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| 1 | Metal-free porous nitrogen-doped carbon nanotubes for enhanced oxygen reduction and evolution reactions显示文摘开发有效没有金属的双性人功能的 electrocatalysts 被要求减少费用并且改进慢氧减小反应(ORR ) 和氧进化反应(OER ) 在电气化学的系统的动力学。多孔的做 N 的碳 nanotubes (NCNT ) 被 KOH 激活和 polypyrrole nanotubes 的热分解制作。NCNT 拥有了超过 1,000 的一个大表面区域 ? m 2?g1 。NCNT electrocatalysts,特别地,那些在 900 点退火了 ? 椠 ? 捡楴楶祴猠慴敧 ? 湡 ? 祤慮業? 敭档湡獩 ??? 桴獩猠畴祤 ? 敷爠灥牯 ? 桴 ? 牁档慥? ㈨?? | Ting Pan Hongying Liu Guangyuan Ren Yunan Li Xianyong Lu Ying Zhu | 2016 | Science Bulletin2016，61，11： | 10 |
| 2 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 3 | SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants显示文摘RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and animals.However,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in plants.Here,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage worldwide.Pelota enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all potyvirids.This allows Pelota to target the virus and act as a viral restriction factor.Furthermore,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in planta.Blocking Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA degradation.These findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants. | Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li Hongying Shan Pan Gong Mingzhen Zhang Hao Li Aiming Wang Xueping Zhou Fangfang Li | 2023 | Molecular Plant2023，16，3： | 2 |
| 4 | Suppressive effect of modified Simiaowan on experimental gouty arthritis: An in vivo and in vitro study显示文摘 | Le Shi Li Xu Yanhua Yang Hengwen Song Hongying Pan Lian Yin | 2013 | Journal of Ethnopharmacology2013，，3： | 1 |
| 5 | Studying the mechanisms of titanium dioxide as ultraviolet-blocking additive for films and fabrics by an improved scheme显示文摘 | Hongying Yang Sukang Zhu Ning Pan | 2004 | Journal of Applied Polymer Science2004，92，5： | 1 |
| 6 | Studying the Mechanisms of Titanium Dioxide as Ultraviolet-Blocking Additive for Films and Fabrics by an Improved Scheme 显示文摘 | YANG Hongying ZHU Sukang PAN Ning | 2004 | Journal of Applied Polymer Science2004，92，5： | 1 |
| 7 | Expression of PEA3 and Lack of Correlation Between PEA3 and HER-2/neu Expression in Breast Cancer显示文摘 | Wei-Ya Xia Huang-Chun Lien Shao-Chun Wang Yung Pan Aysegul Sahin Yau-Hung Kuo King-Jeng Chang Xin Zhou Hongying Wang Zhengming Yu Gabriel Hortobagyi Dar-Ren Shi Mien-Chie Hung | 2006 | Breast Cancer Research and Treatment2006，，3： | 1 |
| 8 | Progress in the correlation between chronic insomnia disorder and cytokines显示文摘Chronic insomnia disorder(CID)is a relatively common clinical sleep disorder,which is es-sentially characterized by dissatisfaction with sleep due to frequent and persistent difficulties in falling asleep or maintaining sleep.The etiology and pathogenesis of CID are not fully understood.In the past decades,medical re-search has explored the interrelationship between cyto-kines(CKs)and sleep disorders,and this paper reviews the correlation between CID and inflammatory factors in the context of domestic and international research on the subject. | Juan Zhou Jun Zhao Hongying Pan Ye Ruan | 2022 | Journal of Translational Neuroscience2022，7，2： | 0 |
| 9 | Research progress on the relationship between proBDNF and alcohol dependence and its related cognitive impairment显示文摘Brain-derived neurotrophic factor(BDNF)plays an important role in the growth,develop-ment,differentiation,injury,repair,survival and apoptosis of nerve cells.Precursor of BDNF(proBDNF)is an im-portant regulator of neurodegeneration,long-term hippo-campal inhibition and synaptic plasticity.Alcohol depen-dence syndrome(ADS)is a group of chronic recurrent diseases with unknown etiology.Current studies believe that proBDNF plays an important role in the occurrence,development and outcome of ADS.Alcohol dependence patients,like other neurodegenerative diseases,will also have different degrees of cognitive impairment.This arti-cle reviews the research progress on the relationship be-tween BDNF,proBDNF,alcohol dependence and cogni-tive impairment. | Hongying Pan Lan Jiang Le Zhang Tiantian Jiang Tiankai Jiang Ye Ruan | 2022 | Journal of Translational Neuroscience2022，7，3： | 0 |
| 10 | Rapid divergent coevolution of Sinopotamon freshwater crab genitalia facilitates a burst of species diversification显示文摘One of the most striking radiations in brachyuran evolution is the considerable morphological diversification of the external reproductive structures of primary freshwater crabs:the male first gonopod(G1)and the female vulva(FV).However,the lack of quantitative studies,especially the lack of data on female genitalia,has seriously limited our understanding of genital evolution in these lineages.Here we examined 69 species of the large Chinese potamid freshwater crab genus Sinopotamon Bott,1967(more than 80%of the described species).We used a landmark-based geometric morphometric approach to analyze variation in the shape of the G1 and FV,and to