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| 1 | Red blood cell distribution width and ischaemic stroke显示文摘The red blood cell distribution width(RDW)is a measure of red blood cell(RBC)size heterogeneity,which is easily calculated by dividing the SD of erythrocyte volumes for the mean corpuscular volume.Recent reporter suggested that,besides haematological diseases and anaemia,many human disorders may be closely associated with the elevated RDW.A literature review has revealed the RDW may be closely related to the development of ischaemic stroke,carotid artery atherosclerosis and cerebral embolism.Higher RDW could independently predict adverse outcomes in patients in these conditions. | Gang-Hua Feng Hai-Peng Li Qiu-Li Li Ying Fu Ren-Bin Huang | 2017 | Stroke & Vascular Neurology2017，2，3： | 24 |
| 2 | Current management of spontaneous intracerebral haemorrhage显示文摘Intracerebral haemorrhage(ICH)is the most devastating and disabling type of stroke.Uncontrolled hypertension(HTN)is the most common cause of spontaneous ICH.Recent advances in neuroimaging,organised stroke care,dedicated Neuro-ICUs,medical and surgical management have improved the management of ICH.Early airway protection,control of malignant HTN,urgent reversal of coagulopathy and surgical intervention may increase the chance of survival for patients with severe ICH.Intensive lowering of systolic blood pressure to<140 mm Hg is proven safe by two recent randomised trials.Transfusion of platelets in patients on antiplatelet therapy is not indicated unless the patient is scheduled for surgical evacuation of haematoma.In patients with small haematoma without significant mass effect,there is no indication for routine use of mannitol or hypertonic saline(HTS).However,for patients with large ICH(volume>30 cbic centmetre)or symptomatic perihaematoma oedema,it may be beneficial to keep serum sodium level at 140–150 mEq/L for 7–10 days to minimise oedema expansion and mass effect.Mannitol and HTS can be used emergently for worsening cerebral oedema,elevated intracranial pressure(ICP)or pending herniation.HTS should be administered via central line as continuous infusion(3%)or bolus(23.4%).Ventriculostomy is indicated for patients with severe intraventricular haemorrhage,hydrocephalus or elevated ICP.Patients with large cerebellar or temporal ICH may benefit from emergent haematoma evacuation.It is important to start intermittent pneumatic compression devices at the time of admission and subcutaneous unfractionated heparin in stable patients within 48 hours of admission for prophylaxis of venous thromboembolism.There is no benefit for seizure prophylaxis or aggressive management of fever or hyperglycaemia.Early aggressive comprehensive care may improve survival and functional recovery. | Cyrus K Dastur Wengui Yu | 2017 | Stroke & Vascular Neurology2017，2，1： | 18 |
| 3 | Advances in understanding and treating liver diseases during pregnancy:A review显示文摘Liver disease in pregnancy is rare but pregnancyrelated liver diseases may cause threat to fetal and maternal survival.It includes pre-eclampsia;eclampsia;haemolysis,elevated liver enzymes,and low platelets syndrome;acute fatty liver of pregnancy;hyperemesis gravidarum;and intrahepatic cholestasis of pregnancy.Recent basic researches have shown the various etiologies involved in this disease entity.With these advances,rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal survival.The other therapeutic options have also been shown in recent reports based on the clinical trials and cooperation and information sharing between hepatologist and gynecologist is important for timely therapeutic intervention.Therefore,correct understandings of diseases and differential diagnosis from the pre-existing and co-incidental liver diseases during the pregnancy will help to achieve better prognosis.Therefore,here we review and summarized recent advances in understanding the etiologies,clinical courses and management of liver disease in pregnancy.This information will contribute to physicians for diagnosis of disease and optimum management of patients. | Kenya Kamimura Hiroyuki Abe Hirokazu Kawai Hiroteru Kamimura Yuji Kobayashi Minoru Nomoto Yutaka Aoyagi Shuji Terai | 2015 | World Journal of Gastroenterology2015，21，17： | 15 |
