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| 1 | A Two-step Estimation Method of Troposphere Delay with Consideration of Mapping Function Errors显示文摘Mapping function errors are usually not taken into consideration, when space geodetic data observed by VLBI, GNSS and some other techniques are utilized to estimate troposphere delay, which could, however, probably bring non-ignorable errors to solutions. After analyzing the variation of mapping function errors with elevation angles based on several-year meteorological data, this paper constructed a model of this error and then proposed a two-step estimation method of troposphere delay with consideration of mapping function errors. The experimental results indicate that the method put forward by this paper could reduce the slant path delay residuals efficiently and improve the estimation accuracy of wet tropospheric delay to some extent. | Haopeng FAN Zhongmiao SUN Liping ZHANG Xiaogang LIU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 11 |
| 2 | Therapeutic strategies of glioblastoma (GBM):The current advances in the molecular targets and bioactive small molecule compounds显示文摘Glioblastoma(GBM)is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable.A variety of treatment options are currently being explored to improve patient survival,including small molecule inhibitors,viral therapies,cancer vaccines,and monoclonal antibodies.Among them,the unique advantages of small molecule inhibitors have made them a focus of attention in the drug discovery of glioblastoma.Currently,the most used chemotherapeutic agents are small molecule inhibitors that target key dysregulated signaling pathways in glioblastoma,including receptor tyrosine kinase,PI3K/AKT/mTOR pathway,DNA damage response,TP53 and cell cycle inhibitors.This review analyzes the therapeutic benefit and clinical development of novel small molecule inhibitors discovered as promising anti-glioblastoma agents by the related targets of these major pathways.Meanwhile,the recent advances in temozolomide resistance and drug combination are also reviewed.In the last part,due to the constant clinical failure of targeted therapies,this paper reviewed the research progress of other therapeutic methods for glioblastoma,to provide patients and readers with a more comprehensive understanding of the treatment landscape of glioblastoma. | Hui Liu Weimin Qiu Tianyu Sun Lei Wang Chenxi Du Yanyu Hu Wenyuan Liu Feng Feng Yao Chen Haopeng Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 3 | 2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides显示文摘Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules.However,their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. | Xianglai Liu Yetong Lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao Yu Wei Li | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 4 | QoS-Aware Power Allocation Scheme for Relay Satellite Networks显示文摘This paper investigated a QoS-aware power allocation for relay satellite networks.For the given QoS requirements,we analyzed the signal model of relay transmission and formulated the power minimization problem which is non-convex and difficult to solve.To find the optimal solution to the considered problem,we first analyzed the optimization problem and equivalently turn it into a convex optimization problem.Then,we provided a Lagrangian dual-based method to obtain the closed-form of the power allocation and provided an iterative algorithm to the optimal solution.Moreover,we also extended the results to the cooperative transmission mode.Finally,simulation results were provided to verify the superiority of the proposed algorithm. | Jin’ao Yu Xiaogang Tang Shibing Zhu Haopeng Sun Lunxin Zhong Guangyu Yang | 2021 | Journal of Beijing Institute of Technology2021，30，1： | 1 |
| 5 | The neuroprotective effects of isoflurane preconditioning in a murine transient global cerebral ischemia- reperfu- sion model: the role of the notch signaling pathway 显示文摘 | Zhang Haopeng Sun Yanyan Chen Xiaomei | 2013 | Neuromolecular medicine2013，16，1： | 1 |
| 6 | Pharmacophore Modeling and in Silico Screening Studies to Design Potential KDR Kinase Inhibitors显示文摘为 KDR kinase 的一个新奇基于 ligand 的 pharmacophore 模型根据 30 个 KDR kinase 禁止者的化学特征被产生。这个 pharmacophore 模型由一个氢契约领受人,一个氢契约施主和二个恐水病的组组成。几个方法被用来验证模型,建议它能用作为便于新奇 KDR 禁止者的发现的虚拟屏蔽的一个可靠工具。模型然后从国家癌症研究所(NCI ) 数据库被用作数据库搜索质问让合理设计识别新点击化合物。 | Xu, Dan Sun, Haopeng Chen, Yadong Sun, Liping You, Qidong | 2011 | Chinese Journal of Chemistry2011，29，6： | 0 |
| 7 | Structural basis of humanα7 nicotinic acetylcholine receptor activation显示文摘Dear Editor,Nicotinic acetylcholine receptors(nAChRs)are a class of pentameric ligand-gated ion channels(pLGICs)widely expressed in nervous system.nAChRs function as neurotransmitter receptors that respond to endogenous acetylcholine and choline,modulating neuronal excitability and synaptic communication.The homomericα7 nAChR is among the most abundant subtypes of nAChR in the brain.Dysfunction ofα7 is found to be associated with several neuropsychiatric and neurologic disorders,including schizophrenia and Alzheimer’s disease.1,2 Stimulation ofα7 has been reported to improve attention,cognitive performance,and neuronal resistance to injury.Therefore,agonists and positive allosteric modulators(PAMs)ofα7 have become hot candidates in the drug development for the treatment ofα7-related