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| 1 | Assessment of the individual and combined effects of Rht8 and Ppd-D1a on plant height, time to heading and yield traits in common wheat显示文摘Grain yield in cereal crops is a complex trait controlled by multiple genes and influenced by developmental processes and environment. Here we report the effects of alleles Rht8 and Ppd-D1 a on plant height, time to heading, and grain yield and its component traits. Association analysis and quantitative trait locus mapping using phenotypic data from 15 environments led to the following conclusions. First, both Rht8 and Ppd-D1 a reduce plant height. However, Ppd-D1 a but not Rht8 causes earlier heading.Second, both Rht8 and Ppd-D1 a promote grain yield and affect component traits. Their combined effects are substantially larger than those conferred by either allele alone.Third, promotion of grain yield by Rht8 and Ppd-D1 a is through increasing fertile spikelet number. We speculate that Rht8 and Ppd-D1 a act independently and additively in control of plant height, grain yield and yield component. Combination of the two alleles is desirable for adjusting plant height and enhancing grain yield and abiotic stress tolerance. | Kunpu Zhang Junjun Wang Huanju Qin Zhiying Wei Libo Hang Pengwei Zhang Matthew Reynolds Daowen Wang | 2019 | The Crop Journal2019，7，6： | 5 |
| 2 | Mapping epistasis and environment × QTX interaction based on four-omics genotypes for the detected QTX loci controlling complex traits in tobacco显示文摘Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation. | Liyuan Zhou Ruiyuan Li Longjiang Fan Yuewei Shi Zhihong Wang Shengdong Xie Yijie Gui Xueliang Ren Jun Zhu | 2013 | The Crop Journal2013，1，2： | 4 |
| 3 | A multivariate partial least squares approach to joint association analysis for multiple correlated traits显示文摘Many complex traits are highly correlated rather than independent. By taking the correlation structure of multiple traits into account, joint association analyses can achieve both higher statistical power and more accurate estimation. To develop a statistical approach to joint association analysis that includes allele detection and genetic effect estimation, we combined multivariate partial least squares regression with variable selection strategies and selected the optimal model using the Bayesian Information Criterion(BIC). We then performed extensive simulations under varying heritabilities and sample sizes to compare the performance achieved using our method with those obtained by single-trait multilocus methods. Joint association analysis has measurable advantages over single-trait methods, as it exhibits superior gene detection power, especially for pleiotropic genes. Sample size, heritability,polymorphic information content(PIC), and magnitude of gene effects influence the statistical power, accuracy and precision of effect estimation by the joint association analysis. | Yang Xu Wenming Hu Zefeng Yang Chenwu Xu | 2016 | The Crop Journal2016，4，1： | 3 |
| 4 | Genetic diversity and association analyses of fruit traits with microsatellite ISSRs in Sapindus显示文摘Sapindus mukorossi Gaertn. and S. delavayi Franchet are among the most valuable species in the genus Sapindus for their commercially exploitable plant oils and chemicals. However, few studies have addressed genetic variation and improvement for either species. We evaluated the genetic diversity of germplasm from selected plus trees within a wide region and established the relationship between fruit traits and molecular markers. An association analysis based on inter-simple sequence repeats(ISSRs)provided a genetic basis for studies of fruit traits. A total of 247 loci were detected by scanning 61 trees of S. mukorossi and S. delavayi using 16 ISSR markers. Genetic diversity parameters were estimated for selected superior trees(or germplasm) and S. mukorossi and S. delavayi were categorized into two main groups, as well as into four groups within S. mukorossi. An association analysis between the ISSR markers and 14 fruit traits used the TASSEL MLM model. A genetic structure analysis differentiated S.mukorossi and S. delavayi. Eighteen ISSR loci associated with 13 fruit traits(P<0.005) were identified, with 13, 1,and 4 loci associated with seed oil production, fruit saponin production, and fruit quality, respectively. Using this information, a core collection was selected with adequate genetic diversity and good seed oil characters. Our results demonstrate the feasibility of effectively estimating fruit trait associations in Sapindus using ISSR markers, and the method is applicable and valuable for select germplasm conservation. The markers obtained in this study are potentially useful for molecular-assisted breeding of Sapindus spp. | Caowen Sun Liming Jia Benye Xi Jiming Liu Lianchun Wang Xuehuang Weng | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 5 | Genetics of coronary heart disease with reference to ApoAICⅡI-AIV gene region显示文摘Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease(CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. Molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific 'candidate genes', which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CⅡI-AIV gene clusters have been discussed. | Suraksha Agrawal Sarabjit Mastana | 2014 | World Journal of Cardiology2014，6，8： | 2 |
