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| 1 | Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer:the FUTURE trial显示文摘Triple-negative breast cancer(TNBC)is a highly heterogeneous disease,and molecular subtyping may result in improved diagnostic precision and targeted therapies.Our previous study classified TNBCs into four subtypes with putative therapeutic targets.Here,we conducted the FUTURE trial(ClinicalTrials.gov identifer:NCT03805399),a phaseⅠb/Ⅱsubtyping-based and genomic biomarker-guided umbrella trial,to evaluate the efficacy of these targets.Patients with refractory metastatic TNBC were enrolled and stratifed by TNBC subtypes and genomic biomarkers,and assigned to one of these seven arms:(A)pyrotinib with capecitabine,(B)androgen receptor inhibitor with CDK4/6 inhibitor,(C)anti PD-1 with nab-paclitaxel,(D)PARP inhibitor included,(E)and(F)anti-VEGFR included,or(G)mTOR inhibitor with nab paclitaxel.The primary end point was the objective response rate(ORR).We enrolled 69 refractory metastatic TNBC patients with a median of three previous lines of therapy(range,1-8).Objective response was achieved in 20(29.0%,95%confidence interval(CI):18.7%-41.2%)of the 69 intention-to-treat(ITT)patients.Our results showed that immunotherapy(arm C),in particular,achieved the highest ORR(52.6%,95%CI:28.9%-75.6%)in the ITT population.Arm E demonstrated favorable ORR(26.1%,95%C:10.2%-48.4%in the ITT population)but with more high grade(23)adverse events.Somatic mutations of TOP2A and CD8 immunohistochemical score may have the potential to predict immunotherapy response in the immunomodulatory subtype of TNBC.In conclusion,the phaseⅠb/ⅡFUTURE trial suggested a new concept for TNBC treatment,demonstrating the clinical beneft of subtyping-based targeted therapy for refractory metastatic TNBC. | Yi-Zhou Jiang Yin Liu Yi Xiao Xin Hu Lin Jiang Wen-ia Zuo Ding Ma Jiahan Ding Xiaoyu Zhu Jianjun Zou Claire Verschraegen Daniel G.Stover Virginia Kaklamani Zhong-Hua Wang Zhi-Ming Shao | 2021 | Cell Research2021，31，2： | 37 |
| 2 | Reply to the Comment on 'Improvement of Controlled Bidirectional Quantum Direct Communication Using a GHZ State' [Chin. Phys. Lett. 30 (2013) 040305]显示文摘Most recently,Liu and Chen[Chin.Phys.Lett.30(2013)079901]used the tool of information theory to analyze the security of our two improved versions of the MX protocol[Chin.Phys.Lett.30(2013)040305],and they found out that our two improved versions still have the information leakage problem.After revisiting them with the tool of information theory again,with respect to the security,we draw the same conclusion as Liu and Chen.In addition,we point out that how to use a single quantum state as the sole quantum resource to design a bidirectional quantum secure direct communication protocol without information leakage is still a big challenge that needs to be solved. | 叶天语 蒋丽珍 | 2013 | Chinese Physics Letters2013，30，7： | 13 |
| 3 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 4 | Sadly,the earth is still round(p<0.05)显示文摘Looking through any exercise science journals today,in fact any science journals including many top Science Citation Index(SCI) journals,one can easily find examples of the wide-spread 'p<0.05/significance' abuse phenomenon,i.e., if the p value from a statistical/hypothesis test is less than 0.05(or 0.01 sometimes),a conclusion that 'the results/ findings are significant' is then drawn.The abuse is so severe that it is already seriously threatening the integrity of scientific inquiry. | Weimo Zhu | 2012 | Journal of Sport and Health Science2012，1，1： | 7 |
| 5 | The First OCCCO Pentadentate Chelates:Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N-Oxide显示文摘of main observation and conclusion Oxygen atom transfer reactions between alkynes and heteroarene N-oxides are currently mediated by transition metal,such as gold,ruthenium or rhodium,but they have never been catalyzed by osmium.Herein,we report stepwise oxidations of terminal alkynes mediated by an osmium carbolong complex,using pyridine N-oxide as the oxidant,yielding novel aldehyde-or carboxylic acid-coordinated osmapentalyne derivatives selectively.The mechanism was illustrated by density functional theory calculations,providing a new route for oxygen atom transfer between heteroarene N-oxides and alkynes. | Jianfeng Lin Qiannan Xu Xinlei Lin Yuhui Hua Dafa Chen Yonghong Ruan Hong Zhang Haiping Xia | 2020 | Chinese Journal of Chemistry2020，38，11： | 4 |