diseases.3,4 EVP-6124(abbreviated as EVP)is a high-affinityα7-selective agonist.5 PNU-120596(abbreviated as PNU)is the first reportedα7-selective PAM that could increase the peak current of the receptor evoked by agonists and delay channel desensitization.6 Both EVP and PNU are in clinical trials for the treatment of Alzheimer’s disease,schizophrenia,and cognitive impairment.Despite the significance ofα7 in physiology and pharmacology,the mechanisms underlying the activation ofα7 upon agonist and/or PAM binding remain elusive.Little is known about the structural basis of the higher selectivity of EVP and PNU forα7,which would be highly valuable for rational drug development targeting the receptor.Herein,we report the structures of full-length humanα7 in apo,EVP-bound and EVP/PNU-bound states at 3.18,2.85 and 3.02Å,respectively(Fig.1a–c;Supplementary information,Figs.S1–S4 and Table S1). | Yue Zhao Sanling Liu Yingxin Zhou Mengge Zhang Haopeng Chen HEric Xu Demeng Sun Lei Liu Changlin Tian | 2021 | Cell Research2021，31，6： | 0 |
| 8 | A Practical and High-Affinity Fluorescent Probe for Butyrylcholinesterase:A Good Strategy for Binding Affinity Characterization显示文摘Butyrylcholinesterase(BChE)is regarded as a promising target for the treatment of Alzheimer's disease(AD),as its level significantly increases along with the progress of this disease.Therefore,the development of potent and high-affinity small-molecule BChE inhibi-tors may be a new strategy for the discovery of anti-AD drugs.However,the current Ellman's method is unable to evaluate the affinity of compounds with BChE,and has a few deficiencies in drug development.Herein,the first small-molecule fluorescence polarization(FP)probes for BChE were rationally designed based on a high affinity inhibitor.Studies indicated that probe F6 exhibited satisfactory fluorescence intensity and suitable fluorescent properties that were compatible with the filters in the FP system.Meanwhile,probe F6 exhibited potent binding affinity to BChE.It is feasible to be applied in detecting the affinity of non-fluorescent compounds to BChE,which lays a solid foundation for the development of small-molecule BChE inhibitors.At the same time,it also can be applied as a val-uable chemical tool for better understanding the molecular biological mechanism of BChE. | Lei Wang Chenxi Du Hui Liu Weimin Qiu Xin Lu Yanyu Hu Yueqing Li Tianyu Sun Yao Chen Haopeng Sun | 2022 | Chinese Journal of Chemistry2022，40，11： | 0 |
| 9 | Discovery of Tryptophan-tetrahydroisoquinoline Derivatives as Multifunctional Agents for Treatment of Alzheimer's Disease显示文摘Comprehensive Summary The cholinesterases are essential targets implicated in the pathogenesis of Alzheimer's disease(AD).We have identified tryptophan-tetrahydroisoquinoline derivatives as selective micro-nanomolar butyrylcholinesterase(BChE)inhibitors.Molecular docking was applied for the rational design and binding mode analysis.They were defined according to their target inhibitory activity,low cytotoxicity,predicted permeability through the blood-brain barrier(BBB),and in vivo cognitive improvement.Additionally,the preferred compound showed ability to decrease self-induced Aβ1-42 aggregation and Aβ1-42 induced SH-SY5Y cell injury.Altogether,these factors indicated their potential as unique lead compounds for AD treatment. | Xin Lu Yijun Liu Nan Qin Chenxi Du Yanyu Hu Yao Chen Haopeng Sun | 2022 | Chinese Journal of Chemistry2022，40，15： | 0 |
| 10 | Docking Study and Three-Dimensional Quantitative Structure- Activity Relationship (3D-QSAR) Analyses and Novel Molecular Design of a Series of 4-Aminoquinazolines as Inhibitors of Aurora B Kinase显示文摘曙光蛋白质为 anticancer 治疗是主要有丝分裂的事件和吸引人的目标的批评管理者。3D-QSAR 研究在 40 4-aminoquinazolines 混合物的数据集上基于分子的停靠被执行。CoMSIA 模型比 CoMFA 模型生产了显著地更好的结果,与 q2=0.652 和 r2=0.991。轮廓分析为禁止曙光 B 为 4-aminoquinazolines 关于结构的要求提供有用信息。支架跳跃方法被用来基于训练和测试集合混合物的最大的普通基础产生新结构。ADMET 性质,有约束力的亲密关系和新设计混合物的禁止的活动分别地被预言。最后, 16 混合物为曙光 B kinase 作为新奇禁止者被识别。 | Sun, Haopeng Zhu, Jia Chen, Yadong Sun, Yuan Zhi, Huijing Li, Hao You, Qidong | 2011 | Chinese Journal of Chemistry2011，29，9： | 0 |
| 11 | Epidemiology and early screening strategies for colorectal cancer in China显示文摘China ranks the first worldwide in the number of new colorectal cancer(CRC) cases and CRC-related deaths. The increasing incidence of early-onset CRC in recent years highlights the challenges related to CRC screening and prevention. High-quality colonoscopy is the universally used gold standard for CRC screening. Risk assessment combined with a two-step screening strategy based on colonoscopy and non-invasive examinations was proven to be highly effective. However, systematic use of well-established risk factors associated with CRC, beyond age, could better identify those who might harbor advanced colorectal neoplasia, improve the diagnostic yield of current screening modalities, and optimize the selection of individuals who might benefit most from preventive strategies.“Personalization” and “Standardization” are the future development directions of CRC screening, from the initiation of screening in those at high risk for CRC to follow-up after treatment, which are the key to ensure the screening efficiency. | Yong Yang Zhaoya Gao An Huang Jingyi Shi Zhuang Sun Haopeng Hong Jin Gu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
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