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| 1 | Research on preservation and enrichment mechanisms of organic matter in muddy sediment and mudstone显示文摘Using multidiscipline methodologies, the differences in preservation and enrichment mechanisms of organic matter (OM) in muddy sediment and mudstone are investigated. In clay fractions, concentra- tions of TOC and chloroform bitumen “A” are significantly higher than those in coarser fractions. This indicates that clay minerals (CM) play an important role in enriching OM. The content of chloroform bitumen “A” increases obviously in the clay fraction, which reveals that dissolvable OM is the main composition of coalesce with clay minerals. Furthermore, TG and DTA data show that OM enrichment mechanisms and preservation forms have multiplicity. Several exothermic peaks in the DTA curves demonstrate that muddy sediment and mudstone contain a number of bioclasts and amorphous OM besides dissolvable OM. Through analyzing with XRD and DTA after mudstone samples were pretreated, the conclusions can be arrived at. Firstly, CM interlayer space of XRD curves and exothermic peaks of DTA curves both change as temperature increases. Secondly, the changes of CM interlayer space and exothermic peaks are concordant and stable around 350℃. All these are the features that OM enters CM interlayers to form stable organo-clay complexes. Therefore, the combination format of OM with CM is not only surface adsorption, partial OM enters CM interlayers to form stable organo-clay complexes. Finally, through the research on OM preservation forms and enrichment mechanisms in muddy sedi- ment and mudstone, the hydrocarbon-generation processes and the global carbon cycle and budget can be explained. | CAI JinGong BAO YuJin YANG ShouYe WANG XingXin FAN DaiDu XU JinLi WANG AiPing | 2007 | Science China Earth Sciences2007，50，5： | 25 |
| 2 | Exploration and research progress of shale gas in China显示文摘There are three types of shale gas resources in China.The resources are present in large amounts and are widely distributed.Marine facies,transitional facies and continental facies resources each account for a third.Based on resource distributions,there are many wells penetrated into the Sinian,Cambrian, Ordovieian,Silurian,Devonian,Carboniferous and Permian strata of the Yangtze plate and its periphery, the North China Craton and the Tarim Basin.Many years of exploration have indicated that the marine Silurian Longmaxi shale gas is widely distributed in south China and has been industrialized in its production in the Siehuan basin.The shale gas from the Cambrian Niutitang Formation and the Sinian Doushantuo Formation are important discoveries in Yichang,Hub ei and Zhenba,Shanxi.There are also shale gas resources found within transitional facies and continental facies in different areas in China.The 'two element enrichment theory'has been summarized during the exploration process of Silurian marine shale gas in the Sichuan Basin.In addition,horizontal drilling and fracturing technologies up to 3500 m in depth have been developed.Based on the understanding of shale gas accumulation in a complex tectonic zone outside the Sichnan basin,a preliminary summary of the formation of the 'converse fault syneline control reservoir'and 'paleo uplift control reservoir'model has been constructed.The dominant theory of 'Trinity'shale gas enrichment and the high yield of the 'deep water Lu Pengxiang sedimentary facies belt, structural preservation conditions and overpressure'is summarized.Guided by the above theories.Anyel well in Guizhou and Eyangyel well in Hubei were drilled.'Four storey'oil and shale 'gas is found in the Permian Qixia group,the Silurian Shiniulan Formation,the Longmaxi Formation and the Ordovician Baota Formation in Anyel well.Good shale gas has been gound in the Cambrian Niutitang formation inian Doushantuo formation in Eyangye lwell.This paper aims to summarize and review the main progress,theoretical technology and problems of shale gas exploration and development in recent years in China,and predicts the future exploration and development direction for shale gas and possible exploration areas. | Gang-yi Zhai Yu-fang Wang Zhi Zhou Shu-fang Yu Xiang-lin Chen Yun-xiao Zhang | 2018 | China Geology2018，1，2： | 15 |
