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| 1 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 2 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 3 | BARRIER LAYER IN THE NORTHEASTERN SOUTH CHINA SEA AND ITS FORMATION MECHANISM显示文摘Robust evidence for the barrier layer (BL) in the northeastern South China Sea (SCS) (16°-25°N, 112°-124°E) is presented. The occurrence rate of the BL peaks in the autumn (45.7%) and then the summer (31.1%) and the spring (23.3%), se-quently. It is estimated that the annual occurrence rate of the BL reaches about 40.0% in the central northeastern SCS (18°-22°N, 112°-120°E) and the Luzon Strait. Stratification-formed (Rain-formed) mechanism is the major factor responsible for the occurrence of the BL in the northeastern SCS in the spring (the summer and autumn), respectively. The rainfall observation from TRMM provides reliable evidence for the latter. | PAN Aijun WAN Xiaofang XU Jindian GUO Xiaogang LI Li | 2006 | Chinese Science Bulletin2006，51，4： | 7 |
| 4 | Mesoscale eddy effects on the wintertime vertical mixing in the formation region of the North Pacific Subtropical Mode Water显示文摘Mesoscale eddy effects on the wintertime verti-cal mixing in the formation region of the North Pacific Sub-tropical Mode Water (NPSTMW) are studied using hydro-graphic data from Argo profiling floats deployed in the Ku-roshio recirculation region in February and March of 2001. Anticyclonic (warm) eddy enhances the wintertime vertical mixing and results in the deep mixed layer and the deep thermocline. Consequently, a large volumetric water mass with low potential vorticity corresponding to the prototype of NPSTMW tends to be formed. By contrast, cyclonic (cold) eddy is unfavorable for the vertical mixing process and halts the deepening of the mixed layer and thus the formation of mode water. Further analysis shows that cyclonic eddies prevail in the late 1990s in the formation region of NPSTMW, which lead to significant suppression of the wintertime ver-tical mixing (96-98) and thus are unfavorable for the for-mation of NPSTMW; while the situation is completely re-versed in the early 1990s (93-95). | PAN Aijun LIU Qinyu | 2005 | Chinese Science Bulletin2005，50，17： | 7 |
| 5 | Responses of the Zhe-Min coastal current adjacent to Pingtan Island to the wintertime monsoon relaxation in 2006 and its mechanism显示文摘In conjunction with synchronous remotely sensed winds and sea surface temperature(SST),the spatiotemporal features of the Zhe-Min coastal current(ZMCC),especially responses of the ZMCC adjacent to Pingtan Island(PT) to the wintertime monsoon relaxation in 2006 and corresponding mechanism are investigated based on the field observations.In situ data are acquired from Conductivity-Temperature-Depth(CTD) cruise and Bottom-Mounted Moorings(BMM),which are conducted during a comprehensive survey for the Chinese Offshore Investigation and Assessment Project in winter 2006.It is revealed that the ZMCC is well mixed vertically in winter 2006.The ZMCC(<14°C) recedes during the relaxation of the wintertime monsoon and is accompanied by the enhanced northward shift of the warm,saline Taiwan Strait Mixed Water(TSMW,higher than 14°C and is constituted by the Taiwan Strait Warm Water and the Kuroshio Branch Water).And greatly enhanced southward intrusion of the ZMCC can be detected when the wintertime monsoon restores.Correspondingly,the thermal interface bounded by the ZMCC and the TSMW moves in the northwest/southeast direction,leading to periodic warm/cold reversals of the near-seabed temperature adjacent to the PT.By EOF(Empirical Orthogonal Function) analysis of the large-scale wind fields and wavelet power spectrum analysis of the water level,ocean current and the near-seabed temperature,responses of the ZMCC off the PT to wintertime monsoon relaxation are suggested to be attributed mainly to the southward propagating coastally trapped waves triggered by the impeding atmospheric fronts.As a result,ocean current and near-seabed temperature demonstrate significant quasi-5 d and quasi-10 d subtidal oscillations.By contrast,the onshore/offshore water accumulation resulted from Ekman advection driven by the local winds has minor contributions. | PAN AiJun WAN XiaoFang GUO XiaoGang JING ChunSheng | 2013 | Science China Earth Sciences2013，56，3： | 5 |
