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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis显示文摘 | Yi Tian Weibing Yang Jianxun Song Yuzhang Wu Bing Ni | 2013 | Molecular and Cellular Biology2013，，15： | 6 |
| 3 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 4 | Reconstruction clipping of ruptured anterior circulation aneurysms via supraorbital lateral keyhole approach显示文摘Background:Intracranial aneurysm(IA)is a serious disease.Analyze and review the cases of anterior circulation ruptured IA by supraorbital lateral keyhole approach,and summarize the experiences of this approach.Methods:Retrospective analysis of 16 cases of ruptured anterior circulation IA in our department from January 2019 to June 2020,CT angiography(CTA)was performed before operation.Analyzing the IA’s parameters by 3D-CT reconstruction.The IA was clipped by supraorbital lateral keyhole approach combined with the 3D-skull reconstruction.Extraventricular drainage was performed before craniotomy.Intraoperative neurophysiological monitoring was performed during the operation.After operation,fluorescein angiography and vascular ultrasound were performed to check the clipping effect.Intracranial pressure monitor was performed postoperatively.CTA was reexamined one week after operation.The modified Rankin Scale(MRS)was performed 6 months after operation.Results:There were 7 males(43.8%)and 9 females(56.2%),and the average age is 52.31±11.12 years old.Among them,11 patients(68.8%)were anterior communicating artery aneurysms and 5(31.2%)were middle cerebral artery aneurysms.All patients were out of hospital within 10 days without any death,without cerebral infarction,cerebrospinal fluid leakage and neurological impairments.About mRS score,after 6 months follow-up,8 cases(50%)had 0 point,4 cases(25%)had 1 point,and 4 cases(25%)had 2 points.Conclusions:For ruptured anterior circulation IA,the supraorbital lateral keyhole approach combined with ventricular drainage,intraoperative electrophysiological monitoring,and intraoperative vascular ultrasound is a safe and minimally invasive treatment.The application of reconstruction clipping can reconstruct the diameter of parent vessel and reduce the recurrence rate of IA. | Yuzhang Wu Yan Zhao Shengping Yu Fan Li Shifei Cai Chao Peng Zhen Wang Yifan Yang Bangyue Wang Xinyu Yang | 2022 | Chinese Neurosurgical Journal2022，8，2： | 2 |
| 5 | CD49a^(+)CD49b^(+) NK cells induced by viral infection reflect an activated state of conventional NK cells显示文摘Natural killer(NK) cells are important innate effectors that play a pivotal role in the defense against tumors and infections and participate in regulating adaptive immunity. Recent studies have revealed phenotypic and functional heterogeneity of NK cells.Here, using murine models of acute and chronic lymphocytic choriomeningitis virus infection, we observed that a CD49a^(+)CD49b^(+) NK cell subset emerged in the liver and other tissues, and underwent vigorous expansion following viral infection,before progressively decreasing in cell number. These viral infection-induced CD49a^(+)CD49b^(+) NK cells displayed an activated and mature phenotype. Moreover, compared with liver-resident NK cells and conventional NK(cNK) cells, CD49a^(+)CD49b^(+) NK cells showed increased functional competence, as evidenced by higher amounts of IFN-γ production and stronger cytotoxic capabilities during viral infection. Generation of these CD49a^(+)CD49b^(+) NK cells was shown to be independent of the T-bet transcription factor. Adoptive transfer experiments revealed that c NK cells could convert into CD49a^(+)CD49b^(+) NK cells following viral infection. Collectively, these results suggest that viral infection-induced CD49a^(+)CD49b^(+) NK cells represent a transiently activated state of cNK cells. | Wenhan Li Jing Zhou Xianwei Wang Yuzhang Wu Lilin Ye Haiming Wei Rui Sun Zhigang Tian Hui Peng | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 6 | Increased CD4 + CD25 + FoxP3 + regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization显示文摘 | Zhao Yang Li Wang Wei Niu Gang Meng YuZhang Wu JingBo Zhang | 2007 | Clinical Immunology2007，，2： | 1 |
| 7 | Transcellular distribution heterogeneity of Annexin A5 represents a protective response to lupus-related thrombophilia: A pilot Proteomics-based study显示文摘 | Di Zhou Na Luo Qiao Wu Yi You Zhifang Zhai Zhirong Mou Yuzhang Wu Fei Hao | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 8 | Identification of leukemia-associated antigens in chronic myeloid leukemia by proteomic analysis显示文摘 | Zou Liyun Wu Yuzhang Pei Li | 2005 | Leuk Res2005，29，： | 1 |