| 3 | An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice显示文摘Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of chronic cerebral ischemia, produced by subjecting adult male C57 BL/6 mice to permanent left middle cerebral artery occlusion. Three days postoperatively, mice were randomly assigned to the environmental enrichment and standard housing groups. Mice in the standard housing group were housed and fed a standard diet. Mice in the environmental enrichment group were housed in a cage with various toys and fed a standard diet. Then, 28 days postoperatively, spatial learning and memory were tested using the Morris water maze. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 in the hippocampus were analyzed by western blot assay. The number of synapses was evaluated by electron microscopy. In the water maze test, mice in the environmental enrichment group had a shorter escape latency, traveled markedly longer distances, spent more time in the correct quadrant(northeast zone), and had a higher frequency of crossings compared with the standard housing group. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 were substantially upregulated in the hippocampus in the environmental enrichment group compared with the standard housing group. Furthermore, electron microscopy revealed that environmental enrichment increased the number of synapses in the hippocampal CA1 region. Collectively, these findings suggest that environmental enrichment ameliorates the spatial learning and memory impairment induced by permanent middle cerebral artery occlusion. Environmental enrichment in mice with cerebral ischemia likely promotes cognitive recovery by inducing plastic changes in synapses. | Chuan-Jie Wang Yi Wu Qun Zhang Ke-Wei Yu Yu-Yang Wang | 2019 | Neural Regeneration Research2019，14，3： | 14 |
| 4 | Non-ammonia enrichment of rare earth by magnesium oxide from rare earth leaching liquor in magnesium salt system显示文摘In order to solve the problem of ammonia-nitrogen pollution in the enrichment process of the ionadsorption type rare earth ore,the technology of non-ammonia precipitation with magnesium oxide precipitant was carried out.It is determined that the rare earth precipitation efficiency is 99.6%and the purity of rare earth concentrates is only 85.89 wt%under the optimum precipitation conditions.And the contents of MgO,SO3 and Al2O3 in the rare earth concentrates are 5.12 wt%,6.77 wt%and 1.78 wt%,respectively.Furthermore,the thermo-decomposition process of precipitates was investigated by TGDSC,XRD and FI-IR.The thermal decomposition process consists of two stages:the dehydration of rare earth hydroxide and alkaline rare earth sulfate within 900℃and the thermal decomposition of RE2O2SO4 at 900-1300℃.Therefore,a high-temperature calcinations method for removing SO3 from precipitates is proposed.When the precipitates are calcined at 1300℃for 2 h,the rare earth concentrates with a purity of 92.03 wt%can be acquired.Moreover,the content of SO3 in the concentrate is only 0.46 wt%.In the MgO precipitation and high-temperature calcinations process,the raw material cost is low and the quality of rare earth concentrates is acceptable.It could have great significance for nonammonia enrichment of rare earth from the rare earth leaching liquor,and finally solve the problem of ammonia nitrogen in the extraction process of the ion-adsorption type rare earth ore within magnesium salt system. | Li Huang Guohua Gao Ran Wu Qian Zhang Fuguo Lai Yanfei Xiao | 2019 | Journal of Rare Earths2019，37，8： | 14 |
| 5 | The influence of tectonic evolution on the accumulation and enrichment of coalbed methane (CBM)显示文摘The current accumulation and enrichment of CBM reservoir is a result of the preservation and destruction of former CBM, after the superposing evolution of reversing-and-uplifting and the subsequent evolution within the coal-bearing basin. The critical moment of the CBM reservoir formation is the time when the burying depth of the overlying net thickness amounts to the least in geological history after the gas generation of coal beds. Except the coal-bearing basins of lower metamorphism, most basins suffered the evolution stage of reversion and uplift. The formation of the CBM reservoir is controlled by the beginning and lasting time, and the intensity of reversing and uplifting. The tectonic evolution after reversing and uplifting also affects the accumulation of CBM in coal-bearing basin. The CBM constantly dissipates in the area of chronically uplifting and de-nudating. The area developed overlying sedimentation is advantageous to the preservation of CBM, but also can lead to the reduction of CBM saturation. | SONG Yan ZHAO Mengjun LIU Shaobo WANG Hongyan CHEN Zhenhong | 2005 | Chinese Science Bulletin2005，50，S1： | 13 |