| 6 | Seasonal variance of salinity tolerance of a copepod Drepanopus bispinosus in an Antarctic littoral saline lake (Burton Lake)显示文摘In Burton Lake (an Antarctic littoral saline lake), as one of the overwinter species, the female Drepanopus bispinosus reach adult form in autumn. and early winter.For the subsequent life period of more than eight months, the animals experience such changing environment as increasing salinities from approximately 33 (in May) to 39 (in November). There is a considerable difference of salinity tolerance of female adults between summer and winter populations.Winter collected copepods survived lower salinities than summer collected copepods in this experiment. The upward shift in their salinity tolerance range is related to the development of field acclimation to salinity. Respiration rates of the summer animals showed a visible increase over those of winter copepods in simitar salinity and temperature conditions, thus supporting the above conclusion. | D.S.Eslake H.R.Burton | 1989 | Acta Oceanologica Sinica1989，8，1： | 3 |
| 7 | EXPERIMENTAL EVIDENCE OF ORDER-DISORDER TRANSITIONS AS OF THE SECOND DEGREE显示文摘There has been considerable controversy as to whether the order-disorder change in alloys should be considered as a phase transition of the first or the second degree. By 'ordered' is meant that the lattice sites can be grouped into sublattices each of which is occupied predominantly by one kind of atom. In the 'disordered' state, no such grouping is possible, each sublattice being occupied by the various constituents at random. | 陆学善 梁敬魁 | 1966 | Chinese Science Bulletin1966，24，10： | 3 |
| 8 | Biochemical Characterization of an Arginine 2,3-Aminomutase with Dual Substrate Specificity显示文摘Summary of main observation and conclusion The radical S-adenosylmethionine(SAM)aminomutases represent an important pathway for the biosynthesis of p-amino acids.In this study,we report biochemical characterization of BlsG involved in blasticidin S biosynthesis as a radical SAM arginine 2,3-aminomutase.We showed that BlsG acts on both£-arginine and L-lysine with comparable catalytic efficiencies.Similar dual substrate specificity was also observed for the lysine 2,3-aminomutase from Escherichia coli(LAMec).The catalytic efficiency of LAMEc is similar to that of BlsG,but is significantly lower than that of the enzyme from Clostridium subterminale(LAMcs),which acts only on L-lysine rather than on L-arginine.Moreover,we showed that enzymes can be grouped into two major phylogenetic clades,each corresponding to a certain C3 stereochemistry of the P-amino acid product.Our study expands the radical SAM aminomutase members and provides insights into enzyme evolution,supporting a trade-off between substrate promiscuity and catalytic efficiency. | Junfeng Zhao Wenjuan Ji Xinjian Ji Qi Zhang | 2020 | Chinese Journal of Chemistry2020，38，9： | 3 |
| 9 | DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells显示文摘Among the various sources of human autologous stem cells,stem cells isolated from dental tissues exhibit excellent properties in tissue engineering and regenerative medicine.However,the distinct potential of these odontogenic cell lines remains unclear.In this study,we analyzed DNA methylation patterns to determine whether specific differences existed among three different odontogenic cell types.Using the HumanMethylation450 Beadchip,the whole genomes of human dental pulp stem cells(DPSCs),periodontal ligament stem cells(PDLSCs),and dental follicle progenitor cells(DFPCs)were compared.Then,the osteogenic potential of these cells was evaluated both in vitro and in vivo,and the methylation levels of certain genes related to bone formation differed among the three cell lines.P values less than 0.05 were considered to indicate statistical significance.The three cell types showed highly similar DNA methylation patterns,although specific differences were identified.Gene ontology analysis revealed that one of the most significantly different gene categories was related to bone formation.Thus,expression of cell surface epitopes and osteogenic-related transcription factors as well as the bone formation capacity were compared.The results showed that compared with DFPCs and DPSCs,PDLSCs had higher transcription levels of osteogenic-related factors,a higher in vitro osteogenic potential,and an increased new bone formation capacity in vivo.In conclusion,the results