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| 1 | 主流Javascript框架比较与分析显示文摘对目前主流MV*Javascript框架:Angular JS、Backbone和Ember进行了比较与分析.对开发人员来说,在项目开始之前选择正确的开发框架至关重要,因为它对项目能否按时交付还有将来维护的成本有很大的影响.开发人员在选择开发框架时面临着两难的选择,因为既想要一个功能强大又稳定的框架,但同时又不想被自己目前所具备的知识所限制.Web的进步一直都很快,而且每个新技术的来临几乎都意味着过去的开发方式和逻辑将会改变.基于以上考虑,本文将对目前主流的Javascript开发框架进行深入的比较与分析,方便开发者和研究人员学习与工作. | 李红 | 2015 | 鞍山师范学院学报2015，17，4： | 8 |
| 2 | Backbone formulation algorithm in wireless sensor network based on cross-entropy method显示文摘In wireless sensor network,virtual backbone is a cost effective broadcasting method.Connected dominating set formation is proposed to construct a virtual backbone.However,it is NP-Hard to find a minimum connected dominating set in an arbitrary graph.In this paper,based on cross-entropy method,we present a novel backbone formulation algorithm(BFA-CE)in wireless sensor network.In BFA-CE,a maximal independent set is got at first and nodes in the independent set are required to get their action sets.Based on those action sets,a backbone is generated with the cross-entropy method.Simulation results show that our algorithm can effectively reduce the size of backbone network within a reasonable message overhead,and it has lower average node degree.This approach can be potentially used in designing efficient broadcasting strategy or working as a backup routing of wireless sensor network. | SHI Weiren JIANG Yisong ZHAO Ying | 2014 | Instrumentation2014，1，1： | 8 |
| 3 | 浅析JavaScript MVC框架在Web开发中的应用显示文摘为实现Web开发中客户端代码的可读性、易测试、可维护性和可扩展性,介绍和分析JavaScript MVC框架的基本结构和设计模式。以Backbone.js框架为例,通过实际应用开发中的部分代码演示了JavaScript MVC框架在Web开发中的应用,并阐述了Web开发中的其他注意事项。 | 代庆梅 | 2014 | 电脑知识与技术2014，，4： | 8 |
| 4 | Deep learning in optical metrology:a review显示文摘With the advances in scientific foundations and technological implementations,optical metrology has become versatile problem-solving backbones in manufacturing,fundamental research,and engineering applications,such as quality control,nondestructive testing,experimental mechanics,and biomedicine.In recent years,deep learning,a subfield of machine learning,is emerging as a powerful tool to address problems by learning from data,largely driven by the availability of massive datasets,enhanced computational power,fast data storage,and novel training algorithms for the deep neural network.It is currently promoting increased interests and gaining extensive attention for its utilization in the field of optical metrology.Unlike the traditional,,physics-basedH approach,deep-learning-enabled optical metrology is a kind of,/data-drivenw approach,which has already provided numerous alternative solutions to many challenging problems in this field with better performances.In this review,we present an overview of the current status and the latest progress of deep-learning technologies in the field of optical metrology.We first briefly introduce both traditional image-processing algorithms in optical metrology and the basic concepts of deep learning,followed by a comprehensive review of its applications in various optical metrology tasks,such as fringe denoising,phase retrieval,phase unwrapping,subset correlation,and error compensation.The open challenges faced by the current deep-learning approach in optical metrology are then discussed.Finally,the directions for future research are outlined. | Chao Zuo Jiaming Qian Shijie Feng Wei Yin Yixuan Li Pengfei Fan Jing Han Kemao Qian Qian Chen | 2022 | Light(Science & Applications)2022，11，4： | 7 |
| 5 | Multimedia Conferencing System and Multicasting显示文摘Themultimediaconferencingsystemprovidesrealtimeinformationforhighlevelcooperativework,anditisalsoarealtimemultimediainterac... | 张海林 赵锦蓉 庄永宙 | 1999 | Tsinghua Science and Technology1999，4，2： | 5 |
| 6 | SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC GRAFT COPOLYMER CONTAINING MICROPHASE SEPARATED AND LONG POLY(ETHYLENE OXIDE) SIDE CHAIN STRUCTURES显示文摘Acryloyl terminated Poly (ethyleneoxide)macromonomers (PEO-A) with different PEO chain lengths have been prepared by deactivation of PEO alkoxide with acryloyl chloride. A new kind of amphiphilic polystyrene-g-poly (ethylene oxide)graft copolymer containing both microphase separated and PEO side chain structures has been synthesized from radical copolymerization of PEO-A macromonomer with styrene. After careful purification by a newly-developed method called 'selective dissolution’, the well-defined structure of the purified copolymers was confirmed by IR, ~1H-NMR and GPC. Various experimental parameters controlling the copolymerization were studied in detail. The results indicated that the feed ratio of styrene to macromonomer(S/M) was the most important determining factor for the composition of the copolymers. A detailed 'comb- model' was proposed to describe the molecular structure of the graft copolymers. Finally, this amphiphilic graft copolymers may readily form microphase separated structures as clearly indicated by transmission electron microscopy. | 邱永兴 俞小洁 封麟先 杨士林 | 1993 | Chinese Journal of Polymer Science1993，11，1： | 4 |