| 4 | The WRKY transcription factor HpWRKY44 regulates CytP450-like1 expression in red pitaya fruit(Hylocereus polyrhizus)显示文摘Red pitaya(Hylocereus polyrhizus)fruit is a high-value,functional food,containing a high level of betalains.Several genes potentially related to betalain biosynthesis,such as cytochrome P450-like(CytP450-like),have been identified in pitaya fruit,while their transcriptional regulation remains unclear.In this work,the potential involvement of a WRKY transcription factor,HpWRKY44,in regulating CytP450-like1 expression in pitaya fruit was examined.HpWRKY44,a member of the Group 1 WRKY family,contains two conserved WRKY motifs and is localized in the nucleus.HpWRKY44 also exhibits trans-activation ability.Gene expression analysis showed that the expression of HpCytP450-like1 and HpWRKY44 increased steadily during pitaya fruit coloration,which corresponded with the production of elevated betalain levels in the fruit.HpWRKY44 was also demonstrated to directly bind to and activate the HpCytP450-like1 promoter via the recognition of the W-box element present in the promoter.Collectively,our findings indicate that HpWRKY44 transcriptionally activates HpCytP450-like1,which perhaps,at least in part,contributes to betalain biosynthesis in pitaya fruit.The information provided in the current study provides novel insights into the regulatory network associated with betalain biosynthesis during pitaya fruit coloration. | Mei-nv Cheng Zi-juan Huang Qing-zhu Hua Wei Shan Jian-fei Kuang Wang-jin Lu Yong-hua Qin Jian-ye Chen | 2017 | Horticulture Research2017，4，1： | 13 |
| 5 | No association between elevated homocysteine levels and carotid atherosclerosis in a rural population in China显示文摘Objectives:We wish to determine if homocysteine(Hcy)is an independent risk factor for carotid atherosclerosis in a rural Chinese population.Methods:2291 individuals(1016 men and 1275 women),aged 64.6±7.4 years,from Lvliang,China participated in this study.Tests performed included carotid artery ultrasound scan and blood analysis,to measure Hcy levels and other blood components.Results:The mean serum Hcy level was 24.7±18.0μmol/L.The overall detection rate of carotid atherosclerotic lesions was 76.3%and the detection rate of plaque was 48.6%.Participants were divided into 4 groups based on their Hcy levels,<14.49,14.49–19.43,19.44–28.30,and≥28.30μmol/L.The relative risk of carotid atherosclerosis for each quartile as compared with the risk for the lowest quartile was estimated as the OR derived from the logistic regression coefficients.After adjusting for age and gender,the OR of carotid atherosclerosis in the third and fourth quartiles of Hcy were 1.219(95%CI 0.922 to 1.612)and 1.156(95%CI 0.859 to 1.555;p>0.05),respectively.After controlling for demographic variables(age,gender,current smoker,fasting blood glucose,low-density lipoprotein and systolic blood pressure)the OR of carotid plaque(s)in the third and fourth quartiles were 1.246(95%CI 0.967 to 1.606)and 1.259(95%CI 0.963 to 1.646;p>0.05).Conclusions:The mean value of Hcy among participants in this study was much higher than that previously reported.However,no significant correlation between elevated Hcy and carotid atherosclerosis was found. | Yang Li Li Wang Wei Zhang Yalan Fang Xiaoyuan Niu | 2016 | Stroke & Vascular Neurology2016，1，4： | 13 |
| 6 | A New Method for Experimental Determination of Compressional Velocities in Rocks and Minerals at High-pressure显示文摘A transmission-reflection-combined new method is presented for measuring elastic velocities of rocks and minerals at elevated temperature and pressure,which resolves the problems of gradients of temperature and pressure existing in original sample assembly with a pyrophyllite cube.At room temperature and pressure up to 3 GPa,single-crystal quartz and eclogite were used to provide samples under test,respectively.The results of this work agree with the previous measurements very well within the error range.By the use of this new technique,more precise and reasonable data of elastic properties of rocks and minerals at elevated temperature and pressure can be achieved. | 刘永刚 谢鸿森 郭捷 周文戈 徐济安 赵志丹 | 2000 | Chinese Physics Letters2000，17，12： | 11 |
| 7 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 8 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 9 | Initiation of Parkinson’s disease from gut to brain byδ-secretase显示文摘Lewy pathology,composed ofα-Synuclein(α-Syn)inclusions,a hallmark of Parkinson’s disease(PD),progressively spreads from the enteric nervous system(ENS)to the central nervous system(CNS).However,it remains unclear how this process is regulated at a molecular level.Here we show thatδ-secretase(asparagine endopeptidase,AEP)cleaves bothα-Syn at N103 and Tau at N368,and mediates their fibrillization and retrograde propagation from the gut to the brain,triggering nigra dopaminergic neuronal loss associated with Lewy bodies and motor dysfunction.