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| 1 | 人参潜在地理分布以及气候变化对其影响预测显示文摘本文以人参为研究对象,基于人参分布点位数据和22个气候环境因子数据,运用BioMod2平台10个物种分布模型对当前我国东北地区人参潜在生境分布进行预测.以受试者工作特征曲线(ROC)为权重集成10个模型的模拟结果,构建组合模型,并基于该模型预测了IPCC第五次评估报告中RCP 8.5、RCP 6.0、RCP 4.5和RCP 2.6等4种排放情景下21世纪50和70年代人参潜在分布范围.结果表明:在基准气候条件下,人参适宜生境面积占研究区总面积的10.4%,此类地区主要分布于研究区东北部长白山地区以及小兴安岭东南部区域的森林地带.在未来不同的排放情景下研究区人参的适宜生境变化显著,总体上分布范围将有一定程度的缩小.同时参与建模的10种模型在统计学精度、预测结果以及变量权重上都有差异.模型精度计算结果表明,MAXENT模拟效果最好,GAM、RF和ANN次之,SRE模拟精度最低.本文构建的组合模型在一定程度上提高了现有物种分布模型的预测精度,从而使模拟效果更优. | 赵泽芳 卫海燕 郭彦龙 顾蔚 | 2016 | 应用生态学报2016，27，11： | 36 |
| 2 | 基于PacBio平台的全长转录组测序显示文摘当前,绝大多数的转录组数据都是基于以Illumina平台为代表的第二代高通量测序技术获得的,但是第二代测序技术无法提供大量的长转录本并且丢失可变剪接等重要信息,因而大大制约了转录组数据的深度利用.通过以PacBio为代表的第三代测序技术,可以获得更长乃至全长转录组,但由于Pac Bio转录组测序近几年才刚兴起,只有少量的物种基于PacBio平台获得了转录组.PacBio全长转录组测序,在国际上才刚开展但发展很快,其实验与数据分析标准和质量控制方面的研究对于未来的大规模应用至关重要.本研究在国际上首次尝试依据PacBio平台最新试剂(P6/C4)优化实验参数,设计质量控制指标并使全长转录组测序标准化.本文基于一组昆虫(麻皮椿)全长转录组数据,对已取得的部分结果进行报告. | 任毅鹏 张佳庆 孙瑜 吴振峰 阮吉寿 贺秉军 刘国卿 高山 卜文俊 | 2016 | 科学通报2016，61，11： | 17 |
| 3 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 4 | 受污染景观水体的生物修复显示文摘应用生物刺激剂BIOE1对受污染的人工景观池水进行生物修复试验。现场试验的结果表明,生物刺激剂BIOE1能有效地对受污染的景观池水进行生物修复,处理后的池水清澈,水体中的溶解氧浓度显著提高,CODCr、氨氮、总磷和浊度的去除率分别为68%、93%、75%和83%。所用生物刺激剂不含外来微生物,对人体和鱼类无毒性。 | 潘涌璋 张娜 叶林顺 谭淑英 李秀玉 | 2005 | 环境污染治理技术与设备2005，6，3： | 10 |
| 5 | Cryogenic Thermophysical Studies for Clinical Medicine显示文摘Cryogenic technology has been widely used in clinical medicine and in pharmaceutics, so thermophysical studies are extremely important to solve problems during freezing and thawing. This paper reports some recent research in clinical medicine, including cryo injury, cryosurgery, and cryopreservation of some important cells and tissues. Microscopic images of the freezing process with a cryomicroscope system show that the dendritic ice growth is affected by the solution concentration, the cooling rate, and the number of embryos. An enthalpy method is used for the freeze thaw analysis of the cryosurgery with a program developed to predict the temperature profile and the interface motion, which compares well with experimental results. A very rapid cooling technique is developed by quenching the samples into subcooled liquid nitrogen for vitrification of cells and tissues. An analytical method developed to prevent the fracture of arteries during freezing has been verified by the electronic microscopic investigation. | 华泽钊 | 2002 | Tsinghua Science and Technology2002，7，2： | 8 |
