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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | RNA m^6A modification and its function in diseases显示文摘 | Jiyu Tong Richard A. Flavell Hua-Bing Li | 2018 | Frontiers of Medicine2018，12，4： | 18 |
| 3 | A dynamic N^6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors显示文摘 | Fei Yan Aref AI-Kali Zijie Zhang Jun Liu Jiuxia Pang Na Zhao Chuan He Mark R. Litzow Shujun Liu | 2018 | Cell Research2018，28，11： | 15 |
| 4 | FTO和MC4R基因多态性与代谢综合征相关性状的关联研究显示文摘目的探讨FTO基因rs9939609多态性和MC4R基因rs12970134多态性与代谢综合征相关性状之间的相关性。方法从北京市18~79岁常住居民中选取983人,包括肥胖组441名,对照组542名。通过问卷调查、代谢综合征相关性状测量和基因多态性测定,对两个基因多态性和代谢综合征相关性状进行关联分析。结果携带FTO基因rs9939609多态性A等位基因者发生代谢综合征的风险增加为1.53倍(95%CI:1.08~2.15,P=0.02)。携带MC4R基因rs12970134多态性A等位基因者发生肥胖的风险增加为1.42倍(95%CI:1.09~1.84,P=0.01)。每个rs12970134多态性A等位基因使血糖升高0.17mmol/L(95%CI:0.03~0.32,P=0.02)。携带两个以上FTO或MC4R风险等位基因者与没有携带风险等位基因者相比,肥胖发生风险增加为2.04倍(95%CI:1.25~3.33,P=0.004)。结论 FTO基因rs9939609多态性和MC4R基因rs12970134多态性在中国成人中与代谢综合征相关性状存在关联,可为代谢综合征的预防和控制提供理论依据。 | 许志远 宋洁云 王海俊 李刚 | 2012 | 现代预防医学2012，39，8： | 13 |
| 5 | 山羊FTO基因克隆及其表达谱显示文摘本研究旨在阐明山羊FTO基因的表达特性,并分析其表达与肌内脂肪沉积的相关性。以简州大耳羊为试验动物,采用RT-PCR方法克隆FTO基因,利用实时荧光定量PCR和Western blotting技术检测其组织表达差异,同时检测该基因在不同发育阶段不同部位山羊肌肉组织中的表达水平,并与IMF含量进行相关分析。结果表明,山羊FTO基因CDS区为1 518bp,编码505个氨基酸,为无跨膜结构的非分泌蛋白。FTO mRNA在山羊的脂肪、脾和肺中表达水平较高(P〈0.01),在背最长肌中表达最低;FTO蛋白在背最长肌和脾中表达较高(P〈0.01),脂肪组织中表达次之。同时结果显示,FTO mRNA在24月龄山羊背最长肌和股二头肌中表达水平显著高于1-3和8-10月龄的表达水平(P〈0.05)。FTO mRNA表达量与背最长肌IMF含量呈显著负相关(P〈0.05),与股二头肌及臂三头肌IMF含量呈不同程度的正相关。本研究指出,FTO基因表达与IMF含量存在相关性,推测可作为IMF沉积的候选基因。 | 林亚秋 廖红海 贺庆华 李倩 王永 | 2016 | 畜牧兽医学报2016，47，5： | 13 |
| 6 | 肥胖成因的解释--基于食物奖赏研究的视角显示文摘肥胖的形成和发展受生物、心理和社会因素的共同作用,其中食物奖赏对肥胖的产生有重要的作用。食物是一种自然奖赏,它指机体天生对食物的渴望和依赖。食物奖赏包括'wanting'、'liking'以及'learning&reinforcement'三个成分,每个成分由相应的神经通路表征。食物奖赏调控机体的摄食行为并以此调控体重变化。目前,关于肥胖与食物奖赏关系的理论模型主要有刺激—敏感化理论、奖赏过度理论以及奖赏不足理论。采用横断面设计、前瞻研究设计和纵向被试内重复测量设计,使用食物图片线索和直接给予美味奶昔的技术方法,人类脑成像研究从不同侧面为以上三个理论模型提供了证据。除此之外,食物奖赏还受基因的调控。目前,研究者关注较多的是多巴胺D2受体基因Taq IA rs1800497的多态性和FTO基因rs9939609的多态性对食物奖赏及体重改变的调控。 | 韩艳 舍英 高笑 | 2017 | 心理科学进展2017，25，3： | 10 |
| 7 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 8 | FTO: linking m^6A demethylation to adipogenesis显示文摘 | Moshe Shay Ben-Haim Sharon Moshitch-Moshkovitz Gideon Rechavi | 2015 | Cell Research2015，25，1： | 8 |
