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| 1 | Service-aware 6G:An intelligent and open network based on the convergence of communication,computing and caching显示文摘With the proliferation of the Internet of Things(IoT),various services are emerging with totally different features and requirements,which cannot be supported by the current fifth generation of mobile cellular networks(5G).The future sixth generation of mobile cellular networks(6G)is expected to have the capability to support new and unknown services with changing requirements.Hence,in addition to enhancing its capability by 10–100 times compared with 5G,6G should also be intelligent and open to adapt to the ever-changing services in the IoT,which requires a convergence of Communication,Computing and Caching(3C).Based on the analysis of the requirements of new services for 6G,this paper identifies key enabling technologies for an intelligent and open 6G network,all featured with 3C convergence.These technologies cover fundamental and emerging topics,including 3C-based spectrum management,radio channel construction,delay-aware transmission,wireless distributed computing,and network self-evolution.From the detailed analysis of these 3C-based technologies presented in this paper,we can see that although they are promising to enable an intelligent and open 6G,more efforts are needed to realize the expected 6G network. | Yiqing Zhou Ling Liu Lu Wang Ning Hui Xinyu Cui Jie Wu Yan Peng Yanli Qi Chengwen Xing | 2020 | Digital Communications and Networks2020，6，3： | 57 |
| 2 | Evolutionary conservation of Dmrt gene family in amphibi-ans, reptiles and birds显示文摘Sex determining gene Mab-3 of C. elegans and doublesex of Drosophila contain a common DNA binding motif called a DM domain, both of which regulate similar aspects of sexual development. Human doublesex-related gene DMRT1 has been identified, which also contains the conserved DM-related DNA-binding domain and plays an essential role in gonadal differentiation. We present the amplification of a broad spectrum of DM domain sequences from phylogenetic diverse vertebrates (Cynops orientalis, Chrysemys scripta elegans and Coturnix coturnix) using degenerate PCR. Our results further reveal the unexpected complexity and the evolutionary conservation of the DM domain gene family. | REN Lili CHENG Hanhua GUO Yiqing HUANG Xiao LIU Li ZHOU Rongjia | 2001 | Chinese Science Bulletin2001，46，23： | 40 |
| 3 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 4 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 5 | Earthquake prediction from China's mobile gravity data显示文摘The relation between plate tectonics and earthquake evolution is analyzed systematically on the basis of 1998e2010 absolute and relative gravity data from the Crustal Movement Observation Network of China. Most earthquakes originated in the plate boundary or within the fault zone. Tectonic deformation was most intense and exhibited discontinuity within the tectonically active fault zone because of the differential movement; the stress accumulation produced an abrupt gravity change, which was further enhanced by the earthquake. The gravity data from China's Mainland since 2000 obviously reflected five major earthquakes(Ms > 7), all of which were better reflected than before 2000. Regional gravity anomalies and a gravity gradient change were observed in the area around the epicenter about 2 or 3 years before the earthquake occurred, suggesting that gravity change may be a seismic precursor. Furthermore, in this study, the medium-term predictions of the Ms7.3 Yutian, Ms8.0 Wenchuan, and Ms7.0 Lushan earthquakes are analytically presented and evaluated, especially to estimate location of earthquake. | Zhu Yiqing Liu Fang You Xinzhao Liang Weifeng Zhao Yunfeng Liu Lian | 2015 | Geodesy and Geodynamics2015，6，2： | 13 |
| 6 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 7 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 8 | Solidification Structure of Low Carbon Steel Strips with Different Phosphorus Contents Produced by Strip Casting显示文摘在现在的纸,有不同的磷内容的低碳钢脱衣用扔过程的成双的转动脱衣被生产。团结结构被学习,它的特征详细被分析。脱衣与模子铸钢相比拥有了好微观结构,这被发现。与增加磷内容,更多的铁酸盐与更好的谷物被形成了。 | Na LI Zhenyu LIU Yiqing QIU Zhaosen LIN Xianghua LIU Guodong WANG | 2006 | Journal of Materials Science & Technology2006，22，6： | 8 |
| 9 | Gravity changes before and after the 2010 Ms7.1 Yushu earthquake显示文摘Absolute and relative gravity observations from 1998-2010 from the China Crustal Movement Observation Network, a major national scientific project, have been used to model the gravity field and its variations associated with the April 14, 2010 Ms7.1 Yushu earthquake. The evolution of the regional gravity field and its relationship with seismicity before and after the Yushu earthquake are studied. The observed gravity changes are closely related to the active Ganzi-Yushu Fault, and gravity measurements can be used to observe the migration of material accompanying active faults and crustal tectonics. The dynamic variation of the gravity field reflects its evolution prior to and during the Yushu earthquake. The gravity measurements near its epicenter are as large as 80×10^(-8) m/s^2, and they show wave-like increases with time prior to the Yushu earthquake. | Zhu Yiqing Liu fang Cao Jianping Zhao Yunfeng | 2012 | Geodesy and Geodynamics2012，3，4： | 7 |
