kan | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 0 |
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