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| 1 | In vitro and in vivo degradation behavior of Mg-2Sr-Ca and Mg-2Sr-Zn alloys显示文摘Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated.Compared with the binary Mg-2Sr alloys,the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance.Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation.The in vivo corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr.The in vitro cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy.Furthermore,these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential. | Kai Chen Xinhui Xie Hongyan Tang Hui Sun Ling Qin Yufeng Zheng Xuenan Gu Yubo Fan | 2020 | Bioactive Materials2020，5，2： | 6 |
| 2 | A review on magnesium alloys as bio- degradable materials显示文摘 | Xuenan Gu Yufeng Zheng | 2010 | Frontiers Materials Science2010，4，6： | 1 |
| 3 | Photocrosslinkable Col/PCL/Mg composite membrane providing spatiotemporal maintenance and positive osteogenetic effects during guided bone regeneration显示文摘Guided bone regeneration membranes have been effectively applied in oral implantology to repair bone defects.However,typical resorbable membranes composed of collagen(Col)have insufficient mechanical properties and high degradation rate,while non-resorbable membranes need secondary surgery.Herein,we designed a photocrosslinkable collagen/polycaprolactone methacryloyl/magnesium(Col/PCLMA/Mg)composite membrane that provided spatiotemporal support effect after photocrosslinking.Magnesium particles were added to the PCLMA solution and Col/PCLMA and Col/PCLMA/Mg membranes were developed;Col membranes and PCL membranes were used as controls.After photocrosslinking,an interpenetrating polymer network was observed by scanning electron microscopy(SEM)in Col/PCL and Col/PCL/Mg membranes.The elastic modulus,swelling behavior,cytotoxicity,cell attachment,and cell proliferation of the membranes were evaluated.Degradation behavior in vivo and in vitro was monitored according to mass change and by SEM.The membranes were implanted into calvarial bone defects of rats for 8 weeks.The Col/PCL and Col/PCL/Mg membranes displayed much higher elastic modulus(p<0.05),and a lower swelling rate(p<0.05),than Col membranes,and there were no differences in cell biocompatibility among groups(p>0.05).The Col/PCL and Col/PCL/Mg membranes had lower degradation rates than the Col membranes,both in vivo and in vitro(p<0.05).The Col/PCL/Mg groups showed enhanced osteogenic capability compared with the Col groups at week 8(p<0.05).The Col/PCL/Mg composite membrane represents a new strategy to display space maintenance and enhance osteogenic potential,which meets clinical needs. | Feilong Wang Dandan Xia Siyi Wang Ranli Gu Fan Yang Xiao Zhao Xuenan Liu Yuan Zhu Hao Liu Yongxiang Xu Yunsong Liu Yongsheng Zhou | 2022 | Bioactive Materials2022，7，7： | 1 |
| 4 | A surface-eroding poly(1,3-trimethylene carbonate)coating for magnesium based cardiovascular stents with stable drug release and improved corrosion resistance显示文摘Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent application.Drug-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis simultaneously.In this paper,poly(trimethylene carbonate)(PTMC)with different molecular weight(50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35)was applied as drug-eluting coatings on magnesium alloys.A conventional antiproliferative drug,paclitaxel(PTX),was incorporated in the PTMC coating.The adhesive strength,corrosion behavior,drug release and biocompatibility were investigated.Compared with the PLGA control group,PTMC coating was uniform and gradually degraded from surface to inside,which could provide long-term protection for the magnesium substrate.PTMC35 coated samples exhibited much slower corrosion rate 0.05μA/cm^(2)in comparison with 0.11μA/cm^(2)and 0.13μA/cm^(2)for PLGA and PTMC5 coated counterparts.In addition,PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle cells.Hemocompatibility test indicated that few platelets were adhered on PTMC5 and PTMC35 coatings.PTMC35 coating,exhibiting surface erosion behavior,stable drug release and good biocompatibility,could be a good candidate as a drug-eluting coating for magnesium-based stent. | Hongyan Tang Shuangshuang Li Yuan Zhao Cunli Liu Xuenan Gu Yubo Fan | 2022 | Bioactive Materials2022，7，1： | 1 |
| 5 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Xuenan Gu Yufeng Zheng Yan Cheng Shengping Zhong Tingfei Xi | 2008 | Biomaterials2008，，4： | 1 |
| 6 | Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses显示文摘 | Gu Xuenan Zheng Yufeng Zhong Shengping | 2010 | Biomaterials2010，31，： | 1 |
| 7 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Gu Xuenan Zheng Yufeng Cheng Yan | 2009 | Biomaterials2009，30，： | 1 |