| 6 | The spatio-temporal variation of wintertime subtidal currents in the western Taiwan Strait显示文摘A new data set of observations by six cruises of ship-mounted acoustic doppler current profiler(SADCP) and three 40 d long bottom-mounted ADCPs(BADCPs) is employed to reveal the spatiotemporal variability of tidal and subtidal currents in the western Taiwan Strait(TWS) during winter season. The results confirm the existence of intense cotidal lines for M_2 tidal current, which is located north of 25°N. In this case, no existence of an amphidromic point can be identified. It is also revealed that the counter-wind current(CWC) can extend through the whole western TWS and even occupy the entire water column during winter monsoon relaxation. However,this CWC is observed to be thoroughly overwhelmed by the downwind China coastal current(CCC) during the two big monsoon bloom events in the winter of 2007, and the CCC consequently extends southward throughout the western TWS instead. Most importantly, the variation of the spatial extent for the CWC and the CCC in the western TWS is found to be well explained by the first two modes of the vector empirical orthogonal function(VEOF) analysis, that is, it is mainly controlled by a wind-driven quasi barotropic current as the first mode and slightly modulated by a relatively weak background current with a first-order baroclinic structure as the second mode. | SHEN Junqiang QIU Yun GUO Xiaogang PAN Aijun ZHOU Xiwu | 2017 | Acta Oceanologica Sinica2017，36，11： | 5 |
| 7 | Responses of Guangdong coastal upwelling to the summertime typhoons of 2006显示文摘The effects of typhoon intrusion on the Guangdong coastal upwelling system were investigated on the basis of in situ CTD (conductivity-temperature-depth) cruise observations and especially upward-looking ADCP (Acoustic Doppler Current Profil- ers) measurements obtained from a comprehensive survey of the Guangdong coastal region carried out by the Chinese Off-shore Investigation and Assessment Project in the summer of 2006. It was found that northeastward geostrophic advection driven by the summer monsoon has a significant near-seabed onshore component adjacent to Shantou, which in conjunction with upper-level offshore Ekman flow, constitutes the canonical Guangdong coastal upwelling system. Further analyses suggested that the Guangdong coastal upwelling system is sensitive to subtle changes in the typhoon intensity and migration pathway. On one hand, as a typhoon approaches from north of the upwelling system (e.g. Typhoon 0604 (Bilis) and Typhoon 0605 (Kaemi)) in the early phase of intrusion, the enhanced southwesterly leads to exceptional enhancement of the onshore flow; i.e., enhanced upwelling. Afterward, irrespective of the forced ocean responses resulting from the stronger local winds (Typhoon 0604) or the moderate typhoon-induced inertial oscillations (Typhoon 0605), the situation is not conducive to sustaining a stable, persistent upwelling system. On the other hand, when there is typhoon intrusion south of the upwelling system (e.g. Typhoon 0606 (Prapiroon)), the favorable southwesterly tends to be substituted by an anomalous northeasterly, which destroys the traditional coastal upwelling pattern. However, the canonical upwelling system tends to recover within 1-2 days of the typhoon passing. | PAN AiJun GUO XiaoGang XU JinDian HUANG Jiang WAN XiaoFang | 2012 | Science China Earth Sciences2012，55，3： | 4 |