of this study suggested that the differential DNA methylation profiles could be related to the osteogenic potential of these human odontogenic cell populations.Additionally,the increased osteogenic potential of PDLSCs might aid researchers or clinicians in making better choices regarding tissue regeneration and clinical therapies. | Tingting Ai Jieni Zhang Xuedong Wang Xiaowen Zheng Xueyan Qin Qian Zhang Weiran Li Wei Hu Jiuxiang Lin Feng Chen | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 10 | Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable NAD(P)H Models显示文摘A facile approach to chiral dihydroquinazolinone derivatives has been described wia biomimetic asym-metric reduction of quinazolinones with chiral and regenerable NAD(P)H models.The utiity of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor. | Zi-Biao Zhao Xiang Li Bo Wu Yong-Gui Zhou | 2020 | Chinese Journal of Chemistry2020，38，7： | 3 |
| 11 | Pd-Catalyzed Dearomatization of Indole Derivatives via Intermolecular Heck Reactions显示文摘Pd-catalyzed intermolecular dearomative Heck reaction of indoles with aryl iodides is described.The challenges on both reactivity and regioselectivity are addressed by the judicious regulation of the geometric and electronic properties of the substrates.An array of indoline derivatives bearing C2-quaternary center is obtained in good to excellent yields(up to 93%)with exclusive regioselectivity under operationally simple conditions.The mechanistic proposal is supported by detailed DFT calculations. | Ping Yang Ren-Qi Xu Chao Zheng Shu-Li You | 2020 | Chinese Journal of Chemistry2020，38，3： | 2 |
| 12 | A Star-Shaped Solvatofluorochromic Pyrene-Triarylamine Derivative as a Fluorescent Thermometer over a Wide Temperature Range显示文摘of main observation and conclusion A star-shaped compound 1 with a pyrene core and four triarylamine arms has been prepared and characterized.It exhibits intense intramolecular-charge-transfer(ICT)emissions with strong solvatofluorochromism.On the basis of the temperature-dependent emission color and wavelength changes,compound 1 behaves as a fluorescent thermometer between 200 and 400 Kwith a high theromosensitivity.In comparison,model compounds with one or two triarylamine arms show distinctly lower thermosensitivity. | Tian-Ge Sun Zhong-Liang Gong Jiang-Yang Shao Yu-Wu Zhong | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 13 | Instability from Steady and Axisymmetric to Steady and Asymmetric Floating Half Zone Convection in a Fat Liquid Bridge of Larger Prandtl Number显示文摘The linear instability analysis of the present paper shows that the thermocapillary convection in a half floating zone of larger Prandtl number has a steady instability mode ωi = 0 and m = 1 for a fat liquid bridge V = 1.2 with small geometrical aspect ratio A = 0.6. This conclusion is different from the usual idea of hydrothermal instability, and implies that the instability of the system may excite a steady and axial asymmetric state before the onset of oscillation in the case of large Prandtl number. | 陈启生 胡文瑞 | 1999 | Chinese Physics Letters1999，16，11： | 2 |
| 14 | Author Correction: Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration显示文摘We apologize for the mistake of the fund information in the acknowledgements.The correct information is as follows.This correction does not affect the conclusion of the work. | Xuan Ming Zhuqiang Zhang Zhuoning Zou Cong Lv Qiang Dong Qixiang He Yangyang Yi Yingfeng Li Hailin Wang Bing Zhu | 2021 | Cell Research2021，31，3： | 2 |
| 15 | High seroprevalence of toxoplasma gondii and HIV-1 co-infection among drug users in Yunnan province, southwest China显示文摘Dear Editor,Toxoplasma gondii was discovered more than 100 years ago and has a broad-spectrum of intermediate hosts in addition to its definitive host,felids.Although it does not cause symptomatic illness in most adults,it can lead to mental retardation in congenitally infected children and | Xin Chen Mei Ye Yan-Heng Zhou Feng-Liang Liu Lin Duo Hong Li Wei Pang Yong-Tang Zheng | 2016 | Science China(Life Sciences)2016，59，8： | 2 |
