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| 1 | Apoptosis induced by norcantharidin in human tumor cells显示文摘INTRODUCTIONThe antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin,wasstudied in the early 1980s in China.NCTD has noside effects on urinary organs which cantharidin hasshown and is easier to synthesize,and it can inhibitthe proliferation of several tumor cell lines as wellas transplanted tumors.Clinical trials with NCTD asa monotherapeutic agent indicated that NCTD hadbeneficial effects in patients with different kinds | Zhen Xiao Sun Qing Wen Ma Tian De Zhao Yu Lin Wei Guang Sheng Wang Jia Shi Li | 2000 | World Journal of Gastroenterology2000，6，2： | 31 |
| 2 | Potential roles of longan flower and seed extracts for anticancer显示文摘Polyphenol-rich plants are known to possess benefits to human health. Recent studies have revealed that many Traditional Chinese Medicines(TCMs) are rich sources of polyphenols and exhibit antioxidant and anti-inflammatory activities, and these TCMs have been shown experimentally to overcome some chronic diseases, including cancer. Longan flowers and seeds, two TCMs traditionally used for relieving pain and urinary diseases, have been revealed in our recent reports and other studies to possess rich amounts of polyphenolic species and exhibit strong anti-oxidant activity, and these could be applied for the treatment of diabetes and cancer. Herein, we review the recent findings regarding the benefits of these two TCMs in the treatment of humancancer and the possible cellular and molecular mechanisms of both substances. | Chih-Cheng Lin Yuan-Chiang Chung Chih-Ping Hsu | 2012 | World Journal of Experimental Medicine2012，2，4： | 1 |
| 3 | API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis显示文摘Lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma) is the most common extranodal B cell tumor and accounts for 8% of non-Hodgkin's lymphomas. Gastric MALT lymphoma is the best-studied example and is a prototypical neoplasm that occurs in the setting of chronic inflammation brought on by persistent infection or autoimmune disease. Cytogenetic abnormalities are commonly acquired during the course of disease and the most common is chromosomal translocation t(11;18)(q21;q21), which creates the API2-MALT1 fusion oncoprotein. t(11;18)-positive lymphomas can be clinically aggressive and have a higher rate of dissemination than t(11;18)-negative tumors. Many cancers, including MALT lymphomas, characteristically exhibit deregulated over-activation of cellular survival pathways, such as the nuclear factor-κB(NF-κB) pathway. Molecular characterization of API2-MALT1 has revealed it to be a potent activator of NF-κB, which is required for API2-MALT1-induced cellular transformation, however the mechanisms by which API2-MALT1 exerts these effects are only recently becoming apparent. The API2 moiety of the fusion binds tumor necrosis factor(TNF) receptor associated factor(TRAF) 2 and receptor interacting protein 1(RIP1), two proteins essential for TNF receptor induced NF-κB activation. By effectively mimicking ligand-bound TNF receptor, API2-MALT1 promotes TRAF2-dependent ubiquitination of RIP1, which then acts as a scaffold for nucleating and activating the canonical NF-κB machinery. Activation occurs, in part, through MALT1 moiety-dependent recruitment of TRAF6, which can directly modify NF-κB essential modulator, the principal downstream regulator of NF-κB. While theintrinsic MALT1 protease catalytic activity is dispensable for this canonical NF-κB signaling, it is critical for noncanonical NF-κB activation. In this regard, API2-MALT1 recognizes NF-κB inducing kinase(NIK), the essential upstream regulator of non-canonical NF-κB, and cleaves it to generate a stable, constitutively active fragment. Thus, API2-MALT1 harnesses multiple unique pathways to achieve deregulated NF-κB activation. Emerging data from our group and others have also detailed additional gain-of-function activities of API2-MALT1 that extend beyond NF-κB activation. Specifically, API2-MALT1 recruits and subverts multiple other signaling factors, including LIM domain and actin-binding protein 1(LIMA1) and Smac/DIABLO. Like NIK, LIMA1 represents a unique substrate for API2-MALT1 protease activity, but unlike NIK, its cleavage sets in motion a major NF-κB-independent pathway for promoting oncogenesis. In this review, we highlight the most recent results characterizing these unique and diverse gain-of-function activities of API2-MALT1 and how they contribute to lymphomagenesis. | Shaun Rosebeck Megan S Lim Kojo SJ Elenitoba-Johnson Linda MMcAllister-Lucas Peter C Lucas | 2016 | World Journal of Biological Chemistry2016，7，1： | 1 |
| 4 | 麻黄果实总黄酮含量的光学分析显示文摘近年来我们对麻黄果实进行了较为全面的研究,结果表明该果实具有抗凝血、降血压等作用。为此我们采用以芦丁为标准,用分光光度法对其总黄酮类物质含量进行了测定。 | 王书华 邓立宏 | 2000 | 神经药理学报2000，，1： | 0 |
| 5 | Molecular mechanisms of leukemia-associated proteindegradation显示文摘Chemical biology,using small molecules as probes to study the cellular signaling network,has developed rapidly in recent years.The interaction between chemistry and biology not only provides new insight into the understanding of cellular activities,but also generates new lead compounds for the treatment of diseases.Transcription factors and kinases such as retinoic acid receptor-alpha(RARα),acute myeloid leukemia 1(AML1),CAAT/enhancer-binding proteinα(C/EBPα),c-myc,and c-abl play important roles in the differentiation of hematopoietic stem/progenitor cells.Abnormalities in these proteins may cause the dysregulation of hematopoi-esis and even the occurrence of leukemia.Ubiquitin-mediated protein degradation represents a critical mechan-ism in regulating the cellular levels and functions of these proteins.Thus,targeting protein degradation has been emerging as an important strategy to conquer malignant diseases.In this review,we will summarize the recent advances in the understanding of the roles of protein degradation in leukemia,with an emphasis on the mechanisms revealed by small molecules. | Ying-Li WU Hu-Chen ZHOU Guo-Qiang CHEN | 2010 | Frontiers of Medicine2010，4，4： | 0 |
| 6 | IMMUNOCYTOCHEMICAL ANALYSIS OF ras RELATED PROTEINS WITH ANTISERUM AGAINST PEPTIDE FRAGMENT OF ras ONCOPROTEIN P21 (56—66) IN HUMAN CANCER TISSUES显示文摘The c-ras and its product P21 have been shown to play an important role in the initiation and development of some malignancies. The activation of c-ras may be associated with two mechanisms: (ⅰ) a point mutation of the codon at position 12 or 61 of the genome leading to a single amino acid alteration in the corresponding product P21; (ⅱ) enhanced expression of ras family encode proteins with | 张红 陈韵能 钮经义 李士谔 林原 刘彤华 | 1989 | Chinese Science Bulletin1989，34，12： | 0 |
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