| 8 | Cyclin-dependent Kinase 18 Promotes Oligodendrocyte Precursor Cell Differentiation through Activating the Extracellular Signal-Regulated Kinase Signaling Pathway显示文摘The correct differentiation of oligodendrocyte precursor cells(OPCs) is essential for the myelination and remyelination processes in the central nervous system.Determining the regulatory mechanism is fundamental to the treatment of demyelinating diseases. By analyzing the RNA sequencing data of different neural cells, we found that cyclin-dependent kinase 18(CDK18) is exclusively expressed in oligodendrocytes. In vivo studies showed that the expression level of CDK18 gradually increased along with myelin formation during development and in the remyelination phase in a lysophosphatidylcholine-induced demyelination model, and was distinctively highly expressed in oligodendrocytes. In vitro overexpression and interference experiments revealed that CDK18 directly promotes the differentiation of OPCs, without affecting their proliferation or apoptosis. Mechanistically, CDK18 activated the RAS/mitogen-activated protein kinase kinase1/extracellular signal-regulated kinase pathway, thus promoting OPC differentiation. The results of the present study suggest that CDK18 is a promising cell-type specific target to treat demyelinating disease. | Yuchen Pan Zeping Jiang Dingya Sun Zhenghao Li Yingyan Pu Dan Wang Aijun Huang Cheng He Li Cao | 2019 | Neuroscience Bulletin2019，35，5： | 4 |
| 9 | Subtropical Mode Water in the Northwestern Pacific显示文摘Based on the in situ XBT and other data sets, by analyzing the seasonal cycle of the mixed layer depth (MLD)and using the conservative potential vorticity (PV) as a tool, a clear description of the formation process of the North PacifNPSTMW reflects well the ventilation process of the isotherms of the permanent thermocline. The formation process can be the sea surface from October, the mixed layer deepens and correspondingly, the water mass with low PV emerges and sinks.After continual cooling from October to March, the mixed layer reaches its maximum value (>300 m) in March. Then, in the second phase (April-June), the mixed layer shoals rapidly from April, a large part of the low PV water mass is sheltered from further air-sea interaction by the emerging seasonal thermocline, and thus forms new NPSTMW. Further analysis indicatesthat the formation region of warm NPSTMW (17-18℃) is limited between 140°-150°E, while the relatively cold NPSTMW (16-17℃) originates in a wider longitude range (140°-170°E).Climate features of NPSTMW are presented with the use of climatological Levitus (1994a, b) dataset. It is shown that NPSTMW lies in the region of(130°-170°E, 22°-34°N) with core temperature ranging from about 16-19℃ and potential density around 25-25.8σ0. NPSTMW has a three-dimensional structure lying below the seasonal thermocline (about 100 m deep) and reaches almost to 350 m depths. | PAN Aijun, LIU QinyuPhysical Oceanography Lab. & Ocean-Atmosphere Interaction and Climate Lab., Ocean University of China, Qingdao 266003, P.R.China | 2003 | Journal of Ocean University of Qingdao2003，2，2： | 3 |
| 10 | Conceptual model about the interaction between El Nio/ Southern Oscillation and Quasi-Biennial Oscillation in far west equatorial Pacific显示文摘Interaction between the Quasi-Biennial Oscillation in far west equatorial Pacific (QBOWP) and the El Ni?o/Southern Oscillation (ENSO) is studied using a new conceptual model. In this con- ceptual model, the QBOWP effects on ENSO are achieved through two ways: (1) the oceanic Kelvin wave along equatorial Pacific, and (2) the Atmospheric Walker Circulation anomaly, while ENSO ef- fects on QBOWP can be accomplished by the atmospheric Walker Circulation anomaly. Diagnosis analysis of the model results shows that the Atmospheric bridge (Walker circulation) plays a more important role in interaction between the ENSO and QBOWP than the oceanic bridge (oceanic Kelvin wave along equatorial Pacific); It is found that by the interaction of the ENSO and QBOWP, a free ENSO oscillation with 3-5 years