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| 1 | Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer显示文摘AIM:To explore the association between AT-rich interactive domain 1A(ARID1A)protein loss by immunohistochemistry and both clinicopathologic characteristics and prognosis in patients with colorectal cancer.METHODS:We retrospectively collected clinicopathologic data and archived paraffin-embedded primary colorectal cancer samples from 209 patients,including 111patients with colon cancer and 98 patients with rectal cancer.The tumor stage ranged from stageⅠto stageⅣaccording to the 7th edition of the American Joint Committee on Cancer tumor-node-metastasis(TNM)staging system.All patients underwent resection of primary colorectal tumors.The expression of ARID1A protein in primary colorectal cancer tissues was examined by immunohistochemical staining.The clinicopathologic association and survival relevance of ARID1A protein loss in colorectal cancer were analyzed.RESULTS:ARID1A loss by immunohistochemistry was not rare in primary colorectal cancer tumors(25.8%).There were 7.4%,24.1%,22.2%and 46.3%of patients with ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively,compared with 20.0%,22.6%,27.7%and 29.7%of patients without ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively.In patients with ARID1A loss,the distant metastasis rate was 46.3%.However,only 29.7%of patients without ARID1A loss were found to have distant metastasis.In terms of pathologic differentiation,there were 25.9%,66.7%and 7.4%with poorly,moderately and well differentiated tumors in patients with ARID1A loss,and 14.2%,72.3%and 13.5%with poorly,moderately and well differentiated tumors in patients without ARID1A loss,respectively.ARID1A loss was associated with late TNM stage(P=0.020),distant metastasis(P=0.026),and poor pathological classification(P=0.035).However,patients with positive ARID1A had worse overall survival compared to those with negative ARID1A in stageⅣcolorectal cancer(HR=2.49,95%CI:1.13-5.51).CONCLUSION:ARID1A protein loss is associated with clinicopathologic characteristics in colorectal cancer patients and with survival in stageⅣpatients. | Xiao-Li Wei De-Shen Wang Shao-Yan Xi Wen-Jing Wu Dong-Liang Chen Zhao-Lei Zeng Rui-Yu Wang Ya-Xin Huang Ying Jin Feng Wang Miao-Zhen Qiu Hui-Yan Luo Dong-Sheng Zhang Rui-Hua Xu | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | Interactive effect of minerals on complex ore flotation: A brief review显示文摘Froth flotation is the most effective industrial method used to separate fine-grained minerals. The main problem of complex ore flotation is the negative effect of interactions among minerals in slurry, leading to variation in surface properties during separation. In this review,studies on the interactive effect among minerals on the flotation of iron ores, magnesite ores, and scheelite ores are summarized, and the main problems and mechanisms that diminish the separation efficiency of minerals are revealed in detail. Recent research progress on the flotation of these ores has confirmed that mineral aggregation, coating, and dissolution, as well as other factors caused by interacting behavior, explain the depressing effects of fine particles on mineral separation. Solvable methods for these effects are further discussed. Novel flotation processes and more selective reagents are critical for further investigations on various approaches to improve the beneficiation efficiency of these ores.This review aims to provide a good reference for conducting studies related to complex ore flotation. | Wan-zhong Yin Yuan Tang | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，5： | 8 |
| 3 | A new method for spatio-temporal prediction of rainfall-induced landslide显示文摘Geological condition and rainfall are two most principal conditions inducing landslides in the Chongqing region. By analyzing the forming conditions of rainfall-induced landslides, a new method for spatio-temporal prediction of rainfall-induced landslide is brought forward on the basis of grading and overlapping geological condition and rainfall factor in this paper. At first, semi-quantitative assessment and grading for the geological condition of a certain area or slope can be carried out with the multi-factor interactive matrix. Then the severity of rainfall in that area is grading according to the maximum daily rainfall and the total rainfall in a rainfall course. Finally, the “landslide probability judgement factor” can be worked out through grading and overlapping “geological condition influenc- ing factor” and “rainfall influencing factor”, by which the landslide can be graded into 4 grades, they are landslide extremely easily happening, landslide