compare the relative degree of variability of the genitalia with non-reproductive structures(the third maxillipeds).We found rapid divergent evolution of the genitalia among species of Sinopotamon when compared to non-reproductive traits.In addition,the reconstruction of ancestral groundplans,together with plotting analyses,indicated that the FV show the most rapid divergence,and that changes in FV traits correlate with changes in G1 traits.Here we provide new evidence for coevolution between the male and female external genitalia of Sinopotamon that has likely contributed to rapid divergent evolution and an associated burst of speciation in this lineage. | Fengxin YAO Boyang SHI Xiaoqi WANG Da PAN Ming BAI Jie YAN Neil CUMBERLIDGE Hongying SUN | 2020 | Integrative Zoology2020，15，3： | 0 |
| 11 | Progress in research on the relationship between autism and folate receptor autoantibody expression显示文摘Autism spectrum disorder(ASD)is a serious neurodevelopmental disorder,the etiology and mechanism of which are not yet clear.Studies have shown that folate deficiency can lead to abnormalities in the de-velopment of the central nervous system.Patients with autism spectrum disorders develop folate-alpha recep-tor autoantibodies.Folate-alpha receptor autoantibodies block folate transport,leading to a deficiency of folate in nerve tissues.Folate is effective in treating patients with folate-alpha receptor autoantibodies. | ZhilanYang Le Zhang Hongying Pan Kang Yang | 2021 | Journal of Translational Neuroscience2021，6，3： | 0 |
| 12 | Construction and validation of a risk-prediction model for anastomotic leakage after radical gastrectomy: A cohort study in China显示文摘Objectives:Anastomotic leakage(AL)stands out as a prevalent and severe complication following gastric cancer surgery.It frequently precipitates additional serious complications,significantly influencing the overall survival time of patients.This study aims to enhance the risk-assessment strategy for AL following gastrectomy for gastric cancer.Methods:This study included a derivation cohort and validation cohort.The derivation cohort included patients who underwent radical gastrectomy at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,from January 1,2015 to December 31,2020.An evidence-based predictor questionnaire was crafted through extensive literature review and panel discussions.Based on the questionnaire,inpatient data were collected to form a model-derivation cohort.This cohort underwent both univariate and multivariate analyses to identify factors associated with AL events,and a logistic regression model with stepwise regression was developed.A 5-fold cross-validation ensured model reliability.The validation cohort included patients from August 1,2021 to December 31,2021 at the same hospital.Using the same imputation method,we organized the validation-queue data.We then employed the risk-prediction model constructed in the earlier phase of the study to predict the risk of AL in the subjects included in the validation queue.We compared the predictions with the actual occurrence,and evaluated the external validation performance of the model using model-evaluation indicators such as the area under the receiver operating characteristic curve(AUROC),Brier score,and calibration curve.Results:The derivation cohort included 1377 patients,and the validation cohort included 131 patients.The independent predictors of AL after radical gastrectomy included age65 y,preoperative albumin<35 g/L,resection extent,operative time240 min,and intraoperative blood loss90 mL.The predictive model exhibited a solid AUROC of 0.750(95%CI:0.694e0.806;p<0.001)with a Brier score of 0.049.The 5-fold cross-validation confirmed these findings with a calibrated C-index of 0.749 and an average Brier score of 0.052.External validation showed an AUROC of 0.723(95%CI:0.564e0.882;p?0.006)and a Brier score of 0.055,confirming reliability in different clinical settings.Conclusions:We successfully developed a risk-prediction model for AL following radical gastrectomy.This tool will aid healthcare professionals in anticipating AL,potentially reducing unnecessary interventions. | Jinrui Wang Xiaolin Liu Hongying Pan Yihong Xu Mizhi Wu Xiuping Li Yang Gao Meijuan Wang Mengya Yan | 2024 | Laparoscopic, Endoscopic and Robotic Surgery2024，7，1： | 0 |
| 13 | Clinical Efficacy and Application Progress of Reduning Injection in Children with Viral Encephalitis显示文摘Viral encephalitis in children caused by multiple viral infections,as a common central nervous system disease in pediatrics,has a high incidence in China.Its clinical symptoms usually include infection,poisoning,intracranial hypertension,and disturbance of consciousness.In severe cases,it can even endanger the lives of patient children.At present,the clinical treatment of the viral encephalitis mainly uses traditional Chinese medicine preparations such as Reduning Injection.The efficacy is significant.It can not only relieve the uncomfortable symptoms in a short time,but also has low incidence of adverse reactions.In this study,the factors that cause viral encephalitis in children were analyzed,and the efficacy,pharmacological action and clinical application of Reduning Injection were comprehensively elaborated,to provide a reference for clinical doctors to rationally treat viral encephalitis in children. | Yuanyuan ZOU Hongying ZHANG Zhiyong XU Ziyi PAN Changsheng DENG Jianping SONG Qi WANG | 2021 | Medicinal Plant2021，12，2： | 0 |
