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| 1 | The role of m6A modification in the biological functions and diseases显示文摘N6-methyladenosine(m6A)is the most prevalent,abundant and conserved internal cotranscriptional modification in eukaryotic RNAs,especially within higher eukaryotic cells.m6A modification is modified by the m6A methyltransferases,or writers,such as METTL3/14/16,RBM15/15B,ZC3H3,VIRMA,CBLL1,WTAP,and KIAA1429,and,removed by the demethylases,or erasers,including FTO and ALKBH5.It is recognized by m6A-binding proteins YTHDF1/2/3,YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1,also known as'readers'.Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions,especially in the initiation and progression of different types of human cancers.In this review,we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic,central nervous and reproductive systems.We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation,its regulators and downstream target genes,during cancer progression in above systems.We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future. | Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 2 | Basic and translational aging research in China: present and future显示文摘The percentage of elderly people in the world is increasing at an unprecedented pace;so it is in China, which has the world s largest population and a high ratio of the seniors (aged 60 and above) to working-age adults. The growing elderly population is presenting a major social challenge. Accordingly, it is not only imperative as a national strategic demand but also promises great scientific values to understand the biological process of aging, explore the mystery of healthy aging, delay the aging process, and treat the age-related diseases. This Perspective summarizes past and present advances of the basic and translational aging research in China and offers perspectives on future endeavors in this area. | Xiaojuan He Moshi Song Jing Qu Yansu Guo Heqi Cao Ruijuan Sun Guang-Hui Liu Yong Shen Major Program Expert Group | 2019 | Protein & Cell2019，10，7： | 8 |
| 3 | 植物再生过程中的表观修饰研究进展显示文摘当前,植物再生的研究正不断促进农业技术发展以及农作物再生效率的提高,有着重要的应用价值。植物的再生过程本质是细胞的命运转变。表观遗传存在于植物各个生长发育过程中,常伴随着细胞命运的转变,因而植物再生为研究表观遗传调控提供了很好的模型。在对植物再生过程的研究中,表观修饰的重要性不断被证实,已经成为再生领域非常重要的组成部分。本文将主要关注植物再生与表观遗传调控,介绍最新研究进展,并探讨植物再生过程中各种表观修饰之间的相互关系。 | 张腾 谢冲 何崇圣 | 2020 | 植物生理学报2020，56，8： | 3 |