| 6 | 泡塑富集ICP-MS测定土壤中痕量金(英文)显示文摘The aim of this study is to determine the trace amount of gold in soil sample using plastic foam enrichment-ICP-MS method.The national standard reference materials including GAu-2,GAu-10,GAu-11 and GAu-13 were used for parallel determination by ICPMS.The results showed that the method performed well in detection limit,precision and accuracy,indicating that the plastic foam enrichment-ICP-MS method could be used to determine the trace amounts of gold in soil sample. | 余波 | 2008 | Agricultural Science & Technology2008，9，4： | 13 |
| 7 | Strengthening iron enrichment and dephosphorization of high-phosphorus oolitic hematite using high-temperature pretreatment显示文摘The efficient development and utilization of high-phosphorus oolitic hematite is of great strategic significance for the sustainable supply of iron-ore resources in China.In this paper,the mechanism of high-temperature pretreatment for enhancing the effect of iron enrichment and dephosphorization in the magnetization roasting–leaching process was studied by X-ray diffraction(XRD),vibration sample magnetometer(VSM),scanning electron microscopy and energy dispersive spectrometry(SEM–EDS).Compared with the process without high-temperature pretreatment,the iron grade of the magnetic separation concentrate after high-temperature pretreatment had increased by 0.98%,iron recovery rate had increased by 1.33%,and the phosphorus content in the leached residue had decreased by 0.12%.High-temperature pretreatment resulted in the dehydration and decomposition of hydroxyapatite,the dehydration of limonite and the thermal decomposition of siderite,which can produce pores and cracks and weaken the compactness of the ore,improve the magnetization characteristics of roasted ore,and strengthen the iron enrichment and dephosphorization during the magnetization roasting and leaching process. | Wen-tao Zhou Yue-xin Han Yong-sheng Sun Yan-jun Li | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，4： | 13 |
| 8 | 'Source-Diagenesis-Accumulation' enrichment and accumulation regularity of marine shale gas in southern China显示文摘After the breakthrough of shale gas exploration and development in the Ordovician Wufeng Formation (Fm.) and Silurian Longmaxi Fm. of Chongqing Jiaoshiba area,Changning-Weiyuan area,etc. in Sichuan basin,a series of discovery and breakthrough were obtained by China Geological Survey in the Cambrian Niutitang Fm. and Sinian Doushantuo Fm. shale of the areas with complicated structure outside Sichuan basin. Based on the understanding of the law of shale gas enrichment in Longmaxi Fm. in the basin,this paper puts forward three elements of the formation and enrichment of shale gas,which are the “Source”,the “Diagenesis ” and the “Accumulation ”,after deeply studying the law shale gas enrichment and accumulation in Sinian-Cambrian reservoir of the complex structure area outside the basin. The “Source”means the sedimentary environment and petrological characteristics of organic shale.The “Diagenesis ”means the basin tectonic subsidence and hydrocarbon generation and expulsion process of organic matter.The “Accumulation” means the tectonic uplift and shale gas preservation. It is proposed that the Sinian-Cambrian and Ordovician-Silurian black shale series in the middle and upper Yangtze region of southern China were both formed in the deep-water shelf environment of rift trough and foreland basin respectively.The dessert intervals were formed in the strong reduction environment under transgressive system tract.The shale lithology belongs to calcium-siliceous and charcoal-siliceous respectively. Based on the summary of structural evolution in Yangtze area,the correlation of structural burial depth with shale diagenesis and the coupling evolution of organic matter with pore structure are discussed. Combining with structural styles,the preservation conditions of shale gas are discussed. Five types of shale gas reservoir control models are further described. Two types of future exploration directions,which are reverse fault syncline and paleo-uplift margin in complex structural area outside the basin,are proposed. | Gang-yi Zhai Yu-fang Wang Zhi Zhou Guo-heng Liu Yu-ru Yang Juan Li | 2018 | China Geology2018，1，3： | 12 |