| 9 | 苋菜红在掺杂氟的二氧化锡导电玻璃上的电化学降解显示文摘构建了一套可以实时监测苋菜红降解情况的设备,探讨了苋菜红在掺杂氟的二氧化锡导电玻璃上的电化学降解方法.考察了支持电解质、外加电压、溶液pH、降解时间等因素对染料去除率的影响.结果表明,控制外加电压为6 V,用含0.03 mol.L-1氯化钠为支持电解质(pH 8.0),电解苋菜红溶液(12.0 mg.L-1)10 min后,苋菜红的去除率可达到87%.同时,通过紫外可见吸收光谱仪、荧光光谱仪、总有机碳测定仪等初步探讨了苋菜红的降解行为,其降解符合一级反应的特性,并有部分有机碳转变成为无机碳. | 陈毅挺 黄露 林棋 | 2011 | 环境化学2011，30，11： | 8 |
| 10 | The association between common genetic variation in the FTO gene and metabolic syndrome in Han Chinese显示文摘为类型 2 糖尿病 mellitus (T2DM ) 的背景染色体宽的协会研究作为与欧洲祖先在许多人口为普通肥胖授与增加的风险的一个地点识别了 FTO 基因。然而,在肥胖或 T2DM 的 FTO 基因的参与联系了新陈代谢的特点一致地没在中国人口被建立。这研究的目的是在我们测试了的汉 Chinese.Methods 与新陈代谢的症候群(MetS ) 调查 FTO 基因多型性的协会为在 FTO 和遇见相关的特点之间的协会的 41 FTO 单个核苷酸多型性(SNP ) 。有 236 个无关的题目( 108 个案例和 128 控制)的一个总数,根据检验的 41 SNP 的国际糖尿病联盟( IDF ) criteria.Results 组织了,仅仅 SNP rs8047395 在一个后退的模型下面展出了统计意义( P=0.026 ),在为多重测试的 Bonferroni 调整以后(或 1.64 ,95% CI 1.11-2.42 ;P=0.014 ) 。在汉语与之中的这多型性的普通分布在控制组的 36% 的次要的等位基因频率(MAF ) 对 48% 为协会研究在一种相对小的样品尺寸在 MetS 组织极大地改进了我们的测试力量。以前识别的肥胖 --( 或 T2DM-) 联系 FTO SNP 用汉汉语是不太普通的并且没在这研究与 MetS 被联系。没有重要协会在我们的 FTO SNP 和 MetS.Conclusions 的任何 endophenotypes 之间被发现为 MetS 的 FTO 的更普通的授与风险的变体用汉汉语被识别。我们的学习证实了那在 FTO 地点的基因变化涉及 MetS 的致病。 | WANG Tong HUANG Yi XIAO Xin-hua WANG Duen-mei DIAO Cheng-ming ZHANG Feng XU Ling-ling ZHANG Yong-biao LI Wen-hui ZHANG Li-li ZHANG Yun SUN Xiao-fang ZHANG Qian | 2010 | Chinese Medical Journal2010，，14： | 8 |
| 11 | 脂肪量和肥胖相关基因Fto可参与调节小鼠的出生后生长显示文摘脂肪量和肥胖相关基因Fto(fat mass and obesity associated)在小鼠中很早就已经被克隆,但研究进展缓慢,直至2007年不同研究小组在人中发现该基因与肥胖有关,才逐渐引起研究人员注意。美国贝勒医学院的研究人员经过努力,发现Fto基因可通过大脑的中枢神经系统调节小鼠的出生后生长。这一研究结果发表在2010年11月的《PLoS ONE》上。 | 王志伟 | 2010 | 农业生物技术学报2010，18，6： | 8 |
| 12 | The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases显示文摘N6-methyladenosine(m6A)RNA methylation is an emerging area of epigenetics,which is a reversible and dynamic modification mediating by‘writers’(methylase,adding methyl groups,METTL3,METTL14,and WTAP),‘erasers’(demethylase,deleting methyl groups,FTO and ALKBH5),and‘readers’(YTHDF1-3,YTHDC1 and YTHDC2).Recent studies in human,animal models and cell levels have disclosed a critical role of m6A modification in regulating the homeostasis of metabolic processes and cardiovascular function.Evidence from these studies identify m6A as a candidate of biomarker and therapeutic target for metabolic abnormality and cardiovascular diseases(CVD).Comprehensive understanding of the complexity of m6A regulation in metabolic diseases and CVD will be helpful for us to understand the pathogenesis of CVD.In this review,we discuss the regulatory role of m6A in metabolic abnormality and CVD.We will emphasize the clinical relevance of m6A dysregulation in CVD. | Beijian Zhang Hao Jiang Zhen Dong Aijun Sun Junbo Ge | 2021 | Genes & Diseases2021，8，6： | 8 |