| 10 | Identification of Flowering Regulatory Genes in Allopolyploid Brassica juncea显示文摘Brassica juncea is an allopolyploid originating from the interspecific hybridization between Brassica rapa and Brassica nigra, which is of multiple usage as a vegetable, oilseed and condiment worldwide. Both vernalization and non-vernalization under long-day photoperiod can promote floral transition in B. juncea suggesting merged flowering pathways of its ancestors and better environmental adaptability. We identified genomewide flowering regulatory genes in B. juncea, which include 84 and 79 genes from A and B sub-genomes, respectively. Ka/Ks analysis revealed a purification effect on both photoperiod and vernalization flowering regulation pathways during evolution. Expression profile of those genes during long-day and vernalization treatments suggested Bju ACO4, Bju AFT1, Bju BFT4, Bju ASOC1 and Bju ASOC4 may be the major functional copies of B. juncea flowering regulation. Further functional studies about Bju COs showed three days delayed flowering time in Bju ACO4 or Bju BCO3 silenced plants. Increased transcription of all BjuFLCs in Bju ACO4 or Bju BCO3 silenced plants suggested interactions between photoperiod and vernalization pathways governing flowering time. Our findings provided flowering regulating networks in allopolyploid B. juncea. | Ning Zhao Chang Liu Yiqing Meng Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2019 | Horticultural Plant Journal2019，5，3： | 6 |
| 11 | Temporal variation of gravity field before and after Wenchuan Ms8.0 earthquake显示文摘Absolute and relative gravity data during 1998 to 2008 were used to study gravity field and temporal variation in the North-South seismic-belt region,and their correlation with seismic activities before and after Wenchuan Ms8.0 earthquake.The temporal variation of gravity field shows that the portentous information of the gravity field reflects the development and occurrence of earthquake more clearly.The variations of gravity field are inhomogeneous in the space-time distribution,and are associated with the development and occurrence of the Wenchuan Ms8.0 earthquake,also closely connected with active fault tectonics. | Zhu Yiqing Liu Fang Guo Shusong | 2011 | Geodesy and Geodynamics2011，2，2： | 6 |
| 12 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 13 | Optimization of the Tuned Mass Damper for Chatter Suppression in Turning显示文摘The tuned mass damper(TMD) has been successfully applied to the vibration control in machining,while the most widely adopted tuning is equal peaks,which splits the magnitude of the frequency response function(FRF) into equal peaks.However,chatter is a special self-excited problem and a chatter-free machining is determined by FRF at the cutting zone.A TMD tuning aiming at achieving the maximum chatter stability is studied,and it is formulated as an optimization problem of maximizing the minimum negative real part of FRF.By employing the steepest descend method,the optimum frequency and damping ratio of TMD are obtained,and they are compared against the equal peaks tuning.The advantage of the proposed tuning is demonstrated numerically by comparing the minimum point of the negative real part,and is further verified by damping a flexible mode from the fixture of a turning machine.A TMD is designed and placed on the fixture along the vibration of the target mode after performing modal analysis and mode shape visualization.Both of the above two tunings are applied to modify the tool point FRF by tuning TMD respectively.Chatter stability chart of the turning shows that the proposed tuning can increase the critical depth of cut 37% more than the equal peaks.Cutting tests with an increasing depth of cut are conducted on the turning machine in order to distinguish the stability limit.The tool vibrations during the machining are compared to validate the simulation results.The proposed damping design and optimization routine are able to further increase the chatter suppression effect. | YANG Yiqing LIU Qiang WANG Min | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 5 |