| 7 | Engineering Hydrogels for Efficient Solar Desalination and Water Purification显示文摘CONSPECTUS:Safe and adequate water is a global challenge due to the growing population and pollution in the wake of natural disasters.Access to clean water is a cornerstone for the further development of our modern society.Solar-powered desalination and water purification have attracted much research attention due to the high solar-to-thermal conversion efficiency and ease of implementation in multiple scales,from compact,stand-alone devices for individual households to large,centralized dimensions for communities.Nevertheless,the generation of water vapor at low temperatures below the boiling point is usually a slow process under natural sunlight.The production rate of clean water relies on the efficiencies of solar energy conversion and utilization,which can be enhanced in two directions:systems optimization and materials innovation.Starting from bottom heating and volumetric heating,interfacial evaporation has been adopted recently to systematically reduce energy loss by localizing heat near the evaporation surface using photothermal materials.Meanwhile,carbonaceous materials,narrow bandgap semiconductors,and polymers with different structures were designed to achieve thermal management and water transport.In this Account,we highlight the recent progress of hydrogels as a highly tunable material platform for solar-powered desalination and water purification.We begin by introducing how gelation chemistry endows hydrogels with desirable properties and multiscale tunability from molecular to macroscopic levels.Then,we review three major strategies to promote efficient solar-to-vapor conversion in terms of reducing water evaporation enthalpy,optimizing heat distribution,and tailoring the evaporation surface.First,by selecting polymeric backbones with hydratable functional groups,the water state in hydrogels can be regulated to facilitate intermediate water,which has a lower evaporation enthalpy compared to that of the bulk water.This polymer−water interaction can be further tuned during synthesis and post-treatment.Second,light-absorbing additives within hydrogels should not only convert solar energy to heat effectively but also confine the heat near the evaporative surfaces.Third,since water molecules are encapsulated in the polymer network of hydrogels,the surface of the hydrogel becomes the evaporation front of liquid water.Hence,tailoring the surface topography and wettability of hydrogels has important effects on the evaporation rate.Next,we discuss key functions that endow hydrogel evaporators with excellent desalination and purification performances,including anti-salt-fouling property for stable and long-term desalination,as well as easy integration of functional materials to remove other contaminants,such as heavy metal ions and organic dyes,for greater distillate quality.Last,existing challenges and future opportunities in both fundamental studies and practical implementation of the hydrogel-based solar water purification systems are discussed. | Youhong Guo Guihua Yu | 2021 | Accounts of Materials Research2021，2，5： | 4 |
| 8 | Ethylene Polymerization and Copolymerization with Polar Monomers by Benzothiophene-bridged BPMO-Pd Catalysts显示文摘A series of new bisphosphine-monoxide(BPMO)ligands based on benzothiophene backbone and the corresponding palladium complexes{k2-P(O)(Ph)2-3-PR1R2-C8H4S}PdMeCl{2a:R1=R2=Ph;2b:R1=R2=2-0Me-Ph;2c:R1=R2=2-CF3-Ph;2d:Rl=Ph,R2=2-(2',6'-(OMe)2C6Hz)-C6H4}were synthesized and fully characterized by1H-,13C-,31P-,and 2D-NMR spectroscopy and single-crystal X-ray dfraction.In the presence of Na+B[3,5-(CF3)2C6H3]4(NaBArF),these complexes showed very high activities(up to 2.0 x 10’g-mol-1.h-)for ethylene polymerization.More significantly,these catalysts enabled the copolymerization of ethylene with a broad scope of commercially available polar comonomers such as acrylates,acrylic acid,acrylonitrile,vinyltrialkoxysilane,allyl acetate,and long-chain 6-chloro-1-hexene to give functionalized polyethylene with reasonable catalytic activities(up to 105 g-mol-l.h-)and incorporations(up to 5.3 mol96).This contribution suggests that,besides the modulation of conventionally steric and electronic factors,the connectivity(at dfferent linking positions)of BPMO(P,O)donors to the heteroaryl backbone also greatly infuences the catalyst properties in terms of catalytic activity,polymer branching content,comonomer scope,and comonomer incorporation. | Hong-Liang Mu Jun-Hao Ye Guang-Lin Zhou Kang-Kang Li Zhong-Bao Jian | 2020 | Chinese Journal of Polymer Science2020，38，6： | 4 |