period could be substituted by a oscillation with the quasi-biennial period, and the dominant period of SST anomaly and wind anomaly in the far west equatorial Pacific tends to be prolonged with enhanced ENSO forcing. Generally, the multi-period variability in the cou- pled Atmosphere-Ocean System in the Tropical Pacific can be achieved through the interaction be- tween ENSO and QBOWP. | LIU Qinyu1, LIU Zhengyu2,1 & PAN Aijun 1,3 1. Physical Oceanography Lab. & Atmosphere-Ocean Interaction and Climate Lab., Ocean University of China, Qingdao 266003, China 2. Center for Climate Research, University of Wisconsin-Madison, Madison, WI 53706-1695, USA 3. Environment and Dynamics Lab., Third Institute of Oceanography, Xiamen 361005, China | 2006 | Science China Earth Sciences2006，49，8： | 3 |
| 11 | Recent Advances in Studies on Formation Mechanism of Subtropical Mode Water and Its Climate Features in North Pacific显示文摘Mode Water’, as a product of air-sea interaction, influences the thermal structure and circulation pattern in upper layer ocean and consequently affects the variations of climate. In this paper the recent research results about the subtropi-cal Mode Water in the North Pacific are overiewed. A detailed description of the three kinds of Mode Water in the subtropical North Pacific and some comparisons of their similarities and differences are introduced. Some science problems that need further exploration have been raised. | LIU Qinyu*, PAN Aijun Physical Oceanography Laboratory, also Ocean-Atmosphere Interaction and Climate, Laboratory Ocean University of Qingdao,Qingdao 266003, P.R.China | 2002 | Journal of Ocean University of Qingdao2002，1，1： | 3 |
| 12 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 13 | North-south difference of water mass properties across the Lembeh Strait, North Sulawesi, Indonesia显示文摘Two field observations were conducted around the Lembeh Strait in September 2015 and 2016, respectively.Evidences indicate that seawater around the Lembeh Strait is consisted of North Pacific Tropical Water(NPTW),North Pacific Intermediate Water(NPIW), North Pacific Tropical Intermediate Water(NPTIW) and Antarctic Intermediate Water(AAIW). Around the Lembeh Strait, there exist some north-south differences in terms of water mass properties. NPTIW is only found in the southern Lembeh Strait. Water mass with the salinity of 34.6 is only detected at 200–240 m between NPTW and NPTIW in the southern Lembeh Strait, and results from the process of mixing between the saltier water transported from the South Pacific Ocean and the lighter water from the North Pacific Ocean and Sulawesi Sea. According to the analysis on mixing layer depth, it is indicated that there exists an onshore surface current in the northern Lembeh Strait and the surface current in the Lembeh Strait is southward.These dramatic differences of water masses demonstrate that the less water exchange has been occurred between the north and south of Lembeh Strait. In 2015, the positive wind stress curl covering the northern Lembeh Strait induces the shoaling of thermocline and deepening of NPIW, which show that the north-south difference of airsea system is possible of inducing north-south differences of seawater properties. | WANG Weibo PAN Aijun EDI Kusmanto MUH Hasanudin DENY Sutisna | 2018 | Acta Oceanologica Sinica2018，37，12： | 2 |
| 14 | Periodic forcing and ENSO suppression in the cane-zebiak model显示文摘 | Pan Aijun Liu Qinyu Liu Zhengyu | 2005 | J of Oceanogr2005，61，1： | 1 |
| 15 | The design of vanadium trapping system for FCC catalysts显示文摘 | Wu Xiaofeng Tang Aijun | 1996 | Chem Eng1996，4，2： | 1 |