| 13 | 表面In掺杂TiO2的N719/TiO2-Inx%/FTO薄膜电极的光电转换效率显示文摘采用溶胶-凝胶法制备出In表面修饰的TiO2(TiO2-Inx%)纳米粒子,x%代表在In掺杂的TiO2样品中In3+与In3+和Ti4+离子摩尔百分含量.利用二(四丁基铵)顺式-双(异硫氰基)双(2,2-联吡啶-4,4-二羧酸)钌(II)(N719)作为敏化剂,制备出N719/TiO2/FTO(氟掺杂锡氧化物)和N719/TiO2-Inx%/FTO染料敏化薄膜电极.光电转换效率实验表明,在薄膜电极+0.5mol.L-1LiI+0.05mol.L-1I2的三甲氧基丙腈(MPN)溶液+Pt光电池体系中,N719/TiO2-Inx%/FTO薄膜电极的光电转换效率均高于N719/TiO2/FTO,其中N719/TiO2-In0.1%/FTO的光电转换效率比N719/TiO2/FTO提高了20%.利用X射线衍射(XRD)、X射线光电子能谱(XPS)、漫反射吸收光谱(DRS)、荧光(PL)光谱和表面光电流作用谱确定了TiO2-Inx%样品中In3+离子的存在方式和能带结构;利用表面光电流作用谱研究了N719/TiO2-Inx%/FTO薄膜电极的光致界面电荷转移过程.结果表明,In3+离子在TiO2表面形成O-In-Cln(n=1,2)物种,该物种的表面态能级位于导带下0.3eV处;在光电流产生过程中,O-In-Cln(n=1,2)表面态能级有效地抑制了光生载流子在TiO2-Inx%层的复合,促进了阳极光电流的增加,从而导致N719/TiO2-Inx%/FTO薄膜电极的光电转化效率高于N719/TiO2/FTO,并进一步讨论了光致界面电荷转移的机理. | 程辉 姚江宏 曹亚安 | 2012 | 物理化学学报2012，28，11： | 6 |
| 14 | 单肥胖基因MC4R及FTO危险等位基因型分布与儿童肥胖的相关性研究显示文摘目的了解单肥胖基因MC4R常见SNP位点、FTO危险等位基因型与儿童单纯性肥胖的相关性。方法纳入伊犁地区7~13岁超重肥胖学龄儿童150例,年龄、性别匹配的202例正常体重儿童为对照组,电离飞行时间质谱(MALDI-TOF MS)法检测两组儿童的MC4R基因rsl7782313以及FTO基因危险等位基因位点rs9939609、rsl421085、rs8050136、“17817449的基因型分布,同时完善生化指标(空腹血糖、胰岛素浓度、血脂等)的检测。结果两组FTO基因rsl421085的等位基因频数差异具有统计学意义(P V0.05),“17782313、rs9939609、rsl421085、rs8050136、rsl7817449的基因型分布差异无统计学意义(P>0.05),两组rs9939609、“1421085、rs8050136、rsl7817449组成的单体型TTCT,CTCT分布差异具有统计学意义(P<0.05)o rs9939609的AA基因型较AT、TT基因型患儿的收缩压更高,腰围更大,空腹胰岛素及胰岛素抵抗因子更高。结论FTO基因单体型TTCT.CTCT与儿童肥胖相关,携带FTO基因rs9939609位点AA基因型的儿童更容易出现血压、腰围及胰岛素代谢异常。 | 李敏 张涛 徐佩茹 | 2020 | 新疆医科大学学报2020，43，1： | 6 |
| 15 | VO_2/FTO复合热致变色薄膜的制备及其光学特性显示文摘在掺氟的SnO2(FTO)导电玻璃衬底上采用直流磁控溅射的方法室温沉积纯钒金属薄膜,再在退火炉中经后退火工艺制备VO2/FTO复合热致变色薄膜,并对复合薄膜的结构及其光学特性进行研究.结果表明,导电玻璃上的FTO并没有改变VO2择优取向生长,但明显改变了VO2薄膜的表面形貌特征.与相同工艺条件下在玻璃衬底上制备的VO2薄膜相比,VO2/FTO复合薄膜的相变温度降低约18℃,热滞回线温宽收窄约4℃,相变前后的红外透过率分别约为42%和21%.说明复合薄膜既可明显降低相变温度和热滞宽度,又可增强VO2薄膜的红外调控能力. | 王锋 李毅 丁杰 佟国香 覃源 严梦 梁倩 方宝英 王晓华 陈少娟 陈建坤 郑鸿柱 袁文瑞 | 2014 | 红外与毫米波学报2014，33，2： | 5 |
| 16 | Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders显示文摘The goal this review is to clarify the effects of the fat mass and obesity-associated protein (FTO) in lipid metabolism regulation and related underlying mechanisms through the FTO-mediated demethylation of m6A modification. FTO catalyzes the demethylation of m6A to alter the processing, maturation and translation of the mRNAs of lipid-related genes. FTO overexpression