| 9 | Achieving of High Density/Utilization of Active Groups via Synergic Integration of C=N and C=O Bonds for Ultra-Stable and High-Rate Lithium-Ion Batteries显示文摘Organic electrode materials are receiving ever-increasing research interest due to their combined advantages,including resource renewability,low cost,and environmental friendliness.However,their practical applications are still terribly plagued by low conductivity,poor rate capability,solubility in electrolyte,and low density/utilization of active groups.In response,herein,as a proof-of-concept experiment,C=N and C=O bonds are synergically integrated into the backbone of pentacene to fnely tune the electronic structures of pentacene.Unexpectedly,the frstly obtained unique 5,7,11,14-tetraaza-6,13-pentacenequinone/reduced graphene oxide(TAPQ/RGO)composite exhibits superior electrochemical performances,including an ultra-stable cycling stability(up to 2400 cycles)and good rate capability(174 mAh g−1 even at a high current density of 3.2 A g−1),which might be attributed to the abundant active groups,�-conjugated molecular structure,leaf-like morphology,and the interaction between TAPQ and graphene. | Tao Sun Zong-Jun Li Xin-Bo Zhang | 2018 | Research2018，，1： | 4 |
| 10 | Recurrent genome duplication events likely contributed to both the ancient and recent rise of ferns^FA显示文摘Ferns, the second largest group of vascular plants, originated ~400 mil ion years ago(Mya). They became dominant in the ancient Earth landscape before the angiosperms and are stil important in current ecosystems.Many ferns have exceptional y high chromosome numbers,possibly resulting from whole-genome duplications(WGDs).However, WGDs have not been investigated molecularly across fern diversity. Here we detected and dated fern WGDs using a phylogenomic approach and by calculating synonymous substitution rates(Ks). We also investigated a possible correlation between proposed WGDs and shifts in species diversification rates. We identified 19 WGDs: three ancient events along the fern phylogenetic backbone that are shared by 66%–97% of extant ferns, with additional lineage-specific WGDs for eight orders, providing strongevidence for recurring genome duplications across fern evolutionary history. We also observed similar Ks peak values for more than half of these WGDs, with multiple WGDs occurring close to the Cretaceous(~145–66 Mya). Despite the repeated WGD events, the biodiversity of ferns declined during the Cretaceous, implying that other factors probably contributed to the floristic turnover from ferns to angiosperms. This study provides molecular evidence for recurring WGDs in ferns and offers important clues to the genomic evolutionary history of ferns. | Chien-Hsun Huang Xinping Qi Duoyuan Chen Ji Qi Hong Ma | 2020 | Journal of Integrative Plant Biology2020，62，4： | 3 |
| 11 | Rational Design of High Brightness NIR-II Organic Dyes with S‑D-AD‑S Structure显示文摘CONSPECTUS:Fluorescence bioimaging in the second nearinfrared window(NIR-II,1000−1700 nm)is a superior visualization tool with deeper penetration and higher spatial resolution than the traditional vis/NIR window(400−1000 nm).Developing desirable NIR-II agents with high brightness(high quantum yield(QY)and absorption coefficient),longer emission wavelengths,light stability,and good biocompatibility is a bottleneck that must be crossed in the process of clinical transformation.NIR-II organic agents attract more attention because of their good biocompatibility.Researchers are committed to develop small organic molecules with an adjustable narrow band gap to emit longer NIR-II wavelengths.However,the reduced band gap of molecular fluorophores generally triggered interactions between the conjugated skeleton and other molecules,leading to a decreased fluorescence QY,especially quenching in aqueous systems.Aiming to enhance NIR-II fluorophores’brightness in aqueous systems,the molecular engineering of a shielding and donor unit is introduced in NIR-II fluorophores,and these molecules are composed of a shielding unit,donor(s),acceptor,donor(s),shielding unit(S-D-A-D-S)structure.We found that the donor’s steric hindrance brings about a molecular twist that can be tuned with electrostatic potential surfaces and the donor’s hydrophobic effects,which can reduce water molecules approaching the excitation center.In addition to the protective effect of the electron shielding units,these changes can be weakened by the interactions between water and fluorophore molecules,which is beneficial to the stability of excited states for fluorophore brightness maintained in watersoluble environments.However,the molecular torsion will reduce intramolecular charge transfer(ICT),the weakened transition from the ground state to the