| 4 | Transcriptome-wide Dynamics of m^(6)A mRNA Methylation During Porcine Spermatogenesis显示文摘Spermatogenesis is a continual process that occurs in the testes,in which diploid spermatogonial stem cells(SSCs)differentiate and generate haploid spermatozoa.This highly efficient and intricate process is orchestrated at multiple levels.N^(6)-methyladenosine(m^(6)A),an epigenetic modification prevalent in mRNAs,is implicated in the transcriptional regulation during spermatogenesis.However,the dynamics of m^(6)A modification in non-rodent mammalian species remains unclear.Here,we systematically investigated the profile and role of m^(6)A during spermatogenesis in pigs.By analyzing the transcriptomic distribution of m^(6)A in spermatogonia,spermatocytes,and round spermatids,we identified a globally conserved m^(6)A pattern between porcine and murine genes with spermatogenic function.We found that m^(6)A was enriched in a group of genes that specifically encode the metabolic enzymes and regulators.In addition,transcriptomes in porcine male germ cells could be subjected to the m^(6)A modification.Our data show that m^(6)A plays the regulatory roles during spermatogenesis in pigs,which is similar to that in mice.Illustrations of this point are three genes(SETDB1,FOXO1,and FOXO3)that are crucial to the determination of the fate of SSCs.To the best of our knowledge,this study for the first time uncovers the expression profile and role of m^(6)A during spermatogenesis in large animals and provides insights into the intricate transcriptional regulation underlying the lifelong male fertility in non-rodent mammalian species. | Zidong Liu Xiaoxu Chen Pengfei Zhang Fuyuan Li Lingkai Zhang Xueliang Li Tao Huang Yi Zheng Taiyong Yu Tao Zhang Wenxian Zeng Hongzhao Lu Yinghua Lv | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 5 | Epigenetic regulation of hematopoietic stem cell homeostasis显示文摘As one of the best characterized adult stem cells,hematopoietic stem cell(HSC)homeostasis is of great importance to hematopoiesis and immunity due to HSC’s abilities of self-renewal and multi-lineage differentiation into functional blood cells.However,excessive self-renewal of HSCs can lead to severe hematopoietic malignancies like leukemia,whereas deficient selfrenewal of HSCs may result in HSC exhaustion and eventually apoptosis of specialized cells,giving rise to abnormalities such as immunodeficiency or anemia.How HSC homeostasis is maintained has been studied for decades and regulatory factors can be generally categorized into two classes:genetic factors and epigenetic factors.Although genetic factors such as signaling pathways or transcription factors have been well explored,recent studies have emerged the indispensable roles of epigenetic factors.In this review,we have summarized regulatory mechanisms of HSC homeostasis by epigenetic factors,including DNA methylation,histone modification,chromatin remodeling,non-coding RNAs,and RNA modification,which will facilitate applications such as HSC ex vivo expansion and exploration of novel therapeutic approaches for many hematological diseases. | Penglei Jiang Hui Wang Jiachen Zheng Yingli Han He Huang Pengxu Qian | 2019 | Blood Science2019，1，1： | 1 |