α-Syn N103 and Tau N368 robustly interact with each other and are highly elevated in PD patients’gut and brain.Chronic oral administration of the neurotoxin rotenone induces AEP activation andα-Syn N103/Tau N368 complex formation in the gut,eliciting constipation and dopaminergic neuronal death in an AEP-dependent manner.Preformed fibrils(PFFs)ofα-Syn N103/Tau N368 are more neurotoxic and compact,and aggregate more quickly along the vagus nerve than their FL/FL counterparts or the individual fragments’fibrils.Colonic injection of PFFs induces PD pathologies,motor dysfunctions,and cognitive impairments.Thus,δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS. | Eun Hee Ahn Seong Su Kang Xia Liu Guiqin Chen Zhentao Zhang Bindu Chandrasekharan Ashfaqul M.Alam Andrew S.Neish Xuebing Cao Keqiang Ye | 2020 | Cell Research2020，30，1： | 9 |
| 10 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 11 | Creep damage characterization of UNS N10003 alloy based on a numerical simulation using the Norton creep law and Kachanov–Rabotnov creep damage model显示文摘The calculation of inelastic creep damage is important for the structural integrity evaluation of the elevated temperature structure in a thorium molten salt reactor(TMSR). However, a creep damage theory model and numerical simulation method have not been proposed for the key materials(UNS N10003 alloy) in the TMSR. In this study, creep damage characterization of UNS N10003 alloy is investigated using the Norton creep law and Kachanov–Rabotnov(K–R) creep damage model. First, the creep experimental data of the UNS N10003 alloy at 650 °C were adopted to fit the material constants of the two models. Then, the creep damage behavior of the UNS N10003 alloy was analyzed and discussed under uniaxial and multi-axial stress states. The results indicated that the K–R creep damage model is more suitable for the UNS N10003 alloy than the Norton model. Finally, the numerical simulation method was developed by a user-defined UMAT subroutine and subsequently verified through a finite element analysis(FEA). The FEA results were in agreement with the theoretical solutions. This study provides an effective method for the inelastic creep damage analysis of the elevated temperature structure in the TMSR. | Xiao-Yan Wang Xiao Wang Xiao-Chun Zhang Shi-Feng Zhu | 2019 | Nuclear Science and Techniques2019，30，4： | 7 |
| 12 | Glycogenic hepatopathy:A narrative review显示文摘Glycogenic hepatopathy(GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis. The association of GH with hyperglycemia in diabetes has not been well established. One of the essential elements in the pathophysiology of development of GH is the wide fluctuation in both glucose and insulin levels. GH and non-alcoholic fatty liver disease(NAFLD) are clinically indistinguishable, and latter is more prevalent in diabetic patients and can progress to advanced liver disease and cirrhosis. Gradient dual-echo MRI can distinguish GH from NAFLD; however, GH can reliably be diagnosed only by liver biopsy. Adequate glycemic control can result in complete remission of clinical, laboratory and histological abnormalities. There has been a recent report of varying degree of liver fibrosis identified in patients with GH. Future studies are required to understand the biochemical defects underlying GH, noninvasive, rapid diagnostic tests for GH, and to assess the consequence of the fibrosis identified as severe fibrosis may progress to cirrhosis. Awareness of this entity in the medical community including specialists is low. Here we briefly reviewed the English literature on pathogenesis involved, recent progress in the evaluation, differential diagnosis, and management. | Jagannath M Sherigar Joline De Castro Yong Mei Yin Debra Guss Smruti R Mohanty | 2018 | World Journal of Hepatology2018，10，2： | 7 |
| 13 | TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling显示文摘Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation.Transcriptional coactivator with PDZ-binding motif(TAZ)is a key downstream effector of the Hippo signaling pathway;it was suggested to be involved in the regulation of bone homeostasis.However,the exact role of TAZ in osteoclasts has not yet been established.In this study,we demonstrated that global knockout and osteoclast-specific knockout of TAZ led to a low-bone mass phenotype due to elevated osteoclast formation,which was further evidenced by in vitro osteoclast formation assays.Moreover,the overexpression of TAZ inhibited RANKL-induced osteoclast formation,whereas silencing of TAZ reduced it.Mechanistically,TAZ bound to TGF-activated kinase 1(TAK1)and reciprocally inhibited NF-κB signaling,suppressing osteoclast differentiation.Collectively,our findings highlight an essential role of TAZ in the regulation of osteoclastogenesis in osteoporosis and its underlying mechanism. | Wanlei Yang Xuanyuan Lu Tan Zhang Weiqi Han Jianlei Li Wei He Yewei Jia Kangxian Zhao An Qin Yu Qian | 2021 | Bone Research2021，9，3： | 6 |