excited state(S_(0)−S_(1)),leading to an undesired decrease in the absorption coefficient.Thus,it is necessary to develop molecular engineering to improve emission QY without sacrificing the absorption coefficient.Therefore,bright NIR-II fluorophores need to have a rational balanced donor unit,which can have decreased backbone distortion to strengthen ICT and better protect the conjugated backbone to reduce the water molecule effect,resulting in improvements to the QY and absorption coefficient simultaneously.In this Account,we will present a concise summary and analysis of the rational molecular design of S-D-A-D-S structural NIR-II fluorophores for tunable enhanced QY and absorption coefficients based on the shielding and donor engineering strategy.We expect that this Account will trigger more research interest to explore the inspiring performance of S-D-A-D-S structural NIR-II fluorophores and employ them in bioimaging to promote the process of clinical transformation. | Qinglai Yang Huilong Ma Yongye Liang Hongjie Dai | 2021 | Accounts of Materials Research2021，2，3： | 3 |
| 12 | The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis显示文摘Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs. | Xiaoyang Xu Haiyan Yuan Xiaqing Yu Suzhen Huang Yuming Sun Ting Zhang Qingquan Liu Haiying Tong Yongxia Zhang Yinjie Wang Chunxiao Liu Lei Wu Menglan Hou Yongheng Yang | 2021 | Horticulture Research2021，8，1： | 2 |
| 13 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 14 | Web主流前端开发框架的设计显示文摘本文在阐述Web前端演化历程的基础上,分别探究了Query、Angular JS、Backbone、ReactJS、VueJS各前端开发框架的主要构成、原理、适用性等,停工检测代码质量、整体应用框架及分析易用性等过程去测试开发框架。希望能和同行分享经验,整体优化前段开发效果。 | 周星岩 王俊淘 | 2021 | 电子技术与软件工程2021，，6： | 2 |
| 15 | NCP-Type Pincer Iridium Complexes Catalyzed Transfer-Dehydrogenation of Alkanes and Heterocycles显示文摘A series of NCP-type pincer iridium complexes,(RNCCp)IrHCl(2a-2c)and(BQ-NCOP)IrHCl 3,have been studied for catalytic transfer alkane dehydrogenation.Complex 3 containing a rigid benzoquinoline backbone exhibits high activity and robustness in dehydrogenation of alkanes to form alkenes.Even more importantly,this catalyst system was also highly effective in the dehydrogenation of a wide range of heterocycles to furnish heteroarenes. | Yulei Wang Lu Qian Zhidao Huang Guixia Liu Zheng Huang | 2020 | Chinese Journal of Chemistry2020，38，8： | 2 |
| 16 | Rationally engineered 3D-dendritic cell-like morphologies of LDH nanostructures using graphene-based core-shell structures显示文摘Functionalization of graphene-based materials using chemical moieties not only modify the electronic structure of the underlying graphene but also enable in limited enhancement of targeted properties.Surface modification of graphene-based materials using other nanostructures enhances the effective properties by minimally modifying the properties of pristine graphene backbone.In this pursuit,we have synthesized bio-inspired hierarchical nanostructures based on Ni–Co layered double hydroxide on reduced graphene oxide core–shells using template based wet chemical approach.The material synthesized have been characterized structurally and electrochemically.The fabricated dendritic morphology of the composite delivers a high specific capacity of 1056 Cg^(−1).A cost effective solid state hybrid supercapacitor device was also fabricated using the synthesized electrode material which shows excellent performance with high energy density and fast charging capability. | Karthik Kiran Sarigamala Shobha Shukla Alexander Struck Sumit Saxena | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 17 | Effects of Main-chain and Chain-ends on the Organogelation of Stearoyl Appended Pendant Valine Based Polymers显示文摘In this work, we investigated the effect of hydrophobic interactions between the polymeric backbone and chain-end groups on the self-assembly pathway of stearoyl appended side-chain valine (Val)-based poly(methacrylate/acrylate) homopolymers in different organic hydrocarbons. Gelation studies conducted revealed that while polymers with polyacrylate as backbone induces gelation in several organic hydrocarbons, polymers with polymethacrylate in the main-chain significantly hinders macroscopic gelation. Morphology of the organogels was analysed by field emission scanning electron microscopy (FESEM), and mechanical strengths of the organogels were determined by rheological measurements. Reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agents (CTA)s,[R1 —S—C=(S)—S—R2] with different —Ri and — R2 groups, have been employed to study the effect of structural variation at the chain-end on macroscopic assembly mechanism. We found that the additional interactions between terminal groups via hydrogenbonding or n-n stacking interactions or both help to build up the self-assembly pathway and thereby produces mechanically stable organogels. | Mridula Nandi Swagata Pan Dipannita Ghosh Priyadarsi De | 2019 | Chinese Journal of Polymer Science2019，37，9： | 1 |