easily happening, landslide difficultly happening and landslide hardly ever happening respectively. More accurate spatio-temporal prediction of rain- fall-induced landslides can come true on the ground of detailed geological survey of some dangerous slopes in an area and more precise weather forecast. Finally, the reliability and feasibility of carrying out the spatio-temporal prediction of rainfall-induced landslides with the method of “two factors” grading and overlapping are validated by the example of Jipazi landslide. | DING Jixin1,2, YANG Zhifa2, SHANG Yanjun2, ZHOU Shenghua1 & YIN Juntao3 1. China Non-ferrous Metals Resource Geological Survey, Beijing 100012, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Key Laboratory of Engineering Geomechanics, Beijing 100029, China 3. School of Geoscience & Environmental Engineering, Central South University, Changsha 410083, China | 2006 | Science China Earth Sciences2006，49，4： | 7 |
| 4 | IMPROVED MAN-COMPUTER INTERACTIVE CLASSIFICATION OF CLOUDS BASED ON BISPECTRAL SATELLITE IMAGERY显示文摘In this paper,improvement on man-computer interactive classification of clouds based onhispeetral satellite imagery has been synthesized by using the maximum likelihood automaticclustering(MLAC)and the unit feature space classification(UFSC)approaches.The improvedclassification not only shortens the time of sample-training in UFSC method,but also eliminatesthe inevitable shortcomings of the MLAC method.(e.g.,1.sample selecting and training isconfined only to one cloud image:2.the result of clustering is pretty sensitive to the selection ofinitial cluster center:3.the actual classification basically can not satisfy the supposition of normaldistribution required by MLAC method;4.errors in classification are difficult to be modified.)Moreover,it makes full use of the professionals’accumulated knowledge and experience of visualcloud classifications and the cloud report of ground observation,having ensured both the higheraccuracy of classification and its wide application as well. | 郁凡 刘长盛 | 1998 | Acta meteorologica Sinica1998，12，3： | 5 |
| 5 | From fluvial dynamics to eco-fluvial dynamics显示文摘Sediment plays a very important role in the functioning of river ecosystems.It is the basic substance for the survival of benthic animals and aquatic plants.On the other hand,the growth of biofilms and biodisturbance of benthos affect the sediment transport characteristics.With the increasing attention to protect aquatic ecosystems,the importance of habitats has become increasingly researched.The need to study the interactions among sediment,flow,riverbed deformation,and aquatic ecosystems naturally leads to the proposed discipline of eco-fluvial dynamics.In this paper,the basic concept and main research content of eco-fluvial dynamics is introduced with the Yarlung Tsangpo River as the research example.This case study is an example of an aquatic ecosystem in an ever-changing environment because of the effects of climate change.The results of analysis of eco-fluvial dynamics will provide a scientific basis for decision support for the government. | Guojian He Hongwei Fang Jianyu Wang Tao Zhang | 2019 | International Journal of Sediment Research2019，34，6： | 4 |
| 6 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 7 | Neurally adjusted ventilator assist in very low birth weight infants:Current status显示文摘Continuous improvements in perinatal care have resultedin increased survival of premature infants.Their immature lungs are prone to injury with mechanical ventilation and this may develop into chronic lung disease(CLD) or bronchopulmonary dysplasia.Strategies to minimize the risk of lung injury have been developed and include improved antenatal management(education,regionalization,steroids,and antibiotics),exogenous surfactant administration and reduction of barotrauma by using exclusive or early noninvasive ventilatory support.The most frequently used mode of assisted ventilation is pressure support ventilation that may lead to patientventilator asynchrony that is associated with poor outcome.Ventilator-induced diaphragmatic dysfunction or disuse atrophy of diaphragm fibers may also occur.This has led to the development of new ventilation modes including neurally adjusted ventilatory assist(NAVA).This ventilation mode is controlled by electrodes embedded within a nasogastric catheter which detect the electrical diaphragmatic activity(Edi) and transmit it to trigger the ventilator in synchrony with the patient's own respiratory efforts.This permits the patient to control peak inspiratory pressure,mean airway pressure and tidal volume.Back up pressure control(PC) is provided when there is no Edi signal and no pneumatic