| 16 | Efficient CO_(2)Reduction to Formate on CsPbI_(3) Nanocrystals Wrapped with Reduced Graphene Oxide显示文摘Transformation of greenhouse gas(CO_(2))into valuable chemicals and fuels is a promising route to address the global issues of climate change and the energy crisis.Metal halide perovskite catalysts have shown their potential in promoting CO_(2)reduction reaction(CO_(2)RR),however,their low phase stability has limited their application perspective.Herein,we present a reduced graphene oxide(rGO)wrapped CsPbI_3 perovskite nanocrystal(NC)CO_(2)RR catalyst(CsPbI_3/rGO),demonstrating enhanced stability in the aqueous electrolyte.The CsPbI_3/rGO catalyst exhibited>92%Faradaic efficiency toward formate production at a CO_(2)RR current density of~12.7 mA cm^(-2).Comprehensive characterizations revealed the superior performance of the CsPbI_3/rGO catalyst originated from the synergistic effects between the CsPbI_3 NCs and rGO,i.e.,rGO stabilized theα-CsPbI_3 phase and tuned the charge distribution,thus lowered the energy barrier for the protonation process and the formation of~*HCOO intermediate,which resulted in high CO_(2)RR selectivity toward formate.This work shows a promising strategy to rationally design robust metal halide perovskites for achieving efficient CO_(2)RR toward valuable fuels. | Minh Tam Hoang Chen Han Zhipeng Ma Xin Mao Yang Yang Sepideh Sadat Madani Paul Shaw Yongchao Yang Lingyi Peng Cui Ying Toe Jian Pan Rose Amal Aijun Du Tuquabo Tesfamichael Zhaojun Han Hongxia Wang | 2023 | Nano-Micro Letters2023，15，10： | 1 |
| 17 | Expert consensus on blood pressure management in critically ill patients显示文摘Introduction For critically ill patients with unstable hemodynamics,goal‑directed therapy for arterial blood pressure is needed with continuous daily bedside monitoring.The prevalence of hypertension in Chinese adults is 25.2%,of which 1–2%of patients may experience a hypertensive emergency,with a mortality rate of 6.9%in the acute phase.The mortality and readmission rates within 90 days of onset are as high as 11%.[1]Furthermore,the mortality rate for patients who experience hypertensive emergencies can reach 50%within 12 months of the incident.[2]The incidence of perioperative hypertension in patients undergoing cardiac surgery is approximately 50%,with this figure dropping to 25%for non-cardiac surgery.Surgery may increase the incidence of perioperative cardio-cerebrovascular adverse events by 3–5%.[3] | Yuetian Yu Ye Gong Bo Hu Bin Ouyang Aijun Pan Jinglun Liu Fen Liu Xiu-Ling Shang Xiang-Hong Yang Guowei Tu Changsong Wang Shaolin Ma Wei Fang Ling Liu Jiao Liu Dechang Chen | 2023 | Journal of Intensive Medicine2023，3，3： | 0 |
| 18 | Sea level anomalies in the northwestern Pacific during 2011 associated with La Nina and negative Indian Ocean Dipole显示文摘The sea level anomalies(SLAs)pattern in the northwestern Pacific delineated significant differences between La Ni?a events occurring with and without negative Indian Ocean Dipole(IOD)events.During the pure La Ni?a events,positive the sea surface level anomalies(SLAs)appear in the northwestern Pacific,but SLAs are weakened and negative SLAs appear in the northwestern Pacific under the contribution of the negative IOD events in 2010/2011.The negative IOD events can trigger significant westerly wind anomalies in the western tropical Pacific,which lead to the breakdown of the pronounced positive SLAs in the northwestern Pacific.Meanwhile,negative SLAs excited by the positive wind stress curl near the dateline propagated westward in the form of Rossby waves until it approached the western Pacific boundary in mid-2011,which maintained and enhanced the negative phase of SLAs in the northwestern Pacific and eventually,it could significantly influence the bifurcation and transport of the North Equatorial Current(NEC). | Fuwen Qiu Yun Qiu Aijun Pan Jing Cha Shanwu Zhang | 2019 | Acta Oceanologica Sinica2019，38，11： | 0 |