in the liver promotes lipogenesis and lipid droplet (LD) enlargement and suppresses CPT-1–mediated fatty acid oxidation via the SREBP1c pathway, promoting excessive lipid storage and nonalcoholic fatty liver diseases (NAFLD). FTO enhances preadipocyte differentiation through the C/EBPβ pathway, and facilitates adipogenesis and fat deposition by altering the alternative splicing of RUNX1T1, the expression of PPARγ and ANGPTL4, and the phosphorylation of PLIN1, whereas it inhibits lipolysis by inhibiting IRX3 expression and the leptin pathway, causing the occurrence and development of obesity. Suppression of the PPARβ/δ and AMPK pathways by FTO-mediated m6A demethylation damages lipid utilization in skeletal muscles, leading to the occurrence of diabetic hyperlipidemia. m6A demethylation by FTO inhibits macrophage lipid influx by downregulating PPARγ protein expression and accelerates cholesterol efflux by phosphorylating AMPK, thereby impeding foam cell formation and atherosclerosis development. In summary, FTO-mediated m6A demethylation modulates the expression of lipid-related genes to regulate lipid metabolism and lipid disorder diseases. | Zhou Yang Guang-li Yu Xiao Zhu Tian-hong Peng Yun-cheng Lv | 2022 | Genes & Diseases2022，9，1： | 5 |
| 17 | NiO薄膜制备及电催化性能测试教学实验设计显示文摘该文针对目前含尿素废水高温水解处理的成本和能耗问题,进行了NiO薄膜制备及电催化分解尿素的综合性教学实验设计。通过控制条件采用水热法,在导电玻璃FTO基底上生长了多孔道网络微结构NiO薄膜,研究了水热时间、煅烧温度、添加表面活性剂等制备条件对NiO薄膜电催化分解尿素性能的影响。对NiO薄膜进行XRD、XPS、SEM、TEM等组成、形貌表征,以及CV、LSV、Tafel曲线、EIS等电化学测试,结果表明:在最优水热12 h,300℃煅烧,添加结构导向剂EDTA条件下,制备的NiO薄膜电极与现有文献报道的镍泡沫电极材料相比,尿素电催化分解起始电位由0.60 V降低为0.36 V。 | 赵增迎 童彬彬 张秀丽 刘煊赫 | 2021 | 实验技术与管理2021，38，1： | 5 |
| 18 | The m^(6)A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG显示文摘N^(6)-methyladenosine(m^(6)A)is the most abundant posttranscriptional methylation modification that occurs in mRNA and modulates the fine-tuning of various biological processes in mammalian development and human diseases.In this study we investigated the role of m^(6)A modification in the osteogenesis of mesenchymal stem cells(MSCs),and the possible mechanisms by which m^(6)A modification regulated the processes of osteoporosis and bone necrosis.We performed systematic analysis of the differential gene signatures in patients with osteoporosis and bone necrosis and conducted m^(6)A-RNA immunoprecipitation(m^(6)A-RIP)sequencing to identify the potential regulatory genes involved in