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| 1 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 2 | Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19:A retrospective cohort study显示文摘Objective:Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019(COVID-19).Tanreqing Capsule(TRQC)was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center.This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19.Methods:A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19;patients were treated with TRQC in one designated hospital.The treatment and control groups consisted of 25 and 57 cases,respectively.The treatment group was given TRQC orally three times a day,three pills each time,in addition to conventional Western medicine treatments which were also administered to the control group.The clinical efficacy indicators,such as the negative conversion time of pharyngeal swab nucleic acid,the negative conversion time of fecal nucleic acid,the duration of negative conversion of pharyngeal-fecal nucleic acid,and the improvement in the level of immune indicators such as T-cell subsets(CD3,CD4 and CD45)were monitored.Results:COVID-19 patients in the treatment group,compared to the control group,had a shorter negative conversion time of fecal nucleic acid(4 vs.9 days,P=0.047)and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid(0 vs.2 days,P=0.042).The level of CD3+T cells increased in the treatment group compared to the control group([317.09±274.39]vs.[175.02±239.95]counts/l L,P=0.030).No statistically significant differences were detected in the median improvement in levels of CD4+T cells(173 vs.107 counts/l L,P=0.208)and CD45+T cells(366 vs.141 counts/l L,P=0.117)between the treatment and control groups.Conclusion:Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group,illustrating the potential therapeutic benefits of using TRQC as a complement to conventional medicine in patients with mild and moderate COVID-19.The underlying mechanism may be related to the improved levels of the immune indicator CD3+T cells. | Xing Zhang Yan Xue Xuan Chen Jia-min Wu Zi-jian Su Meng Sun Lu-jiong Liu Yi-bao Zhang Yi-le Zhang Gui-hua Xu Miao-yan Shi Xiu-ming Song Yun-fei Lu Xiao-rong Chen Wei Zhang Qi Chen | 2021 | Journal of Integrative Medicine2021，19，1： | 8 |
| 3 | Network pharmacology studies on the effect of Chai-Ling decoction incoronavirus disease 2019显示文摘Background:Chai-Ling decoction(CLD),derived from a modification of Xiao-Chai-Hu(XCH)decoction and Wu-Ling-San(WLS)decoction,has been used to treat the early-stage of coronavirus disease 2019(COVID-19).However,the mechanisms of CLD in COVID-19 remain unknown.In this study,the potential mechanisms of CLD in COVID-19 were preliminarily investigated based on network pharmacology and molecular docking method.Methods:Initially,the active components and targets of CLD were screened based on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper database.The targets of COVID-19 were obtained from GeneCards database.The protein-protein interaction network was established using STRING database to analyze the key targets.Gene Oncology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes analysis were also conducted to evaluate the pathways related to the targets of CLD on COVID-19.Moreover,the compound-target-pathway network was established using Cytoscape 3.2.7.Subsequently,the molecular docking method was performed to select the active compounds with high binding affinity on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and angiotensin-converting enzyme 2(ACE2),which is the key target of SARS-CoV-2 in entering target cells.The possible binding sites were also visualized by a three-dimensional graph.Results:Network pharmacology analysis showed that there were 106 active components and 160 targets of CLD.Additionally,251 targets related to COVID-19 were identified,and 24 candidates of CLD on COVID-19 were selected.A total of 283 GO terms of CLD on COVID-19 were identified,and 181 pathways were screened based on GO and Kyoto Encyclopedia of Genes and Genomes analyses.CLD might alleviate the inflammatory response and improve lung injury to treat COVID-19 through interleukin 17 signaling,T helper cell 17 differentiation,tumor necrosis factor signaling,and hypoxia inducible factor-1 signaling.Besides,molecular docking indicated that beta-sitosterol,kaempferol,and stigmasterol were the top three candidates in CLD with the highest affinity to SARS-CoV-2 and ACE2.Conclusion:Our study identifies the potential mechanisms of CLD on COVID-19 and beta-sitosterol,kaempferol,and stigmasterol may be the key compounds that exert antiviral effects against SARS-CoV-2. | Lu Yang Yu-Ting Li Jing Miao Li Wang Hui Fu Qin Li Wei-Bo Wen Zhai-Yi Zhang Rui-Wen Song Xiang-Guo Liu Hong-Wu Wang Huan-Tian Cui | 2020 | Traditional Medicine Research2020，5，3： | 4 |
| 4 | 从中医“食复”理论谈外感热病初愈饮食调理显示文摘预防食复是外感热病康复中的一个关键环节,也是中医食疗学中的一个重要内容。中医食复理论的“食肉则复,多食则遗”提示了热病后要注意忌食腥膻肥甘、切莫骤然盲进,更强调了“贵得所宜”的原则,并提倡通过药食同源的思想进行“辨证施食”,其理论对外感热病康复中的饮食调理起到重要作用。 | 张旭 佟丽 袁怿 栗琼洋 马艳新 | 2021 | 环球中医药2021，14，3： | 4 |