| 19 | Site-Selective Palladium-Catalyzed 1,1-Arylamination of Terminal Alkenes显示文摘Many of the commonly used pharmaceuticals and biologically active natural products are nitrogencontaining compounds.Recently,the transitionmetal-catalyzed or the radical-mediated 1,2-carboamination of alkenes has been well explored to access amine scaffolds.However,synthetic strategies toward the 1,1-carboamination of alkenes are severely limited.Herein,we describe a method to achieve the 1,1-arylamination using readily available building blocks enabled by palladium catalysis.This sequential three step-Heck arylation,metal migration,followed by aza-1,6-Micheal addition process exhibits excellent chemo-and regioselectivity.To showcase the potential as a method for diversity-oriented drug discovery,the modification of numerous structurally complex bioactive molecules was also successfully performed. | Chunhua Han Libo Cai Dongquan Zhang Rui Pan Qiuyu Li Aijun Lin Hequan Yao | 2022 | CCS Chemistry2022，4，2： | 0 |
| 20 | Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study显示文摘Background:A new type of silver alloy hydrogel-coated(SAH)catheter has been shown to prevent bacterial adhesion and colonization by generating a microcurrent,and to block the retrograde infection pathway.However,these have only been confirmed in ordinary patients.This study aims to evaluate the effectiveness of a SAH catheter for preventing urinary tract infections in critically ill patients.Methods:This was a prospective single-center,single-blind,randomized,controlled study.A total of 132 patients requiring indwelling catheterization in the intensive care unit(ICU)of the First Affiliated Hospital of the University of Science and Technology of China between October 2022 and February 2023 and who met the study inclusion/exclusion criteria were randomly divided into two groups.Patients in the SAH catheter group received a SAH catheter,while patients in the conventional catheter group received a conventional siliconized latex Foley catheter.The main outcome measure was the incidence of catheter-associated urinary tract infections(CAUTIs).Secondary outcome indicators included urine positivity for white blood cells and positive urine cultures on 3 days,7 days,10 days,and 14 days after catheterization,number of viable bacteria in the catheter biofilm on day 14,pathogenic characteristics of positive urine cultures,length of ICU stay,overall hospital stay,ICU mortality,and 28-day mortality.All the data were compared between the two groups.Results:A total of 68 patients in the conventional catheter group and 64 patients in the SAH catheter group were included in the study.On day 7 after catheter placement,the positivity rate for urinary white blood cells was significantly higher in the conventional catheter group than in the SAH catheter group(33.8%vs.15.6%,P=0.016).On day 10,the rates of positive urine cultures(27.9%vs.10.9%,P=0.014)and CAUTIs(22.1%vs.7.8%,P=0.023)were significantly higher in the conventional catheter group than in the SAH catheter group.On day 14,the numbers of viable bacteria isolated from the catheter tip([3.21±1.91]×10^(6) colony-forming units[cfu]/mL vs.[7.44±2.22]×10^(4) cfu/mL,P<0.001),balloon segment([7.30±1.99]×10^(7) cfu/mL vs.[3.48±2.38]×10^(5) cfu/mL,P<0.001),and tail section([6.41±2.07]×10^(5) cfu/mL vs.[8.50±1.46]×10^(3) cfu/mL,P<0.001)were significantly higher in the conventional catheter group than in the SAH catheter group.The most common bacteria in the urine of patients in both groups were Escherichia coli(n=13)and Pseudomonas aeruginosa(n=6),with only one case of Candida in each group.There were no significant differences between the two groups in terms of ICU hospitalization time,total hospitalization time,ICU mortality,and 28-day mortality.Conclusion:SAH catheters can effectively inhibit the formation of catheter-related bacterial biofilms in critically ill patients and reduce the incidence of CAUTIs,compared with conventional siliconized latex Foley catheters;however,regular replacement of the catheter is still necessary. | Menglong Zhao Shike Geng Lei Zhang Xiaoqin Fan Fei Tong Xianlin Meng Tianfeng Wang Xiaowei Fang Qing Mei Aijun Pan | 2024 | Journal of Intensive Medicine2024，4，1： | 0 |
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