| 14 | A novel mouse model of hyperuricemia and gouty nephropathy显示文摘To the Editor:Hyperuricemia,the second most common metabolic disease after diabetes mellitus in China,is characterized by the elevated serum uric concentration which is due to the overactive uric acid production or underexcretion.[1]Recent study supported the notion that hyperuricemia is implicated in renal tubular injury,subsequent tubulointerstitial fibrosis,and finally gouty nephropathy.[2]However,the lack of a suitable and stable mouse model to study hyperuricemia and gout nephropathy delays and limits the development of mechanism research and new drugs.Further understanding of the pathogenesis of hyperuricemia and gouty nephropathy has been largely hampered by a lack of preclinical animal models that reliably capture the characteristic phenotypes of hyperuricemia and gouty nephropathy.In this study,we aimed to develop a novel mouse model for hyperuricemia and gouty nephropathy. | Jin Guan Xiao-Qi Huang Jia-Le Dong Hui-Min Lu Yue-Wei Lin Mei Liu Zhi-Biao Yi Li-Min Wu Yong-Ming Huang Tian Lan | 2020 | Chinese Medical Journal2020，，16： | 5 |
| 15 | Mean platelet volume in the first trimester as a predictor of gestational diabetes mellitus显示文摘Gestational diabetes mellitus(GDM)manifests as different degrees of carbohydrate intolerance during pregnancy.According to several studies,GDM affects 4%to 25%of pregnant women.The majority of patients with GDM have varying levels of insulin resistance and chronic low-grade inflammation,which are related to vascular injury and dysfunction and subsequent platelet activation.[1]Consequently,platelet activation may be closely related to GDM severity.The mean platelet volume(MPV)is one of the indexes used to evaluate platelet morphology and activity.An elevated MPV has been demonstrated to be related to cardiovascular diseases and other conditions,such as hypertension and nonalcoholic fatty liver disease. | Zhuo Ren Li Lin Zhi Li Xin-Ping Sun Kai Yang Hui-Xia Yang | 2020 | Chinese Medical Journal2020，，11： | 5 |
| 16 | A new approach on necking constitutive relationships of ductile materials at elevated temperatures显示文摘A new method is presented to determine the full-range, uniaxial constitutive relationship of materials by tensile tests on funnel specimens with small curvature radius and finite element analysis(FEA). An iteration method using FEA APDL(ANSYS parametric design language) programming has been developed to approach the necking constitutive relationship of materials. Test results from SAE 304 stainless steel at room temperature show that simulated load vs displacement curve,diameter at funnel root vs displacement curve, and funnel deformation contours are close to modeled results. Due to this new method, full-range constitutive relationships and true stress and effective true strain at failure are found for 316 L stainless steel, TA17 titanium alloy and A508-III stainless steel at room temperature, and 316 L stainless steel at various elevated temperatures. | Yao Di Cai Lixun Bao Chen | 2016 | Chinese Journal of Aeronautics2016，29，6： | 5 |
| 17 | Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids显示文摘Background Hyperprolactinemia is a common adverse reaction in patients with schizophrenia who take antipsychotic drugs;it often leads to treatment noncompliance in patients and has an adverse effect on their prognosis.Aims This study aimed to explore the risk factors of elevated prolactin(PRL)caused by risperidone(RIS)and olanzapine(OLZ)and the relationship between PRL and fasting plasma glucose and lipids.Methods Patients with schizophrenia were divided into two groups:264 patients who were taking RIS and 175 patients who were taking OLZ.These two groups were further divided according to serum PRL levels:an elevated PRL group(>30ng/mL)and a normal PRL group(PRL<30ng/mL).The demographics,medication dosage,fasting plasma glucose,total cholesterol and triglycerides were compared in the two groups.Logistic regression analysis was performed to explore the risk factors of elevated PRL levels.Results Compared with the OLZ group,the RIS group had a greater number of patients with elevated PRL(155/264 vs 58/175).Either the RIS or the OLZ group,the proportion of elevated PRL was greater in female