| 16 | Evaluation of bacterial contamination rate of the anterior chamber during phacoemulsification surgery using an automated microbial detection system显示文摘·AIM: To assess the incidence of anterior chamber bacterial contamination during phacoemulsification surgery using an automated microbial detection system(BacT/Alert).·METHODS: Sixty-nine eyes of 60 patients who had uneventful phacoemulsification surgery, enrolled in this prospective study. No prophylactic topical or systemic antibiotics were used before surgery. After antisepsis with povidone-iodine, two intraoperative anterior chamber aqueous samples were obtained, the first whilst entering anterior chamber, and the second at the end of surgery. BacT/Alert culture system was used to detect bacterial contamination in the aqueous samples.·RESULTS: Neither aqueous samples obtained at the beginning nor conclusion of the surgery was positive for microorganisms on BacT/Alert culture system. The rate of bacterial contamination during surgery was 0%. None of the eyes developed acute-onset endophthalmitis after surgery.· CONCLUSION: In this study, no bacterial contamination of anterior chamber was observed during cataract surgery. This result shows that meticulous surgical preparation and technique can prevent anterior chamber contamination during phacoemulsification cataract surgery. | Ibrahim Kocak Funda Kocak Bahri Teker Ali Aydin Faruk Kaya Hakan Baybora | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 2 |
| 17 | Genkwadane F-I,New Daphnane-type Diterpenes from the Flower Buds of Daphne genkwa Sieb.et Zucc.Exhibit Anti-tumor Activities via lnducing Apoptosis显示文摘of main observation and conclusion Genkwadane F-I(1-4),four new diterpenes,along with four known ones(5-8),were isolated from the flower buds of D.genkwa.The structures including absolute configurations of 1-4 were determined based on the analysis of NMR and ECD calculations.All compounds were evaluated for their cytotoxicities against MCF-7 and Hep3B cell lines,among which compounds 3 and 4 showed significant activities.Compound 4 exhibited the most potent activity with IC50 values of 1.33μM against MCF-7,and the IC50 values of compound 3 against MCF-7 and Hep3B were 5.54μM and 8.73μM;respectively.Further studies by Hoechst 33258 staining and Annexin V/PI analysis demonstrated that compounds 3 and 4 could induce apoptosis to exhibit anti-tumor activities. | Xuewen Hou Jingjie Chen Xuefen Hou Pinyi Gao Jinlin Wang Shaojiang Song Lingzhi Li | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
| 18 | Iron-Catalyzed Primary C-H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidinest显示文摘of main observation and conclusion The direct amination of unactivated primary C-H bonds is extremely challenging due to their inert nature.Herein,we report an intramolecular primary C-H amination of sulfamate esters using an iron catalyst derived from iron(Ⅱ)triflate and bipyridine.An array of oxathiazinanes were synthesized in moderate to good yields,which were further converted into biologically important azetidines by a one-pot procedure.This research demonstrates the potential of applying simple nitrogen ligands in iron-catalyzed C-H functionalization and offers an accessible alternative to state-of-the-art iron-nitrene chemistry. | Yan Zhang Dayou Zhong Muhammad Usman Peng Xue Wen-Bo Liu | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
| 19 | Author Correction:Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘Correction to:Cell Research https://doi.org/10.1038/s41422-022-00635-9,published online 10 March 2022 We found that the information in the original Supplementary Figs.S2–S4 was not fully displayed due to an error in the image upload.The correct images are shown below for better display.These corrections do not affect the description of the results or the conclusion of this work.No change of the original figure legends is needed.We apologize for the mistake.The original article has been corrected. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2023 | Cell Research2023，33，7： | 1 |
| 20 | Heating Finite Beta Tokamak-Plasmas by Alfven Waves显示文摘Heating finite betas(relative to low beta)tokamak plasmas by Alfven waves is studied by means of a linearized kinetic model which takes into account ion sound and transit time magnetic pumping as well as the effect considered by preceding authors.In cylindrical geometry,a set of three second-order differential equations in r for the perturbed fields Er,E_(⊥),and E_(||) is solved numerically.The results lead to a significant conclusion that Alfven wave heating may be an advanced way of heating plasmas in future tokamaks. | HUANG Lin QIN Xiaoming DING Ning LONG Yongxing | 1991 | Chinese Physics Letters1991，8，5： | 1 |
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