trigger.Compared with standard conventional ventilation,NAVA improves blood gas regulation with lower peak inspiratory pressure and oxygen requirements in preterm infants.NAVA is safe mode of ventilation.The majority of studies have shown no significant adverse events in neonates ventilated with NAVA nor a difference in the rate of intraventricular hemorrhage,pneumothorax,or necrotizing enterocolitis when compared to conventional ventilation.Future large size randomized controlled trials should be established to compare NAVA with volume targeted and pressure controlled ventilation in newborns with mature respiratory drive.Most previous studies and trials were not sufficiently large and did not include longterm patient oriented outcomes.Multicenter,randomized,outcome trials are needed to determine whether NAVA is effective in avoiding intubation,facilitating extubation,decreasing time of ventilation,reducing the incidence ofCLD,decreasing length of stay,and improving long-term outcomes such as the duration of ventilation,length of hospital stay,rate of pneumothorax,CLD and other major complications of prematurity.In order to prevent barotrauma,next generations of NAVA equipment for neonatal use should enable automatic setting of ventilator parameters in the backup PC mode based on the values generated by NAVA.They should also include an upper limit to the inspiratory time as in conventional ventilation.The manufacturers of Edi catheters should produce smaller sizes available for extreme low birth weight infants.Newly developed ventilators should also include leak compensation and high frequency ventilation.A peripheral flow sensor is also essential to the proper delivery of all modes of conventional ventilation as well as NAVA. | Hassib Narchi Fares Chedid | 2015 | World Journal of Methodology2015，5，2： | 4 |
| 8 | Modeling of UAV path planning based on IMM under POMDP framework显示文摘In order to enhance the capability of tracking targets autonomously of unmanned aerial vehicle (UAV), the partially observable Markov decision process (POMDP) model for UAV path planning is established based on the POMDP framework. The elements of the POMDP model are analyzed and described. The state transfer law in the model can be described by the method of interactive multiple model (IMM) due to the diversity of the target motion law, which is used to switch the motion model to accommodate target maneuvers, and hence improving the tracking accuracy. The simulation results show that the model can achieve efficient planning for the UAV route, and effective tracking for the target. Furthermore, the path planned by this model is more reasonable and efficient than that by using the single state transition law. | YANG Qiming ZHANG Jiandong SHI Guoqing | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 4 |
| 9 | Future vehicles:interactive wheeled robots显示文摘Owing to the lack of variety of interactions in automatic driving,the interactive cognition and evolution growth of self-driving vehicles in uncertain and complex environments have been proposed,making future vehicles interactive wheeled robots. | Nan MA Deyi LI Wen HE Yue DENG Jiahong LI Yue GAO Hong BAO Huan ZHANG Xinkai XU Yuansheng LIU Zhixuan WU Li CHEN | 2021 | Science China(Information Sciences)2021，64，5： | 4 |
| 10 | LOCAL FLEXIBILITY BEHAVIOR OF TUBULAR JOINTS AND ITS EFFECT ON GLOBAL ANALYSIS OF TUBULAR STRUCTURES显示文摘In the tubular frames with simple joints, the joints may show considerable local flexibility, which causes excessive deformation and affects internal force distributions. It is useful and important to study turbular joint flexibility as well as the effect of joint local flexibility on the global behavior of tubular structure for the design and building of offshore platforms. A new method for computing the stiffness coefficients of simple tubular joints is developed in this paper based on two previous computing models. According to this method, the local flexibility of T, Y, TY tubular joints are computed. This method has merits of clear physical sense, simplicity of computations and less c. p. u. time. The effect of flexibility of tubular joints on the global behavior of framed tubular structures is investigated by comparing the computed results of tubular structures with flexible tubular joints with those with rigid connections. The comparison shows that the consideration of local flexibility of tubular joints and its effect on the stress analysis of offshore structures has its practical significance. | Yang, Lixian Chen, Tieyun Wu, Shuiyun | 1990 | China Ocean Engineering1990，5，4： | 3 |