| 6 | Vacuolar invertase genes SbVIN1 and SbVIN2 are differently associated with stem and grain traits in sorghum (Sorghum bicolor)显示文摘In higher plants, vacuolar invertases play essential roles in sugar metabolism, organ development, and sink strength. In sorghum(Sorghum bicolor), two vacuolar invertase genes,Sb VIN1(Sobic. 004 G004800) and Sb VIN2(Sobic. 006 G160700) have been reported, but their enzymatic properties and functional differences are largely unknown. We combined molecular, biochemical and genomic approaches to investigate their roles in sorghum stem and grain traits. Sb VIN1 and Sb VIN2 showed different expression levels in internodes,leaves, and panicles, indicating that their importance in each organ was different. In an in vitro sucrose hydrolysis assay, proteins of both genes heterologously expressed in Pichia pastoris displayed similar enzyme properties including the same optimum reaction p H(5)and similar Kmfor sucroe(49 mmol L-1 and 45 mmol L-1 for Sb VIN1 and Sb VIN2,respectively). The optimum reaction temperatures of Sb VIN1 and Sb VIN2 were 45 °C and65 °C, respectively. Sb VIN2 showed higher tolerance to high temperature than Sb VIN1. We characterized the sequence variation of these two vacuolar invertase genes in a panel of 216 diverse inbred lines of sweet and grain sorghum and performed gene-based association analysis. Sb VIN1 showed significant associations with stem traits including stem length,stem diameter, internode number, stem fresh weight, and Brix, as well as grain traits including hundred-grain weight and grain width. Significantly associated variation sites were mainly in 5′ upstream and intron regions. Sb VIN2 only associated with grain width and stem water-soluble carbohydrates(WSCs) content. We conclude that the vacuolar invertase genes Sb VIN1 and Sb VIN2 are differently associated with stem and grain traits in sorghum. | Yunhua Chi Kimani Wilson Zhiquan Liu Xiaoyuan Wu Li Shang Limin Zhang Haichun Jing Huaiqing Hao | 2020 | The Crop Journal2020，8，2： | 2 |
| 7 | Identification of SNPs and expression patterns of FZD3 gene and its effect on wool traits in Chinese Merino sheep(Xinjiang Type)显示文摘As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits are not clear. The objectives of this study were to identify the single nucleotide polymorphisms (SNPs) and the expression patterns of FZD3 gene, and then to determine whether it affected wool traits of Chinese Merino sheep (Xinjiang Type) or not. PCR-single stranded conformational polymorphism (PCR-SSCP) and sequencing were used to identify mutation loci, and general linear model (GLM) with SAS 9.1 was used for the association analysis between wool traits and SNPs. Quantitative real-time PCR (qRT-PCR) was used to investigate FZD3 gene expression levels. The results showed that six exons of FZD3 gene were amplified and two mutation loci were identified in exon 1 (NC_019459.2: g.101771685 T>C (SNP1)) and exon 3 (NC_019459.2: g.101810848, A>C (SNP2)), respectively. Association analysis showed that SNP1 was significantly associated with mean fiber diameter (MFD)(P=0.04) and live weight (LW)(P=0.0004), SNP2 was significantly associated with greasy fleece weight (GFW)(P=0.04). The expression level of FZD3 gene in skin tissues of the superfine wool (SF) group was significantly lower (P<0.05) than that of the fine wool (F) group. Moreover, it had a higher expression level (P<0.01) in skin tissues than in other tissues of Chinese Merino ewes. While, its expression level had a fluctuant expression in skin tissues at different developmental stages of embryos and born lambs, with the highest expression levels (P<0.01) at the 65th day of embryos. Our study revealed the genetic relationship between FZD3 variants and wool traits and two identified SNPs might serve as potential and valuable genetic markers for sheep breeding and lay a molecular genetic foundation for sheep marker-assisted selection (MAS). | ZHAO Bing-ru FU Xue-feng TIAN Ke-chuan HUANG Xi-xia DI Jiang BAI Yan XU Xin-ming TIAN Yue-zhen WU Wei-wei ABLAT Sulayman ZENG Wei-dan HANIKEZI Tulafu | 2019 | Journal of Integrative Agriculture2019，18，10： | 2 |
| 8 | Mining and Correlation Analysis of Association Rules between Properties and Therapeutic Efficacy of Chinese Materia Medica Based on Strategy Pattern显示文摘To the Editor:Chinese physicians often address the combination of the properties and therapeutic efficacy of Chinese materia medica (CMM).They believe that the properties and therapeutic efficacy of traditional Chinese medicines (TCMs)should be considered as an 'organic whole.''Use based on therapeutic efficacy'can lead to omission of the properties of CMM.It also fails to meet the requirements of 'differential diagnosis and treatment,'thus restricting the flexibility in using CMM. | Di-Yao Wu Xin-You Zhang Xiao-Ling Zhou | 2018 | Chinese Medical Journal2018，，22： | 1 |