osteogenesis.We showed that fat mass and obesity(FTO),a primary m^(6)A demethylase,was significantly downregulated in patients with osteoporosis and osteonecrosis.During the differentiation of human MSCs into osteoblasts,FTO was markedly upregulated.Both depletion of FTO and application of the FTO inhibitor FB23 or FB23-2 impaired osteogenic differentiation of human MSCs.Knockout of FTO in mice resulted in decreased bone mineral density and impaired bone formation.PPARG,a biomarker for osteoporosis,was identified as a critical downstream target of FTO.We further revealed that FTO mediated m^(6)A demethylation in the 3’UTR of PPARG mRNA,and reduced PPARG mRNA stability in an YTHDF1-dependent manner.Overexpression of PPARG alleviated FTO-mediated osteogenic differentiation of MSCs,whereas knockdown of PPARG promoted FTO-induced expression of the osteoblast biomarkers ALPL and OPN during osteogenic differentiation.Taken together,this study demonstrates the functional significance of the FTO-PPARG axis in promoting the osteogenesis of human MSCs and sheds light on the role of m^(6)A modification in mediating osteoporosis and osteonecrosis. | Liu-shan Chen Meng Zhang Peng Chen Xiao-feng Xiong Pei-qing Liu Hai-bin Wang Jun-jian Wang Juan Shen | 2022 | Acta Pharmacologica Sinica2022，43，5： | 5 |
| 19 | FTO介导RNA的m6A修饰与发育的研究进展显示文摘人类脂肪和肥胖相关蛋白FTO作为第一个被确证的N6⁃甲基腺苷(m6A)去甲基化酶,证明了RNA修饰存在可逆性,同时也揭开了m6A修饰的研究序幕。越来越多的学者试着从m6A修饰角度探讨基因表达调控的具体机制。m6A修饰功能需要甲基化酶、去甲基化酶、结合蛋白的共同参与完成。FTO可催化mRNA上m6A修饰的去甲基化,且在人体组织中广泛表达并参与调控多种生物学过程。本文综述去甲基化酶FTO及其介导的m6A/RNA修饰与体脂发育、胚胎发育、大脑发育、神经发育的关系,以期能够深入了解FTO的功能以及作用机制。 | 潘明敏 王启阳 杨丽萍 | 2022 | 基础医学与临床2022，42，10： | 4 |
| 20 | Mixed-cation perovskite solar cells in space显示文摘The metal halide perovskite materials demonstrate outstanding performance in photovoltaics because of their excellent optoelectronic properties (1-7)The perovskite solar cells (PSCs) exhibiting outstanding efficiency [8,9], high power-per-weight [10], and excellent radiation resistance[11-13] are considered to be promising for developing the new-generation energy technology for space application. | YongGuang Tu GuoNing Xu XiaoYu Yang YiFei Zhang ZhaoJie Li Rui Su DeYing Luo WenQiang Yang Ying Miao Rong Cai LuHua Jiang XiaoWei Du YanChu Yang QianShi Liu Yang Gao Shuai Zhao Wei Huang QiHuang Gong Rui Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 4 |
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