| 8 | Corrosion of, and cellular responses to Mg–Zn–Ca bulk metallic glasses显示文摘 | Xuenan Gu Yufeng Zheng Shengping Zhong Tingfei Xi Junqiang Wang Weihua Wang | 2009 | Biomaterials2009，，6： | 1 |
| 9 | A review on magnesium alloys as biodegradable materials显示文摘 | GU Xuenan ZHENG Yufeng | | 0，，02： | 1 |
| 10 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Xuenan Gu Yufeng Zheng Yan Cheng Shengping Zhong Tingfei Xi | 2008 | Biomaterials2008，，4： | 1 |
| 11 | In vitro corrosion and biocompatibility of binary magnesium alloys 显示文摘 | Gu Xuenan Zheng Yufeng Cheng Yan | 2009 | Biornaterials2009，30，4： | 1 |
| 12 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Gu Xuenan Zheng Yufeng Cheng Yan | 2009 | Biomaterials2009，30，： | 1 |
| 13 | Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials显示文摘Over the past two decades,biodegradable metals(BMs)have emerged as promising materials to fabricate temporary biomedical devices,with the purpose of avoiding potential side effects of permanent implants.In this review,we first surveyed the current status of BMs in neuroscience,and briefly summarized the representative stents for treating vascular stenosis.Then,inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents,we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke.For these novel applications,some key factors should also be considered in designing BM brain stents,including the anatomic features of the cerebral vasculature,hemodynamic influences,neuro-cytocompatibility and selection of alloying elements.This work may provide insights into the future design and fabrication of BM neurological devices,especially for brain stents. | Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang Xuenan Gu Ang Li Jiancheng Fang Xunming Ji | 2022 | Bioactive Materials2022，7，5： | 0 |
| 14 | In vitro and in vivo evaluation of micro-alloyed magnesium for potential application in alveolar bone fixation screws显示文摘Alveolar bone augmentation with fixation screws has difficulties such as non-degradable materials that could lead to secondary surgery and insufficient osseointegration due to the subgingival environment in dental practice.With degradability and a high degree of osteogenesis,Mg alloy is a successful biodegrad-able material for orthopedic applications,and its application in dentistry has made certain progress.How-ever,considering the unique subgingival healing properties of oral implants,there is still a gap between the desired material properties for clinical applications and available materials.Indeed,studies on the use of Mg-based fixation screws for dentistry applications are still rare.In this study,we reported a magnesium alloy with low combined addition of strontium and lanthanum.The mechanical properties,degradation behavior,osteogenesis,and gingival compatibility were systematically investigated for assess-ing its potential application in alveolar bone fixation screws.With the alloying element content restricted to 0.3 wt.%,Mg-Sr-La alloy still exhibited good mechanical properties,with yield tensile and compressive strength twice higher than those of pure Mg.The in vitro degradation rate of this alloy was 0.10 mm y-1,which was slightly slower than high-purity Mg.The indirect and direct cell assay confirmed the elevated osteoblastic differentiation of MC3T3-E1 and migration of HGF-1 cells.Moreover,Mg-Sr-La alloy demon-strated a relatively slow degradation in the maxillary bone of Beagles.A remarkable promotion of the bone-implant contacts and significantly decreased fibrous encapsulation was observed in the subgingival environment,implying superior osseointegration of the experimental alloy than the titanium control.The empirical findings here reveal the great potential of Mg-Sr-La alloy for the application in alveolar bone fixation devices. | Hongyan Tang Qing Li Min Li Xuenan Gu Chengkung Cheng Yubo Fan | 2023 | Journal of Materials Science & Technology2023，，13： | 0 |
| 15 | Fluid-induced corrosion behavior of degradable zinc for stent application显示文摘The influence of laminar flow on the corrosion of pure zinc(Zn) and cell response was investigated and compared with the static measurements.The results revealed that laminar flow accelerated the corrosion and enhanced the localized corrosion of pure Zn.The dynamic corrosion rate was 0.184 mm/yr after 168 h corrosion.More corrosion products were formed under flow condition,which were mainly composed of Zn_(3)(PO_(4))_(2)·4 H_(2) O,Ca_(3)(PO_(4))_(2),ZnO and Zn_(5)(OH)_(6)(CO_(3))_(2).Moreover,the adhered rat aortic endothelial cells(RAEC) on Zn samples exhibited notably cell loss and round configuration under laminar flow. | Kai Chen Xuenan Gu Hui Sun Hongyan Tang Hongtao Yang Xianghui Gong Yubo Fan | 2021 | Journal of Materials Science & Technology2021，，32： | 0 |
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