Apoptosis induced by norcantharidin in human tumor cells

查看全文 作　　者：Zhen Xiao [1]Sun;Qing Wen [1]Ma;Tian De [2]Zhao;Yu Lin [2]Wei;Guang Sheng [3]Wang;Jia Shi [4]Li 机构地区：[1]Liaocheng Teachers University,Liaocheng 252059,Shandong Province,China;[2]China-Japan Friendship Institute of Clinical Medical Sciences,Beijing 100029,China;[3]Institute of Pharmacy,Beijing Fourth Pharmaceutical Factory,Beijing 100081,China;[4]Beijing University of Traditional Chinese Madicine,Beijing 100029,China 出　　处：《World Journal of Gastroenterology》索引2000年第6卷第2期,共3页 基　　金：the Educational Committee of Shandong Province 摘　　要：INTRODUCTIONThe antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin,wasstudied in the early 1980s in China.NCTD has noside effects on urinary organs which cantharidin hasshown and is easier to synthesize,and it can inhibitthe proliferation of several tumor cell lines as wellas transplanted tumors.Clinical trials with NCTD asa monotherapeutic agent indicated that NCTD hadbeneficial effects in patients with different kinds 关 键 词：NORCANTHARIDIN ONCOPROTEIN Bcl-2 APOPTOSIS liver NEOPLASMS IMMUNOHISTOCHEMISTRY Western BLOT analysis