| 5 | Traditional Chinese and Western Medicines Jointly Beat COVID-19 Pandemic显示文摘The novel coronavirus disease(COVID-19)infection has been spreading for more than 2 months since it broke out early 2020.(1)The alarming levels of spread and severity have made this virus characterized as a pandemic which has been affecting at least 200 countries,areas or territories around the world.And 1051,635 cases and 56,985 deaths were confirmed by 10:00 CET April 4,2020. | QING Guang-chao ZHANG Hong BAI Yang LUO Yang | 2020 | Chinese Journal of Integrative Medicine2020，26，6： | 4 |
| 6 | 质量4.0技术有助提升中医药在新冠肺炎期间应对医疗保健挑战显示文摘质量4.0的概念源自第四次工业革命,即工业4.0。质量4.0是质量的未来,新兴数字化和颠覆性技术被用来保持组织的质量,其同样适合保持中医药的质量。这场质量革命目的在于通过整合新兴技术将物理系统与自然界联系起来,从而提高工业和服务部门的质量。所提出的数字化理念可以革新和增强整个中医药治疗方法论,使其在目前制药和临床行业的竞争结构中变得更加有效且更具吸引力。因而,在医疗保健领域,这场革命在新冠肺炎大流行期间可提升治疗质量。在大流行期间,医疗保健领域的一个基本要求是保持医疗工具、设备及治疗过程的质量。数字技术可以广泛用于为中医药提供高质量的创新产品和服务。在本文中,我们探讨了质量4.0的重要作用,以及如何在大流行期间用它来保持医疗保健的质量及应对挑战。同时,我们讨论了新冠肺炎大流行期间质量4.0在医疗保健领域的主要应用。这些技术将为在整个治疗过程中保持中医药质量提供独特的优势。借助质量4.0,可以应用创新和先进的数字技术来保证质量。 | Abid Haleem Mohd Javaid Ravi Pratap Singh Rajiv Suman | 2021 | Digital Chinese Medicine2021，4，2： | 1 |
| 7 | India’s indigenous idea of herd immunity:the solution for COVID-19?显示文摘Note:Shepherds in rural India are performing the herd immunity for their livestock with the help of herbal produces in order to prevent the virus-causing epidemics.They attenuate the virulence of virus with help of leaf juice extracted from Amma Talli plant before inoculation or viriolation.This photograph was taken at Urumadla-Ramchandrapur village of Siddipet district in Telangana State,India in May,2020.Bheenaveni Rajaiah(left)and his son Bheenaveni Laxman(right)are conducting the viriolation to the uninfected sheep to achieve herd immunity. | Ram Shepherd Bheenaveni | 2020 | Traditional Medicine Research2020，5，4： | 0 |
| 8 | Chinese Medicine,Which Targets Body's Response State,Is An Effective Way to Treat Epidemic Infectious Diseases显示文摘In the fight against epidemic infectious diseases in the past 2,000 years,Chinese medicine(CM)has gradually developed a complete response system including diagnosis and treatment.The focal point of CM in the treatment of infectious diseases is the personalized response state to pathogen,which is a treatment method consistent with the personalized concept of precision medicine.Compared with the methods of directly killing or inactivating pathogens,which are used in modern medicine,CM is an effective treatment modality that has a wider range of points of action in the human body.The remarkable effects achieved while treating SARS in 2003 and the current coronavirus disease 2019(COVID-19)pneumonia and the history of the effective responses to epidemics in the past 2,000 years have fully demonstrated the effectiveness of CM in treating infectious diseases.This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods,which will reacquaint the world with CM.The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases. | YUAN Bing | 2022 | Chinese Journal of Integrative Medicine2022，28，2： | 0 |
| 9 | Xiaochaihu decoction alleviates viral pneumonia by regulating macrophage polarization显示文摘Background:In this investigation,we sought to evaluate the benefits of Xiaochaihu decoction(XCHD)on polyinosinic:polycytidylic acid-induced viral pneumonia in mice and elucidate its mechanisms of action.Method:A viral pneumonia model was established in mice using polyinosinic:polycytidylic acid,with mice being intragastrically administered different doses of XCHD.The benefits of XCHD therapy for mice with viral pneumonia were assessed by determining the weight ratio of lung tissue,wet-to-dry,overall protein concentrations,and total cell counts in bronchoalveolar lavage fluid,and hematoxylin and eosin staining of lung tissues.By determining the interleukin-1βlevels,interleukin-6,tumor necrosis factor-alpha,nitric oxide,interleukin-10,and interleukin-4,and the mRNA and protein expression of nitric oxide synthase 2,arginase-1,and macrophage mannose receptor 1 in bronchoalveolar lavage fluid,we assessed consequences of XCHD on macrophage polarization with mice suffering from viral pneumonia.Results:XCHD was found to significantly reduce lung tissue wet-to-dry and the total protein content and total number of cells of bronchoalveolar lavage fluid,while ameliorating pathological modifications to the lung tissues of rodents suffering from viral pneumonia,thereby indicating that this medicinal preparation has a healing impact on model mice with viral pneumonia.In addition,XCHD was found to reduce the magnitudes of interleukin-1β,interleukin-6,tumor necrosis factor-alpha,and nitric oxide and the mRNA and protein manifestation of nitric oxide synthase 2,and promote an increase in the levels of interleukin-10 and interleukin-4 and the mRNA and protein expression of arginase-1 and macrophage mannose receptor 1,thereby indicating that XCHD can favorably mediate polarization of macrophages in mice with viral pneumonia.Conclusion:XCHD has notable therapeutic effects on viral pneumonia in mice,the fundamental workings of action of which may be connected to regulation of macrophage polarization. | Feng Chen Fei Qu Yu-Long Shi Feng Zhang | 2023 | Integrative Medicine Discovery2023，7，34： | 0 |
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