| 6 | 基于SMRT测序技术的16S rRNA基因全长测序及其分析方法显示文摘被称为第三代测序技术的单分子测序是最近几年发展起来的高通量测序技术。其中,由Pacbio Bio Sciences公司开发的单分子实时测序技术(SMRT)是最先商用的技术。SMRT测序技术通过对模板序列循环测序产生环形一致序列(CCS),成功克服第三代测序技术准确率低的弊病。通过SMRT测序技术,科学家可以更深入准确地探究复杂环境微生物的结构和功能。介绍SMRT测序技术在微生物16S rRNA基因测序中的优势和劣势,并就基于SMRT测序技术所得的全长16S rRNA基因序列的质量控制、错误序列排除、聚类和注释分析等重要分析环节进行概述,同时,提出利用SMRT测序技术研究复杂环境微生物可能存在的问题及其解决方法,期望能为研究人员提供参考。 | 唐勇 刘旭 | 2017 | 生物技术通报2017，33，8： | 8 |
| 7 | 模型及ChemBioOffice在有机化学实验中的应用显示文摘有机化学是药学专业非常重要又较难学习的一门专业基础课,认识有机化合物的结构是学好这门课程的基础,单纯平面教学无法深入地将分子的实际空间结构加以充分展示。通过在有机化学实验课中开设球棍模型搭建及Chem Bio Office软件应用这一内容,利用立体、形象的原子间的相对位置,可以促进学生迅速地理解、掌握化合物的立体结构,把握有机分子构成的基本方式,为后续的教学内容打下良好的基础。 | 陈莉敏 林友文 王津 | 2014 | 广州化工2014，42，21： | 4 |
| 8 | Overview of In—Situ Biodegradation and Enhancement显示文摘Microbial degradation technologies have been developed to restore ground water quality in aquifers polluted by organic contaminants effectively in recent years. However, in course of the degradation, the formation of biofilms in ground water remediation technology can be detrimental to the effectiveness of a ground water remediation project. Several alternatives are available to a remedial design engineer, such as Permeable Reactive Barriers (PRBs) and in -situ bioremediation, Hydrogen Releasing Compounds (HRCs) barrier, Oxygen Releasing Compounds (ORCs) barrier etc. which are efficient and cost- effective technologies. Excessive biomass formation renders a barrier ineffective in degrading the contaminants, Efforts are made to develop kinetics models which accurately determine bio - fouling and bio - filn formation and to control excessive biomass formation. | DONG Jun, Anthony ADZOMANI and ZHAO Yongsheng(College of Environment and Resources, Jilin University, Changchun 130026, P. R.China) | 2002 | Global Geology2002，7，1： | 4 |
| 9 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 10 | 矮牵牛转基因体系的建立及转BIO和bio基因研究初报显示文摘BIO ORGANS(BIO)是百脉根中调控器官形态及大小的基因。首先改良了矮牵牛愈伤诱导和再生体系,并进一步利用根癌农杆菌介导法定向将BIO及其突变基因bio导入矮牵牛中进行功能研究。结果证实含0.1mg/L6-BA的MS培养基有利于矮牵牛组培苗的增殖,添加了1.0mg/L 6-BA和0.1mg/L NAA的MS培养基有利于愈伤以及不定芽的诱导。对转基因植株目的基因的PCR检测结果显示,BIO及其突变基因bio被成功转入了矮牵牛中。表型观察结果显示:转BIO及其突变基因bio的植株叶片边缘均呈现不规则形态,部分叶片缺刻,出现由一个叶片向两个叶片分裂的趋势。其中转BIO基因植株部分叶片面积减小,叶片变窄或几乎只剩主叶脉。该研究证实BIO基因对保持叶片器官形态起到关键的作用,从而为进一步探索BIO基因的调控机制提供了实验依据。 | 李颖 刘姬艳 胡江琴 陈哲皓 胡灵芝 王利琳 | 2013 | 浙江大学学报(农业与生命科学版)2013，39，1： | 4 |