| 9 | A Survey of SNP Data Analysis显示文摘Every person differs from every other person regarding their physical appearance, susceptibility to disease, response to medications, and so on. However, 99.9 percent of human DNA is the same. As such,differences in human genomes are very worthy of study. Single-Nucleotide Polymorphisms(SNPs) are the simplest form and most common source of genetic polymorphism. SNPs have been used to successfully identify defective genes that cause Mendelian diseases. However, most common human diseases are complex and are caused by multiple SNPs. Each SNP explains only a small fraction of genetic causes. Experiments on individual SNPs may reveal their non-detectable effects on complex diseases. Pathogenesis is a complicated topic, and it is difficult to correctly predict multiple SNPs. As such, the analysis of SNP data is a critical task in the study of genetic diseases.In this paper, we divide the methods for genome-wide SNP data analysis into two categories: single-trait GenomeWide Association Studies(GWAS) in which pathology is mined from data of a single phenotype, and multiple-trait GWAS which identifies cross-phenotype associations. For single-trait GWAS, we review methods ranging from the simple to the complex, including TEAM, BOOST, AntEpiSeeker, SNPRuler, EDCF, HiSeeker, ORF, MLR-tagging,MSCD, and MIC. For multiple-trait GWAS, we describe methods in terms of their employed regression models,dimension-reduction methods, and meta-analysis methods. We also list the advantages and disadvantages of these methods. Finally, we discuss the future directions of SNP data analysis for genome-wide association. | Xiaojun Ding Xuan Guo | 2018 | Big Data Mining and Analytics2018，1，3： | 1 |
| 10 | dCAPS markers developed for nitrate transporter genes TaNRT2L12s associating with 1000-grain weight in wheat显示文摘Nitrate transporters(NRTs)are regulators of nitrate assimilation and transport.The genome sequences of TaNRT2L12-A,-B and-D were cloned from wheat(Triticum aestivum L.),and polymorphisms were analyzed by sequencing.TaNRT2L12-D in a germplasm population was highly conserved.However,38 single nucleotide polymorphisms(SNPs)in TaNRT2L12-A coding region and 11 SNPs in TaNRT2L12-B coding region were detected.Two derived cleaved amplified polymorphic sequences(dCAPS)markers A-CSNP1 and A-CSNP2 were developed for TaNRT2L12-A based on SNP-351 and SNP-729,and three haplotypes were identified in the germplasm population.B-CSNP1 and B-CSNP2 were developed for TaNRT2L12-B based on SNP-237 and SNP-1227,and three haplotypes were detected in the germplasm population.Association analyses between the markers and agronomic traits in 30 environments and phenotypic comparisons revealed that A-CSNP2-A is a superior allele of shorter plant height(PH),length of penultimate internode(LPI)and peduncle length(PL),B-CSNP2-G is a superior allele of higher grain number per spike(GNS).Hap-6B-1 containing both superior alleles B-CSNP1-C and B-CSNP2-A is a superior haplotype of 1 OOO-grain weight(TGW).Expression analysis showed that TaNRT2L12-B is mainly expressed in the root base and regulated by nitrate.Therefore,TaNRT2L12 may be involved in nitrate transport and signaling to regulate TGW in wheat.The superior alleles and dCAPS markers of TaNRT2L12-A/B are beneficial to genetic improvement and germplasm enhancement with molecular markers-assisted selection. | HUANG Jun-fang LI Long MAO Xin-guo WANG Jing-yi LIU Hui-min LI Chao-nan JING Rui-lian | 2020 | Journal of Integrative Agriculture2020，19，6： | 1 |
| 11 | Research on Association Analysis Technology of Network User Accounts显示文摘As large numbers of user information on various network services are becoming valuable resources for social computing,how to associate user information scattered in a variety of services turns to one of the key issues of user identity mining.First this paper outlines the difficulties of dealing with account association,then describes the basis of account association method.After that,this paper sums up account association methods mainly from five aspects which are user naming conventions,user profiles,user writing styles,user online behavior,and user community relationship.Finally,this paper points out the development direction and prospects of account association. | Yunpeng Guo Yan Liu Junyong Luo | 2015 | 国际计算机前沿大会会议论文集2015，，B12： | 0 |
| 12 | A practical approach to improve alarm system performance: Application to power plant显示文摘Process safety in chemical industries is considered to be one of the important goals towards sustainable development. This is due to the fact that, major accidents still occur and continue to exert significant reputational and financial impacts on process industries. Alarm systems constitute an indispensable component of automation as they draw the attention of process operators to any abnormal conditi on in the plant. Therefore, if deployed properly, alarm systems can play a critical role in helping plant operators ensure process safety and profitability. How-ever, in practice, many process plants suffer from poor alarm system configuration which leads to nuisance alarms and alarm floods that compromise safety. A vast amount of research has primarily focused on developing sophisticated alarm management algorithms to address specific issues. In this article, we provide a simple, practical, systematic approach that can be applied by plant engineers (i.e., non-experts) to improve industrial alarm system performance. The proposed approach is demonstrated using an industrial power plant case study. | Jay Sompura Amit Joshi Babji Srinivasan Rajagopalan Srinivasan | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 0 |