patients(RIS:x^2=6.76,p=0.009;OLZ:x^2=12.98,p<0.001)and with higher doses of the related drugs(RIS:U=-3.73,p<0.001;OLZ:U=-2.31,p=0.021).In patients taking RIS,the elevated PRL subgroup took the drug for a longer period(U=-2.76,p=0.006)and had lower triglyceride levels(U=2.76,p=0.006).In patients taking OLZ,the elevated PRL subgroup had lower fasting plasma glucose levels(U=2.29,p=0.022).Logistic regression analysis showed that gender,dose and fasting glucose levels were significantly associated with elevated PRL levels(RIS:p=0.001,OLZ:p<0.001;RIS:p<0.001;OLZ:p=0.003;RIS:p=0.020,OLZ:p=0.001,respectively).Conclusion Compared with OLZ,RIS had a greater effect on PRL in patients with schizophrenia,and in patients with schizophrenia taking RIS or OLZ,gender and dose were significantly correlated with the PRL value.Moreover,the plasma glucose level of the group with elevated PRL was lower than that of the group with normal PRL.The results also showed that high serum PRL may be associated with a favourable glucose metabolic profile in patients with schizophrenia taking RIS or OLZ.Further studies are warranted to confirm this association. | Sidi He Wen Juan Yu Xiaoliang Wang Lei Zhang Nan Zhao Guanjun Li Yi Feng Shen Huafang Li | 2020 | General Psychiatry2020，33，4： | 5 |
| 18 | Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging显示文摘Hyperglycemia induces chronic low-grade inflammation(inflammaging),which is a newly identified contributor to diabetes-related tissue lesions,including the inflammatory bone loss in periodontitis.It is also a secondary senescent pattern mediated by an increased burden of senescent cells and senescence-associated secretory phenotype(SASP).Macrophage is a key SASPspreading cell and may contribute to the maintenance of SASP response in the periodontal microenvironment.Using a transgenic diabetic model(BLKS/J-Lepr^(db)/lepr^(db)mice)we identified striking senescence of the periodontium in young(18-wk)-diabetic mice accompanied by amassed p16^(+)-macrophages and enhanced early SASP response.Exposed to high glucose in vitro,bone marrow-derived macrophage(BMDM)revealed a strong GLUT1 m RNA response driving the elevated-glucose uptake.GLUT1 is a representative and facilitative glucose transporter in macrophages with potential roles in hyperglycemia-induced inflammation.In this study,both GLUT1 and the downstream GTPase Rheb expression upregulated in the gingiva of diabetic mice with impaired condition.Furthermore,SASP release and p16/p21 signaling were proven to be triggered by m TOR phosphorylation in BMDM and antagonized by restricting glucose uptake in GLUT1^(-/-)BMDM.Taken together,our findings suggest that elevated-GLUT1 sensor responded to high glucose is important for macrophage senescence and SASP response,generated as a result of hyperglycemia,and it is a potential molecular mechanism for the exacerbation of periodontitis in diabetes. | Qian Wang Lulingxiao Nie Pengfei Zhao Xinyi Zhou Yi Ding Qianming Chen Qi Wang | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 19 | Complement:a global immunometabolic regulator in amyotrophic lateral sclerosis显示文摘Recently,McDonald et al.(2020)proposed that complement causes a metabolic switch to lipid consumption in amyotrophic lateral sclerosis(ALS),which raises the possibility of complement as a global immunometabolic regulator.In ALS,neuromuscular degeneration occurs concurrently with complement-mediated inflammation,glucose intolerance,and elevated lipid consumption.Moreover,complement is being increasingly recognized as a metabolic regulator that can induce insulin resistance and alter fuel source selection.Thus,the authors propose that chronic complement activation may be driving metabolic reprogramming in ALS,which has broad implications for the field of immunometabolism and would be the first mechanistic explanation of the“lipid switch”in ALS.Specifically,it suggests that complement can drive a global shift in resources during inflammation,in which glucose is redirected from peripheral tissues to immune cells to support their inflammatory actions. | Martin W.Lo John D.Lee | 2021 | Neural Regeneration Research2021，16，6： | 4 |
| 20 | 星形细胞上调基因1(AEG -1)在肝细胞癌中的研究进展显示文摘星形细胞上调基因1(Astrosyte elevated gene 1, AEG-1)自2002年作为艾滋病病毒诱导的新型癌基因被发现以来,有关其在细胞中的生物学功能及人类肿瘤中的作用一直是研究热点。本文详细阐述了近年来发现AEG-1的重要生物学功能以及它的一些生化特性,包括一些氨基酸序列及核定位信号通路,并总结了AEG-1在肝细胞癌( Hepatocellular carcinoma ,HCC)中的相关研究进展。认识到AEG-1发挥生物学效应的分子机制及作用的具体信号通路,能够帮助我们对AEG-1本身及其在HCC中的重要作用有更深入的了解。 | 李聪(综述) 龙江(综述) 生守鹏(综述) 孙玉(综述) 张洪海(综述) 李建军(综述) 郑加生(审校) | 2014 | 实用肿瘤学杂志2014，28，1： | 4 |
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