| 11 | A Study on Modular Fixture Design with Intelligent Selection of Elements and Interactive Assembly显示文摘AStudyonModularFixtureDesignwithIntelligentSelectionofElementsandInteractiveAssemblyLIUWenjian;HUANGYongqiang;CHANGWei(刘文剑),(... | 刘文剑 黄永强 常伟 | 1996 | Journal of Harbin Institute of Technology(New Series)1996，3，4： | 3 |
| 12 | 信息图的前世今生显示文摘信息图又称信息图形,是指数据、信息或知识的可视化表现形式,其能把内容复杂的信息通过图形清晰地表现出来。信息图的沿革就全世界范围而言,信息图或信息图形设计早已有之,它并不是信息时代的诞生物。信息图的雏形可以追溯到十八世纪,比如William Playfair在1781年发表的苏格兰进出口情况柱形图表。1虽然该表形式简单, | 自国天然 冯岚 | 2015 | 青年记者2015，，29： | 3 |
| 13 | A KIND OF FUZZY MULTI-OBJECTIVE LINEAR PROGRAMMING PSOBLEMS BASED ON INTER VALVALUED FUZZY SETS显示文摘This paper presents a general solution procedure and an interactive fuzzy satisfying method for a kind of fuzzy multi-objective linear programming-problems based on interval valued fuzzy sets. Firstly, a fuzzy set of the fuzzy solutions, which can be focused on providing complete information for the final decision, can be obtained by the proposed tolerance analysis of a non-dominated set. Secondly, the satisfying solution for the decisionmaker can be derived from Pareto optimal solutions by updating the current reference membership levels on the basis of the current levels of the membership functions together with the trade-off rates between the membership functions. | XU Jiuping (Department of Applied Mathematics, Sichuan University, Chengdu 610065, China) | 2001 | Journal of Systems Science & Complexity2001，14，2： | 2 |
| 14 | ARX中复杂实体的Jig实现实例显示文摘结合锥度标注的互动创建实例分析了在ARX中复杂实体的Jig特性实现的原理,包括定制复杂实体及其Jig实现,并给出主要代码。 | 张静 齐学义 郜立焕 侯炜华 马希金 | 2004 | 机械设计与制造2004，，5： | 2 |
| 15 | 因素交互影响分析法在优化体育院系教学计划中的应用初探显示文摘 | | 1999 | 浙江体育科学1999，21，4： | 2 |
| 16 | NUMERICAL SIMULATION ANALYSIS FOR MIGRATION-ACCUMULATION OF OIL AND WATER显示文摘IntroductionThenumericalsimulationoftheevolutionaryhistoryofthebasinisconductedacordingtothemechanismofpetroleumgeologyandmec... | 袁益让 赵卫东 程爱杰 韩玉笈 | 1999 | Applied Mathematics and Mechanics(English Edition)1999，20，4： | 2 |
| 17 | 多媒体交互时代的高等摄影教育创新显示文摘一、多媒体交互
多媒体交互(interactive multimedia)是在传统媒体的基础上加入了交互功能,通过交互行为并以多种感官来呈现信息,受众不仅可以看得到、听得到,还可以触摸到、感觉到、闻到,并且可以与之相互作用。它带给人们全新的体验,是一种崭新的媒介形式。 | 严昊 | 2014 | 画刊·学校艺术教育2014，0，10： | 1 |
| 18 | Three-dimensional reconstructed magnetic resonance scans:Accuracy in identifying and defining knee meniscal tears显示文摘AIM To determine whether three-dimensional(3D) reconstruction from conventional magnetic resonance imaging(MRI) is able to accurately detect a meniscal tear, and define the configuration.METHODS Thirty-three patients' 3T MRI scan data were collected and sagittal uni-planar 3D reconstructions performed from the preoperative MRI. There were 24 meniscal tears in 24 patients, and nine controls. All patients had arthroscopic corroboration of MRI findings. Two independent observers prospectively reported on all 33 reconstructions. Meniscal tear presence or absence was noted, and tear configuration subsequently categorised as either radial, bucket-handle, parrot beak, horizontal or complex.RESULTS Identification of control menisci or meniscal tear presence was excellent(Accuracy: observer 1 = 90.9%; observer 2 = 81.8%). Of the tear configurations, bucket handle tears were accurately identified(Accuracy observer 1 and 2 = 80%). The remaining tear configurations were notaccurately discernable.CONCLUSION Uni-planar 3D reconstruction from 3T MRI knee scan sequences are useful in identifying normal menisci and menisci with bucket-handle tears. Advances in MRI sequencing and reconstruction software are awaited for accurate identification of the remaining meniscal tear configurations. | Neil Kruger Eugene Mc Nally Sami Al-Ali Raj Rout Jonathan L Rees Andrew J Price | 2016 | World Journal of Orthopedics2016，7，11： | 1 |
| 19 | 互动教学在高校英语教学中的作用显示文摘在高校英语教学过程中,采取科学、有效的课堂互动策略,充分调动起学生的学习积极性和主动性,使学生真正成为教学主体,使各教学要素充分互动起来,树立并加强学生的成就动机,是当前英语教师的课堂重点,也是破解这一难题的根本所在。通过对英语教学互动性的研究,探讨实现教学目标,培养高素质人才的方法。 | 邹宇 | 2012 | 校园英语2012，，21： | 1 |
| 20 | Interactive platform for peer review:A proposal to improve the current peer review system显示文摘Peer review is the cornerstone in scientific publication.Although peer review has paramount importance in ensuring the quality of the published literature,it still has a number of shortcomings.The present manuscript proposes a new method to improve the current peer review system by providing an interactive,dynamic platform that allows direct,anonymous interaction between the authors of submitted manuscripts and the reviewers.Such real-time interaction may help eliminate any problems related to misunderstanding or misinterpretation of the reviewer’s comments or the authors’response,and would save time while keeping the identity of both parties anonymous. | Sameh Hany Emile | 2021 | World Journal of Clinical Cases2021，9，6： | 1 |
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