| 13 | Association Mapping of Quantitative Trait Loci for Grain Size in Introgression Line Derived from Oryza rufipogon显示文摘Grain size is one of the critical agronomic traits governing grain yield and quality in rice.However,the underlying genetic mechanisms that control grain size in rice are poorly understood.We used an introgression line derived from Zhonghui 8015 and Oryza rufipogon Griff.This introgression line was evaluated under two different environmental conditions to dissect the quantitative trait loci controlling grain size.Genome-wide association study(GWAS)was performed using 28193 SNPs through a general linear model,and 56 significant SNPs on different loci associated with the 4 grain size traits were detected.Cloned genes including GS3 and q GL3 showed substantial effects on grain length and size.Seven new stable loci were identified with pleiotropic effects on grain size.Haplotype,gene expression analyses,combined gene-based associations,and functional annotations permitted the shortlisting of important dominant genes including GS3 and q GL3. | Kashif HUSSAIN ZHANG Yingxing Workie ANLEY Aamir RIAZ Adil ABBAS MdHasanuzzaman RANI WANG Hong SHEN Xihong CAO Liyong CHENG Shihua | 2020 | Rice science2020，27，3： | 0 |
| 14 | Analysis of the operation of professional textile and apparel markets in 2018显示文摘From January to December 2018, the total turnover of 45 professional markets surveyed by CATA (China Commercial Circulation Association of Textile and Apparel), CNTAC, was 1,209.334 billion yuan, a year-onyear increase of 6.55%. | | 2019 | China Textile2019，，3： | 0 |
| 15 | An Object Extraction Model Using Association Rules and Dependence Analysis显示文摘Extracting objects from legacy systems is a basic step in system’s object orientation to improve the maintainability and understandability of the systems. A new object extraction model using association rules and dependence analysis is proposed. In this model data are classified by association rules and the corresponding operations are partitioned by dependence analysis. | Li Shen zhi 1, Chen Zhen qiang 1, Zhou Yu ming 1,Xu Bao wen 1,2 1. Department of Computer Science and Engineering, Southeast University, Nanjing 210096,China 2. State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072,Ch | 2001 | Wuhan University Journal of Natural Sciences2001，6，Z1： | 0 |
| 16 | VideoMap: An interactive and scalable visualization for exploring video content显示文摘Large-scale dynamic relational data visualization has attracted considerable research attention recently. We introduce dynamic data visualization into the multimedia domain, and present an interactive and scalable system, Video Map, for exploring large-scale video content. A long video or movie has much content; the associations between the content are complicated. Video Map uses new visual representations to extract meaningful information from video content. Map-based visualization naturally and easily summarizes and reveals important features and events in video. Multi-scale descriptions are used to describe the layout and distribution of temporal information, spatial information, and associations between video content. Firstly, semantic associations are used in which map elements correspond to video contents. Secondly, video contents are visualized hierarchically from a large scale to a fine-detailed scale. Video Map uses a small set of sketch gestures to invoke analysis, and automatically completes charts by synthesizing visual representations from the map and binding them to the underlying data. Furthermore,Video Map allows users to use gestures to move and resize the view, as when using a map, facilitating interactive exploration. Our experimental evaluation of Video Map demonstrates how the system can assist in exploring video content as well as significantly reducing browsing time when trying to understand and find events of interest. | Cui-Xia Ma Yang Guo Hong-An Wang | 2016 | Computational Visual Media2016，2，3： | 0 |
| 17 | SEQUENTIAL ALGORITHM FOR MULTISENSOR PROBABILISTIC DATA ASSOCIATION显示文摘Based upon a multisensor sequential processing filter, the target states in a3D Cartesian system are projected into the measurement space of each sensor to extend thejoint probabilistic data association (JPDA) algorithm into the multisensor tracking systemsconsisting of heterogeneous sensors for the data association. | Hu Wenlong Mao Shiyi(Dept of Electronic Engineering, Bejiing University of Aeronauticsand Astronatutics, Beijing, 100083, China) | 1997 | Chinese Journal of Aeronautics1997，10，2： | 0 |
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