| 14 | Numerical study of laser-induced collision process in Eu-Sr in strong field显示文摘Theoretically based on the four-level model, one LICET process in Eu-Sr system in both weak and strong fields was calculated by immediate numerical integrations. Numerical results in weak field are in fair to good agreement with analytical ones. Numerical results in strong field show that: (a) the peak of the LICET profiles moves to the violet side and the tuning range of the profiles obviously becomes narrower when the laser field intensity increases; and (b) numerical results in strong field differ a lot from analytical ones, which indicates that in strong field, the analytical expressions are not applicable any longer. | ZHANG Hongying XlAYuanqin CHEN Deying XIAO Pan FAN Rongwei MA Zuguang | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，1： | 0 |
| 15 | Why is the SARS-CoV-2 Omicron variant milder?显示文摘In November 2021,a new SARS-CoV-2 variant emerged in South Africa and was designated the fifth variant of concern and named Omicron.It was detected in more than 26 countries worldwide,including China.The Omicron variant is highly transmissible and has extensive morbidity,which has raised concerns related to antiviral therapy.Recent reports have revealed that the Omicron variant exhibits a longer cycle of viral shedding and a decreased replication capacity and results in substantially attenuated lung pathology,indicating that the pathogenic ability of the Omicron variant is lower than that of previous variants.1Omicron has the largest number(>30)of substitutions,deletions,or insertions,with a mutation frequency of higher than 1%in the spike(S)protein.Mutation studies of the spike protein receptor-binding domain have provided a plausible explanation for the increased transmissibility and antibody resistance of this variant.However,the molecular basis for its attenuated pathogenicity and replication capacity remains elusive. | Bingqing Xia Yi Wang Xiaoyan Pan Xi Cheng Hongying Ji Xiaoli Zuo Hualiang Jiang Jia Li Zhaobing Gao | 2022 | The Innovation2022，3，4： | 0 |
| 16 | Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia显示文摘Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal(HPA)axis.The LIM-homeobox gene 3(LHXS)and early growth response 1(EGR1)can affect pituitary function.Because the synapsin 2(SYN2)gene polymorphism regulates the activity of LHX3 and EGR1,it may cause the occurrence of schizophrenia.This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1,then to afiect the HPA axis. | Zhilan Yang Hongying Pan Lan Jiang Yuhang Liang Jie Wu | 2022 | Journal of Translational Neuroscience2022，7，1： | 0 |
| 17 | Research progress on the mechanism of N6-methylade-nosine methylation modification and proteolipid protein 1 gene in schizophrenia显示文摘Schizophrenia (SCZ) is a serious mental illness with unknown etiology, high recurrence rate and high disability rate, which has caused a great burden to individuals and society. There is no clear etiology and pathogenesis. Methylation of N6-methyladenosine (m6A) can regulate the nervous and mental system, and affect the function of the nervous system. Proteolipid protein 1 (PLP1) is a risk gene for schizophrenia. In this study we review the research progress on the pathogenesis of schizophrenia, m6A methylation, and PLP1 gene. | Zhilan Yang Hongying Pan Lan Jiang Tiankai Jiang Yinhang Li Jie Wu | 2022 | Journal of Translational Neuroscience2022，7，1： | 0 |
| 18 | Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia显示文摘Schizophrenia(SCZ)is a serious mental illness whose etiology and pathogenesis are not yet clear.The level of miRNA may be a crucial factor in the occurrence and development of SCZ.This study found that miR-495 may regulate the susceptibility gene of SCZ and that proteolipid protein 1(PLP1)as a risk gene for schizophrenia may be involved in its pathogenesis.In this article we review the research progress related to hsa-miR-495-3p(miR-495),PLP1,and schizophrenia. | Zhilan Yang Hongying Pan Lan Jiang Tiantian Jiang Jie Wu | 2022 | Journal of Translational Neuroscience2022，7，1： | 0 |
| 19 | Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the future.Human exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018). | Yabin Hu Jun Chen Jing Yang Zhanpeng Liu Xiaoyue Zhang Qian Wu Lulu Liu Shishan Teng Rongzhang He Bo Liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei Liu Xiaowang Qu | 2024 | Virologica Sinica2024，39，1： | 0 |
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