| 18 | Single-step-fabricated disordered metasurfaces for enhanced light extraction from LEDs显示文摘While total internal reflection(TIR)lays the foundation for many important applications,foremost fibre optics that revolutionised information technologies,it is undesirable in some other applications such as light-emitting diodes(LEDs),which are a backbone for energy-efficient light sources.In the case of LEDs,TIR prevents photons from escaping the constituent high-index materials.Advances in material science have led to good efficiencies in generating photons from electron–hole pairs,making light extraction the bottleneck of the overall efficiency of LEDs.In recent years,the extraction efficiency has been improved,using nanostructures at the semiconductor/air interface that outcouple trapped photons to the outside continuum.However,the design of geometrical features for light extraction with sizes comparable to or smaller than the optical wavelength always requires sophisticated and timeconsuming fabrication,which causes a gap between lab demonstration and industrial-level applications.Inspired by lightning bugs,we propose and realise a disordered metasurface for light extraction throughout the visible spectrum,achieved with single-step fabrication.By applying such a cost-effective light extraction layer,we improve the external quantum efficiency by a factor of 1.65 for commercialised GaN LEDs,demonstrating a substantial potential for global energy-saving and sustainability. | Peng Mao Changxu Liu Xiyan Li Mengxia Liu Qiang Chen Min Han Stefan A.Maier Edward H.Sargent Shuang Zhang | 2021 | Light(Science & Applications)2021，10，10： | 1 |
| 19 | Monofluoromethyl-Substituted Sulfonium Ylides:Preparation,Structure-Reactivity Study and Substrate Scope显示文摘of main observation and conclusion Structure-reactivity study of a family of electrophilic monofluoromethylating reagents based on sulfonium ylide skeleton with different steric hindrance and electron-withdrawing properties was described.These studies led us to discover two highly reactive reagents 3 with a cyclic malonate backbone and 6 with an electron-poor 1,1,1,5,5,5-hexafluoropentane-2,4-dione backbone.The high reactivity of reagent 6 allowed to highly selectively access either C-monofluoromethylated or O-monofluoromethylated p-ketoesters in high yields by the use of different bases.In addition,reactions of reagent 3 with a variety of nucleophiles including phenols,carboxylic acids,thiophenols or heteroaryl nucleophiles occurred in full conversion within 10 min at room temperature and the scopes for these reactions were reported in detail. | Xin Hong Yafei Liu Long Lu Qilong Shen | 2020 | Chinese Journal of Chemistry2020，38，11： | 1 |
| 20 | The Thermogel Chronicle——From Rational Design of Thermogelling Copolymers to Advanced Thermogel Applications显示文摘CONSPECTUS:Temperature responsive supramolecular hydrogels,also known as thermogels,are produced by the self-assembly of amphiphilic copolymers in solution following temperature stimulus.They are a class of high caliber novel materials possessing highly attractive properties such as injectability,ability to undergo temperature controlled reversible sol−gel phase transitions,high biocompatibility,and tunable biodegradability.Much research vigor has been dedicated to designing advanced amphiphilic copolymers and investigating their molecular interactions in order to enhance the properties of the thermogelling systems and expand the scope of their applications.As such,thermogelling systems have since become well established in the field of sustained localized drug or protein delivery and have also been demonstrated as high potential materials for niche applications such as threedimensional cell culture,wound healing patches,and vitreous endotamponades.Recent developments saw the advent of thermogelling systems with advanced biomedical applications ranging from enhanced cancer therapy to radiology imaging to tissue engineering,and these are usually achieved by the conjugating of biologically relevant molecules such as drugs and peptides to the thermogel copolymer or by incorporating nanoparticles into the thermogel systems.New developments in this field see a shift away from employing traditional synthetic polymers such as polypropylene glycol(PPG)and poly(lactic-co-glycolic acid)(PLGA)to utilizing more advanced nature-derived bioactive molecules and also introducing chiral moieties in the thermogelling copolymer backbone. | Qianyu Lin Cally Owh Jason Y.C.Lim Pei Lin Chee Michelle P.Y.Yew Eilis T.Y.Hor Xian Jun Loh | 2021 | Accounts of Materials Research2021，2，10： | 1 |
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