| 6 | N6-甲基腺苷(m6A)修饰调控配子发生、胚胎发育和性别决定的研究进展显示文摘N6-甲基腺苷(m6A)是真核生物mRNA中含量最为丰富的甲基化修饰形式,甲基转移酶(writers)、脱甲基酶(erasers)、甲基结合蛋白(readers)3种蛋白共同保证着m6A的动态可逆修饰。最近的研究显示,m6A的差异表达与配子发生相关,并且对胚胎发育和性别决定也显示出重要作用。对m6A的研究明显改变了对胚胎种植、分化和发育的认识,为此,本文就m6A与配子发生、胚胎发育及性别决定的相关研究进行综述。 | 麻婷 孙小燕 张学红 | 2020 | 中华生殖与避孕杂志2020，40，4： | 1 |
| 7 | 6-甲基腺嘌呤RNA甲基化对造血调控作用的研究进展显示文摘RNA存在150多种化学修饰,其中以甲基化为主,广泛分布于信使RNA、转运RNA、核糖体RNA、非编码小RNA和长链非编码RNA等各类RNA上。近年来,RNA甲基化修饰酶的鉴定以及转录组水平高通量测序技术的发展为揭示RNA化学修饰如何调控基因的表达和功能奠定了基础。本综述主要总结了有关RNA甲基化,尤其是6-甲基腺嘌呤(m^(6)A)在血液系统中的相关进展,包括RNA甲基转移酶、RNA去甲基酶以及RNA结合蛋白通过RNA甲基化水平的调节从而发挥对正常造血和恶性造血的调控作用。 | 王妮妮 李亚朴 程涛 程辉 | 2021 | 中国实验血液学杂志2021，29，6： | 0 |
| 8 | m^(6)A阅读蛋白YTHDF2在肿瘤中作用的研究进展显示文摘N^(6)-甲基腺苷(N^(6)-methyladenosine,m^(6)A)修饰是真核生物最常见的RNA修饰类型之一,在多种生理过程和疾病进展中起着关键作用。YT521-B同源性域家族2(YT521-B homology domain family proteins 2,YTHDF2)是m^(6)A修饰的重要结合蛋白之一,影响mRNAs的翻译和稳定性,研究证实YTHDF2参与了肺癌、肝癌、急性髓系白血病等多种恶性肿瘤的发生发展,本文总结了YTHDF2在肿瘤发生发展中的调控机制,为基于YTHDF2的抗肿瘤研发提供新思路。 | 杨婕 李晓琴 杨艳丽 朱萌 刘喆 马琳娜 李亚玲 舍雅莉 | 2024 | 现代肿瘤医学2024，32，2： | 0 |
| 9 | N^(6)-甲基腺苷修饰在心肌再生中作用研究进展显示文摘N^(6)-甲基腺苷(N^(6)-methyladenosine,m^(6)A)修饰是真核生物常见的mRNA转录后修饰方式,受甲基化酶和去甲基化酶动态调控,与胚胎干细胞自我更新和分化、器官发育、组织细胞再生等密切相关。心脏病与心肌细胞损伤或功能障碍有关,心肌损伤后形成心肌纤维化瘢痕,导致心律失常、心力衰竭甚至死亡。临床治疗可改善心脏病患者的心功能,但无法使已丢失的心肌细胞再生。m^(6)A修饰作为一种常见的表观遗传调控方式,在心肌再生中发挥重要作用。本文就m^(6)A修饰在心肌再生中作用的研究进展作一综述。 | 陈琳明 刘柯妤 张良清 | 2022 | 中华实用诊断与治疗杂志2022，36，7： | 0 |
| 10 | EGFR m^(6)A修饰参与肺动脉高压发病机制的研究进展显示文摘肺动脉高压(pulmonary hypertension,PH)是一种严重的心血管疾病,其发病机制尚不十分明确.N6-甲基腺苷(N6-methyladenosine,m^(6)A)修饰是真核生物mRNA最普遍的内部修饰,m^(6)A通过调节mRNA的转录、翻译和降解,调控多种生物过程.最近的研究表明,mRNA m^(6)A修饰与PH的形成有关,同时,m^(6)A结合蛋白YTH-DF2在该过程中发挥重要作用.YTHDF2通过调控表皮生长因子受体(epidermal growth factor receptor,EGFR)mRNA的稳定性和转录水平,影响PH的发病过程.文章以m^(6)A修饰、YTHDF2和EGFR的关系为切入点,对近期PH领域相关研究成果进行综述. | 赵帅帅 颜诺 李晓贵 吴起才 周学亮 | 2023 | 实用临床医学(江西)2023，24，3： | 0 |
| 11 | m^6A-RNA甲基化在正常造血和急性髓系白血病中的研究进展显示文摘m^6A-RNA甲基化是一种类似于DNA甲基化或组蛋白修饰的表观遗传修饰方式。是由甲基化转移酶、去甲基转移酶和相关阅读蛋白共同调节的一种动态可逆的生物学过程,可以对mRNA产生不同的生物学作用,包括mRNA剪切、出核、降解、影响mRNA稳定性和翻译效率等。越来越多的研究表明m^6A-RNA甲基化在正常造血和急性髓系白血病中发挥重要的调控作用。本文就m^6A-RNA甲基化在正常造血和AML中的研究进展作一综述,旨在从表观转录组学层面深入了解AML的发病机制,为探索AML靶向治疗药物提供一种新的研究策略。 | 张津京 李艳 张蕊 | 2020 | 现代肿瘤医学2020，28，9： | 0 |
| 12 | m^(6)A修饰在哺乳动物生理发育与疾病发生中的功能和机制显示文摘基因时空特异性表达在机体发育和疾病发生中起重要调控作用。N6-甲基腺苷(N6-methyladenosine,m^(6)A)是真核生物RNA中最常见的表观遗传修饰方式。m^(6)A修饰通过改变RNA结构、RNA与RNA结合蛋白的相互作用,调控RNA剪接、亚细胞定位、翻译和稳定性等过程,保证基因及时准确的表达。研究表明,m^(6)A不仅在机体发育中发挥重要作用,其功能障碍通过改变细胞功能,参与多种疾病的发生。本文总结了m^(6)A修饰在哺乳动物生理发育与疾病发生中的功能和机制,以期为m^(6)A修饰进行转化研究和临床治疗应用提供理论依据。 | 谢梅英 侯连杰 | 2023 | 生命科学研究2023，27，5： | 0 |