| 11 | Carbon nanotubes:Evaluation of toxicity at biointerfaces显示文摘Carbon nanotubes (CNTs) are a class of carbon allotropes with interesting properties that make them productive materials for usage in various disciplines of nanotechnology such as in electronics equipments, optics and therapeutics. They exhibit distinguished properties viz., strength, and high electrical and heat conductivity. Their uniqueness can be attributed due to the bonding pattern present between the atoms which are very strong and also exhibit high extreme aspect ratios. CNTs are classified as singlewalled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) on the basis of number of sidewalls present and the way they are arranged spatially. Application of CNTs to improve the performance of many products, especially in healthcare, has led to an occupational and public exposure to these nanomaterials. Hence, it becomes a major concern to analyze the issues pertaining to the toxicity of CNTs and find the best suitable ways to counter those challenges. This review summarizes the toxicity issues of CNTs in vitro and in vivo in different organ systems (bio interphases) of the body that result in cellular toxicity. | Debashish Mohanta Soma Patnaik Sanchit Sood Nilanjan Das | 2019 | Journal of Pharmaceutical Analysis2019，9，5： | 4 |
| 12 | 美国生物法1,4-丁二醇工业化生产显示文摘美国吉诺玛蒂卡公司(Genomatica)和杜邦泰特乐利生物产品公司(DuPont Tate&Lyle Bio Products)联合宣布,使用常规糖类为原料,采用直接发酵方法,历时5周生产出约2 268 t 1,4-丁二醇(BDO)。 | 郑宁来 | 2013 | 合成纤维2013，，5： | 4 |
| 13 | 基于ASP网络聊天室设计与实现显示文摘随着互连网技术普及与发展,互联网与人们生活关系越来越紧密相连。其中ASP技术的使用更加剧了网络通信技术的发展。本文在论述过程中,主要针对ASP及其相关技术的基本知识和应用做了较为详细的介绍,同时在进行系统设计过程中,由于使用到了ASPScript、数据库连接技术(ADO)和BIO(内置对象)技术,因此在本文中也对以上技术进行较为详尽的介绍,详细地分析了各个模块的功能及实现方法。 | 常颖 | 2017 | 电子技术与软件工程2017，，5： | 3 |
| 14 | 帕金森综合征治疗药——罗替戈汀显示文摘 | 马传江 | 2008 | 齐鲁药事2008，27，7： | 3 |
| 15 | 基于Java的socket I/O流技术显示文摘传统的BIO技术在网络通信中需要服务器为每一个链接都建立一个线程,如果其中已连接的请求没有任何操作,将造成线程浪费。本文分析了BIO技术、NIO技术、AIO技术在网络通信中的应用场合,解决了传统BIO技术的不足,给出了其基本实现步骤及应用场景。 | 王少辉 陈晓鹏 | 2017 | 电子技术与软件工程2017，，9： | 2 |
| 16 | 一种新结构的DM-multipath与动态负载平衡显示文摘对于存储设备,Linux在多路径I/O方面主要有两种类型的解决方案:位于I/O调度器之上的顶层方案(BIO映射器)和位于底层的子系统具体方案(如IDE,SCSI)。因为实施它们的所在存储堆栈中的位置不同,每种方案各有优势。通过与第一种方案比较,介绍具体硬件子系统之上的另一种解决方案,新结构中重点实现移动内核当前多路径层——多路径设备映射器(dm-multipath)到I/O调度层之下,这种方案能够有效地支持动态的负载平衡。 | 阚闯 戚玮玮 | 2008 | 计算机应用2008，28，2： | 2 |