| 9 | Discriminated sgRNAs-Based SurroGate System Greatly Enhances the Screening Efficiency of Plant Base-Edited Cells显示文摘The development of CRISPR/Cas9-mediated base editing has made genomic modification more efficient. However, selection of genetically modified cells from millions of treated cells, especially plant cells, is still challenging. In this study, an efficient surrogate reporter system based on a defective hygromycin resistance gene was established in rice to enrich base-edited cells. After step-by-step optimization, the Discriminated sgRNAs-based SurroGate system (DisSUGs) was established by artificially differentiating the editing abilities of a wild-type single guide RNA (sgRNA) targeting the surrogate reporter gene and an enhanced sgRNA targeting endogenous sites. The DisSUGs enhanced the efficiency of screening base-edited cells by 3- to 5-fold for a PmCDA1-based cytosine-to-tyrosine base editor (PCBE), and 2.5- to 6.5-fold for an adenine base editor (ABE) at endogenous targets. These targets showed editing efficiencies of <25% in the conventional systems. The DisSUGs greatly enhanced the frequency of homozygous substitutions and expanded the activity window slightly for both a PCBE and an ABE. Analyses of the total number of single-nucleotide variants from whole-genome sequencing revealed that, compared with the no-enrichment PCBE strategy, the DisSUGs did not alter the frequency of genome-wide sgRNA-independent off-target mutations, but slightly increased the frequency of target-dependent off-target mutations. Collectively, the DisSUGs developed in this study greatly enhances the efficiency of screening plant base-edited cells and will be a useful system in future applications. | Wen Xu Yongxing Yang Ya Liu Guiting Kang Feipeng Wang Lu Li Xinxin Lv Si Zhao Shuang Yuan Jinling Song Ying Wu Feng Feng Xiaoqing He Chengwei Zhang Wei Song Jiuran Zhao Jinxiao Yang | 2020 | Molecular Plant2020，13，1： | 8 |
| 10 | The enrichment characteristics of mercury in the sediments of Dongjiu and Xijiu, Taihu Lake catchment, in the past century显示文摘The concentration and the enrichment factors of mercury (Hg) in the sediment cores of Dongjiu and Xijiu, Taihu Lake catchment, were studied. The accumulation fluxes, anthropogenic input concentration and anthropogenic accumulation fluxes of Hg in recent 100 years were also analyzed based on the 210Pb dating. The results indicate that the increasing concentrations of Hg in the sediments are influ-enced by natural factors and anthropogenic input simultaneously. Generally, about 2/3 of the Hg in the sediment was from anthropogenic sources. In the early 20th century, the anthropogenic input was owing to the urban development and fossil fuel consumptions surrounding the Taihu Lake and the worldwide atmospheric deposition of Hg since the industrial revolution. The concentration and an-thropogenic fluxes of Hg increased with the industrial development in the catchment since the 1930s. It reached the maximum during the middle 1970s and middle 1990s, and decreased since the middle 1990s with constraints on high pollution industries. | WU YanHong JIANG XueZhong LIU EnFeng YAO ShuChun ZHU YuXin SUN ZhaoBin | 2008 | Science China Earth Sciences2008，51，6： | 8 |
| 11 | The enhanced element enrichment in the supercritical states of granite–pegmatite systems显示文摘In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles; principally H_2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them. | Rainer Thomas Paul Davidson Karen Appel | 2019 | Acta Geochimica2019，38，3： | 8 |
| 12 | Three-microRNA signature identified by bioinformatics analysis predicts prognosis of gastric cancer patients显示文摘AIM To identify multiple micro RNAs(mi RNAs) for predicting the prognosis of gastric cancer(GC) patients by bioinformatics analysis.METHODS The original microarray dataset GSE93415,which included 20 GC and 20 tumor adjacent normal gastric mucosal tissues,was downloaded from the Gene Expression Omnibus database and used for screening differentially expressed mi RNAs(DEMs).The cutoff criteria were P < 0.05 and fold change > 2.0.In addition,we acquired the mi RNA expression profiles and clinical information of 361 GC patients from The Cancer Genome Atlas database to assess the prognostic role of the DEMs.The target genes of mi RNAs were predicted using Target Scan,mi RDB,mi RWalk,and DIANA,and then the common target genes were selected for functional enrichment analysis.RESULTS A total of 110 DEMs including 19 