| 13 | m^(6)A修饰在免疫系统中的研究进展显示文摘N^(6)-甲基腺嘌呤(N^(6)-methyladenosine,m^(6)A)修饰是RNA分子的转录后变化,m^(6)A最早是上世纪70年代在细胞mRNA上发现的,但直到全基因组m^(6)A定位方法发展后才被广泛研究。近年来m^(6)A在调节mRNA中的作用及其在各种细胞类型中的功能及其重要性已经得到了证实,m^(6)A调控多种生理过程中基因表达的机制研究也越来越多。此综述总结了最近一些关于m^(6)A修饰在免疫反应中的作用的研究进展,讨论了m^(6)A修饰在调节先天和适应性免疫反应以及免疫系统发育中的功能。 | 陈艺苒 范斌 | 2022 | 医学分子生物学杂志2022，19，3： | 0 |
| 14 | Research progress on the mechanism of N6-methylade-nosine methylation modification and proteolipid protein 1 gene in schizophrenia显示文摘Schizophrenia (SCZ) is a serious mental illness with unknown etiology, high recurrence rate and high disability rate, which has caused a great burden to individuals and society. There is no clear etiology and pathogenesis. Methylation of N6-methyladenosine (m6A) can regulate the nervous and mental system, and affect the function of the nervous system. Proteolipid protein 1 (PLP1) is a risk gene for schizophrenia. In this study we review the research progress on the pathogenesis of schizophrenia, m6A methylation, and PLP1 gene. | Zhilan Yang Hongying Pan Lan Jiang Tiankai Jiang Yinhang Li Jie Wu | 2022 | Journal of Translational Neuroscience2022，7，1： | 0 |
| 15 | ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells显示文摘ALKBH3,a demethylase responsible for demethylating N1-methyladenosine(m^(1)A)in mRNA and N1-methyldeoxyadenosine in single-stranded DNA,plays an important role in DNA repair and cancer cell proliferation.However,its function in hematopoietic stem cells(HSCs)is unknown.In this study,we generated Alkbh3 knockout mice and observed that the deletion of Alkbh3 does not impair the reconstitution capacity of HSCs in both primary and secondary transplantation.Aged hematopoietic stem and progenitor cells exhibit increased expression of ALKBH3.Forced ALKBH3 rescued the differentiation skewing without affecting the reconstitution capacity of aged HSCs.In brief,our study for the first time investigated the functional role of ALKBH3 in hematopoietic system,and observed that ALKBH3 is dispensable for HSCs maintenance and differentiation,but overexpression of ALKBH3 rectified the differentiation skewing of aged HSCs. | Hanqing He Yuqian Wang Jianwei Wang | 2020 | Blood Science2020，2，4： | 0 |
| 16 | YTH结构域家族蛋白在结直肠癌中的研究进展显示文摘N^(6)-甲基腺嘌呤(m^(6)A)甲基化修饰通过调控修饰RNA广泛参与多种生物学行为,其与结直肠癌的发生、发展、预后和治疗密切相关。YTH结构域家族蛋白(YTHDF)作为研究最深入的m^(6)A阅读蛋白,通过调控甲基化的RNA影响结直肠癌的进展。部分YTHDF分子通过调控肿瘤相关通路促进结直肠癌进展,而其他YTHDF分子可能抑制结直肠癌进展,且不同研究对同一种YTHDF分子的结论也不同。未来深入研究YTHDF作为新的肿瘤标志物的潜力将为结直肠癌的诊疗提供新思路。 | 周善一 姚添 张皓凡 马列 贾天航 黄河 | 2023 | 医学综述2023，29，16： | 0 |
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