| 9 | Frequencies of epitope-specific cytotoxic T lymphocytes in active chronic viral hepatitis B infection by using MHC class Ⅰpeptide tetramers显示文摘 | WU Yuzhang ZHANG Jinbo CHEN Shiyuan | 2004 | Immunol Lett2004，92，3： | 1 |
| 10 | Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine显示文摘 | WAN Ying WU Yuzhang BIAN Jiang | 2001 | Vaccine2001，19，2022： | 1 |
| 11 | An altered CD8^(+) T cell epitope of insulin prevents type 1 diabetes in humanized NOD mice显示文摘Autoreactive CD8^(+)T cells,which play an indispensable role inβcell destruction,represent an emerging target for the prevention of type 1 diabetes(T1D).Altered peptide ligands(APLs)can efficiently induce antigen-specific T cells anergy,apoptosis or shifts in the immune response.Here,we found that HLA-A*0201-restricted CD8^(+)T cell responses against a primaryβ-cell autoantigen insulin epitope InsB15–14 were present in both NOD.β2m null.HHD NOD mice and T1D patients.We generated several APL candidates for InsB15–14 by residue substitution at the p6 position.Only H6F exhibited an inhibitory effect on mInsB1_(5–14)-specific CD8^(+)T cell responses in vitro.H6F treatment significantly reduced the T1D incidence,which was accompanied by diminished autoreactive CD8^(+)T cell responses to mInsB15-14,inhibited infiltration of CD8^(+)and CD4^(+)T cells in the pancreas and reduced pro-inflammatory cytokine production in pancreatic and splenic T cells in NOD.β2m^(null).HHD mice.Mechanistically,H6F treatment significantly augmented a tiny portion of CD8^(+)CD25^(+)Foxp3^(+)T cells in the spleen and especially in the pancreas.This subset exhibited typical Treg phenotypes and required peptide-specific restimulation to exert immunosuppressive activity.Therefore,this APL H6F may be a promising candidate with potential clinical application value for antigen-specific prevention of T1D. | Mengjun Zhang Shufeng Wang Binbin Guo Gang Meng Chi Shu Wenli Mai Qian Zheng Xiaoling Chen Yuzhang Wu Li Wang | 2019 | Cellular & Molecular Immunology2019，16，6： | 1 |
| 12 | Identification and modification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from Ran antigen显示文摘 | Fan Li Di Yang Yiqin Wang Baohua Liu Yijing Deng Li Wang Xiaoyun Shang Weidong Tong Bing Ni Yuzhang Wu | 2009 | Cancer Immunology Immunotherapy2009，，12： | 1 |
| 13 | Intrahepatic Expression of Programmed Death-1 and its Ligands in Patients with HBV-Related Acute-on-Chronic Liver Failure显示文摘 | Dayan Cao Huan Xu Guoning Guo Zhihua Ruan Lei Fei Zhunyi Xie Yuzhang Wu Yongwen Chen | 2013 | Inflammation2013，，1： | 1 |
| 14 | An altered peptide ligand for na?ve cytotoxic T lymphocyte epitope of TRP-2(180–188) enhanced immunogenicity显示文摘 | Yan Tang Zhihua Lin Bing Ni Jing Wei Junfeng Han Huiming Wang Yuzhang Wu | 2007 | Cancer Immunology Immunotherapy2007，，3： | 1 |
| 15 | Induced B7-H1 expression on human renal tubular epithelial cells by the sublytic terminal complement complex C5b-9显示文摘 | Yongwen Chen Jingbo Zhang Guoning Guo Zhihua Ruan Man Jiang Shengxi Wu Sheng Guo Lei Fei Yuyu Tang Chengying Yang Zhengcai Jia Yuzhang Wu | 2008 | Molecular Immunology2008，，3： | 1 |
| 16 | The role of microRNAs in B-cell development and function显示文摘MicroRNA (miRNA ) 调停了在翻译水平的基因 silencing 为众多的生物过程导致了新奇发现。最近,在那里一直在增加证据显示 miRNAs 涉及正常有免疫力的功能和发炎。在这评论,我们在 B 房间开发,区别, apoptosis 和功能在阐明了的最近的进展上集中 miRNAs 的角色。当在控制并且维持 B 房间命运的 miRNAs 的规章的机制大部分仍然是 uncharacterized 时,在 miRNAs 和他们的目标愿望增加上推进研究我们 B 房间开发和功能的理解。如此的研究也许能为治疗自体免疫的疾病提供新治疗学的策略。 | Jingyi Li Ying Wan Qing Ji Yongfei Fang Yuzhang Wu | 2013 | Cellular & Molecular Immunology2013，10，2： | 1 |
| 17 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 18 | Pivotal roles of the interleukin‐23/T helper 17 cell axis in hepatitis B显示文摘 | Zemin Huang Jennifer C. Velkinburgh Bing Ni Yuzhang Wu | 2012 | Liver Int2012，，6： | 1 |
| 19 | Use of a novel electrotopological descriptor for the prediction of biological activity of peptide analogues显示文摘 | Lin Zhihua Wu Yuzhang Quan Xuejun | 2002 | Letters in Peptide Science2002，9，： | 1 |
| 20 | The fire-retardant properties of the melamine-modified urea-formaldehyde resins mixed with ammonium polyphosphate 显示文摘 | MA Xingxia WU Yuzhang ZHU Hailong | 2013 | J Wood Sci2013，59，5： | 1 |
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