up-regulated and 91 down-regulated mi RNAs were identified between 20 pairs of GC and tumor adjacent normal tissues,and the Kaplan-Meier survival analysis found that a threemi RNA signature(mi R-145-3 p,mi R-125 b-5 p,and mi R-99 a-5 p) had an obvious correlation with the survival of GC patients.Furthermore,univariate and multivariate Cox regression analyses indicated that the three-mi RNA signature could be a significant prognostic marker in GC patients.The common target genes of the three mi RNAs are added up to 108 and used for Gene Functional Enrichment analysis.Biological Process and Molecular Function analyses showed that the target genes are involved in cell recognition,gene silencing and nucleic acid binding,transcription factor activity,and transmembrane receptor activity.Cellular Component analysis revealed that the genes are portion of nucleus,chromatin silencing complex,and TORC1/2 complex.Biological Pathway analysis indicated that the genes participate in several cancer-related pathways,such as the focal adhesion,PI3 K,and m TOR signaling pathways.CONCLUSION This study justified that a three-mi RNA signature could play a role in predicting the survival of GC patients. | Cheng Zhang Chun-dong Zhang Ming-hui Ma Dong-qiu dai | 2018 | World Journal of Gastroenterology2018，24，11： | 7 |
| 13 | Geological Factors Controlling the Accumulation and High Yield of Marine-Facies Shale Gas: Case Study of the Wufeng-Longmaxi Formation in the Dingshan Area of Southeast Sichuan, China显示文摘The main geological factors controlling the accumulation and yield of marine-facies shale gas reservoirs are the focus of the current shale gas exploration and development research.In this study,the Wufeng-Longmaxi Formation in the Dingshan area of southeast Sichuan was investigated.Shale cores underwent laboratory testing,which included the evaluation of total organic carbon(TOC),vitrinite reflectance(Ro),whole-rock X-ray diffraction(XRD),pore permeability,and imaging through field emission scanning electron microscopy(FE-SEM).Based on the results of natural gamma ray spectrum logging,conventional logging,imaging logging,and seismic coherence properties,the exploration and development potential of shale gas in the Dingshan area have been discussed comprehensively.The results showed that(1)layer No.4(WF2-LM4)of the Wufeng-Longmaxi Formation has a Th/U ratio<2 and a Th/K ratio of 3.5–12.Graptolites and pyrite are relatively abundant in the shale core,indicating sub-high-energy and low-energy marine-facies anoxic reducing environments.(2)The organic matter is mainly I-type kerogen with a small amount of II1-type kerogen.There is a good correlation among TOC,Ro,gas content,and brittle minerals;the fracturing property(brittleness)is 57.3%.Organic and inorganic pores are moderately developed.A higher pressure coefficient is correlated with the increase in porosity and the decrease in permeability.(3)The DY1 well of the shale gas reservoir was affected by natural defects and important latestage double destructive effects,and it is poorly preserved.The DY2 well is located far from the Qiyueshan Fault.Large faults are absent,and upward fractures in the Longmaxi Formation are poorly developed.The well is affected by low tectonic deformation intensity,and it is well preserved.(4)The Dingshan area is located at the junction of the two sedimentary centers of Jiaoshiba and Changning.The thickness of the high-quality shale interval(WF2-LM4)is relatively small,which may be an important reason for the unstable production of shale gas thus far.Based on the systematic analysis of the geological factors controlling high-yield shale gas enrichment in the Dingshan area,and the comparative analysis with the surrounding typical exploration areas,the geological understanding of marine shale gas enrichment in southern China has been improved.Therefore,this study can provide a useful reference for shale gas exploration and further development. | FAN Cunhui ZHONG Cheng ZHANG Yu QIN Qirong HE Shun | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 7 |