| 14 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 15 | Platelet-mediated adhesion facilitates leukocyte sequestration in hypoxia-reoxygenated microvessels显示文摘Leukocyte transendothelial migration and sequestration are two distinct outcomes following leukocyte adhesion to endothelium during ischemia-reperfusion injury, in which platelets may play a pivotal role. In the present study, we established an in vitro hypoxia-reoxygenation model to mimic ischemia-reperfusion injury and found platelet pre-incubation significantly increased leukocyte adhesion to endothelial cells after hyoxia-reoxygenation(over 67%). Blockade of endothelial-cell-expressed adhesion molecules inhibited leukocyte direct adhesion to endothelial cells, while platelet-mediated leukocyte adhesion was suppressed by blockade of platelet-expressed adhesion molecules. Further experiments revealed platelets acted as a bridge to mediate leukocyte adhesion, and platelet-mediated adhesion was the predominant pattern in the presence of platelets. However, platelet pre-incubation significantly suppressed leukocyte transendothelial migration after hypoxia-reoxygenation(over 31%), which could be aggravated by blockade of endothelial-cell-expressed adhesion molecules, but alleviated by blockade of platelet-expressed adhesion molecules. This would indicate that platelet-mediated adhesion disrupted leukocyte transendothelial migration. An in vivo mesenteric ischemia-reperfusion model demonstrated leukocyte transfusion alone caused mild leukocyte adhesion to reperfused vessels and subsequent leukocyte infiltration, while simultaneous leukocyte and platelet transfusion led to massive leukocyte adhesion and sequestration within reperfused microvessels. Our studies revealed platelets enhanced leukocyte adhesion to endothelial cells, but suppressed leukocyte transendothelial migration. Overall, this leads to leukocyte sequestration in hypoxia-reoxygenated microvessels. | Senfeng Zheng Yanting Cao Wenjian Zhang Honglin Liu Jia You Yiqing Yin Jinning Lou Chenghui Li | 2016 | Science China(Life Sciences)2016，59，3： | 3 |
| 16 | Gravity variations before the Menyuan Ms6.4 earthquake显示文摘In order to study the relationship between gravity variation and Menyuan Ms6.4 earthquake, gravity variation characteristics in mid-eastern of Qilian Mountain were analyzed based on the 2012-2015 relative gravity datasets. The results indicated that the gravity changes in mid-eastern of Qilian Mountain increased gradually, while gravity changes around Menyuan remarkably. Besides, great positive-negative gravity changing gradients appeared along the Lenglongling Fault which was located at the north of Menyuan, and the 2016 Menyuan Ms6.4 earthquake occurred near the junction of positive and negative gravity changes. | Weifeng Liang Guoqing Zhang Yiqing Zhu Yunma Xu Shusong Guo Yunfeng Zhao Fang Liu Lingqiang Zhao | 2016 | Geodesy and Geodynamics2016，7，4： | 3 |
| 17 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 18 | The influence of hyaluronic acid on vascular endothelial cell proliferation and the relationship with ezrin/merlin expression显示文摘它被建立了那玻尿的酸(哈) glycans (nHA ) 和 oligosaccharide (oHA ) 在脉管的 endothelial 房间(EC ) 的生物功能上施加不同效果,导致 angiogenesis 的改变的规定。然而,特定的机制仍然是不清楚的。我们的学习在 EC 在 ezrin 和灰背隼蛋白质上集中了于 nHA 和 oHA 的效果。ezrin 和灰背隼的表示在 EC 生长以及 mRNA 表示上是由 siRNA,和规定的 silenced, ezrin 和灰背隼的激活(phosphorylation ) 由 oHA 刺激了, nHA 被调查。结果表明当与 nHA 对待时,在 ezrin 表示或激活没有重要变化。在与 oHA 被对待以后,而在灰背隼表示没有明显的变化, ezrin 的表示和激活决定性地被增加(包括它的 phosphorylation ) 。与 ezrin 表示 silenced,象它的 phosphorylation 一样的灰背隼的表示在刺激 nHA 的人的脐的静脉 endothelial 房间铺平显著地被提高,当没有重要变化, oHA 导致时。与灰背隼表示 silenced,没有明显的变化在 ezrin 的表示被发现(包括它的 phosphorylation ) 由 nHA 导致了。相反地, ezrin 的表示和它的激活显著地在与 oHA 被对待以后被改进。结果建议为由 oHA 的 EC 增长的提升的机制与 ezrin 的表示和激活有关是可能的,并且由 nHA 的 EC 增长的抑制与灰背隼的表示和激活有关是可能的。 | Wei Mo Cuixia Yang Yiwen Liu Yiqing He Yingzhi Wang Feng Gao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 3 |
| 19 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 20 | Time-domain ICIC and optimized designs for 5G and beyond: a survey显示文摘Time-domain enhanced inter-cell interference coordination(eI CIC) is an effective technique to reduce the cross-tier inter-cell interference(ICI) in long term evolution(LTE)-based heterogeneous small cell networks(HetSCNs). This paper first clarifies two main communication scenarios in HetSCNs, i.e., macrocells deployed with femtocells(macro-femto) and with picocells(macro-pico). Then, the main challenges in HetSCNs, particularly the severe cross-tier ICI in macro-femto caused by femtocells with closed subscribe group(CSG) access or in macro-pico caused by picocells with range expansion are analyzed. Based on the prominent feature of dominant interference in HetSCNs, the main idea of time-domain interference coordination and two basic schemes in the eI CIC standardization, i.e., almost blank subframe(ABS) and orthogonal frequency division multiplexing symbol shift are presented, with a systematic introduction to the interactions of these techniques with other network functions. Then, given macro-femto and macro-pico HetSCNs, an overview is provided on the advanced designs of ABS-based eI CIC, including self-optimized designs with regard to key parameters such as ABS muting ratio, and joint optimized designs of ABS-based eI CIC and other radio resource management techniques, such as user association and power control. Finally, the open issues and future research directions are discussed. | Ling LIU Yiqing ZHOU Athanasios V.VASILAKOS Lin TIAN Jinglin SHI | 2019 | Science China(Information Sciences)2019，62，2： | 3 |
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