| 17 | Citric acid-assisted synthesis of nano-Ag/BiO Br with enhanced photocatalytic activity显示文摘In this study, silver nano-particles have been anchored in the surface of Bi OBr photocatalysts by a citric acid-assisted photoreduction method. The citric acid was served as a chelating and reductive agent for the preparation of Ag-decorated Bi OBr photocatalysts(named as Ag/Bi OBr-2). The as-synthesized samples were characterized by X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), scanning electron microscopy(SEM), transmission electron microscopy(TEM), and UV-Vis diffuse reflection spectroscopy(DRS). The Ag/Bi OBr-2 photocatalyst exhibited excellent and stable photocatalytic activities on MO and phenol degradation under simulated sunlight irradiation. The enhanced photocatalytic activity could be ascribed to the smaller size, rough surface, and the surface plasma resonance(SPR) effect of Ag. Also, the Schottky junction, between the surface of the Bi OBr and silver nanoparticles, accelerated the efficient transfer and separation of photoinduced electron-hole pairs and promoted the photocatalytic performance. The active species tests indicated that the superoxide radical(·O-2) was responsible for the enhanced photocatalytic performance of Ag/Bi OBr-2. Finally, a possible photocatalytic mechanism was proposed. | Xiuli Li Xiaoming Mao Xiaochao Zhang Yunfang Wang Yawen Wang Hui Zhang Xiaogang Hao Caimei Fan | 2015 | Science China Chemistry2015，58，3： | 2 |
| 18 | 匹配牙槽窝的根形种植体即刻种植的动物实验研究显示文摘目的探讨更加完善成熟的即刻种植技术和方法。方法选用当地生产杂种犬9只,采用自身对照方式,拔除所有动物下颌双侧第三、四前磨牙,每个前磨牙均为2个根即近中根与远中根,在右侧第三、四前磨牙远中根拔牙窝、左侧第三、四前磨牙近中根拔牙窝,直接植入直径与拔牙窝相匹配的种植体为Sim组;在左侧第三、四前磨牙远中根拔牙窝,采用直径小于拔牙窝的种植体和Bio-oss骨粉联合植入为Bio组。分别于术后1个月、2个月、3个月随机处死3只实验动物,制成HE染色组织切片,做光镜及骨组织形态计量学观察。结果 Sim组种植体成功率高。光镜观察Sim组骨板连续性较好、较厚、周围有大量成骨细胞。骨组织形态计量学观察:Sim组在1个月时的骨性结合率(CLF)、界面新骨生长率(BIF)均大于Bio组,两组之间有显著的统计学差异﹙P<0.05﹚,Sim组在2个月、3个月时的骨性结合率,界面新骨生长率均稍大于Bio组,两组之间无显著的统计学差异(P>0.05)。结论直接植入与牙槽窝相匹配的根形种植体可加速种植体的骨性结合,其骨结合率高于种植体周围骨缺损充填Bio-oss骨粉。 | 杜义军 董福生 栗兴超 张雪敏 | 2015 | 口腔医学2015，35，9： | 2 |
| 19 | BIO PERFOR体系室内暂堵评价及现场应用显示文摘在修井作业中,因井下地层压力亏空常常导致大量修井液进入储层,从而造成对储层不同程度的伤害。有效控制修井液进入储层的漏失量是储层保护的一项重要措施。这就要求选用有效的暂堵剂建立井筒液柱实现过平衡压井。对BIO PERFOR暂堵液体系基本配方的承压指标、酸溶、储保、综合性能以及高温配方所需破胶时间等5个方面进行了室内评价。评价结果表明,该体系具有良好的暂堵效果,储保效果优,配套的隐形酸完井液对该体系具有辅助破胶功能,且耐高温配方具有自行破胶和易于破胶的特点。BIO PERFOR暂堵液体系应用在一油田5口井修井作业过程中获得成功,暂堵储保效果令人满意。 | 黄华祥 王靖 罗少锋 | 2014 | 长江大学学报(自科版)(上旬)2014，11，5： | 2 |
| 20 | 水解稳定剂BIOSW-100研发成功显示文摘日前,山西省化工研究所年产100t水解稳定剂BIO SW-100中试项目获得成功,标志着山化所在生物基和生物可降解塑料配套助剂工程化技术开发方面再获佳绩。 | 王克智 张惠芳 | 2013 | 塑料工业2013，41，3： | 2 |
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