| 14 | REE Geochemistry in the Weathered Crust of Granites, Longnan Area,Jiangxi Province显示文摘Warm and humid climate and gentle hilly topography have provided favourable conditions for the devel-opment of the weathering crust of the granite intrusions in the Longnan area, Jiangxi Province. REE is mostlyconcentrated in an adsorption state in clay in the wholly weathered zone. The rare-earth minerals enriched inthe parent rocks provided the source material for the REE enrichment. Exchangeable REE accounts for48-86%. Extraction experiments and stable isotopic study of clay minerals suggest that the downward infiltra-tion of meteoric water and increasing gradient of pH values have played an important role in the enrichment ofREE during the progressive weathering. Slight fractionation of individual REE can not change their distribu-tion patterns in the profiles. which are inherited from the parent rocks. | Wu Chengyu Huang Dianhao Guo Zhongxun Institute of Mineral Deposits, Chinese Academy of Geological Sciences, Beijing Geological Survey Party of South Jiangxi, Jiangxi Bureau of Geology and Mineral Resources, Ganzhou, Jiangxi | 1990 | Acta Geologica Sinica(English Edition)1990，64，2： | 7 |
| 15 | Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer显示文摘Aptamers are a class of single oligonucleotide molecules(DNA or RNA)that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology.The selected aptamers are capable of specifically binding to different targeting molecules,which is achieved by the three-dimensional structure of aptamers.Aptamers are similar in function to monoclonal antibodies,and therefore,they are also referred to as'chemical antibodies'.Due to their high affinity and specificity and low immunogenicity,aptamers are topics of intense interest in today's biological targeting research especially in tumor research.They not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor therapy.Various experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for application.This paper summarizes the structure,characteristics,and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer. | Guo-Qing Zhang Li-Ping Zhong Nuo Yang Yong-Xiang Zhao | 2019 | World Journal of Gastroenterology2019，25，26： | 7 |
| 16 | Separation and Enrichment of Rare Earth Elements in Phosphorite in Xinhua,Zhijin,Guizhou显示文摘The phosphorite ores-deposits rich in rare earth elements(REE) in Zhijin, Xinhua, Guizhuo occurs in the early Cambrian Meishucun and at the bottom part of Qiongzhusi stage (the upper layer of phosphorites), belonging to Yangzi stratum section. The living creature scraps was proved existent in dolomitic-phosphorites by experiments, The REE could be extracted to provide the worthy data for the further using. Adopting the HNO3 to extract REE, through the ion exchange method, the REE recovery rate could be reached 85.44%, having certain reference value. | 张杰 孙传敏 杨国峰 谢飞 | 2006 | Journal of Rare Earths2006，24，z2： | 6 |
| 17 | Upregulated KPNA2 promotes hepatocellular carcinoma progression and indicates prognostic significance across human cancer types显示文摘Hepatocellular carcinoma(HCC)is one of the most aggressive cancers worldwide.Identification of the molecular mechanisms underlying the development and progression of HCC is particularly important.Here,we demonstrated the expression pattern,clinical significance,and function of Karyopherin α2(KPNA2)in HCC.The expression of KPNA2 was upregulated in tumor tissue and negatively associated with the survival time,and a significant correlation between KPNA2 expression and aggressive clinical characteristics was established.Both in vitro and in vivo experiments demonstrated that knockdown of KPNA2 reduced migration and proliferation capacities of HCC cells,while over-expression of KPNA2 increased these malignant characteristics.The analysis of the Cancer Genome Atlas cohorts also reveals that high-KPNA2 expression is associated with poor outcome in multiple cancer types.In addition,gene sets enrichment analysis exhibited cell cycle and DNA replication as the top altered pathways in the high-KPNA2 expression group in HCC and other two cancer types.Overall,this study identified KPNA2 as a potential diagnostic and prognostic biomarker in HCC and other neoplasms,probably by regulating cell cycle and DNA replication. | Xinggang Guo Zhiheng Wang Jianing Zhang Qingguo Xu Guojun Hou Yuan Yang Chuanpeng Dong Gang Liu Chenhua Liang Lei Liu Weiping Zhou Hui Liu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 6 |
| 18 | Sources and Ecological Risks of Heavy Metals in Soils Under Different Land Uses in Bangladesh显示文摘Soil heavy metal pollution, influenced by both natural and anthropogenic factors, significantly reduces environmental quality. In this study, Cr, Ni, Cu, As, Cd, and Pb in eight different land-use soils from Patuakhali District in Bangladesh were assessed. Concentrations of Cr, Ni, Cu, As, Cd, and Pb in soils were 1-87, 5-271, 4-181, 0-80, 0.2-24.0, and 5-276 mg kg-1, respectively, measured using an inductively coupled plasma-mass spectrometer. The enrichment factor, pollution load index (PLI), and contamination factor (CJ) of metal i were used to assess the ecological risk posed by metals in soils. The PLI ranged from 0.78 to 2.66, indicating baseline levels to progressive deterioration of soil due to metal contamination. However, C;of Cd ranged from 1.8 to 12.0, which showed that the studied soils were strongly impacted by Cd. Considering the severity of the potential ecological risk of a single metal, the descending order was Cd > As > Pb > Cu > Ni > Cr. Soils under all land uses showed moderate to very high potential ecological risk. | Mohammad Saiful ISLAM Mohammad Kawser AHMED Mohammad Habibullah AL-MAMUN Shah Mohammad Asraful ISLAM | 2019 | Pedosphere2019，29，5： | 5 |
| 19 | Ge-rich hydrothermal solutions and abnormal enrichment of Ge in coal显示文摘AT present, the main source of germanium includes two types of ore deposits: some sulfide-rich Pb, Zn,Cu, Ag and An deposits and some coal deposits. Germanium occurs as an associated element in these oredeposits. The Lincang germanium deposit discovered recently in China occurs in a basin where there areexposed the Neogene coal-bearing clastic rocks with Indosinian Ge-rich ((1.9-5.0)×10-6) granitesas the basement in Lincang County, Yunnan Province. Germanium is mainly concentrated in the coalseams of the first coal-bearing horizon (Nth2) and in regard to its grade (normally n×100×10-6 with themaximum over 1000×10-6) and scale (the proven reserve about 800 t), no such germanium mineralization has been reported so far in other parts of the world. What is the reason? The available studies have indicated that this germanium deposit is of epigenetic origin, whichdetermines that germanium must have been transferred into coal with the help of a kind of medium. It isnoticed that (i) organic germanium in natural waters is stable and it is never involved in its | HU Ruizhong, BI Xianwu, SU Wenchao, QI Huawen and YE Zaojun Intitue of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China | 1999 | Chinese Science Bulletin1999，44，S2： | 5 |
| 20 | Identifying changes in the wheat kernel proteome under heat stress using iTRAQ显示文摘Wheat(Triticum aestivum L.) is one of the three major global food crops. Hightemperature stress can affect its yield and quality. Studies of the effect of hightemperature stress on wheat kernel development are important because they can reveal the stability of wheat quality and lead to the genetic improvement of wheat quality traits. In this study, the isobaric tags for relative and absolute quantitation(iTRAQ)method was adopted to analyze changes in the protein expression profile of wheat cultivars under high temperature stress. The protein content of wheat grain increased under heat stress, while the SDS-sedimentation value and starch content decreased.Grain filling was deficient under high temperature stress, which reduced thousandkernel weight but did not affect wheat kernel length. The 207 differentially expressed proteins identified in Gaocheng 8901 under heat stress were associated with energy metabolism, growth and development, and stress response. Gene Ontology enrichment analysis showed that the annotated proteins that were differentially expressed in Gaocheng 8901 under heat stress were involved mainly in stimulus response, abiotic stress response, stress response, and plasma membrane. A set of 78 differentially expressed proteins were assigned to 83 KEGG signaling/metabolic pathways. KEGG pathway enrichment analysis showed that this set of proteins was significantly enriched in members of 51 pathways, and the proteins participated mainly in protein synthesis in the endoplasmic reticulum, starch and sucrose metabolism, and reaction on ribosomes. Five differentially expressed proteins were involved in protein–protein interaction networks that may greatly influence the yield and quality of wheat grain. In wheat, high-temperature stress leads to a variety of effects on protein expression and may ultimately cause changes in yield and quality. | Yufeng Zhang Hongyao Lou Dandan Guo Ruiqi Zhang Meng Su Zhenghong Hou Haiying Zhou Rongqi Liang Chaojie Xie Mingshan You Baoyun Li | 2018 | The Crop Journal2018，6，6： | 5 |
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